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S-Adenosylmethionine clinical trials
Also written SAMe and S-adenosyl-L-methionine.
- studies test it
- 34
- open now
- 4
- in phase 3
- 6
- first study started
- 2003
Keep track of what changes. Save the S-Adenosylmethionine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Name
Brand
Other names
Combined with it in one product
Studies by the year they started
34 studies that test it; most in 2013 (5)
| Year | Studies |
|---|---|
| 2003 | 1 |
| 2004 | 2 |
| 2005 | 4 |
| 2007 | 2 |
| 2008 | 3 |
| 2009 | 1 |
| 2010 | 1 |
| 2012 | 1 |
| 2013 | 5 |
| 2014 | 2 |
| 2015 | 2 |
| 2017 | 1 |
| 2020 | 1 |
| 2022 | 2 |
| 2023 | 1 |
| 2025 | 2 |
| 2026 | 3 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 4
- Phase 2
- 11
- Phase 3
- 6
- Phase 4
- 3
- No phase
- 12
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 6 · Other 28
Mayo Clinic (3) · Bonafide Health (2) · MSI Methylation Sciences, Inc. (2) · Emory University (2) · Abbott (2) · Cedars-Sinai Medical Center (2) · Medical University of Warsaw (1) · Dartmouth-Hitchcock Medical Center (1)
Often tested with
Tested in the same studies.
Zinc (2) · Zinc Sulfate (1) · Tablets (1) · Lenalidomide (1)
Studies
Open first, then newest update. How each study uses S-Adenosylmethionine is read from its arms, and is right about nine times in ten.
Testing it · 34
- SAMe in Prevention of Oxaliplatin-associated Liver InjuryNot yet recruitingPhase 2Cedars-Sinai Medical CenterNCT06258525Written as S-adenosylmethionine (SAMe) supplement
- S-Adenosylmethionine (SAMe) for Chemoprevention of Colorectal AdenomasNot yet recruitingPhase 1Jun Gong, MDNCT07582003Written as S-Adenosylmethionine (SAMe)
- SAMe for Prevention of Liver Cancer in MASLD-Related CirrhosisNot yet recruitingPhase 2Cedars-Sinai Medical CenterNCT07495995Written as S-adenosyl-L-methionine (SAMe)
- SAMe Trial for Patients With Alcoholic CirrhosisRecruitingPhase 2Indiana UniversityNCT04250259Written as SAMe 400 mg tablet
- Bonafide Sleep Supplement for Menopausal Women With Sleep ComplaintsCompletedNot applicableBonafide HealthNCT07839312Written as S-Adenosyl Methionine (SAMe), Propyl Gallate, Gamma-Aminobutyric Acid (GABA), L-Theanine, and Magnesium Glycinate
- Bonafide Sleep Supplement for Menopausal Women With Impaired SleepCompletedNot applicableBonafide HealthNCT07839299Written as S-Adenosyl Methionine (SAMe), Propyl Gallate, Gamma-Aminobutyric Acid (GABA), L-Theanine, and Magnesium Glycinate
- S-adenosylmethionine (SAMe) in Patients With Primary Sclerosing Cholangitis (PSC)CompletedNot applicableMedical University of WarsawNCT06026865Written as S-Adenosyl-L-methionine (SAMe)
- S-Asenosyl-L-Methionine vs Placebo for Osteoarthritis of the HandsCompletedPhase 4Dartmouth-Hitchcock Medical CenterNCT05363020Written as S-Adenosyl-L-Methionine (Sam-E)
- Examination of Zinc, S-adenosylmethionine, and Combination Therapy Versus Placebo in AlcoholicsCompletedNot applicableVA Office of Research and DevelopmentNCT01899521Written as S-adenosylmethionine 400 mg twice daily
- Immunomodulators on HIV-1 ReservoirStatus unknownPhase 4First Affiliated Hospital of Zhejiang UniversityNCT05598580Written as Adenosylmethionine
- Evaluation of the Safety and Pharmacokinetics of MSI-195 to a Commercial S-AdenosylmethionineCompletedPhase 1MSI Methylation Sciences, Inc.NCT04623034Written as Ademetionine
- The Efficacy of S-adenosyl Methionine (SAMe) Versus Pentoxiphylline in Patients With Non-alcoholic Steatohepatitis With FibrosisCompletedNot applicableInstitute of Liver and Biliary Sciences, IndiaNCT02231333Written as S-adenosylmethionine (SAMe)
- Immune Enhancement for Immunological Non-responders to ARTCompletedNot applicableEmory UniversityNCT01806870Written as Zinc and SAMe
- Researching Alveolar Macrophage Improvements With Supplements in HIVCompletedNot applicableEmory UniversityNCT02264860Written as Zinc and SAMe
- A Trial of SAMe for Treatment-Resistant Bipolar DepressionCompletedNot applicableMclean HospitalNCT00762268Written as SAMe
- Evaluation of SAMe for Hot FlashesCompletedPhase 2Mayo ClinicNCT01140646Written as S-adenosyl-L-methionine disulfate p-toluene-sulfonate
- Liver Cancer Prevention Trial in Patients With Chronic Hep C InfectionCompletedPhase 2Chao Family Comprehensive Cancer CenterNCT00513461Written as S-adenosyl-L-methionine disulfate p-toluene-sulfonate
- Evaluation of S-adenosyl Methionine (SAM-e) for Recurrent Abdominal Pain in ChildrenCompletedNot applicableHuang, Jeannie, M.D.NCT00694564Written as S-adenosyl methionine
- Effect of S-adenosylmethionine (SAMe) on Blood Levels of HomocysteineCompletedPhase 1Baylor Research InstituteNCT00473200Written as S-adenosylmethionine
- SAMe to Treat Biliary Cirrhosis SymptomsTerminatedPhase 2National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NCT00125281Written as S-adenosyl-methionine (SAMe) capsules
See all 34 studies that test S-Adenosylmethionine →
As the comparator · 1 — what is tested is compared with S-Adenosylmethionine
Codes
What other systems call S-Adenosylmethionine · ClinicalTrials.gg INT008171
- MeSH (NLM) D012436S-AdenosylmethionineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 564ROC9U09S-ADENOSYL-L-METHIONINE DISULFATE TOSYLATEConfirmed FDA, NLM
- RxNorm 9506One source FDA
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D012436 | S-Adenosylmethionine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 564ROC9U09 | S-ADENOSYL-L-METHIONINE DISULFATE TOSYLATE | Confirmed FDA, NLM |
| RxNorm | 9506 | — | One source FDA |
Also registered as ademetionine (UNII 7LP2MPO46S · RxNorm 9504).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.