Intracranial Hypertension clinical trials
The registry lists 165 studies for Intracranial Hypertension across more than 10 countries. 36 are recruiting or about to start. 90 of them are mainly about Intracranial Hypertension (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its narrower condition Pseudotumor Cerebri too: 209 studies, 53 open.
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Who runs them
HeadSense Medical (5) · Assiut University (4) · Duke University (3) · Capital Medical University (3) · Rigshospitalet, Denmark (3) · University Hospital, Montpellier (3) · Konya City Hospital (2) · University Hospital, Grenoble (2)
What is being tested here
Drugs under test in Intracranial Hypertension studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Mannitol | 1 | 2 | 5 |
| Sodium Lactate | 1 | 3 | 4 |
| Bupivacaine | 0 | 0 | 1 |
| Azd-4017 | 0 | 0 | 1 |
| Acetazolamide | 0 | 0 | 1 |
| FS 069 | 0 | 0 | 1 |
| Ketamine | 0 | 0 | 1 |
| Propofol | 0 | 0 | 1 |
| Cisatracurium | 0 | 0 | 1 |
| Dexmedetomidine | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Posterior Fossa Intracranial Pressure (ICP) Measurement: Clinical Study · University of Valencia
- Nov 2026Ocular Characteristics in Patients With Craniosynostosis · Centre Hospitalier Universitaire, Amiens
- Nov 2026Intracranial PrEssure Time dOse (ImPETO) · University of Milano Bicocca
- Dec 2026Non-invasive Intracranial Pressure Monitoring in Brain Tumor Patients · Tanta University
- Dec 2026TCD and ONSD for Noninvasive Assessment of Increased ICP in TBI · Ain Shams University
- Jan 2027Non-Invasive Triage for Intracranial Hypertension in Prehospital Care · Juliana Caldas
- Feb 2027Assessment of Optic Sheat Diameter (ONSD) and Eyeball Transverse Diameter (ETD) Ratio Measurement From Ocular Ultrasound · Gaziantep City Hospital
- Apr 2027Low Pneumoperitoneum Pressure for Delirium Prevention in Elderly Laparoscopy · Benha University
- May 2027Effects of Extracorporeal Circulation Techniques on Cerebral Perfusion in CABG Surgery · Kartal Kosuyolu High Speciality Training and Research Hospital
- Jun 2027Effectiveness of Surgical Procedures for Acute Cranial Expansion in Traumatic Brain Injury · Meditech Foundation
Who these studies take
Of the 23 Intracranial Hypertension studies recruiting now, 11 (48%) set no upper age limit and 5 (22%) stop at 75 or younger. 3 (13%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 5 (22%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (13%) | 3 (13%) |
| 18 | 22 (96%) | 22 (96%) |
| 30 | 21 (91%) | 21 (91%) |
| 40 | 21 (91%) | 21 (91%) |
| 50 | 21 (91%) | 21 (91%) |
| 65 | 21 (91%) | 21 (91%) |
| 75 | 19 (83%) | 19 (83%) |
| 85 | 13 (57%) | 13 (57%) |
Across all 165 studies, recruiting or not: 35% stop at 75 or younger and 24% at 65; 21% take children; 4% are for women only and 2% for men only; 18% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Intracranial Hypertension studies take
Of 44 observational studies under Intracranial Hypertension, half reached primary completion within 31 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 18 mo6–39 · 38 studies | — | 15 mo6–39 · 37 studies |
| Observational | 31 mo11–62 · 44 studies | — | 31 mo11–62 · 42 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Newly registered3
- Tissue Penetration of Paracetamol in Pediatric Intensive Care PatientsNov 4, 2026NCT07916831
- Low Pneumoperitoneum Pressure for Delirium Prevention in Elderly LaparoscopyOct 30, 2026NCT07906444
- Decompressive Craniectomy After Aneurysmal Subarachnoid Hemorrhage (DECIDE-SAH)Oct 14, 2026NCT07872774
Studies
Recruiting first, then most recently updated. Showing 50 of 165. Browse all 165 → or search them.
- Non-Invasive and Non-Contact Intracranial Pressure Waveform Recording Using Dynamic Video OphthalmoscopyRecruitingNCT04046523Not applicable1 country
- Assessment of Optic Sheat Diameter (ONSD) and Eyeball Transverse Diameter (ETD) Ratio Measurement From Ocular UltrasoundNot yet recruitingNCT07784361
- Low Pneumoperitoneum Pressure for Delirium Prevention in Elderly LaparoscopyRecruitingNCT07906444Not applicable1 country
- Decompressive Craniectomy After Aneurysmal Subarachnoid Hemorrhage (DECIDE-SAH)Not yet recruitingNCT078727741 country
- TCD and ONSD for Early Risk Stratification of Traumatic Brain InjuryNot yet recruitingNCT078205271 country
- Bedside Ultrasound Measurement of Optic Nerve Sheath Diameter for Detecting Raised Intracranial PressureNot yet recruitingNCT07799714
- Comparison of Hyperosmolar Agent in Reduction of Increased Intracranial Pressure in Patients With Traumatic Brain Injury Using UltrasonographyNot yet recruitingNCT07786324Not applicable1 country
- Non-Invasive Triage for Intracranial Hypertension in Prehospital CareNot yet recruitingNCT07747636Not applicable
- Effects of Extracorporeal Circulation Techniques on Cerebral Perfusion in CABG SurgeryRecruitingNCT074207381 country
- Strategies for Weaning From External Ventricular DrainageNot yet recruitingNCT07630051Not applicable1 country
- Conservative vs Interventional Management of Postsurgical CSF PseudomeningoceleRecruitingNCT07614399Not applicable1 country
- External Lumbar Drainage to Reduce ICP in Severe TBI: a Phase 1 Clinical TrialRecruitingNCT05889650Not applicable1 country
- Posterior Fossa Intracranial Pressure (ICP) Measurement: Clinical StudyRecruitingNCT046752161 country
- Study SOLACE SEPSISRecruitingNCT06634069Phase 21 country
- Venous Stenting Evaluation in Patients With Intracranial Hypertension Under Long-term AcetazolamideRecruitingNCT06945848Not applicable1 country
- Ocular Characteristics in Patients With CraniosynostosisRecruitingNCT069287271 country
- Optic Nerve Ultrasound for Assessing Cerebral Inflammation and Intracranial Hypertension in Cerebral PathologiesRecruitingNCT073322341 country
- Non-invasive Intracranial Pressure Monitoring in Brain Tumor PatientsNot yet recruitingNCT072863961 country
- Multifocal Chromatic Pupilloperimetry in Patients With Pseudotumor Cerebri and Healthy Subjects.RecruitingNCT03304314Not applicable1 country
- Intracranial Venous Stenting Evaluation in Patients With Idiopathic Intracranial Hypertension in the Early PhaseRecruitingNCT06919744Not applicable1 country
- Intracranial PrEssure Time dOse (ImPETO)RecruitingNCT044598061 country
- Prospective Ocular Imaging for Intracranial Pressure EvaluationRecruitingNCT068553421 country
- Correlation Between Noninvasive Blood Vessel Functionality Parameters and Cerebral Hemodynamics in Neurocritical Care PatientsRecruitingNCT065118041 country
- Security and Effectiveness Assessment of Locking Systems in Ventriculostomy for Traumatic Brain InjuryNot yet recruitingNCT06772155
- Effectiveness of Surgical Procedures for Acute Cranial Expansion in Traumatic Brain InjuryNot yet recruitingNCT06776614
- Lidocaine, Dexmedetomidine, Esmolol and Magnesium Effect on Optic Nerve Sheath Diameter After LaryngoscopyRecruitingNCT06254534Not applicable1 country
- Non Invasive Measurement With Trans Cranial Doppler Versus Invasive Measurement in Pediatric AgeRecruitingNCT053400621 country
- Lung Recruitment and PEEP Effects on Intracranial Pressure in Cranial SurgeryNot yet recruitingNCT067712321 country
- Effect of Lithotomy Position on Optic Nerve Sheath DiameterRecruitingNCT064644191 country
- Assessment of Optic Nerve Sheath Diameter in Preeclamptic Pregnant Women Using Ultrasonography and Anesthetic ManagementNot yet recruitingNCT065222951 country
- Biomarkers in the Etiology of Idiopathic Intracranial HypertensionRecruitingNCT06059703Not applicable1 country
- Intra-operative Evaluation of the External Ventricular Drain Catheter Position With Structured Light for Patients (Bullseye EVD)RecruitingNCT059319911 country
- The Effect of a Laryngeal Mask Airway on Optic Nerve Sheath DiameterRecruitingNCT064035921 country
- Intracranial Pressure and Optic Nerve Sheath Diameter With CLOSED BundleNot yet recruitingNCT060571551 country
- Estimation of Intracranial Pressure Using Non-invasive Fundus VideosRecruitingNCT033828601 country
- Infra- and Supratentorial NeuromonitoringRecruitingNCT05346471Not applicable1 country
- Tissue Penetration of Paracetamol in Pediatric Intensive Care PatientsCompletedNCT079168311 country
- Different Intraperitoneal Pressures on Optic Nerve Sheath Diameter in Laparoscopic SurgeriesCompletedNCT07155109Not applicable1 country
- Invasive Versus Non-Invasive Intracranial Pressure-Guided Management in Neurosurgical PatientsCompletedNCT07853963Not applicable1 country
- TCD and ONSD for Noninvasive Assessment of Increased ICP in TBIActive, not recruitingNCT078165881 country
- Effect of Central Venous Catheterization on Brain Pressure in Acute Brain Injury PatientsActive, not recruitingNCT077045281 country
- Vasopressin in Intraabdominal Pressure ElevationCompletedNCT03707054Not applicable1 country
- The Value of Doppler Study of Central Retinal Artery in Diagnosis of Increased ICPCompletedNCT05891678Not applicable1 country
- Intraoperative Optic Nerve Sheath Diameter Changes After Laparoscopic SurgeryCompletedNCT06209034Not applicable1 country
- Evaluation of Supraclavicular Brachial Plexus Blocks at Various Volumes: Impact on Optic Nerve Sheath DiameterCompletedNCT06428461Not applicable1 country
- Effect of Different Positive End-Expiratory Pressure (PEEP) Levels on Optic Nerve Sheath DiameterCompletedNCT070859491 country
- Effect of Optıc Nerve Dıameter ın Tymphanoplasty Surgery Performed ın Lateral Head PosıtıonCompletedNCT07407972Not applicable1 country
- Bleeding Intracerebral Hemorrhage With Early Invasive Intracranial Pressure Monitoring TrialCompletedNCT05593380Not applicable1 country
- Ketamine for Sedation in Severe Traumatic Brain InjurySuspendedNCT06429657Phase 41 country
- Comparison of Narcotrend and Cerebral Function Analysing Monitor in Intensive Care to Monitor Seizures and Deep SedationCompletedNCT060677501 country