An interventional study of ascorbic acid, and Placebo (saline) in Hyperlactatemia, Cardiac Disease and Bypass Complication, sponsored by University Medical Centre Maribor. Completed at 1 site in Slovenia. Open to participants aged 18 Years to 100 Years. Per ClinicalTrials.gov, last updated 2025-02-21.
Sponsored by University Medical Centre Maribor · Not applicable, Interventional, and Supportive care
The aim of our study is to find out whether high doses of vitamin C before cardiopulmonary bypass and during the first 24 hours after that have and impact of lowering the incidence of hyperlactatemia.
Exclusion Criteria:
2g vitamin C (ascorbic acid) iv before cardiopulmonary bypass, 2 g vitamin C iv before removing the aortic clamp, 1g vitamin C iv 8 h after aortic clamp removal and every 8 h thereafter(2 times)
Dietary Supplement: ascorbic acid,
placebo (saline) iv before cardiopulmonary bypass, placebo before removing the aortic clamp, placebo iv 8 h after aortic clamp removal and every 8 h (2 times)
Other: Placebo (saline)
The vitamin C group will get high dose of intravenous vitamin C (ascorbic acid) before starting cardiopulmonary bypass, before removing aortic clamp and every 8 hours thereafter for additionaly 24 hours
Also known as: Vitamin C
The placebo group will get saline before starting cardiopulmonary bypass, before removing aortic clamp and every 8 hours thereafter for additionaly 24 hours
Concentration of lactate
Measuring the concentration of lactate before cardiopulmonary bypass, after aortic clamp removal, at ICU admission,then every 6 hours
Time frame: up to 30 hours
dose of noradrenaline and other vasopressors
The need for noradrenaline and other vasopressors (e.g. vasopresin) during the surgery and in the 24-hours after the end of the surgery
Time frame: up to 36 hours
Concentration of glucose
Measuring the concentration of glucose before cardiopulmonary bypass, after aortic clamp removal, at ICU admission, then every 6 hours
Time frame: up to 30 hours
Plan to share: No
This study is completed, as verified in Feb 2025. You cannot join it, but the record below documents what was studied.
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University Medical Centre Maribor