Intervertebral Disc Displacement clinical trials
The registry lists 474 studies for Intervertebral Disc Displacement across more than 10 countries. 100 are recruiting or about to start. 322 of them are mainly about Intervertebral Disc Displacement (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its narrower condition Intervertebral disc disease too: 524 studies, 115 open.
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Status
Who runs them
Marmara University (15) · Jaseng Medical Foundation (11) · Intrinsic Therapeutics (9) · Medipol University (8) · Assiut University (7) · Hacettepe University (7) · Peking University Third Hospital (6) · Dartmouth-Hitchcock Medical Center (5)
What is being tested here
Drugs under test in Intervertebral Disc Displacement studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Dexamethasone | 1 | 0 | 3 |
| Pregabalin | 0 | 1 | 4 |
| Gabapentin | 0 | 1 | 3 |
| Ropivacaine | 0 | 1 | 3 |
| Bupivacaine | 0 | 1 | 3 |
| Acetaminophen | 0 | 0 | 2 |
| Lidocaine | 0 | 1 | 2 |
| Triamcinolone | 0 | 1 | 2 |
| Liposomal Bupivacaine | 0 | 0 | 2 |
| Pentoxifylline | 0 | 0 | 1 |
Drug classes tested here Corticosteroids 1 open · Local anesthetics 8
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Precision Treatment of Lumbar Spine Surgery Through Advanced Nerve Root Blockade · University of Aarhus
- Nov 2026Flow-Controlled Versus Volume-Controlled Ventilation in Lumbar Disc Herniation Surgery · Ankara Etlik City Hospital
- Nov 2026Gelified Radiopaque Ethanol (Absolute Gel) in Cervical Disc Herniation: an Observational Study in Routine Clinical Practice (GENESIS) · Aurel Mengri
- Nov 2026The Influence of the Timing of Postoperative Rehabilitation Intervention on the Clinical Efficacy of Unilateral Biportal Endoscopic Spine System in the Treatment of Lumbar Disc Herniation · Li Xiang
- Nov 2026Effectiveness of High Intensity Laser Therapy in Management of Lumbar Disc Herniation · Baskent University
- Dec 2026Intradiscal Ozone/Oxygen Injection for Treatment of Contained Lumbar Disc Herniation · Beam Research, Inc.
- Dec 2026Subjective Intraoperative Use of Epidural Steroid Administration Following Discectomy · University of Missouri-Columbia
- Dec 2026Prediction of TEI Success in Sciatica · Eduard Verheijen
- Dec 2026The Selective Intraperineural Nerve Root Block Study · Xi'an Honghui Hospital
- Dec 2026CGM-Based Glycemic Analysis After ESI · Korea University Anam Hospital
Who these studies take
Of the 50 Intervertebral Disc Displacement studies recruiting now, 20 (40%) set no upper age limit and 26 (52%) stop at 75 or younger. 3 (6%) take children under 18. 2 (4%) are for women only and 0 (0%) for men only; 6 (12%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (4%) | 2 (4%) |
| 18 | 42 (84%) | 40 (80%) |
| 30 | 50 (100%) | 48 (96%) |
| 40 | 49 (98%) | 47 (94%) |
| 50 | 48 (96%) | 46 (92%) |
| 65 | 43 (86%) | 42 (84%) |
| 75 | 32 (64%) | 32 (64%) |
| 85 | 21 (42%) | 21 (42%) |
Across all 474 studies, recruiting or not: 64% stop at 75 or younger and 46% at 65; 5% take children; 1% are for women only and 1% for men only; 16% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Intervertebral Disc Displacement studies take
Of 14 phase 4 interventional studies under Intervertebral Disc Displacement, half reached primary completion within 34 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 4 | 34 mo12–101 · 14 studies | — | — |
| Interventional, no phase | 12 mo5–27 · 191 studies | — | 11 mo5–23 · 178 studies |
| Observational | 35 mo13–82 · 49 studies | — | 31 mo12–69 · 45 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Stopped1
- Conduit Cages and Fibergraft BG PuttyTerminatedNov 10, 2026NCT06704919
Newly registered9
- Disability and Psychological Symptoms After Injection or Conservative Care for Lumbar Disc HerniationNov 10, 2026NCT07930156
- Cortical Surface Functional Changes After Lever Positioning Manipulation for Lumbar Disc HerniationNov 4, 2026NCT07914842
- Effects of Spinal Mobilization With and Without Clinical Pilates in Patients With Lumbar Disc Herniationc HerniationNov 3, 2026NCT07912047
- Intradiscal Ozone/Oxygen Injection for Treatment of Contained Lumbar Disc HerniationNov 2, 2026NCT07910422
- Perioperative Nutrition Management in Patients Undergoing Open Posterior Lumbar SurgeryOct 26, 2026NCT07893938
Show 4 moreShow fewer
- Selective Nerve Root Block Versus Sham to Reduce Surgery for Lumbar Disc HerniationOct 26, 2026NCT07895589
- Telerehabilitation After Lumbar Disc Herniation SurgeryOct 22, 2026NCT07889817
- Nurse-Led Early Standing Exercise After Lumbar Fusion in Older AdultsOct 13, 2026NCT07870993
- H-Reflex-Guided Direction-Sensitive Exercise Versus Standard Extension Exercise for Functional Recovery in Patients With Lumbar Disc ProlapseOct 13, 2026NCT07871422
Studies
Recruiting first, then most recently updated. Showing 50 of 474. Browse all 474 → or search them.
- Cortical Surface Functional Changes After Lever Positioning Manipulation for Lumbar Disc HerniationNot yet recruitingNCT07914842Not applicable1 country
- Effects of Spinal Mobilization With and Without Clinical Pilates in Patients With Lumbar Disc Herniationc HerniationNot yet recruitingNCT07912047Not applicable1 country
- Intradiscal Ozone/Oxygen Injection for Treatment of Contained Lumbar Disc HerniationEnrolling by invitationNCT079104221 country
- Selective Nerve Root Block Versus Sham to Reduce Surgery for Lumbar Disc HerniationNot yet recruitingNCT07895589Not applicable1 country
- H-Reflex-Guided Direction-Sensitive Exercise Versus Standard Extension Exercise for Functional Recovery in Patients With Lumbar Disc ProlapseNot yet recruitingNCT07871422Not applicable1 country
- Pulmonary Mechanics and Cerebral Oxygenation During Prone Lumbar Disc SurgeryRecruitingNCT078622571 country
- Randomized Evaluation of Lumbar Injection Effectiveness and FunctionNot yet recruitingNCT07856810Not applicable
- More Realistic Spine Patients: Assessing the Effect of Dialogue Support Tool.RecruitingNCT07788872Not applicable1 country
- Discogen for Low Back PainRecruitingNCT06611397Not applicable1 country
- Effect of Irrigation Pressure on Postoperative Complications and Surgical Field Clarity in Unilateral Biportal Endoscopic SurgeryRecruitingNCT07837427Not applicable1 country
- Gelified Radiopaque Ethanol (Absolute Gel) in Cervical Disc Herniation: an Observational Study in Routine Clinical Practice (GENESIS)RecruitingNCT078329291 country
- Non-pharmacological Treatment vs Pharmacological Treatment for Non-acute Lumbar Disc HerniationRecruitingNCT06024460Not applicable1 country
- Comparing Three Epidural Steroid Injection Approaches for Lumbar Radicular PainNot yet recruitingNCT07813988Phase 41 country
- Postoperative Pain and Analgesic Use Following Lumbar Discectomy: A Comparative Study of Endoscopic Surgery and Open SurgeryRecruitingNCT07766031Not applicable1 country
- Assesment of Epidural Platelet-Rich Plasma (PRP) Injection During Uniportal Endoscopic Lumbar Disc Herniation Excision on Residual NeuropathiesNot yet recruitingNCT07770750Not applicable1 country
- Lower Back Muscle Size and Recovery After Lumbar Disc Herniation SurgeryNot yet recruitingNCT077682411 country
- Validation of a Methodology Using Isometric Dynamometer for Ankle STrength Assessment to Quantify LDH-induced ParesisEnrolling by invitationNCT07763522Not applicable1 country
- CGM-Based Glycemic Analysis After ESINot yet recruitingNCT072807801 country
- Comparison of 5 vs 8 cmH₂O PEEP on Respiratory Mechanics in Prone Lumbar SurgeryNot yet recruitingNCT07545733Not applicable
- Fear-Avoidance Beliefs and Physical Function in Patients With Lumbar Disc HerniationRecruitingNCT076744071 country
- Comparison of TLIP Block and QIP Block for Postoperative Analgesia After Lumbar Spine SurgeryNot yet recruitingNCT077504181 country
- Biologic Injection For Adults With Lumbar Disc HerniationRecruitingNCT07386548Not applicable1 country
- Brain Connectomic Mechanisms of Spinal Manipulative Therapy on LDH Analgesia Based on Multimodal MRINot yet recruitingNCT07728149Not applicable1 country
- "Lumbar Operatively Inserted PerQdisc Artificial Implant Following Nulcectomy" (LOPAIN2)RecruitingNCT05508360Not applicable5 countries
- Evaluation of the Effect of Reiki on Pain After Lumbar SurgeryRecruitingNCT07722117Not applicable1 country
- Acute Effects of Neurodynamics on Strength and Endurance in AthletesRecruitingNCT07721220Not applicable1 country
- High-Intensity Laser Therapy Versus Transforaminal Epidural Steroid Injection in Chronic Lumbar Disc Herniation-Related Low Back and Radicular PainRecruitingNCT07688915Not applicable1 country
- Return to Activity After Surgery for Lumbar Disc HerniationNot yet recruitingNCT07667348Phase 41 country
- Magnesium Sulfate for Prevention of Emergence Agitation in Lumbar Disc SurgeryNot yet recruitingNCT07139847
- Evaluation of the Effectiveness of Physical Therapy for Low Back Pain According to Magnetic Resonance Imaging FindingsNot yet recruitingNCT07648927Not applicable1 country
- Subjective Intraoperative Use of Epidural Steroid Administration Following DiscectomyRecruitingNCT04182997Phase 41 country
- Flow-Controlled Versus Volume-Controlled Ventilation in Lumbar Disc Herniation SurgeryRecruitingNCT07614555Not applicable1 country
- Electroacupuncture for Insomnia in Patients With Chronic Sciatica Due to Lumbar Disc Herniation: a Randomized Controlled TrialNot yet recruitingNCT07576348Not applicable
- Neural Control and Mechanosensation in Spine MuscleEnrolling by invitationNCT07003802Not applicable1 country
- GA + ESP vs. SA + ESP in Lumbar Decompression SurgeriesEnrolling by invitationNCT05444751Phase 31 country
- Effectiveness of High Intensity Laser Therapy in Management of Lumbar Disc HerniationNot yet recruitingNCT07550569Not applicable1 country
- The Selective Intraperineural Nerve Root Block StudyNot yet recruitingNCT07531485Not applicable1 country
- Daytime vs Evening Rehabilitation in Lumbar Disc Herniation Patients at High Risk for Obstructive Sleep ApneaNot yet recruitingNCT07522021Not applicable
- Clinical and MRI Findings in Lumbar Disc DiseaseNot yet recruitingNCT07516613
- Comparison of Virtual Reality-Based and Routine Preoperative Education on Surgical Anxiety and Salivary CortisolNot yet recruitingNCT07443111Not applicable
- Regional Anesthesia in Minimally Invasive Lumbar Spine SurgeryRecruitingNCT05029726Phase 41 country
- Investigation of Preoperative Factors Influencing the Outcome of Motor Deficits in Patients Undergoing Lumbar MicrodiskectomyRecruitingNCT074133021 country
- Comparison of Artificial Disc Implants in Cervical Disc ArthroplastyRecruitingNCT057010591 country
- PLDD With or Without Transforaminal Epidural Steroid Injection in Lumbar Disc HerniationNot yet recruitingNCT074000681 country
- Dose Responsiveness as a Measure of Clinical Effectiveness During Neuromonitored Spine SurgeryEnrolling by invitationNCT051108331 country
- The Role of Temporal Changes in Pain Response After Transforaminal Epidural Steroid Injection on Treatment SuccessNot yet recruitingNCT073671911 country
- Evaluation of the Effectiveness of Focused Radiofrequency (TECAR) Therapy on Pain, Disability, Function, and Quality of Life in Patients With Lumbar Disc HerniationRecruitingNCT073357181 country
- Safety And Performance Of Disc Care To Prevent Lumbar Disc Herniation RecurrenceRecruitingNCT06023719Not applicable1 country
- Smartwatch Accuracy for Measuring Vitals and Anxiety Before Disc SurgeryRecruitingNCT073225231 country
- Comparison Between Insertion of Bilateral Straight Cages Versus Unilateral Banana Cage in Lumbar Fusion SurgeryNot yet recruitingNCT07312747Not applicable