An observational study in Acute Brain Injury, Hyperglycemia and Hyperlactatemia, sponsored by Rigshospitalet, Denmark. Completed at 1 site in Denmark. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-07-29.
Sponsored by Rigshospitalet, Denmark · Observational
Among 20 studies in Brain Injuries by Rigshospitalet, Denmark — 5 open to participants now, 7 under way, none of them phase 3. Brain Injuries · Rigshospitalet, Denmark.
Among the 20 studies in Brain Injuries by Rigshospitalet, Denmark, this one has the largest enrollment of the 13 observational ones, is the only one that started in 2022, is one of 12 observational ones, and was the 11th registered.
946 studies on the registry are indexed under Brain Injuries; 235 are open to participants now.
This study's enrollment of 459 is above the median of 100 across 302 observational studies indexed under Brain Injuries.
Browse Brain Injuries studies →5 of the 20 studies in Brain Injuries by Rigshospitalet, Denmark are open now, in 1 country. Each count lists the studies.
Of the 152 Brain Injuries studies recruiting now, 75 (49%) set no upper age limit and 55 (36%) stop at 75 or younger; 39 take children under 18; 23 take healthy volunteers.
This study: 18 Years and older · all sexes.
The full table on the hub →20 studies; the count open now beside each. This study's row is marked.
First in 2003; this study’s year is marked. 1 started in 2022.
Median enrollment 98 across the 6 interventional studies, 100 across the 13 observational. Of the 10 that completed or were terminated, 0 (0%) have results posted.
Rigshospitalet, Denmark is the lead sponsor of 1,007 studies on the registry; 175 are open to participants now.
2 of the studies in Brain Injuries by Rigshospitalet, Denmark that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07380477Rigshospitalet, DenmarkVentricuLostomy AssoCiaTed InfeCtions (LACTIC): Focus on CSF Lactate and Sampling Site | 2027-01-15 |
| NCT07590726Rigshospitalet, DenmarkPIRe 2.0: A Stepped-Care Model for Involving Relatives Across Sectors | 2027-04-01 |
Among the 20 studies in Brain Injuries by Rigshospitalet, Denmark, from their registry updates:
Nothing recorded among them since 2026-09-25.
This is an observational study of patients with severe acute brain injury, which aims to characterize the development of hyperglycaemia and hyperlactataemia and the influence of these markers on clinical outcome.
Additionally, in a subgroup of patients undergoing advanced multimodal neuromonitoring on either clinical or research indication, the relationship between hyperglycaemia and brain glucose levels as well as systemic and microdialysis lactate will be examined.
The study will include all patients with severe acute brain injury, admitted to the neuro intensive care department at Rigshospitalet, Denmark. Mainly, it will be patients with TBI, SAH, ICH or acute ischaemic stroke.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Blood HbA1c, insulin, C-peptide and IL-6 measured at admission. Glucose and lactate measured every 4 hours during intensive care stay. Daily sampling of CSV analysed for glucose and lactate in patients with EVD.
Functional outcome at 6 months as evaluated by the modified Rankin Scale.
Modified Rankin Scale ranges from 0-6, where 0 is the best and 6 is the worst outcome.
Time frame: 6 months after admission.
All-cause mortality at 6 months (dichotomous).
Time frame: 6 months after admission.
Length of stay in the neuro-ICU (continuous).
Time frame: Day of discharge, typically 1-30 days after admission.
Plan to share: Undecided — IPD will only be shared with a data sharing agreement.
No publications or documents are linked to this record.
This study is completed, as verified in Jul 2025. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.