Heartburn clinical trials
The registry lists 99 studies for Heartburn across more than 10 countries. 10 are recruiting or about to start. Per ClinicalTrials.gov, last updated 2026-09-24.
Status
- Completed
- 75
- Recruiting
- 7
- Status unknown
- 7
- Active, not recruiting
- 3
- Terminated
- 3
- Not yet recruiting
- 2
Phase
- Phase 4
- 22
- Phase 3
- 22
- Phase 1
- 8
- Phase 2
- 6
Where
- United States
- 45
- Korea, Republic of
- 5
- Germany
- 4
- Thailand
- 3
- Belgium
- 3
- Russian Federation
- 3
Who runs them
AstraZeneca (12) · Novartis (6) · Bayer (5) · Phathom Pharmaceuticals, Inc. (4) · Takeda (4) · Eisai Inc. (3) · Seoul National University Bundang Hospital (2) · Chang Gung Memorial Hospital (2)
Studies
Recruiting first, then most recently updated. Showing 50 of 99 — search for more.
- A Study of the Safety of Vonoprazan Exposure in Pregnant Women and Their OffspringRecruitingNCT066603421 country
- Antireflux Surgery Without Preoperative Esophageal ManometryNot yet recruitingNCT07659080Not applicable2 countries
- Potassium Competitive Acid Blocker (PCAB) Test-Guided vs Physiologic Test-Guided Treatment in Patients With Typical Reflux SymptomsEnrolling by invitationNCT07707011Not applicable1 country
- New Topical tReatment Options for Symptomatic patiEnts With Nonerosive gastroesophageaL Reflux dIsease (The RELIEF Trial)RecruitingNCT07624383Not applicable1 country
- Study on Hydrotalcite for Relief of Acid Symptoms Due to Acid Rebound After Stopping Long-Term PPI TherapyRecruitingNCT072917001 country
- A Study of Breath Testing for Small Intestinal Bacterial OvergrowthRecruitingNCT05976165Not applicable1 country
- Comparative Pharmacodynamics and Pharmacodynamics Equivalence of Antareit 800 mg/10 ml Oral Suspension and Riopan 800 mg Chewable Tablets in Healthy VolunteersRecruitingNCT06098742Not applicable1 country
- The Effect of the LEFT Smartwatch App as Sleep Positional Therapy for Nocturnal Gastroesophageal Reflux Symptoms.RecruitingNCT06075082Not applicable1 country
- A Study to Evaluate the Efficacy and Safety of Tegoprazan in GERD Patients With Nighttime HeartburnRecruitingNCT05701540Phase 41 country
- Prevalence of Fuctional Heartburn in Patients With IBS .Not yet recruitingNCT05901740
- Domperidone in Treating Patients With Gastrointestinal DisordersActive, not recruitingNCT01696734Phase 31 country
- Registry of Outcomes From AntiReflux SurgeryCompletedNCT029233621 country
- Multi-Center Study of Panosyl-Isomaltooligosaccharides Adjunctive to PPI Therapy to Treat GERDCompletedNCT05556824Phase 21 country
- A Clinical Trial of PepZinGI® for Acute Heartburn Relief and Sleep OutcomesCompletedNCT07379645Not applicable1 country
- A Pre-market, Two-stages Interventional Clinical Investigation to Evaluate the Safety and the Performance of Fibroin Syrup in Reducing the Gastroesophageal Reflux Disease (GERD) Symptomatology in Nonerosive Reflux Disease (NERD) PatientsCompletedNCT07563790Not applicable1 country
- Outcomes After Medical and Surgical Treatment of Gastroesophageal Reflux DiseaseActive, not recruitingNCT002605721 country
- Trial of Itopride 150mg Once a Day Versus Itopride 50 mg Thrice a Day; in Patients With Functional DyspepsiaCompletedNCT06217393Phase 35 countries
- Effectiveness of a Butyrate Formulation and Butyrate + Polyphenol Formulation on Gut Health, Permeability and Associated SymptomsCompletedNCT06419231Not applicable1 country
- The Anti-gastroesophageal Reflux Effect of Anvitra Gastric Suspension on Outpatients With Gastroesophageal Reflux DiseaseCompletedNCT06889246Not applicable1 country
- Observationa Study is a Prospective and Multi-institutional Observational Study.CompletedNCT069528551 country
- A Study to Evaluate Vonoprazan Concentrations in Breast Milk of Healthy Lactating Women Receiving Vonoprazan 20 mg Once Daily or Vonoprazan 20 mg Twice DailyCompletedNCT06391177Phase 11 country
- A Clinical Study to Assess the Safety and Effectiveness of Test Product in Healthy Adult Human Subjects Having Symptoms of Gut Dysbiosis (Heart Burn, Bloating, Constipation and Gut Immunity).CompletedNCT06572358Not applicable1 country
- Smartphone App-assisted PPICompletedNCT06094062Not applicable1 country
- Primary carE PPi dEprescRibing TrialActive, not recruitingNCT05629143Phase 41 country
- Remote Guided Caffeine ReductionCompletedNCT04560595Not applicable1 country
- Comparative Pharmacodynamics and Pharmacodynamics Equivalence of Antareit 800 mg Chewable Tablets and Riopan 800 mg Chewable Tablets in Healthy VolunteersCompletedNCT06552624Not applicable1 country
- A First-in-Human Study to Learn How Well a Bi-Layer Calcium Carbonate Antacid Tablet Works Compared to a Standard, Non-Layered Calcium Carbonate Tablet in Healthy Male ParticipantsCompletedNCT06293326Phase 11 country
- A Study to Evaluate the Efficacy and Safety of Vonoprazan Compared to Placebo for Relief of Heartburn in Participants With Symptomatic Non-Erosive Gastroesophageal Reflux Disease (NERD)CompletedNCT05195528Phase 31 country
- Implementation of a Minor Ailment Service in Community Pharmacy PracticeCompletedNCT05247333Not applicable1 country
- Tolerability Study of Panosyl-Isomaltooligosaccharides (PIMO) and a Placebo in Subjects With HeartburnCompletedNCT05363618Not applicable1 country
- A Study to Evaluate the Efficacy and Safety of Vonoprazan Compared to Placebo in Participants With Symptomatic Non-Erosive Gastroesophageal Reflux DiseaseCompletedNCT04799158Phase 21 country
- Symptom Control Satisfaction With Proton Pump Inhibitor RegimenCompletedNCT02623816Phase 41 country
- Study to Evaluate the Efficacy and Safety of Tegoprazan in ERD Patients With Nighttime Heartburn and Sleep DisturbanceCompletedNCT04309916Phase 41 country
- Study of Dietary Patterns and Food Diversity in Russian GERD PatientsStatus unknownNCT04252144Not applicable1 country
- Study to Evaluate the Efficacy of Arrae's Bloat & Calm Alchemy Capsules to Reduce Bloating, Heartburn and Gas, and Alleviate the Intensity of IBS SymptomsCompletedNCT05197413Not applicable1 country
- Protocol for the ESREFLUJO Study: Epidemiological Study of Heartburn and Gastroesophageal Reflux in Community PharmacyStatus unknownNCT05162079
- Bile Reflux Gastropathy: Prevalence and Risk Factors After Therapeutic Biliary InterventionsCompletedNCT051318021 country
- Upset Stomach Relief for Mild and Moderate Indigestion and HeartburnCompletedNCT04153552Not applicable1 country
- Mipolixin® Compared to Poliprotect® in Moderate Functional Dyspepsia and Heartburn.CompletedNCT03531372Not applicable1 country
- Fermented Soy and Heartburn Symptom ReliefCompletedNCT03867591Not applicable1 country
- Citalopram for Reflux Hypersensitivity and Functional HeartburnStatus unknownNCT03499171Phase 41 country
- Efficacy and Safety of Dexlansoprazole on Heartburn Relief in Chinese PatientsCompletedNCT02873689Phase 31 country
- Efficacy Study of Articaine Lozenge to Enhance the Procedural Compliance of the Adults Undergoing GastroduodenoscopyStatus unknownNCT02105090Phase 41 country
- An Open-Label Trial of Dexlansoprazole 60mg for the Relief of Heartburn During the Fasting Month of RamadanCompletedNCT03079050Phase 41 country
- Pilot Study To Investigate The Association Between Acid Control And Heartburn Symptoms After Proton Pump Inhibitor TreatmentCompletedNCT02708355Phase 41 country
- PPI Versus Placebo in Severe Functional HeartburnWithdrawnNCT00222989Not applicable1 country
- Response to Supplement and Placebo in GERDCompletedNCT01915173Not applicable1 country
- A Study to Assess the Bioequivalence of Famotidine Chewable Tablets and Film-Coated Tablets (0208-144)CompletedNCT00945750Phase 1
- Efficacy and Safety of Itopride vs Placebo in HeartburnCompletedNCT00382577Phase 31 country
- Can E-cadherin Found in Tissue/Blood be Valuable in Identifying & Monitoring Patients With Post-proton Pump Inhibitor (PPI)-Responsive HeartburnCompletedNCT01149395Phase 11 country