An observational study in Preterm Premature Rupture of Membrane, sponsored by Second Affiliated Hospital of Wenzhou Medical University. Status unknown. Open to female participants aged 18 Years to 40 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2022-01-26.
Sponsored by Second Affiliated Hospital of Wenzhou Medical University · Observational
Objective: The aim of this study was to investigate the predictive value of maternal serum pentraxin 3 (PTX3) and heparin-binding protein (HBP) for chorioamnionitis in preterm premature rupture of membranes (PPROM).
Method: This observational prospective cohort study included a total of 180 pregnant women at 24-40 gestational weeks. There were 60 cases of term premature rupture of membranes (TPROM), 60 cases of preterm premature rupture of membranes（PPROM）and 60 cases of healthy women. The concentrations of PTX3 and HBP were measured in maternal blood and amniotic fluid using an enzyme-linked immunosorbent assay (ELISA). Western immunoblotting was used to analyze the expression of PTX3 and HBP in placental tissue. The localization and immunoreaction of PTX3 and HBP in placenta were determined via immunohistochemistry (IHC).
75 studies on the registry are indexed under Preterm Premature Rupture of the Membranes; 17 are open to participants now.
This study's planned enrollment of 180 is above the median of 100 across 24 observational studies indexed under Preterm Premature Rupture of the Membranes.
Browse Preterm Premature Rupture of the Membranes studies →Second Affiliated Hospital of Wenzhou Medical University is the lead sponsor of 137 studies on the registry; 46 are open to participants now.
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pregnant women
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A yellow substance made when red blood cells are broken down, which the liver clears. A high level can mean a problem with the liver or the bile ducts.
Criteria often allow more for people with Gilbert’s syndrome, a harmless inherited condition that raises bilirubin.
Bilirubin
A yellow substance made when red blood cells are broken down, which the liver clears. A high level can mean a problem with the liver or the bile ducts.
Criteria often allow more for people with Gilbert’s syndrome, a harmless inherited condition that raises bilirubin.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
healthy pregnant woman
Other: The concentrations of PTX3 and HBP were monitored in maternal blood, placental tissue and amniotic fluid.
pregnant women with term premature rupture of membranes
Other: The concentrations of PTX3 and HBP were monitored in maternal blood, placental tissue and amniotic fluid.
pregnant women with preterm premature rupture of membranes
Other: The concentrations of PTX3 and HBP were monitored in maternal blood, placental tissue and amniotic fluid.
The concentrations of PTX3 and HBP were monitored in maternal blood, placental tissue and amniotic fluid.
PTX3 and HBP concentrations in maternal blood
PTX3 and HBP concentrations in maternal blood
Time frame: 24 weeks to 40 weeks gestation
PTX3 and HBP concentrations in placental tissue
PTX3 and HBP concentrations in placental tissue
Time frame: 24 weeks to 40 weeks gestation
PTX3 and HBP concentrations in amniotic fluid
PTX3 and HBP concentrations in amniotic fluid
Time frame: 24 weeks to 40 weeks gestation
No study locations are listed for this record.
Start is estimated for Feb 2022; primary completion for Dec 2022, 10 months later.
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This study is status unknown, as verified in Jan 2022. You cannot join it, but the record below documents what was studied.
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Preterm Premature Rupture of the Membranes →
Second Affiliated Hospital of Wenzhou Medical University →