Intervertebral disc disease clinical trials
The registry lists 63 studies for Intervertebral disc disease across more than 10 countries. 18 are recruiting or about to start. 37 of them are mainly about Intervertebral disc disease (how this is decided). Per ClinicalTrials.gov, last updated 2026-08-26.
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Who runs them
University of Valencia (2) · NuTech Medical, Inc (2) · Medipol University (2) · GCS Ramsay Santé pour l'Enseignement et la Recherche (2) · Hospital for Special Surgery, New York (2) · Keimyung University Dongsan Medical Center (2) · Mersin University (2) · Cantonal Hospital of St. Gallen (2)
What is being tested here
Drugs under test in Intervertebral disc disease studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Ropivacaine | 0 | 0 | 2 |
| Condoliase | 0 | 2 | 2 |
| Bupivacaine | 0 | 0 | 2 |
| Pentoxifylline | 0 | 0 | 1 |
| Ketorolac | 0 | 0 | 1 |
| Acetaminophen | 0 | 0 | 1 |
| Tramadol | 0 | 0 | 1 |
| Liposomal Bupivacaine | 0 | 0 | 1 |
| Propranolol | 0 | 0 | 1 |
Drug classes tested here Local anesthetics 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 4
- Dec 2026A Single Dose of BRTX 100 for Patients With Chronic Lumbar Disc Disease (cLDD) · BioRestorative Therapies
- Feb 2027Relationship of Periostin and ODI, EQ-5D · Keimyung University Dongsan Medical Center
- Apr 2027Clinical and MRI Findings in Lumbar Disc Disease · Assiut University
- Aug 2027Mirror Image Spine Correction Exercises Versus Conservative Physiotherapy for Lumbar Radiculopathy · University of Sharjah
Who these studies take
Of the 8 Intervertebral disc disease studies recruiting now, 4 (50%) set no upper age limit and 1 (13%) stop at 75 or younger. 1 (13%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (13%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (13%) | 1 (13%) |
| 18 | 5 (63%) | 5 (63%) |
| 30 | 8 (100%) | 8 (100%) |
| 40 | 8 (100%) | 8 (100%) |
| 50 | 8 (100%) | 8 (100%) |
| 65 | 7 (88%) | 7 (88%) |
| 75 | 7 (88%) | 7 (88%) |
| 85 | 4 (50%) | 4 (50%) |
Across all 63 studies, recruiting or not: 41% stop at 75 or younger and 22% at 65; 2% take children; 0% are for women only and 0% for men only; 10% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Intervertebral disc disease studies take
Of 15 interventional studies with no phase under Intervertebral disc disease, half reached primary completion within 40 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 40 mo12–46 · 15 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 63. Browse all 63 → or search them.
- LDGraft in Single Level Anterior Lumbar Interbody Fusion (ALIF)RecruitingNCT06462729Phase 1/22 countries
- Relationship of Periostin and ODI, EQ-5DRecruitingNCT076649041 country
- The Effect of NSAID on Serum PeriostinRecruitingNCT076626681 country
- Mirror Image Spine Correction Exercises Versus Conservative Physiotherapy for Lumbar RadiculopathyNot yet recruitingNCT07558993Not applicable1 country
- GA + ESP vs. SA + ESP in Lumbar Decompression SurgeriesEnrolling by invitationNCT05444751Phase 31 country
- Postoperative Scar in the Control Excess of Mobility Induced by Annulus Removal on Inserting a Lumbar Disc ProsthesisRecruitingNCT04641039Not applicable1 country
- Clinical and MRI Findings in Lumbar Disc DiseaseNot yet recruitingNCT07516613
- Patient Satisfaction During Lomber Transforaminal Epidural Steroid Injection: The Role of Sedation, Anxiety, and PainNot yet recruitingNCT074955011 country
- AuriculoTherapy NeuroImagingRecruitingNCT06825390Not applicable1 country
- RenewDisc Trial: Endoscopic Discectomy and Autologous Stem Cell Therapy for Discogenic Low Back PainEnrolling by invitationNCT073388771 country
- Development of a Fascial Training Based Mobile Application and Investigation of Its Effectiveness in Patients With Disc HerniationEnrolling by invitationNCT07060235Not applicable1 country
- A Single Dose of BRTX 100 for Patients With Chronic Lumbar Disc Disease (cLDD)RecruitingNCT04042844Phase 21 country
- A Post Market Surveillance on INFUSE Bone GraftRecruitingNCT052997621 country
- A Clinical Trial to Evaluate the Safety and Efficacy of Single-use Fibrous Ring Sutures for the Suture of Fibrous Ring Incision After Nucleus Pulposus RemovalNot yet recruitingNCT06386666Not applicable
- Ultrasound-Guided Microendoscopic Versus Fluoroscopic-Guided Lumbar Transforaminal Epidural Steroid InjectionsNot yet recruitingNCT05729022Not applicable1 country
- Identification of Biomarkers and Molecular Targets Involved on Intervertebral Disc Degeneration and Discogenic PainRecruitingNCT063492261 country
- The Effect of Mediclore as an Anti-adhesion Agent and Safety in Full-endoscopic Spine Surgery: a Preliminary StudyNot yet recruitingNCT06034041Phase 41 country
- NOCISCAN-Lumbar Spine (LS) Clinical Evaluation StudyNot yet recruitingNCT040157911 country
- Evaluation of the Contribution of Intraoperative Scans Coupled With the Navigation for the Precision of the Positioning of the Pedicle Screws During a Lumbar Spine Surgery: a Prospective Randomised StudyCompletedNCT04134975Not applicable1 country
- Validation of the STarT Back Screening Tool in the MilitaryCompletedNCT03127826Not applicable1 country
- Total Lumbar Disc Prosthesis and Subsequent Work Activity at at Least Five Years After Total Lumbar Disc ReplacementCompletedNCT069896321 country
- Determinants of Clinical Outcome After Caudal Epidural Adhesiolysis for Chronic Lumbar Radicular PainActive, not recruitingNCT074879351 country
- Ultrasound-Guided vs. Surgeon-Performed (Free-hand) Erector Spinae Plane BlockCompletedNCT07454304Not applicable1 country
- The Effect of Menthol Ice and Frozen Saline Applications After Lumbar Disc SurgeryCompletedNCT06939842Not applicable1 country
- PRP Spinoplasty for Chronic Low Back Pain With Multiple Pathologies: A Quasi-Experimental StudyCompletedNCT07268885Phase 21 country
- Study of the Long-Term Outcomes of Posterior Spinal Fixation With the Karma DeviceCompletedNCT049842131 country
- Clinical Outcomes Associated With the Use of ViviGen® for the Treatment of Lumbar Degenerative Disc DiseaseCompletedNCT03733626Not applicable1 country
- Pentoxifylline and Lumbar RadiculopathyActive, not recruitingNCT03060434Phase 41 country
- Effects of Kinesio Taping on Pain, Endurance, Proprioception, Mobility and Disability in Lumbar Disc HerniationCompletedNCT06777095Not applicable1 country
- Liposomal Bupivacaine in One-level Instrumented Posterior Spinal FusionSuspendedNCT03745040Phase 41 country
- Treatment of Degenerative Disc Disease With Allogenic Mesenchymal Stem Cells (MSV)CompletedNCT01860417Phase 1/21 country
- Erector Spinae Plane Block as Pain Management After Lumbar Fusion SurgeryCompletedNCT05345249Phase 41 country
- The Effects of Anesthesia on Cerebral Perfusion in Patients With High Blood PressureCompletedNCT04587401Not applicable1 country
- PatientSpot Formerly Known as ArthritisPowerStatus unknownNCT038409281 country
- PASS OCT® Post-market Clinical Follow-upCompletedNCT029312791 country
- Post-op Acetaminophen vs NSAID Use on Lumbar Spinal Fusion OutcomesCompletedNCT02700451Not applicable1 country
- A Study of SI-6603 in Patients With Lumbar Disc HerniationCompletedNCT02421601Phase 34 countries
- A Study of SI-6603 in Patients With Lumbar Disc HerniationCompletedNCT01941563Phase 31 country
- Modified-Thoracolumbar Interfascial Plane Block and Erector Spinae Plane Block Following Lumbar Instrumentation SurgeryWithdrawnNCT04189341Not applicable1 country
- Efficacy of Mechanical Traction and Spinal Decompression Treatments in Patients With Low Back PainCompletedNCT056179241 country
- Clinical and Radiological Evaluation of Patients With DDD Following TLIF With 3-D Printed Titanium CageCompletedNCT03018392Not applicable
- The Six-Minute Walking Test (6MWT) as a Measure of Functional Impairment in Lumbar Degenerate Disc Disease.CompletedNCT039779611 country
- The Six-Minute Walking Test (6WT) and Timed-Up-and-Go (TUG) Test as Measures of Objective Functional Impairment in Patients Undergoing Interlaminar or Transforaminal Epidural Steroid Injection for Lumbar Degenerative Disc Disease (DDD)CompletedNCT040629421 country
- Efficacy of the ATLAS Medical Device on Pain in Patients With Low Back Pain Due to Lumbar Disc DiseaseTerminatedNCT04585386Not applicable1 country
- Erector Spinae Plane Block in Spine SurgeriesStatus unknownNCT05247021Phase 41 country
- Injection of Autologous Bone Marrow Aspirate in Patients With Degenerative Disc Disease.Status unknownNCT051465831 country
- Prospective Robotic Global Research Study (PROGRESS)Status unknownNCT04257279Not applicable1 country
- Spine Surgery for Adhesions in Patients Evaluated for Efficacy and Safety of MedicurtainⓇ (Pivotal Study)CompletedNCT04688281Not applicable1 country
- Analgesic Effects of Perioperative Propranolol Administration for Spine SurgeryWithdrawnNCT04421209Phase 21 country
- Physiotherapy in Lumbar Disc PathologiesCompletedNCT04061759Not applicable1 country