Headache Disorders, Secondary clinical trials
The registry lists 52 studies for Headache Disorders, Secondary across more than 10 countries. 13 are recruiting or about to start. 29 of them are mainly about Headache Disorders, Secondary (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 2 narrower conditions too, such as Post-Traumatic Headache: 361 studies, 92 open.
Get an email when these change. Save the Headache Disorders, Secondary studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
University of Florence (5) · Danish Headache Center (4) · IRCCS National Neurological Institute "C. Mondino" Foundation (3) · Norwegian University of Science and Technology (2) · Second Affiliated Hospital, School of Medicine, Zhejiang University (2) · Ankara City Hospital Bilkent (2) · Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta (2) · University Hospital, Akershus (2)
What is being tested here
Drugs under test in Headache Disorders, Secondary studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Islet Amyloid Polypeptide | 1 | 0 | 1 |
| Lidocaine | 1 | 0 | 1 |
| Eptinezumab | 0 | 1 | 2 |
| Topiramate | 0 | 0 | 2 |
| Erenumab | 0 | 0 | 1 |
| Botulinum toxin type A | 0 | 0 | 1 |
| Frovatriptan | 0 | 0 | 1 |
| Propofol | 0 | 0 | 1 |
| Sumatriptan | 0 | 0 | 1 |
| Ibudilast | 0 | 0 | 1 |
Drug classes tested here Serotonin receptor agonists 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3
- Dec 2026Personalized Pulsed Radiofrequency of the Greater Occipital Nerve for Medication Overuse Headache · Ankara City Hospital Bilkent
- Dec 2026i-NEED: NEw migrainE Drugs Database · IRCCS San Raffaele Roma
- Jan 2027RimegepAnt effectIvenesS and tolErability as Migraine Preventive Treatment · University of Florence
Who these studies take
Of the 11 Headache Disorders, Secondary studies recruiting now, 5 (45%) set no upper age limit and 2 (18%) stop at 75 or younger. 3 (27%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 4 (36%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (18%) | 2 (18%) |
| 18 | 11 (100%) | 11 (100%) |
| 30 | 11 (100%) | 11 (100%) |
| 40 | 11 (100%) | 11 (100%) |
| 50 | 11 (100%) | 11 (100%) |
| 65 | 11 (100%) | 11 (100%) |
| 75 | 9 (82%) | 9 (82%) |
| 85 | 7 (64%) | 7 (64%) |
Across all 52 studies, recruiting or not: 48% stop at 75 or younger and 38% at 65; 10% take children; 4% are for women only and 0% for men only; 13% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 50 of 52. Browse all 52 → or search them.
- Greater Occipital Nerve Block for Migraine With Medication Overuse HeadacheRecruitingNCT07568496Not applicable1 country
- Efficacy and Central Mechanisms of Electroacupuncture for Medication Overuse HeadacheRecruitingNCT06802471Not applicable1 country
- Osteopathic Care Combined With Physiotherapy and Pain Education for Cervicogenic HeadacheNot yet recruitingNCT07794319Not applicable1 country
- China HeadAche DIsorders RegiStryRecruitingNCT053349271 country
- RimegepAnt effectIvenesS and tolErability as Migraine Preventive TreatmentRecruitingNCT064098321 country
- i-NEED: NEw migrainE Drugs DatabaseRecruitingNCT071036941 country
- Personalized Pulsed Radiofrequency of the Greater Occipital Nerve for Medication Overuse HeadacheRecruitingNCT07360782Not applicable1 country
- Gepant treAtments: EffectIveNess and tolERability (GAINER)RecruitingNCT059030271 country
- Hypersensitivity to Amylin in Post-Traumatic HeadacheNot yet recruitingNCT07340775Not applicable1 country
- China Headache and Vertigo Registry StudyRecruitingNCT049399221 country
- International Headache Registry StudyRecruitingNCT054182181 country
- NUMITOR Study: Nummular Headache Iberian Study on the Treatments and Outcomes in Real-World SettingRecruitingNCT054757691 country
- Longitudinal Study of the Patients With Medication-overuse Headache or Migraine That Completed Baseline MRIRecruitingNCT055280811 country
- Feasibility of Exercise and Transcranial Direct Current Stimulation for the Treatment of Post-traumatic HeadacheCompletedNCT07928492Phase 11 country
- Treatment Response in Patients With Medication-Overuse HeadacheCompletedNCT074876491 country
- Effectiveness and Tolerability of EptinezumabCompletedNCT064098451 country
- Non-Invasive Brain Stimulation as Add-on Treatment in Chronic Migraine With Medication OveruseCompletedNCT07442916Not applicable1 country
- Greater Occipital Nerve Pulsed Radiofrequency in Cervicogenic HeadacheCompletedNCT06764433Not applicable1 country
- A Study of Eptinezumab in Participants With Migraine and Medication Overuse HeadacheCompletedNCT05452239Phase 411 countries
- Italian Real-life obServational Study on the effecTiveness, sAfety and Tolerability of Atogepant in Migraine PatientsActive, not recruitingNCT064140441 country
- Ditan Acute tReatments: Effectiveness and Tolerability (DART)CompletedNCT059030401 country
- A Study to Evaluate the Efficacy and Safety of Erenumab in Adults With Medication Overuse HeadacheCompletedNCT03971071Phase 412 countries
- Cannabidiol 133mg + Cannabigerol 66mg + Tetrahydrocannabinol 4mg Vs Placebo As Adjuvant Treatment in Chronic Migraine -TerminatedNCT04989413Phase 2/31 country
- Mindfulness Therapy for Chronic MigraineCompletedNCT03671681Phase 41 country
- An Open Internet-based Survey and Natural Language Processing Project Analysing Written Monologues by Headache PatientsCompletedNCT051538761 country
- Biofeedback-VR for Treatment of Chronic MigraineCompletedNCT05720819Not applicable1 country
- Medication-overuse Headache: The Effect of a Patient Educational Programme as an add-on to Standard TreatmentCompletedNCT02768233Not applicable
- Intravenous Treatments Used in Medication Overuse Headache Bridge TreatmentStatus unknownNCT05608642Not applicable1 country
- Eptinezumab in Adults With Migraine and Medication Overuse HeadacheCompletedNCT04772742Phase 35 countries
- The Effect of Botulinum Toxin A on Headache Attributed to TMDCompletedNCT03346252Early Phase 11 country
- Medication-overuse Headache (MOH): Withdrawal or Use of Preventative Medications Directly?CompletedNCT00159588Not applicable1 country
- Association Between Chronic Headache and Back Pain With ChildbirthCompletedNCT040913211 country
- Endocrinological Profile in Patients With Medication-overuse Headache Before and After Withdrawal TherapyCompletedNCT040903331 country
- Thoracic Spine Thrust Manipulation for Cervicogenic Headaches: A Randomized Clinical TrialCompletedNCT02708953Not applicable1 country
- Medication-overuse Headache: 4 Years Follow upCompletedNCT009186711 country
- Is Detoxification Needed in Medication-overuse Headache?Status unknownNCT02993289Not applicable1 country
- Anodal tDCS in Chronic Migraine With Medication OveruseCompletedNCT04336267Not applicable
- tDCS in Chronic Migraine With Medication Overuse (Edisom)CompletedNCT04228809Not applicable
- Peripheral Nerve Block and Topiramate in the Treatment of Medication Overuse HeadachesCompletedNCT03767062Not applicable1 country
- An Observation Study on Neuropsychology and Serum Melatonin Level in Patients With Medication Overuse HeadacheStatus unknownNCT036551841 country
- Frovatriptan as a Transitional Therapy in Medication Overuse HeadacheCompletedNCT01044251Phase 21 country
- Comparison of Two Detoxification Protocols for Treatment of Medication-overuse HeadacheCompletedNCT02903329Not applicable1 country
- Pilot Study of DFN-11 Injection in Medication Overuse HeadacheTerminatedNCT02583425Phase 21 country
- Propofol Injection for Daily HeadacheCompletedNCT00228267Phase 21 country
- Brief Intervention for Medication Overuse HeadacheCompletedNCT01314768Not applicable1 country
- Short Intervention for Medication Overuse Headache (MOH) - PilotCompletedNCT01078012Not applicable1 country
- Medication Overuse Headache (MOH) and an Innovative ApproachCompletedNCT02435056Not applicable
- Ibudilast in the Treatment of Medication Overuse HeadacheStatus unknownNCT01317992Phase 1/21 country
- CBT in Patients With Medication Overuse HeadacheStatus unknownNCT01754571Early Phase 11 country
- Effects of Transcranial Direct Current Stimulation in Refractory Chronic Migraine and Medication-overuse HeadacheStatus unknownNCT01752439Not applicable