SupplementDrug
Levomefolic acid clinical trials
Also written L-methylfolate.
- studies test it
- 21
- open now
- 7
- in phase 3
- 3
- first study started
- 1998
Keep track of what changes. Save the levomefolic acid studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
21 studies that test it; most in 2025 (3)
| Year | Studies |
|---|---|
| 1998 | 1 |
| 2004 | 1 |
| 2006 | 1 |
| 2010 | 1 |
| 2011 | 1 |
| 2012 | 1 |
| 2014 | 1 |
| 2017 | 1 |
| 2019 | 2 |
| 2020 | 1 |
| 2022 | 1 |
| 2023 | 2 |
| 2024 | 2 |
| 2025 | 3 |
| 2026 | 2 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 2
- Phase 2
- 3
- Phase 3
- 3
- Phase 4
- 3
- No phase
- 12
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 2 · Other 19
University of British Columbia (4) · University of Ulster (1) · Oklahoma State University Center for Health Sciences (1) · Dr. Soetomo General Hospital (1) · Alexandria University (1) · Riphah International University (1) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (1) · University of Iowa (1)
Often tested with
Tested in the same studies.
Riboflavin (2) · Mecobalamin (2) · Vitamin B 12 (2) · Magnesium (2) · Omega-3 fatty acid (1) · Niacinamide (1) · Taurine (1) · Creatine (1)
Studies
Open first, then newest update. How each study uses levomefolic acid is read from its arms, and is right about nine times in ten.
Testing it · 21
- The Effects of 5-methyltetrahydrofolate Supplementation in Patients With Metabolic Dysfunction-Associated Steatotic Liver DiseaseNot yet recruitingNot applicableTabriz University of Medical SciencesNCT07740109Written as 5-methyltetrahydrofolate (5-MTHF)
- Interest of Myo-inositol Supplementation in Women With Polycystic Ovarian SyndromeRecruitingPhase 3University Hospital, LilleNCT03059173Written as Myo-Inositol + Levomefolic acid
- Pharmacokinetic Study of Eicosapentaenoic Acid (EPA) and Calcium L-5-Methyltetrahydrofolate (L-5-MTHF) After Administration of CreNeuroS® CNS Fish Oil Plus Softgels in Healthy Subjects Under Fasting ConditionsNot yet recruitingNot applicableSichuan Credit Pharmaceutical Co., Ltd.NCT07461649Written as Eicosapentaenoic Acid (EPA) and Calcium L-5-Methyltetrahydrofolate (L-5-MTHF)
- Adjunctive Treatment With L-methylfolate for Treatment-Resistant Generalized Anxiety Disorder: a Pilot StudyRecruitingPhase 4Queen's UniversityNCT06218030Written as L-methylfolate
- 5-MTHF Supplementation for Treatment of Type 1 Diabetes PatientsNot yet recruitingNot applicableShanghai Changzheng HospitalNCT06930144Written as active folate
- PREconception Folic Acid Clinical Efficacy (PREFACE) TrialNot yet recruitingNot applicableUniversity of British ColumbiaNCT06641245Written as 5-MTHF (5-methyltetrahydrofolate)
- Impact of High-dose Folic Acid Supplementation on Pathways Linked to DNA FormationNot yet recruitingNot applicableUniversity of British ColumbiaNCT01687127Written as 5-methyltetrahydrofolate, calcium salt
- Comparison of The Effect of 5-MTHF and Folic Acid Supplementation in Increasing Red Blood Cell Folate in Pregnant WomenCompletedNot applicableDr. Soetomo General HospitalNCT06935630Written as 5-MTHF (5-methyltetrahydrofolate)
- Optimal Nutrition for Prevention of Hypertension in PregnancyActive, not recruitingNot applicableUniversity of UlsterNCT04723836Written as 5-methyltetrahydrofolate (400µg)
- Efficacy of L-methylfolate and Methylcobalamine in Treating Resistant Hypertension Associated with Elevated Serum Homocysteine in Hemodialysis Patients.CompletedPhase 4Alexandria UniversityNCT05807711Written as L-Methyl Folate and methylcobalamine
- Combination Therapy of Different Antidepressants With Dietary SupplementsCompletedNot applicableRiphah International UniversityNCT05931965Written as L-methylfolate
- Food and Alcohol Behavior Study: Meaningful EnhancementActive, not recruitingNot applicableOklahoma State University Center for Health SciencesNCT04095052Written as Methyl Folate
- Natural Folate vs. Synthetic Folic Acid in PregnancyCompletedNot applicableUniversity of British ColumbiaNCT04022135Written as (6S)-5-methyltetrahydrofolic acid
- Effectiveness of Folic Acid Supplementation in Acute Watery Diarrhea Among Children Under 5 Years of AgeStatus unknownPhase 4King Edward Medical UniversityNCT04782037Written as L-Methylfolate Calcium
- 5-methyltetrahydrofolate Survival and Inflammation in ESRD PatientsCompletedNot applicableIRCCS Azienda Ospedaliero-Universitaria di BolognaNCT00626223Written as 5-MTHF (5-methyltetrahydrofolate)
- Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS)CompletedPhase 1University of IowaNCT01381354Written as methyl folate
- L-methylfolate Supplementation to OROS-Methylphenidate Pharmacotherapy in ADHD AdultsCompletedPhase 2/3Massachusetts General HospitalNCT01853280Written as L-methylfolate
- Folic Acid vs 5-methyltetrahydrofolate (5MTHF) in Recurrent AbortionCompletedPhase 2/3National Nutrition and Food Technology InstituteNCT01976676Written as 5-methyltetrahydrofolate
- Bioavailability of Folic Acid Fortified BreadCompletedPhase 2University of British ColumbiaNCT01570088Written as L-5-MTHF
- Investigation of Bioequivalence of Ethinylestradiol (EE) and Drospirenone (DRSP) in Two Different Tablet Formulations: YAZ and YAZ + Levomefolate Calcium (Metafolin) & L-5-MTHF in Two Different Tablet Formulations: Levomefolate Calcium (Metafolin) and YAZ + Levomefolate Calcium (Metafolin)CompletedPhase 1BayerNCT01253187Written as L-5-MTHF 0.451mg (Metafolin)
See all 21 studies that test levomefolic acid →
Given in every arm · 2 — levomefolic acid is usual care beside what is tested
- China Stroke Primary Prevention Trial 2 for Participants with Hypertension and MTHFR 677 TT GenotypeRecruitingPhase 4Shenzhen Ausa Pharmed Co.,LtdNCT04974151Written as 5-methyltetrahydrofolate (5-MTHF)
- Pilot Study: Combining Nutritional Supplements With Standard Antidepressant to Treat Depression.WithdrawnNot applicableJohn D. Dingell VA Medical CenterNCT02223299Written as deplin
Codes
What other systems call levomefolic acid · ClinicalTrials.gg INT002357
- UNII (FDA) 8S95DH25XCLEVOMEFOLIC ACIDConfirmed FDA, NLM, Wikidata
- RxNorm 1025342Confirmed FDA, Wikidata
- Wikidata Q192553levomefolic acidConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C81119Levomefolic AcidConfirmed FDA, Wikidata
- DrugBank DB11256One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| UNII (FDA) | 8S95DH25XC | LEVOMEFOLIC ACID | Confirmed FDA, NLM, Wikidata |
| RxNorm | 1025342 | — | Confirmed FDA, Wikidata |
| Wikidata | Q192553 | levomefolic acid | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C81119 | Levomefolic Acid | Confirmed FDA, Wikidata |
| DrugBank | DB11256 | — | One source Wikidata |
Also registered as 5-methyltetrahydrofolic acid (UNII TYK22LML8F · RxNorm 1313966).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.