Laryngopharyngeal Reflux clinical trials
The registry lists 56 studies for Laryngopharyngeal Reflux across more than 10 countries. 8 are recruiting or about to start. 43 of them are mainly about Laryngopharyngeal Reflux (how this is decided). Per ClinicalTrials.gov, last updated 2026-09-10. Counting its narrower condition Respiratory Aspiration of Gastric Contents too: 83 studies, 14 open.
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Who runs them
University Hospital Ostrava (6) · University of California, San Diego (3) · Northwestern University (2) · Medical College of Wisconsin (2) · Takeda (2) · Nutricia Research (2) · Kazakh Medical University of Continuing Education (2) · Loma Linda University (1)
What is being tested here
Drugs under test in Laryngopharyngeal Reflux studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Fosamprenavir | 1 | 0 | 1 |
| Omeprazole | 0 | 0 | 4 |
| Dexlansoprazole | 0 | 1 | 4 |
| Lansoprazole | 0 | 0 | 3 |
| Esomeprazole | 0 | 0 | 2 |
| Lidocaine | 0 | 0 | 1 |
| Alginates | 0 | 1 | 1 |
| Rabeprazole | 0 | 1 | 1 |
| Ranitidine | 0 | 0 | 1 |
| Pantoprazole | 0 | 0 | 1 |
Drug classes tested here Proton pump inhibitors (PPIs) 14
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The study
- Jul 2027Fosamprenavir for Laryngopharyngeal Upper Airway Tissue Treatment and Enzyme Reduction · Medical College of Wisconsin
Who these studies take
Of the 5 Laryngopharyngeal Reflux studies recruiting now, 1 (20%) set no upper age limit and 2 (40%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 5 (100%) | 5 (100%) |
| 30 | 5 (100%) | 5 (100%) |
| 40 | 5 (100%) | 5 (100%) |
| 50 | 5 (100%) | 5 (100%) |
| 65 | 4 (80%) | 4 (80%) |
| 75 | 3 (60%) | 3 (60%) |
| 85 | 2 (40%) | 2 (40%) |
Across all 56 studies, recruiting or not: 41% stop at 75 or younger and 30% at 65; 20% take children; 0% are for women only and 0% for men only; 30% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Laryngopharyngeal Reflux studies take
Of 14 interventional studies with no phase under Laryngopharyngeal Reflux, half reached primary completion within 23 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 23 mo22–41 · 14 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 56. Browse all 56 → or search them.
- Fosamprenavir for Laryngopharyngeal Upper Airway Tissue Treatment and Enzyme ReductionRecruitingNCT04383262Phase 21 country
- The Johns Hopkins Heartburn Center RegistryEnrolling by invitationNCT038537721 country
- New Topical tReatment Options for Symptomatic patiEnts With Nonerosive gastroesophageaL Reflux dIsease (The RELIEF Trial)RecruitingNCT07624383Not applicable1 country
- Comparative Effectiveness of Alginate, Magaldrate, Sucralfate, Proton Pump Inhibitors, and Diet in Laryngopharyngeal Reflux DiseaseNot yet recruitingNCT07611162Phase 41 country
- Comprehensive Analysis of the Swallowing Mechanism Using High-resolution Manometry With ImpedanceNot yet recruitingNCT07365046Not applicable1 country
- The Mechanism Versus PPI TrialRecruitingNCT06999577Phase 41 country
- Clinical Study of Jinsang Liyan Capsules Combined With PPI in the Treatment of LPRDRecruitingNCT05879029Phase 41 country
- Individualized Diagnosis and Treatment of Extraesophageal Reflux in Patients With Chronic CoughRecruitingNCT04984304Not applicable1 country
- Registry of Outcomes From AntiReflux SurgeryCompletedNCT029233621 country
- Effect of Topical Anesthesia on the Phonation Process During High-Speed Digital Imaging Laryngoscopy in Patients With Laryngopharyngeal RefluxCompletedNCT07696429Not applicable1 country
- Benefit of Pharyngeal and Oesophageal pH-impedance of Patients With High Suspicion of Laryngopharyngeal RefluxCompletedNCT01854970Not applicable1 country
- Reflux Band in Laryngopharyngeal RefluxActive, not recruitingNCT04827355Not applicable1 country
- Application of Diaphragmatic Breathing in Patients With Disorders of Gut-brain InteractionCompletedNCT06205446Not applicable1 country
- Transition to Infant Formula Feeding on Gastrointestinal Regurgitation (TIGER) StudyCompletedNCT05363553Not applicable1 country
- Transoral Incisionless Fundoplication (TIF) for Laryngopharyngeal Reflux (LPR) PatientsWithdrawnNCT055795871 country
- Positive Predictive Value of the Dx-pH Probe for Predicting PPI Response in LPRCompletedNCT017552211 country
- One-stop-shop Endoscopy in Reflux-patients: Evaluation of ENT and GI FeaturesCompletedNCT056341871 country
- To Assess the Safety and Tolerance of Infant Formula With Locust Bean Gum in Infants With RegurgitationCompletedNCT04042454Not applicable3 countries
- The Efficacy of Potassium-competitive Acid Blocker in Patients With Laryngopharyngeal Reflux DiseaseCompletedNCT05871398Phase 31 country
- Method of Early Diagnosis of Laryngopharyngeal RefluxCompletedNCT04771221Not applicable1 country
- Extraesophageal Reflux - Feasibility of Measurement of Pepsin in Saliva as a Diagnostic OptionCompletedNCT03904758Not applicable1 country
- Prevalence of Pharyngolaryngeal Reflux in Patients Treated for Obstructive Sleep Apnea SyndromeCompletedNCT05110352Not applicable1 country
- LPR Fluorescence PilotStatus unknownNCT052043031 country
- Laryngopharyngeal Reflux Before and After Cricopharyngeal MyotomyCompletedNCT01880892Not applicable1 country
- Kazakh Version of Reflux Symptom IndexCompletedNCT052966551 country
- Evaluation of the Tolerance and Safety of a New Partly Fermented Anti-regurgitation Infant FormulaCompletedNCT03371615Not applicable1 country
- Precision Approach to PPI Therapy in Gastroesophageal Reflux DiseaseCompletedNCT03619811Not applicable1 country
- Omeprazole 20 mg in Patients With Laryngopharyngeal reflux and Comorbid Chronic RhinosinusitisCompletedNCT03086070Phase 4
- CDx Biopsies for Detection of Laryngopharyngeal Reflux and Laryngeal LesionsWithdrawnNCT03214835Not applicable
- Efficacy of Reza Band for the Treatment of Laryngopharyngeal RefluxWithdrawnNCT03463395Not applicable1 country
- Assessing the Impacts of a UESAD on Laryngeal Symptoms and Salivary PepsinCompletedNCT02552966Not applicable
- The Effects of Dexlansoprazole for the Treatment of Throat-Related RefluxTerminatedNCT01317472Not applicable1 country
- Efficacy of Esomeprazole for Non-Allergic Rhinitis: A Double-blind, Placebo Controlled TrialCompletedNCT00745849Not applicable1 country
- Anti-reflux Control to Decrease Post Tonsillectomy PainTerminatedNCT01777854Phase 41 country
- Comparison of Voice Therapy and Antireflex Therapy in LPRWithdrawnNCT02530879Phase 41 country
- Effect of CPAP Therapy on LPR Among Patients With OSASStatus unknownNCT03455803
- Screening for Barrett's Esophagus in Otolaryngology PatientsCompletedNCT00695227Not applicable1 country
- Twice Daily Prevacid for the Treatment of Laryngopharyngeal RefluxCompletedNCT00864396Phase 11 country
- The Study of Eustachian Tube Dysfunction and Laryngopharyngeal RefluxWithdrawnNCT02123498Phase 41 country
- The Diagnostics of Extraesophageal Reflux With the Restech SystemCompletedNCT01819454Not applicable1 country
- Trial of Proton Pump Inhibitor With Prokinetics or Placebo in Patients With Laryngopharyngeal Reflux DiseaseStatus unknownNCT02533349Phase 31 country
- Treatment of Extraesophageal Reflux With the Reza Band UES Assist DeviceCompletedNCT01857713Not applicable1 country
- Efficacy and Safety of Alginos Oral Suspension to Treat Laryngopharyngeal RefluxCompletedNCT01450748Phase 31 country
- Hypoallergenic Infant Formula Containing Starch and the Probiotic: Effect on Gastric EmptyingCompletedNCT01956682Phase 41 country
- Three Methods Used in the Diagnosis of EER in Children With OMECompletedNCT02183961Not applicable1 country
- Suitable Method for Routine Diagnostics of EER in Children With Otitis Media With EffusionCompletedNCT02183974Not applicable1 country
- Study of an Oropharyngeal Aerosolized pH Probe for Diagnosing Laryngopharyngeal Reflux (LPR)CompletedNCT003215031 country
- Predictive Value of Subjective and Objective Measurement Tools for Extraesophageal RefluxStatus unknownNCT01829074
- Safety and Efficacy of Lansoprazole 30mg Twice Daily in Treatment of Laryngitis Associated With Gastroesophageal RefluxTerminatedNCT00369265Phase 41 country
- A New Nasopharyngeal pH Probe for Diagnosis of Laryngopharyngeal RefluxWithdrawnNCT01308502Phase 41 country