An observational study in Lumbar Disc Herniation and Postoperative Pain, sponsored by Vezirköprü State Hospital. Not yet recruiting at 1 site in Turkey (Türkiye). Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-08-06.
Sponsored by Vezirköprü State Hospital · Observational
This study compares two regional anesthesia techniques used for pain control after lumbar spine surgery: the classic thoracolumbar interfascial plane (TLIP) block and the quadratus lumborum-iliac plane (QIP) block. Patients between 18 and 65 years of age who undergo elective lumbar discectomy (up to two spinal levels) will be observed based on which block their treating anesthesiologist chooses to use as part of routine clinical practice. No randomization or additional intervention beyond standard care will be performed. Researchers will record the total amount of opioid pain medication used in the first 24 hours after surgery, the time until the first request for pain medication, pain scores at several time points after surgery (0, 1, 2, 4, 8, 12, and 24 hours), and any side effects (such as nausea, vomiting, or sedation) or complications related to the block. The aim is to compare the effectiveness and safety of these two techniques in reducing pain and opioid use after lumbar spine surgery.
Patients undergoing elective lumbar discectomy at up to two levels, ASA physical status I-II, aged 18-65 years, who receive either a classic TLIP block or a QIP block as part of routine clinical anesthesia practice will be included in this prospective observational study. The choice of block technique is determined solely by the treating anesthesiologist's routine practice, not by study allocation. Both blocks are performed under ultrasound guidance at the end of surgery, before emergence from anesthesia, using bilateral injections of 20 mL (40 mL total) of 0.25% bupivacaine. All patients receive standardized general anesthesia and a multimodal analgesic regimen (intravenous paracetamol, dexketoprofen, and tramadol as rescue analgesia for VAS ≥ 4). Outcomes recorded include total opioid consumption in the first 24 postoperative hours, time to first opioid request, VAS pain scores at PACU (0h), 1, 2, 4, 8, 12, and 24 hours, postoperative side effects (nausea, vomiting, pruritus, sedation, hypotension), and block-related complications (hematoma, local anesthetic systemic toxicity, infection).
474 studies on the registry are indexed under Intervertebral Disc Displacement; 100 are open to participants now.
This study's planned enrollment of 60 is below the median of 100 across 117 observational studies indexed under Intervertebral Disc Displacement.
Browse Intervertebral Disc Displacement studies →Vezirköprü State Hospital is the lead sponsor of 3 studies on the registry; 2 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Patients aged 18-65 years, ASA physical status I-II, undergoing elective lumbar discectomy at up to two spinal levels under general anesthesia at Vezirköprü State Hospital, who receive either a classic TLIP block or a QIP block for postoperative analgesia as part of routine clinical practice.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Hypersensitivity
An allergy, or another reaction of the immune system, to a substance. “Hypersensitivity to the study drug” means a known allergic reaction to it — not every side effect a medicine can have.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients who receive a classic thoracolumbar interfascial plane (TLIP) block for postoperative analgesia after lumbar discectomy, as determined by the treating anesthesiologist's routine clinical practice. The block is performed under ultrasound guidance in the fascial plane between the multifidus and longissimus muscles, using bilateral injections of 20 mL (40 mL total) of 0.25% bupivacaine
Procedure: Thoracolumbar Interfascial Plane (TLIP) Block of bupivacaine
Patients who receive a quadratus lumborum-iliac plane (QIP) block for postoperative analgesia after lumbar discectomy, as determined by the treating anesthesiologist's routine clinical practice. The block is performed under ultrasound guidance in the interfascial plane between the erector spinae and quadratus lumborum muscles at the iliac crest level, using bilateral injections of 20 mL (40 mL total) of 0.25% bupivacaine.
Procedure: Quadratus Lumborum-Iliac Plane (QIP) Block
Ultrasound-guided injection of 20 mL bilaterally (40 mL total) of 0.25% bupivacaine into the fascial plane between the multifidus and longissimus muscles at the relevant lumbar level, performed at the end of surgery before emergence from anesthesia, as part of routine postoperative analgesia.
Also known as: TLIP Block
Ultrasound-guided injection of 20 mL bilaterally (40 mL total) of 0.25% bupivacaine into the interfascial plane between the erector spinae and quadratus lumborum muscles at the iliac crest level, performed at the end of surgery before emergence from anesthesia, as part of routine postoperative analgesia.
Also known as: QIP Block
Total Opioid Consumption in the First 24 Postoperative Hours
Cumulative amount of intravenous tramadol (mg) administered as rescue analgesia during the first 24 hours after surgery in each group.
Time frame: 0 to 24 hours after surgery
Time to First Opioid Request
Time elapsed from end of surgery to the first patient request for rescue opioid analgesia (VAS ≥ 4)
Time frame: Up to 24 hours after surgery
Postoperative Pain Score (Visual Analog Scale)
Pain intensity measured using the Visual Analog Scale (VAS, 0 = no pain, 10 = worst imaginable pain) at PACU (0h) and at 1, 2, 4, 8, 12, and 24 hours after surgery.
Time frame: 0, 1, 2, 4, 8, 12, and 24 hours after surgery
Incidence of Postoperative Side Effects
Number of patients experiencing nausea, vomiting, pruritus, sedation, or hypotension after surgery.
Time frame: Up to 24 hours after surgery
Incidence of Block-Related Complications
Number of patients experiencing hematoma, local anesthetic systemic toxicity, or infection related to the block procedure.
Time frame: Up to 24 hours after surgery
Plan to share: No
Start is estimated for Aug 2026; primary completion for Dec 2026, 4 months later.
Of 45 non-industry observational studies under Intervertebral Disc Displacement, half reached primary completion within 31 months of starting (the median), counting those still running; a quarter within 12 and three quarters within 69. This study's planned 4 months is below that.
Counting every sponsor, half of 49 studies reached it within 35 months; a quarter within 13 and three quarters within 82.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Intervertebral Disc Displacement →
Vezirköprü State Hospital