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CompletedNCT01391416Updated Jul 12, 2011

Prevalence Of Hyperhomocysteinemia In Thai Chronic Kidney Disease (CKD) Patients

An observational study in Cardiovascular Disease and Hyperhomocysteinemia, sponsored by Bangkok Metropolitan Administration Medical College and Vajira Hospital. Completed. Open to participants aged 18 Years to 75 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2011-07-12.

Sponsored by Bangkok Metropolitan Administration Medical College and Vajira Hospital · Observational

Study type
Observational
Model
Case-only
Time perspective
Cross-sectional
Enrollment
98
Ages
18 Years to 75 Years
Sex
All
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Study summary

It is well recognized that patients with chronic kidney disease (CKD) have an increased risk for cardiovascular disease (CVD) and hyperhomocysteinemia appears to be a predictor of future CVD events. Hyperhomocysteinemia has been reported to bo of high prevalence in patients with CKD. The investigators aim to study the prevalence of hyperhomocysteinemia in Thai CKD patients by using Thai Screening and Early Evaluation of Kidney Disease (SEEK) study database and their relationship to CVD.

Read the detailed description

Ninety eight subjects were sampling from Thai SEEK study database Traditional Traditional risk factors of CVD such as total cholesterol, triglyceride, age, sex, history of smoking and blood pressure levels were examined and recorded. Stored sera of these subjects were analyzed for the total homocysteine (tHcy) level. Analysis of variance was used to evaluate the different of mean tHcy among groups

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Conditions studied

  • Cardiovascular Disease
  • Hyperhomocysteinemia

Keywords

  • Hyperhomocysteinemia
  • Chronic kidney disease
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In context

Cardiovascular Diseases

5,368 studies on the registry are indexed under Cardiovascular Diseases; 939 are open to participants now.

This study's enrollment of 98 is below the median of 506 across 1,572 observational studies indexed under Cardiovascular Diseases.

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Lead sponsor

Bangkok Metropolitan Administration Medical College and Vajira Hospital is the lead sponsor of 23 studies on the registry; 1 is open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years to 75 Years
Sexes eligible
All
Accepts healthy volunteers
Yes
Sampling method
Probability sample

Study population

Ninety eight subjects from CKD stages 3-4 were randomly sampling from Thai- SEEK study database. Thai-SEEK study is a community-based cross-sectional survey that was conducted between August 2007-june 2008 in four regions of Thailand (i.e Northern, Northeastern, Central and Southern) and Bangkok (Metropolitan).

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  • CKD stages 3-4 from Thai SEEK Study

Exclusion criteria

Exclusion Criteria:

  • CKD stage 5
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Study design

Observational model
Case-only
Time perspective
Cross-sectional
Enrollment
98 participants (actual)
Biospecimen retention
Samples without dna

Groups and cohorts

  • CKD stage 3-4

    CKD stage 3-4 from Thai SEEK study

  • hyperhomocysteine group

    CKD stage 3-4 from Thai SEEK study

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What researchers measure

Primary outcomes

  1. Level of Homocysteine

    Level of homocysteinemia according to each CKD level

    Time frame: 3 months

Secondary outcomes

  1. Association of cardiovascular event to the level of homocysteine

    Hugh level of homocysteine will have association with cardiovascular events or not

    Time frame: 3 months

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Study locations

No study locations are listed for this record.

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References and documents

Publications

  • Ingsathit A, Thakkinstian A, Chaiprasert A, Sangthawan P, Gojaseni P, Kiattisunthorn K, Ongaiyooth L, Vanavanan S, Sirivongs D, Thirakhupt P, Mittal B, Singh AK; Thai-SEEK Group. Prevalence and risk factors of chronic kidney disease in the Thai adult population: Thai SEEK study. Nephrol Dial Transplant. 2010 May;25(5):1567-75. doi: 10.1093/ndt/gfp669. Epub 2009 Dec 27. PubMed 20037182 ↗
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Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 12, 2011, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT01391416
Lead sponsor
Bangkok Metropolitan Administration Medical College and Vajira Hospital
First posted
Jul 12, 2011
Start date
Jun 2010
Primary completion
Nov 2010
Completion
Jan 2011
Last update
Jul 12, 2011

Study contacts

Thananda Trakarnvanich, M.D.
principal investigator · Renal Unit,Department of Medicine,Faculty of Medicine,Vajira Hospital,University of Bangkok Metropolis

Oversight

Data monitoring committee
Yes
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is completed, as verified in May 2010. You cannot join it, but the record below documents what was studied.

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