Chorioamnionitis clinical trials
The registry lists 39 studies for Chorioamnionitis across more than 10 countries. 9 are recruiting or about to start. 24 of them are mainly about Chorioamnionitis (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-26.
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Who runs them
Hospital de Santa Maria, Portugal (2) · Pediatrix (2) · Ohio State University (2) · Medical University of South Carolina (2) · Stanford University (2) · United States Naval Medical Center, Portsmouth (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · Guangdong Women and Children Hospital (1)
What is being tested here
Drugs under test in Chorioamnionitis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 5
- Nov 2026Planned Early Induction of Labor vs Expectant Management for PROM · Pakistan Institute of Medical Sciences
- Dec 2026Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT) · Ohio State University
- Feb 2027Comparing Infectious Morbidity Among Women With Meconium-stained Amniotic Fluid at Term, Between Those Treated With Prophylactic Antibiotics Zinacef vs. Placebo · Western Galilee Hospital-Nahariya
- Mar 2027IL-6 and Lactates in Cord Blood and Neonatal Outcomes · Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- May 2027Antipyretic Treatment for Intrapartum Fever: Dipyrone vs Acetaminophen (RCT) · Wolfson Medical Center
Who these studies take
Of the 6 Chorioamnionitis studies recruiting now, 4 (67%) set no upper age limit and 2 (33%) stop at 75 or younger. 1 (17%) take children under 18. 5 (83%) are for women only and 0 (0%) for men only; 3 (50%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 6 (100%) | 1 (17%) |
| 30 | 6 (100%) | 1 (17%) |
| 40 | 6 (100%) | 1 (17%) |
| 50 | 5 (83%) | 1 (17%) |
| 65 | 4 (67%) | 1 (17%) |
| 75 | 4 (67%) | 1 (17%) |
| 85 | 4 (67%) | 1 (17%) |
Across all 39 studies, recruiting or not: 33% stop at 75 or younger and 33% at 65; 46% take children; 82% are for women only and 0% for men only; 44% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 11, 2026.
Started recruiting1
- Amnioinfusion for Chorioamnionitis: Targeting Neonatal Brain Injury BiomarkersOct 26, 2026NCT07610642
Studies
Recruiting first, then most recently updated. Showing 39 of 39. search them.
- Amnioinfusion for Chorioamnionitis: Targeting Neonatal Brain Injury BiomarkersRecruitingNCT07610642Not applicable1 country
- Comparing Infectious Morbidity Among Women With Meconium-stained Amniotic Fluid at Term, Between Those Treated With Prophylactic Antibiotics Zinacef vs. PlaceboRecruitingNCT06849037Not applicable1 country
- Planned Early Induction of Labor vs Expectant Management for PROMEnrolling by invitationNCT07802041Not applicable1 country
- Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT)RecruitingNCT06396078Phase 41 country
- Amniotic Fluid & the Preterm GutRecruitingNCT071521061 country
- Antipyretic Treatment for Intrapartum Fever: Dipyrone vs Acetaminophen (RCT)Not yet recruitingNCT06950840Phase 41 country
- Preterm Rupture of Membranes Optimising Antibiotics TrialNot yet recruitingNCT06906757Not applicable
- Management of Prelabor Rupture of the Membranes at TermRecruitingNCT04307069Not applicable1 country
- Intrapartum Ultrasound in Labor: Sonography Only, Few Internal ExaminationsRecruitingNCT06261710Not applicable1 country
- IL-6 and Lactates in Cord Blood and Neonatal OutcomesActive, not recruitingNCT072115031 country
- Association Between Neuraxial Labor Analgesia and Maternal and Neonatal Infectious OutcomesActive, not recruitingNCT07751666
- Treatment of Chorioamnionitis After DeliveryWithdrawnNCT00814905Not applicable1 country
- Selective Use of Antibiotics in Neonates Born to Mothers With Suspected ChorioamnionitisCompletedNCT035765601 country
- Maternal Effects of Bacterial Vaginosis (BV) Treatment in PregnancyCompletedNCT00153517Phase 21 country
- Maternal Plasmatic Regulatory T Cells and Th17 as Possible Diagnosis Markers of Acute ChorioamnionitisCompletedNCT01610258Not applicable1 country
- Effect of Sterile Versus Clean Gloves Intrapartum and Postpartum Infections at TermTerminatedNCT05603624Not applicable1 country
- A Chart Review of Newborns With the Presence of Confirmed or Suspected Maternal Chorioamnionitis and Utilization of the Early Onset Sepsis CalculatorCompletedNCT045136911 country
- Circulating Markers in Preterm Infants With Perinatal and Neonatal InflammationTerminatedNCT033207851 country
- Predictive Value of Maternal Serum Pentraxin 3 (PTX 3) and Heparin-binding Protein (HBP) for Chorioamnionitis in Preterm Premature Rupture of MembranesStatus unknownNCT05207800
- Antibiotics to Reduce Chorioamnionitis-Related Perinatal HIV TransmissionCompletedNCT00021671Phase 31 country
- Safety of N-acetylcysteine in Maternal Chorioamnionitis (NAC in Chorio)CompletedNCT00724594Phase 1/21 country
- Assessment of Labour Progress by Intrapartum UltrasoundCompletedNCT04651309Not applicable1 country
- Safety and Efficacy Study of Intentional Delivery in Women With Preterm and Prelabour Rupture of the MembranesTerminatedNCT00259519Not applicable1 country
- Chorioamnionitis: Observation of at Risk Infants vs Standard CareWithdrawnNCT02886910Not applicable1 country
- Multimodal Monitoring of Fetal Risk of Inflammation in Preterm Premature Rupture of MembranesCompletedNCT027022971 country
- Intrapartum Fever: Antibiotics Versus no TreatmentWithdrawnNCT03168178Phase 41 country
- N-acetylcysteine in Intra-amniotic Infection/InflammationCompletedNCT00397735Phase 1/21 country
- Effect of Chorioamnionitis on Platelet Activation and Placental Vessel Among Preterm Infants by Wnt-Flt1 Signal PathwayCompletedNCT03636698
- Ampicillin / Sulbactam vs. Ampicillin / Gentamicin for Treatment of ChorioamnionitisCompletedNCT00879190Phase 2/31 country
- Intrapartum Study of Sterile and Clean GlovesCompletedNCT01852188Not applicable1 country
- Closure of Skin in ChorioAmnionitis Research Pilot StudyStatus unknownNCT01988168Not applicable1 country
- Chorioamnionitis and Proinflammatory S100A12CompletedNCT02996279
- Immediate Versus Delayed Induction in Term-PROM Using or Not Antibiotic ProphylaxisStatus unknownNCT02985086Not applicable1 country
- Antibiotic Prophylaxis in Prelabor Rupture of Membranes at TermCompletedNCT01633294Phase 2/31 country
- Perinatal Infections in PakistanCompletedNCT000707461 country
- Early Identification of Brain Insult in ChorioamnionitisStatus unknownNCT017787251 country
- Comparison of Once Daily Versus 8 Hour Dosing of Gentamicin for the Treatment of Intrapartum ChorioamnionitisCompletedNCT00185991Not applicable1 country
- Evaluation of Fever Occurring in Labor in Patients Receiving Epidural AnesthesiaStatus unknownNCT003265211 country
- Changes in Blood Flow in MCA of Fetuses to Mothers Having Clinical ChorioamnionitisStatus unknownNCT002996371 country