An observational study in Trigeminal Neuralgia, Tic Douloureux and Facial Pain, sponsored by Gerrit A Schubert. Not yet recruiting at 2 sites in 2 countries. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2025-08-21.
Sponsored by Gerrit A Schubert · Observational
The aim of the registry is a multicenter, prospective long-term data collection of patients suspected neurovascular conflict and referred for possible microvascular decompression (Jannetta procedure). The registry relies exclusively on routinely collected clinical data, which are gathered in a standardized and privacy-compliant manner as part of everyday clinical practice. By systematically compiling this information across multiple centers, valuable insights into the effectiveness, potential side effects, and long-term outcomes of this surgical treatment can be gained. The registry will serve as a foundation for future scientific analyses and is intended to help answer relevant research questions regarding the treatment of trigeminal neuralgia based on solid evidence.
140 studies on the registry are indexed under Trigeminal Neuralgia; 44 are open to participants now.
This study's planned enrollment of 5,001 is above the median of 84 across 38 observational studies indexed under Trigeminal Neuralgia.
Browse Trigeminal Neuralgia studies →This is the only study on the registry with Gerrit A Schubert as lead sponsor.
Counted across the registry records on this site, refreshed daily.
Study cohort will be selected from local Department of Neurosurgery of participating hospitals
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Exclusion Criteria:
Pain relief after surgical treatment
Efficacy of microvascular decompression surgery, defined by the change in pain as assessed by the patient using the Visual Analog Scale (VAS) from 0 to 100 mm, with higher scores representing worse outcomes.
Time frame: From enrolment to last follow-up 5 yrs after surgery
Face specific pain relief after surgical treatment
Efficacy of microvascular decompression surgery, defined by the change in facial pain and pain interference as assessed by the patient using the Brief Pain Inventory-Facial (BPI-Facial), with numerical scores ranging from 0 to 10, where higher scores represent worse outcomes.
Time frame: From enrolment to last follow-up 5 yrs after surgery
Surgical complications
any complications directly attributable to the surgical intervention
Time frame: three months after index surgery
Need for additional treatment
rate of patients having to undergo additional surgery / intervention / medication after microvascular decompression
Time frame: 5 years after index surgery
Patient satisfaction
Perceived benefit of surgery as determined by Patient global impression of change (PGIC) scores. The PGIC is a 7-point, patient-reported scale that captures an individual's overall perception of change in their condition. It ranges from "very much improved" to "very much worse," enabling patients to rate whether they feel their health has improved, remained the same, or declined.
Time frame: 5yrs after index surgery
Effect of surgical treatment on quality of life
Efficacy of microvascular decompression surgery as defined by change of Quality of Life Questionaire as measured by EQ-5D-5L. The EQ-5D-5L is a standardized, patient-reported outcome measure that assesses health-related quality of life across five dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. Each dimension has five levels of severity, ranging from "no problems" to "extreme problems.
Time frame: 5 years after index surgery
Plan to share: Undecided
No publications or documents are linked to this record.
Start is estimated for Oct 2025; primary completion for Oct 2030, 60 months later.
Of 19 observational studies under Trigeminal Neuralgia, half reached primary completion within 37 months of starting (the median), counting those still running; a quarter within 24 and three quarters within 59. This study's planned 60 months is above that.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Aug 2025. You cannot join it, but the record below documents what was studied.
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