Fetal Membranes, Premature Rupture clinical trials
The registry lists 100 studies for Fetal Membranes, Premature Rupture across more than 10 countries. 23 are recruiting or about to start. 79 of them are mainly about Fetal Membranes, Premature Rupture (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-27. Counting its narrower condition Chorioamnionitis too: 133 studies, 31 open.
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Who runs them
University Hospital, Clermont-Ferrand (3) · Hillel Yaffe Medical Center (3) · Assiut University (3) · Ain Shams University (3) · Hospital de Santa Maria, Portugal (2) · Ain Shams Maternity Hospital (2) · Puerta de Hierro University Hospital (2) · Cairo University (2)
What is being tested here
Drugs under test in Fetal Membranes, Premature Rupture studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 8
- Nov 2026Planned Early Induction of Labor vs Expectant Management for PROM · Pakistan Institute of Medical Sciences
- Dec 2026Microbiological and Biochemical Profiling of Amniotic Fluid in Women With Short Cervix or Premature Rupture of Membranes · Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Dec 2026Prevalence of Carriage of Extended-Spectrum Beta-Lactamase (ESBL)-Producing Enterobacteria in Preterm Premature Rupture of Membranes : A French Multicenter Cohort Study · Centre Hospitalier de Saint-Denis
- Jan 2027PROMab Trial: Ampicillin With or Without Gentamicin for Term Prelabour Rupture of Membranes · Sarawak General Hospital
- Mar 2027Effects of Emotional Freedom Technique and Music Therapy in High-Risk Pregnancy · Selcuk University
- Mar 2027Prediction of Latency Interval in Patients With Preterm Prelabor Rupture of Membranes · Ain Shams Maternity Hospital
- Apr 2027Intravenous Papaverine for Term Prelabor Rupture of Membranes · Wolfson Medical Center
- Oct 2027I.V Papavrine for Labor Induction in Term PROM · Western Galilee Hospital-Nahariya
Who these studies take
Of the 12 Fetal Membranes, Premature Rupture studies recruiting now, 7 (58%) set no upper age limit and 5 (42%) stop at 75 or younger. 3 (25%) take children under 18. 11 (92%) are for women only and 0 (0%) for men only; 5 (42%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (8%) | 0 (0%) |
| 18 | 10 (83%) | 0 (0%) |
| 30 | 11 (92%) | 0 (0%) |
| 40 | 11 (92%) | 0 (0%) |
| 50 | 9 (75%) | 0 (0%) |
| 65 | 7 (58%) | 0 (0%) |
| 75 | 7 (58%) | 0 (0%) |
| 85 | 7 (58%) | 0 (0%) |
Across all 100 studies, recruiting or not: 54% stop at 75 or younger and 54% at 65; 31% take children; 95% are for women only and 0% for men only; 41% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Fetal Membranes, Premature Rupture studies take
Of 23 interventional studies with no phase under Fetal Membranes, Premature Rupture, half reached primary completion within 28 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 28 mo13–62 · 23 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 15, 2026.
Started recruiting1
Stopped1
- Balloon + Oxytocin Versus Oral Misoprostol to Induce Labor in Case of PROM (RUBAPRO2)TerminatedOct 15, 2026NCT05568745
Studies
Recruiting first, then most recently updated. Showing 50 of 100. Browse all 100 → or search them.
- Selective Antibiotics When Symptoms Develop Versus Universal Antibiotics for Preterm NeonatesRecruitingNCT06377397Phase 31 country
- Prediction of Latency Interval in Patients With Preterm Prelabor Rupture of MembranesNot yet recruitingNCT078415871 country
- Enhancing Prediction of Adverse Pregnancy Outcomes in Africa Through Partnerships and InnovationRecruitingNCT078448761 country
- Intravenous Papaverine for Term Prelabor Rupture of MembranesRecruitingNCT07826533Not applicable1 country
- Effects of Emotional Freedom Technique and Music Therapy in High-Risk PregnancyRecruitingNCT07559071Not applicable1 country
- Planned Early Induction of Labor vs Expectant Management for PROMEnrolling by invitationNCT07802041Not applicable1 country
- Microbiological and Biochemical Profiling of Amniotic Fluid in Women With Short Cervix or Premature Rupture of MembranesRecruitingNCT07792083Not applicable1 country
- Impact of Early Rupture of the Residual Membrane on Latency Before Labour BeginsRecruitingNCT07301957Not applicable1 country
- Systematic Screening of Lower Genital Tract InfectionsNot yet recruitingNCT07592286Not applicable
- PROMab Trial: Ampicillin With or Without Gentamicin for Term Prelabour Rupture of MembranesNot yet recruitingNCT07563504Phase 41 country
- I.V Papavrine for Labor Induction in Term PROMRecruitingNCT07517796Phase 41 country
- PPROM Registry (Preterm Premature Rupture of Membranes)RecruitingNCT029973451 country
- PGE2 Followed by Oxytocin vs Oxytocin in Term PROM (POXY-PROM)RecruitingNCT07366359Not applicable1 country
- Prevalence of Carriage of Extended-Spectrum Beta-Lactamase (ESBL)-Producing Enterobacteria in Preterm Premature Rupture of Membranes : A French Multicenter Cohort StudyNot yet recruitingNCT072009991 country
- Oxytocin/Foley vs. Oxytocin for Induction in Patients With PPROMRecruitingNCT07119398Phase 41 country
- Group B Streptococcus Infection and PROM IncidinceNot yet recruitingNCT06735703
- Magnesium Sulphate in Premature Rupture of MembranesNot yet recruitingNCT05134688
- Outcome of Conservative Management in Cases of Pre Mature Rupture of Membranes (PROM) Between 20 and 28 Weeks of Pregnancy in Sohag City HospitalsEnrolling by invitationNCT062718631 country
- Emotional Support for Women Experiencing PPROMNot yet recruitingNCT06262308Not applicable1 country
- PeRinatal Outcomes With ACTive Versus Expectant Management of Women With Pre-labor Rupture Of MembranesNot yet recruitingNCT05958953Phase 31 country
- Oxytocin Induction in Full Term Pregnant Women With Cesarean Section of Prelabor Rupture of MembranesRecruitingNCT053337311 country
- Premature Rupture Membranes and tPTL: a Personalised Approach (PROMPT)Not yet recruitingNCT04878978Not applicable
- Latency Antibiotics in Previable PPROM, 18 0/7- 22 6/7 WGARecruitingNCT04047849Phase 41 country
- Erythromycin Versus Azithromycin for Preterm Prelabor Rupture of MembranesActive, not recruitingNCT06273891Phase 31 country
- Balloon + Oxytocin Versus Oral Misoprostol to Induce Labor in Case of PROM (RUBAPRO2)TerminatedNCT05568745Phase 41 country
- Novel Use of Central Venous Pressure (CVP) Set With McDonald Cerclage Technique for Amnioinfusion in Preterm Premature Rupture of Membranes Improves Amniotic Fluid Index and Neonatal OutcomesCompletedNCT07774832Not applicable1 country
- Predictive Score for Neonatal Mortality for Women With Premature Rupture of Membranes Between 22 and 28 Weeks of GestationTerminatedNCT031084041 country
- Outpatient Antibiotics Following Previable Rupture of Membranes (pPPROM) Between 18 0/7 and 22 6/7 Weeks Gestational AgeTerminatedNCT05345457Phase 41 country
- Latency Antibiotics for Previable Rupture Of Membranes TrialWithdrawnNCT06917157Phase 4
- Biochemical and Histological Changes in Pregnant Women With Preterm Premature Rupture of MembraneCompletedNCT066399191 country
- Intravenous Dexamethasone for Inducing Labor in Women With Term Pregnancy and Pre-Labour Rupture of MembranesCompletedNCT07503184Phase 41 country
- Intervention for Fear of Childbirth in High-Risk Pregnant WomenCompletedNCT06716710Not applicable1 country
- Early V/S Delayed Induction of Labour in Patients With Prelabour Rupture of MembranesCompletedNCT07261332Not applicable1 country
- Cranberry, Hibiscus, and Vitamin C Extracts Versus Placebo in Latency of Premature Rupture of Membranes.CompletedNCT06788132Not applicable1 country
- PROMMO Trial: Oral Misoprostol vs IV OxytocinCompletedNCT04478942Early Phase 11 country
- Safety Study of Membrane Sweeping in PregnancyCompletedNCT00294242Not applicable1 country
- Dilapan-S®: A Multicenter US E-registryActive, not recruitingNCT044511091 country
- Perinatal Conditions Influencing Morbidity, Mortality, and Medical Care in NewbornsCompletedNCT066533741 country
- Effects of Acupuncture in Spontaneous Rapture of Membranes: Applicability and EffectivenessCompletedNCT06623175Not applicable1 country
- Randomized Control Trial of Intracervical Balloon Placement vs Oxytocin in Women With Term PROM and Unripe CervicesWithdrawnNCT03172858Not applicable1 country
- Identification of Microbial DNA in Maternal Plasma After PPROMCompletedNCT043184701 country
- Biomarkers in Obstetrical ComplicationsCompletedNCT034801391 country
- Microarray Expression Profiling to Identify Stereotypic mRNA Profiles in Human ParturitionCompletedNCT003422774 countries
- Dinoprostone Induction vs. Expectant Management After PROM at TermStatus unknownNCT05430711Phase 4
- The Effects of Labor Stages and Interventions on Hemodynamic Measures During & After Childbirth With Noninvasive SensorsCompletedNCT03838965Not applicable1 country
- Induction of Labor in Pregnant Women With Prelabor Rupture of Membranes - Oxytocin or MisoprostolCompletedNCT05215873Phase 41 country
- An Individualised and Patient-centred Follow-up Program for Women With Gynaecological CancerStatus unknownNCT03838861Not applicable1 country
- Early Detection of Chorioamnionitis in Preterm Premature Rupture of MembranesCompletedNCT029017951 country
- Predictive Value of Maternal Serum Pentraxin 3 (PTX 3) and Heparin-binding Protein (HBP) for Chorioamnionitis in Preterm Premature Rupture of MembranesStatus unknownNCT05207800
- Cervical Ripening in Premature Rupture of MembranesCompletedNCT02314728Not applicable1 country