Hyperlactatemia clinical trials
The registry lists 50 studies for Hyperlactatemia across more than 10 countries. 7 are recruiting or about to start. 26 of them are mainly about Hyperlactatemia (how this is decided). Per ClinicalTrials.gov, last updated 2026-07-16.
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Who runs them
University of Aarhus (3) · Pontificia Universidad Catolica de Chile (2) · Rigshospitalet, Denmark (2) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (1) · Central Hospital, Nancy, France (1) · Arrowhead Regional Medical Center (1) · Lindenwood University (1) · Erasmus Medical Center (1)
What is being tested here
Drugs under test in Hyperlactatemia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Dobutamine | 1 | 0 | 1 |
| Metformin | 0 | 0 | 3 |
| Thiamine | 0 | 0 | 2 |
| Sodium Lactate | 0 | 0 | 2 |
| Ascorbic Acid | 0 | 0 | 1 |
| Glycerol | 0 | 0 | 1 |
| Ringer's Lactate | 0 | 0 | 1 |
| Tranexamic Acid | 0 | 0 | 1 |
| Protease Inhibitor Formulation LB1148 | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 4
- Nov 2026Effect of Preoperative Prewarming on Serum Lactate Levels in Patients Undergoing Elective Nephrectomy · Beyzanur Aydoğdu
- Dec 2026A Validation Study of the Lab Clasp Device: A Point of Care Sepsis Risk Monitor · Brigham and Women's Hospital
- Dec 2026Electric Cardiometry-Guided Standard Versus Restricted Fluid Therapy In Robotic Prostaectomy · Nazmy Edward Seif
- Feb 2027Submental Tissue Oxygenation and Arterial Lactate in Major Surgery · Bursa Sevket Yilmaz Training and Research Hospital
Who these studies take
Of the 3 Hyperlactatemia studies recruiting now, 0 (0%) set no upper age limit and 1 (33%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 1 (33%) for men only; 1 (33%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 2 (67%) | 2 (67%) |
| 30 | 2 (67%) | 2 (67%) |
| 40 | 2 (67%) | 3 (100%) |
| 50 | 2 (67%) | 3 (100%) |
| 65 | 2 (67%) | 3 (100%) |
| 75 | 1 (33%) | 2 (67%) |
| 85 | 1 (33%) | 1 (33%) |
Across all 50 studies, recruiting or not: 36% stop at 75 or younger and 32% at 65; 14% take children; 0% are for women only and 16% for men only; 36% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Hyperlactatemia studies take
Of 17 interventional studies with no phase under Hyperlactatemia, half reached primary completion within 8 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 8 mo3–12 · 17 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 50. search them.
- Effect of Preoperative Prewarming on Serum Lactate Levels in Patients Undergoing Elective NephrectomyRecruitingNCT077024871 country
- Electric Cardiometry-Guided Standard Versus Restricted Fluid Therapy In Robotic ProstaectomyRecruitingNCT07626151Not applicable1 country
- Role of Elevated Lactate Levels on Lipid and Carbohydrate Metabolism.RecruitingNCT07426172Not applicable1 country
- Submental Tissue Oxygenation and Arterial Lactate in Major SurgeryNot yet recruitingNCT073992751 country
- The Lactate Project: Investigating the Impact of Lactate to Preserve Vital Organ Blood Supply and Function in Heart and BrainNot yet recruitingNCT06665763Not applicable1 country
- Use of Dobutamine in Patients With Sepsis and Maintained Hypoperfusion After Initial Volemic Resuscitation.Not yet recruitingNCT05953142Phase 21 country
- Hyperlactacidemia in Major Abdominal Surgery and Monocarboxylate ReceptorsNot yet recruitingNCT06222021Not applicable1 country
- A Validation Study of the Lab Clasp Device: A Point of Care Sepsis Risk MonitorActive, not recruitingNCT04796285Not applicable1 country
- Effects of Different Types of Exercise on BDNF and Cognitive Performance (Exercise-BDNF)CompletedNCT07137611Not applicable1 country
- Treatment of Hyperlactatemia in Acute Circulatory Failure Based on Analysis of CO2: a Prospective Randomized Superiority Study (The LACTEL Study)CompletedNCT05032521Phase 41 country
- Hyperglycaemia and Hyperlactataemia in Patients With Severe Acute Brain InjuryCompletedNCT055053961 country
- Influence of High Vitamin C Dose on Lactate During and After Extracorporeal CirculationCompletedNCT04046861Not applicable1 country
- The Relationship of Anesthesia Method With Serum Lactate Level in CraniotomiesCompletedNCT051450491 country
- Central Venous to Arterial CO2 Difference and Low Cardiac Output Syndrome Related Outcomes in Children After Cardiac SurgeryCompletedNCT062929101 country
- Pilot Testing a Novel Non-invasive Lactate SensorCompletedNCT05649358Not applicable1 country
- The Role of Lactate in Viral and Bacterial InfectionCompletedNCT047777471 country
- Pilot Study to Examine the Acute Impact of Veillonella Supplementation on Exercise and Lactate ResponsesCompletedNCT05816291Not applicable1 country
- Sodium Lactate Infusion in GLUT1DS PatientsCompletedNCT04112862Early Phase 11 country
- The Thiamine Administration After Cardiac Surgery TrialCompletedNCT04641104Phase 41 country
- Lactate Monitoring in Traumatic Long Bone Fractures Requiring Emergent Surgical InterventionCompletedNCT056113981 country
- Hyperlactatemia During and After TumorcraniotomyCompletedNCT044103151 country
- Saving Lives by Early Detection and Treatment of Sepsis and Septic Shock by Point of Care Lactate Test in AdultsStatus unknownNCT051084671 country
- Swimming Economy in Swimmers and Paraswimmers as a Function of SR(Stroke Rate) and V(Velocity) Manipulations (NePTUNE-3)Status unknownNCT05011591Not applicable1 country
- Effects of Acute Glycerol Ingestion on Performance, Metabolic and Biochemical Markers in International AthletesCompletedNCT05295836Not applicable1 country
- The Role of Lactate in Lipolysis and Catabolism in HumansCompletedNCT04710875Not applicable1 country
- Sodium Bicarbonate Ringer's Solution for Preventing and Treating Hyperlactacidemia During HepatectomyStatus unknownNCT04547296Not applicable1 country
- Goal-directed Fluid Therapy in Elderly Patients Undergoing Lumbar SurgeryCompletedNCT03974906Not applicable1 country
- NEW MONITORING IN DIFFERENTIAL DIAGNOSIS OF HYPERLACTATHEMIA IN CARDIOPULMONARY BYPASS SURGERYCompletedNCT047068841 country
- Lactate in the GutCompletedNCT04299815Not applicable1 country
- The Prognostic Value of Lactate is Different Among Septic PatientsCompletedNCT041550601 country
- Metformin in Moderate and Severe Renal Failure (CKD 3-4): A Follow-up StudyWithdrawnNCT02848508Phase 21 country
- Treatment of Septic Shock by Inhibiting Autodigestion and Preserving Gut Integrity With Enteric LB1148TerminatedNCT02317549Phase 22 countries
- Fluid REsponsiveness and Arterial ELASTANCE in Patients With Septic Shock or After Aortic SurgeryStatus unknownNCT043882671 country
- Lactate Acidosis in Postoperative HeartsCompletedNCT030256591 country
- RCA for CRRT in Hyperlactatemia Patient With Increased Bleeding RiskStatus unknownNCT04315623Not applicable1 country
- Optimal Blood Sampling Site for Point of Care Lactate AssessmentCompletedNCT04291989Not applicable1 country
- Perioperative Continuation of Metformin Therapy in Patients With Typ 2 Diabetes Mellitus Undergoing Non-cardiac SurgeryStatus unknownNCT04284722Phase 4
- Lithothamnion Species on Blood Lactate During Exhaustive Exercise in Trained CyclistsStatus unknownNCT03980678Not applicable
- Does Intravenous Lactated Ringer Solution Raise Measured Serum Lactate?CompletedNCT02950753Early Phase 11 country
- Blood Lactate Level for Pre-hospital Orientation of Septic ShockStatus unknownNCT038316851 country
- Peripheral Perfusion Versus Lactate Targeted Fluid Resuscitation in Septic ShockStatus unknownNCT03762005Not applicable1 country
- Pancreatic Exocrine Insufficiency and Pancreatic Enzyme Supplementation in Critically Ill Adult PatientsCompletedNCT017530241 country
- Thiamine As An Adjuvant Therapy For Hyperlactatemia In Septic Shock PatientsStatus unknownNCT03649009Not applicable1 country
- Early Goal Directed Therapy Using a Physiological Holistic View. The ANDROMEDA-SHOCK StudyCompletedNCT03078712Not applicable1 country
- Feasibility of Lactate Level Evaluation in Prehospital Care in TraumaStatus unknownNCT03115970
- Serum Lactate in Convulsive Syncopes Compared to Non-convulsive SyncopesStatus unknownNCT030626831 country
- Lactate Metabolism After an Endotoxin Challenge in Healthy HumansCompletedNCT01647997Not applicable1 country
- Effects of Uridine Supplementation on Metabolic Side Effects of Stavudine and ZidovudineCompletedNCT00471614Phase 21 country
- Effect of Metformin on Lactate MetabolismCompletedNCT00390273Phase 1/21 country
- Early Lactate-Directed Therapy in the Intensive Care Unit (ICU)CompletedNCT00270673Phase 31 country