An interventional study of supplementation of compound nutrients and placebo control in Hyperhomocysteinemia, sponsored by Huilian Zhu. Status unknown at 1 site in China. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2019-05-14.
Sponsored by Huilian Zhu · Not applicable, Interventional, and Basic science
The purpose of this study is to determine whether supplementation of compound nutrients,including folic acid, vitamin B6, vitamin B12, betaine and zinc, will decrease the level of plasma homocysteine in Chinese adults with hyperhomocysteinemia.
Exclusion Criteria:
Betaine、(6S)-5-methyltetrahydrofolic acid、vitamin B6、vitamin B12 and zinc are provided as a 800mg tablet. And the tablet is orally taken once a day, four tablets at a time for 12 weeks.
Dietary Supplement: supplementation of compound nutrients
The placebo is an excipient and the color, flavor, shape, taste and weight are same with the tablet of betaine、(6S)-5-methyltetrahydrofolic acid、vitamin B6、vitamin B12 and zinc supplement.
Dietary Supplement: placebo control
Betaine、 (6S)-5-methyltetrahydrofolic acid、vitamin B6、vitamin B12 and zinc per day orally for 12 weeks.
Also known as: Betaine、 (6S)-5-methyltetrahydrofolic acid、vitamin B6、vitamin B12 and zinc supplement
The placebo is an excipient and the color, flavor, shape, taste and weight are same with the tablet of supplement.
levels of homocysteine
At baseline, 4 weeks and 12 weeks, blood samples will be drawn and levels of homocysteine will be tested in two groups.
Time frame: 12 weeks
levels of 5-methyltetrahydrofolic acid, vitamin B6, vitamin B12 and betaine
At baseline, 4 weeks and 12 weeks, blood samples will be drawn and levels of 5-methyltetrahydrofolic acid, vitamin B6, vitamin B12 and betaine will be tested in two groups.
Time frame: 12 weeks
levels of s-adenosyl-methionine and s-adenosyl-homocysteine
At baseline, 4 weeks and 12 weeks, blood samples will be drawn and levels of s-adenosyl-methionine (SAM) and s-adenosyl-homocysteine (SAH) will be tested in two groups.
Time frame: 12 weeks
anthropomorphic measurements and blood biochemical markers
Anthropomorphic measurements such as height, weight, waist circumference, hip circumference, vascular endothelial function, cardiopulmonary function, body composition and so on, and blood biochemical markers such as overnight fasting serum total cholesterol (TC), triglyceride (TG), LDL cholesterol (LDLc), HDL cholesterol (HDLc), fasting blood glucose and so on will be measured.
Time frame: 12 weeks
This study is status unknown, as verified in May 2019. You cannot join it, but the record below documents what was studied.
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Huilian Zhu