Diarrhea clinical trials
The registry lists 877 studies for Diarrhea across more than 10 countries. 76 are recruiting or about to start. 519 of them are mainly about Diarrhea (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its narrower condition Diarrhea, Infantile too: 897 studies, 80 open.
ClinicalTrials.gov finds 1,215 studies for Diarrhea. How that becomes 876 here
This page counts the studies the registry files under Diarrhea, and those it files under no condition that list Diarrheathemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 1,215Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −20Filed under a narrower condition, counted on its own pageDiarrhea, Infantile 20
- −103List Diarrhea as a condition, but the registry did not file them under itMost often written as “Irritable Bowel Syndrome With Diarrhea” (16), “Antibiotic-associated Diarrhea” (9), and “Chronic Diarrhea” (8). The registry filed them under other conditions only, most often Irritable Bowel Syndrome (31) and Dysentery (13).
- −216Match it another way140 name it in the title, 38 in a keyword, and 38 by a synonym or other text the search reads.
- 876The count on this page175 of them list Diarrhea in their own words; the registry filed them under no condition.
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Who runs them
International Centre for Diarrhoeal Disease Research, Bangladesh (17) · London School of Hygiene and Tropical Medicine (16) · Mayo Clinic (13) · Johns Hopkins Bloomberg School of Public Health (12) · Bausch Health Americas, Inc. (11) · PATH (10) · Centers for Disease Control and Prevention (10) · Medical University of Warsaw (9)
What is being tested here
Drugs under test in Diarrhea studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Rifaximin | 1 | 10 | 16 |
| Azithromycin | 1 | 2 | 8 |
| Loperamide | 1 | 3 | 6 |
| Mesalamine | 1 | 2 | 4 |
| Lactoferrin | 1 | 2 | 2 |
| Bacillus clausii | 1 | 0 | 1 |
| Brenipatide | 1 | 0 | 1 |
| Vedolizumab | 1 | 1 | 1 |
| Mirtazapine | 1 | 0 | 1 |
| Muramidase | 1 | 1 | 1 |
Drug classes tested here Antiemetics 10 · 5-HT3 antagonists 10 · Corticosteroids 5
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2026Efficacy and Safety of Changkang Granules in the Treatment of Irritable Bowel Syndrome With Predominant Diarrhea (Liver qi Affecting the Spleen Pattern) · Phase 3 · Tasly Pharmaceutical Group Co., Ltd
- Nov 2026A Clinical Trial to Evaluate the Effects of a Supplement on Gut Health · Peach Perfect
- Nov 2026Safety of Lactobacillus LB Postbiotic in Immunocompromised Paediatric Patients With Diarrhoeal Disease · Hospital Infantil de Mexico Federico Gomez
- Dec 2026Small Intestinal Bacterial Overgrowth: A Prospective Registry · Indiana University
- Dec 2026Effect of Probiotics on Immunosuppressive-drug-associated Diarrhea Among Renal Transplant Recipients · State University of New York - Upstate Medical University
- Dec 2026Viome Nutritional Programs to Improve Clinical Outcomes for Gastrointestinal Conditions · Viome
- Dec 2026The Use of MicroRNAs Dysregulation as Potential Biomarkers for Effective Diagnosis of Endometriosis · Asian Institute of Gastroenterology, India
- Dec 2026Defining Ileorectal Syndrome: a Prospective Observational Study · Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
- Dec 2026Novel Pilot Study to Treat Symptoms of IBS With Diarrhea Using Combination Therapy of a Low-FODMAP Diet and a Neuromodulator · Mayo Clinic
- Dec 2026Inactivated Bacteroides Fragilis for Prevention of Chemotherapy-Induced Diarrhea · Shenzhen Hospital of Southern Medical University
Who these studies take
Of the 45 Diarrhea studies recruiting now, 21 (47%) set no upper age limit and 22 (49%) stop at 75 or younger. 19 (42%) take children under 18. 4 (9%) are for women only and 0 (0%) for men only; 15 (33%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 9 (20%) | 7 (16%) |
| 18 | 32 (71%) | 28 (62%) |
| 30 | 33 (73%) | 29 (64%) |
| 40 | 33 (73%) | 29 (64%) |
| 50 | 32 (71%) | 28 (62%) |
| 65 | 31 (69%) | 27 (60%) |
| 75 | 26 (58%) | 23 (51%) |
| 85 | 22 (49%) | 19 (42%) |
Across all 877 studies, recruiting or not: 58% stop at 75 or younger and 50% at 65; 42% take children; 3% are for women only and 2% for men only; 34% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Diarrhea studies take
Of 47 phase 2 interventional studies under Diarrhea, half reached primary completion within 15 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 14 mo6–23 · 22 studies | — | — |
| Phase 2 | 15 mo11–29 · 47 studies | 13 mo11–20 · 24 studies | — |
| Phase 3 | 29 mo19–38 · 30 studies | — | — |
| Phase 4 | 32 mo14–46 · 37 studies | — | 37 mo14–48 · 32 studies |
| Interventional, no phase | 14 mo5–35 · 164 studies | 11 mo3–23 · 35 studies | 17 mo6–36 · 129 studies |
| Observational | 28 mo12–43 · 42 studies | — | 28 mo12–47 · 34 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting2
- Rural Water Filtration and Health StudyNov 9, 2026NCT07818902
- Long-Term Immunogenicity of the altSonflex1-2-3 Shigella Vaccine in African ChildrenNov 5, 2026NCT07320716
Results posted1
Newly registered3
- A Clinical Trial to Evaluate the Effects of a Supplement on Gut HealthNov 10, 2026NCT07927907
- Comparison of Two Probiotics for Reducing Diarrhea Frequency in Children Aged 6-24 MonthsNov 6, 2026NCT07921836
- A Study to Evaluate the Effects of a Supplement on Gut Comfort in GLP-1 Receptor Agonist UsersOct 27, 2026NCT07898189
Studies
Recruiting first, then most recently updated. Showing 50 of 877. Browse all 877 → or search them.
- A Clinical Trial to Evaluate the Effects of a Supplement on Gut HealthRecruitingNCT07927907Not applicable1 country
- Rural Water Filtration and Health StudyRecruitingNCT07818902Not applicable1 country
- Cholera-Hospital-Based-Intervention-for-7-Days (CHoBI7) Water, Sanitation, and Hygiene (WASH) Case Area Targeted Intervention (CATI)RecruitingNCT06003816Not applicable1 country
- Comparison of Two Probiotics for Reducing Diarrhea Frequency in Children Aged 6-24 MonthsNot yet recruitingNCT07921836Not applicable
- Long-Term Immunogenicity of the altSonflex1-2-3 Shigella Vaccine in African ChildrenRecruitingNCT07320716Phase 21 country
- Prophylactic Mesalamine to Prevent Colitis Following Treatment With Ipilimumab/Nivolumab (Ipi/Nivo)RecruitingNCT05663775Phase 21 country
- A Study of Brenipatide (LY3537031) in Participants With Irritable Bowel Syndrome-Diarrhea (IBS-D)RecruitingNCT07545759Phase 210 countries
- Green Banana Added Diet on Prolong Diarrhea in 6-59 Months Old Children (GB in ProD)Not yet recruitingNCT07848789Phase 21 country
- Fecal Microbiota Transplantation in Treating Immune-Checkpoint Inhibitor Induced-Diarrhea or Colitis in Genitourinary Cancer PatientsRecruitingNCT04038619Phase 11 country
- Impact Evaluation of Accelerating Climate-Resilient Water, Sanitation and Hygiene Services for Schools and Healthcare Facilities in KaramojaRecruitingNCT07823231Not applicable1 country
- Evaluating the LGG of on Acute Infectious Diarrhea in ChildrenRecruitingNCT07342101Not applicable1 country
- Efficacy and Safety of Saccharomyces Boulardii in Treatment of Acute Diarrhea in Children Aged 6 Months to 5 Years OldNot yet recruitingNCT07813182Not applicable1 country
- Hens Hatching HopeRecruitingNCT04721197Not applicable1 country
- Vedolizumab for the Prevention of ICI Related Diarrhea or Colitis in Patients With CancerRecruitingNCT06337695Phase 2/31 country
- Rifaximin 200 mg Plus Oral Rehydration vs Oral Rehydration Alone in Children With Acute DiarrheaRecruitingNCT07285785Phase 41 country
- Safety of Lactobacillus LB Postbiotic in Immunocompromised Paediatric Patients With Diarrhoeal DiseaseNot yet recruitingNCT07758933Phase 1/21 country
- Rash & Diarrhea Prophylaxis With CapivasertibRecruitingNCT07426822Phase 21 country
- A Study of SER-155 to Treat Diarrhea in People on ImmunotherapyRecruitingNCT06801067Phase 11 country
- Huanghou Zhixie Diwan in the Treatment of Irritable Bowel Syndrome With Diarrhea (IBS-D)Not yet recruitingNCT07721012Phase 21 country
- Gut Microbiota and Diarrhea in Breast Cancer Patients Receiving PyrotinibRecruitingNCT072649851 country
- A Post-marketing Observational Study of Oral Cholera VaccineEnrolling by invitationNCT07300462Phase 41 country
- Clinical Efficacy and Safety of Jingfang Granules in Treating Diarrhea-Predominant Irritable Bowel Syndrome With Cold-Dampness Disturbing Spleen SyndromeNot yet recruitingNCT07688161Phase 31 country
- Bristol Stool Scale-Based Care Pathway for Enteral Nutrition-Associated Diarrhea in Critically Ill PatientsNot yet recruitingNCT07683364Not applicable1 country
- GLP-1 Receptor Agonists and Early Proctologic Effects in Morbid ObesityNot yet recruitingNCT076687651 country
- Probiotics for Prevention of Neratinib-Induced Diarrhea in Breast Cancer PatientsRecruitingNCT06892093Not applicable1 country
- Small Intestinal Bacterial Overgrowth: A Prospective RegistryEnrolling by invitationNCT018224701 country
- Enabling Microbiomics- Driven Personalized NutritionEnrolling by invitationNCT066570011 country
- Inactivated Bacteroides Fragilis for Prevention of Chemotherapy-Induced DiarrheaRecruitingNCT07309315Not applicable1 country
- Balanced Crystalloid vs Normal Saline in Pediatric Acute GastroenteritisRecruitingNCT076103821 country
- Evaluating In-line Chlorination in NigeriaNot yet recruitingNCT07601503Not applicable1 country
- Fecal Microbiota Transplantation for IBSRecruitingNCT05776914Phase 21 country
- Effect of Ramosetron in Patients With Diarrhea Predominant Irritable Bowel SyndromeNot yet recruitingNCT07574320Phase 4
- Improved Child Nutrition and Development Through Social TransfersNot yet recruitingNCT07569172Not applicable1 country
- The Impact of Shigellosis and Recommended Treatment in ChildrenRecruitingNCT07433426Phase 22 countries
- Defining Ileorectal Syndrome: a Prospective Observational StudyRecruitingNCT073851961 country
- The Auxiliary Effect of Artificial Intelligence in the Detection of Precancerous Lesions in Proximal Colon CancerNot yet recruitingNCT073386431 country
- Evaluating a Water Safety Plan Intervention in GhanaEnrolling by invitationNCT07317167Not applicable1 country
- Novel Pilot Study to Treat Symptoms of IBS With Diarrhea Using Combination Therapy of a Low-FODMAP Diet and a NeuromodulatorRecruitingNCT06684470Early Phase 11 country
- Diagnostic PCR Panel in Children With Acute Gastrointestinal SymptomsNot yet recruitingNCT07280624Not applicable
- Expanding Access to Safe Water in NigeriaRecruitingNCT07246824Not applicable1 country
- Use of A Complex Gut Bacterial Consortium (MITI 001) for the Treatment of Irritable Bowel Syndrome With DiarrheaNot yet recruitingNCT07238790Early Phase 11 country
- First in Human Dose Escalation Study Evaluating the Safety and Immunogenicity of IVT's Shigella-04 Vaccine in Healthy Young AdultsRecruitingNCT07205926Phase 11 country
- FMT in Checkpoint Inhibitor-mediated Diarrhea and ColitisRecruitingNCT06206707Not applicable1 country
- Lactoferrin and Lysozyme Supplementation for Long-term Diarrhea SequelaeRecruitingNCT05519254Phase 31 country
- Effect of Use of Probiotics on Systemic Infection in Critically Ill Patients: a Double Blind, Randomized, Placebo-controlled TrialEnrolling by invitationNCT07164781Not applicable1 country
- Impact of Probiotics on Antibiotic-associated Diarrhea in Community-acquired PneumoniaNot yet recruitingNCT06990568Phase 4
- Evaluation of Butyrate Effect on DiarrheaEnrolling by invitationNCT06982703Not applicable1 country
- Clinical Study on Fecal Microbiota Transplantation for Diarrhea After Total PancreatectomyNot yet recruitingNCT06960122Not applicable1 country
- A Study to Evaluate the Efficacy and Safety of Live SK08 Powder in Patients With IBS-DRecruitingNCT06247046Phase 31 country
- Paromomycin or Metronidazole for Symptomatic Dientamoeba Fragilis in AdultsRecruitingNCT06907498Not applicable1 country