Drug
Loperamide clinical trials
Also written Imodium.
- studies test it
- 29
- open now
- 2
- in phase 3
- 7
- first study started
- 1997
Keep track of what changes. Save the Loperamide studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Brand
Combined with it in one product
Studies by the year they started
29 studies that test it; most in 2014 (5)
| Year | Studies |
|---|---|
| 1997 | 1 |
| 2002 | 3 |
| 2004 | 2 |
| 2007 | 1 |
| 2008 | 3 |
| 2009 | 1 |
| 2013 | 1 |
| 2014 | 5 |
| 2015 | 1 |
| 2016 | 1 |
| 2017 | 1 |
| 2018 | 1 |
| 2019 | 1 |
| 2020 | 3 |
| 2021 | 1 |
| 2022 | 2 |
| 2023 | 1 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 1
- Phase 1
- 10
- Phase 2
- 5
- Phase 3
- 7
- Phase 4
- 7
- No phase
- 3
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 9 · Other 20
Jiangsu HengRui Medicine Co., Ltd. (2) · The University of Texas Health Science Center, Houston (2) · Johnson & Johnson Consumer and Personal Products Worldwide (2) · University of Pennsylvania (1) · Janssen Research & Development, LLC (1) · Rush University Medical Center (1) · Centre de recherche du Centre hospitalier universitaire de Sherbrooke (1) · Eastern Cooperative Oncology Group (1)
Often tested with
Tested in the same studies.
Simethicone (2) · Bentonite (2) · Butylscopolammonium Bromide (1) · Octreotide (1) · Pyrotinib (1) · Shr-1258 dimaleate (1) · Senna Extract (1) · Sennosides (1)
Studies
Open first, then newest update. How each study uses Loperamide is read from its arms, and is right about nine times in ten.
Testing it · 29
- Fecal Microbiota Transplantation in Treating Immune-Checkpoint Inhibitor Induced-Diarrhea or Colitis in Genitourinary Cancer PatientsRecruitingPhase 1M.D. Anderson Cancer CenterNCT04038619Written as Loperamide
- Antibiotics and Vaccine Immune Responses StudyRecruitingPhase 4South Australian Health and Medical Research InstituteNCT06148025Written as Loperamide HCl
- Multi-System Analysis of Opioid Receptor BindingActive, not recruitingPhase 1University of PennsylvaniaNCT05528848Written as Loperamide Hydrochloride
- A Study to Evaluate the Effects of Loperamide (JNJ-289679) on Electrocardiogram Intervals in Healthy Adult ParticipantsCompletedPhase 1Janssen Research & Development, LLCNCT04225078Written as Loperamide
- Topical Loperamide Gel for Pain Reduction During Repeat Finger LancingCompletedEarly Phase 1Rush University Medical CenterNCT02711891Written as Loperamide
- 4FMFES-PET Imaging of Endometrial and Ovarian CancersCompletedPhase 1/2Centre de recherche du Centre hospitalier universitaire de SherbrookeNCT04823065Written as Loperamide Pill
- Octreotide Compared With Loperamide Hydrochloride for Chemotherapy-Related Diarrhea in Patients With Colorectal CancerCompletedPhase 3Eastern Cooperative Oncology GroupNCT00003057Written as loperamide hydrochloride
- Effect of Montmorillonite Power or Loperamide on the Pharmacokinetics of Pyrotinib in Healthy SubjectsCompletedPhase 1Jiangsu HengRui Medicine Co., Ltd.NCT05252546Written as Loperamide
- A Drug-drug Interaction Trial of Loperamide Pharmacokinetics Effect on Pyrotinib MaleateCompletedPhase 1Jiangsu HengRui Medicine Co., Ltd.NCT04315116Written as Loperamide
- Gut Transit Effect on Enterohepatic CirculationCompletedNot applicableUniversity Hospital Plymouth NHS TrustNCT03501498Written as Loperamide
- Prevention and Treatment of Pyrrolitinib-associated DiarrheaStatus unknownPhase 2/3Tianjin Medical University Cancer Institute and HospitalNCT04736186Written as Loperamide
- A Study of Combination Caplet With Loperamide Hydrochloride and Simethicone, and Imodium Express Tablets-lyophilizate Coadministered With Espumisan Capsule in Healthy VolunteersCompletedPhase 1McNeil ABNCT04186936Written as Loperamide HCl
- A Study of Abemaciclib in Healthy ParticipantsCompletedPhase 1Eli Lilly and CompanyNCT02677844Written as Loperamide
- Controlling Anal Incontinence by Performing Anal Exercises With Biofeedback or Loperamide (CAPABLe)CompletedPhase 3NICHD Pelvic Floor Disorders NetworkNCT02008565Written as Loperamide
- Use of Post Operative Loperamide in Colorectal Patients After Diverting IleostomiesTerminatedPhase 3Cedars-Sinai Medical CenterNCT02263365Written as Loperamide
- Pilot Study to Assess Dimethyl Fumarate Related GI Symptom MitigationTerminatedPhase 4Rocky Mountain MS Research Group, LLCNCT02217982Written as Loperamide
- Loperamide vs. Placebo's Effect on Ileostomy Output: A Clinical Randomized Blinded Cross-over StudyTerminatedPhase 3Odense University HospitalNCT02266849Written as Loperamide
- Novel Topical Therapies for the Treatment of Genital PainCompletedPhase 2/3University of RochesterNCT02099006Written as Loperamide
- Efficacy of Loperamide for C. Difficile Colitis and Other Diarrheal Diseases Associated With Antibiotic TherapySuspendedPhase 4Michael E. DeBakey VA Medical CenterNCT00591357Written as loperamide
- Evaluation of the Efficacy of Low-dose Acetylsalicylic Acid on Diarrhea Induced by Anti-cancer Targeted Therapies.WithdrawnPhase 2Centre Francois BaclesseNCT02323516Written as Acetylsalicylic acid + loperamide
See all 29 studies that test Loperamide →
Given in every arm · 20 — Loperamide is usual care beside what is tested
- A Bowel Management Program (Retrograde Rectal Enema) for the Treatment of Low Anterior Resection Syndrome in Rectal Cancer PatientsRecruitingNot applicableOhio State University Comprehensive Cancer CenterNCT06424522Written as Loperamide Hydrochloride
- Rash & Diarrhea Prophylaxis With CapivasertibRecruitingPhase 2Maryam LustbergNCT07426822Written as Loperamide
- Probiotics for Prevention of Neratinib-Induced Diarrhea in Breast Cancer PatientsRecruitingNot applicableSun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityNCT06892093Written as Loperamide
- Single Dose Antibiotic Treatment of Acute Watery Diarrhea, Rifaximin Versus Azithromycin, With Loperamide AdjunctRecruitingPhase 4Henry M. Jackson Foundation for the Advancement of Military MedicineNCT05677282Written as Loperamide
- E7 TCR T Cells for Human Papillomavirus-Associated CancersCompletedPhase 1/2National Cancer Institute (NCI)NCT02858310Written as Loperamide
- A Study of LY2835219 (Abemaciclib) in Combination With Therapies for Breast Cancer That Has SpreadActive, not recruitingPhase 1Eli Lilly and CompanyNCT02057133Written as Loperamide
- Sacituzumab Govitecan for Relapsed Ovarian, Endometrial, and Cervical CarcinomasTerminatedPhase 2National Cancer Institute (NCI)NCT06865677Written as Loperamide
- Preventive stRategy for IMMU132-relatED AEs in TNBC or Luminal Breast Cancer- PRIMEDCompletedPhase 2MedSIRNCT05520723Written as Loperamide
- Incidence and Severity of Diarrhea in Patients With HER2 Positive Breast Cancer Treated With Trastuzumab and NeratinibCompletedPhase 2University of California, San FranciscoNCT03094052Written as Loperamide
- Three Antidiarrheal Strategies in HER2+/HR+ Early Breast Cancer Patients Treated With Extended Adjuvant NeratinibActive, not recruitingPhase 2Spanish Breast Cancer Research GroupNCT05252988Written as Loperamide
- A Study of Poziotinib in Patients With Epidermal Growth Factor Receptor (EGFR) or Human Epidermal Growth Factor Receptor 2 (HER2) Activating Mutations in Advanced MalignanciesTerminatedPhase 2Spectrum Pharmaceuticals, IncNCT04172597Written as Loperamide
- A Study to Characterize Colon Pathology in Patients With HER2 Amplified Breast Cancer Treated With NeratinibCompletedPhase 2Puma Biotechnology, Inc.NCT04366713Written as Loperamide
- An Open-Label Study to Characterize the Incidence and Severity of Diarrhea in Patients With Early-Stage HER2+ Breast Cancer Treated With Neratinib and LoperamideCompletedPhase 2Puma Biotechnology, Inc.NCT02400476Written as Loperamide
- A Neoadjuvant Study of Abemaciclib (LY2835219) in Postmenopausal Women With Hormone Receptor Positive, HER2 Negative Breast CancerCompletedPhase 2Eli Lilly and CompanyNCT02441946Written as Loperamide
- Probiotics as Adjuvant Therapy in the Treatment of Metastatic Colorectal CancerStatus unknownPhase 2Marin GolčićNCT03705442Written as loperamide ("Seldiar")
- ADAM-Afatinib Diarrhea Assessment and ManagementCompletedPhase 3Boehringer IngelheimNCT01814553Written as loperamide
- Fecal Microbiota Therapy for Recurrent Clostridium Difficile InfectionStatus unknownPhase 2/3Queen Elizabeth II Health Sciences CentreNCT02686645Written as Loperamide
- Tibial Nerve Stimulation in Combination With BiofeedbackStatus unknownNot applicableUniversity Hospital, LinkoepingNCT02888899Written as Loperamide
- A Study to Determine Effective Prophylaxis and Treatment of Nelfinavir-Associated DiarrheaTerminatedPhase 3PfizerNCT00650637Written as loperamide
- Duration of P-glycoprotein Inhibition After Oral Administration of HM30181AK TabletCompletedPhase 1Hanmi Pharmaceutical Company LimitedNCT00954304Written as Loperamide 2mg
As the comparator · 3 — what is tested is compared with Loperamide
- Tirzepatide for Ileal Pouch-anal Anastomosis (IPAA) and Chronic High Bowel Frequency (I8F-NS-X008)Not yet recruitingPhase 4University of North Carolina, Chapel HillNCT07756359Written as Loperamide
- Efficacy and Safety Study of Loperamide Hydrochloride/Simethicone Chewable Tablet in Treatment of Acute Diarrhea With Abdominal Discomfort and FlatulenceCompletedPhase 3Xian-Janssen Pharmaceutical Ltd.NCT02340481Written as Loperamide hydrochloride
- Acupuncture for Patients With Diarrhea-predominant IBS or Functional Diarrhea: a Randomized Controlled TrialCompletedPhase 2/3Chengdu University of Traditional Chinese MedicineNCT01350570Written as Loperamide
Codes
What other systems call Loperamide · ClinicalTrials.gg INT007747
- MeSH (NLM) D008139LoperamideConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 6X9OC3H4IILOPERAMIDEConfirmed FDA, NLM, Wikidata
- RxNorm 6468Confirmed FDA, Wikidata
- Wikidata Q423751loperamideConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C618LoperamideOne source FDA
- DrugBank DB00836One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D008139 | Loperamide | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 6X9OC3H4II | LOPERAMIDE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 6468 | — | Confirmed FDA, Wikidata |
| Wikidata | Q423751 | loperamide | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C618 | Loperamide | One source FDA |
| DrugBank | DB00836 | — | One source Wikidata |
Also registered as loperamide hydrochloride (UNII 77TI35393C · RxNorm 82038).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.