An interventional study of Saccharomyces Boulardii Probiotic Supplement and The child will be treated with standard method in Acute Diarrhea, sponsored by Can Tho University of Medicine and Pharmacy. Not yet recruiting at 1 site in Vietnam. Open to participants aged 6 Months to 60 Months, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-10.
Sponsored by Can Tho University of Medicine and Pharmacy · Not applicable, Interventional, and Treatment
This study aimed to evaluate the effectiveness of saccharomyces-based treatment in children with acute diarrhea aged 6 months to 5 years compared to children treated with standard methods.
A total of 206 children diagnosed with acute diarrhea will be evaluated and divided into two groups based on a random distribution list: Group A and Group B.
Group A will be treated with standard methods including fluid replacement and zinc according to the Ministry of Health's protocol.
Group B will be treated similarly to Group A, but with the addition of Saccharomyces boulardii at a dose of 250 to 750 mg per day until discharge.
Both groups of children will receive the same counseling and monitoring, with guidance provided to parents.
Caregivers are advised to record symptoms and stool diaries daily.
877 studies on the registry are indexed under Diarrhea; 76 are open to participants now.
This study's planned enrollment of 206 is above the median of 137 across 738 interventional studies indexed under Diarrhea.
Browse Diarrhea studies →Can Tho University of Medicine and Pharmacy is the lead sponsor of 35 studies on the registry; 8 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Immunosuppression
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Saccharomyces boulardii is a type of yeast that helps to quickly restore the intestinal mucosal barrier and the gut microbiome, significantly shortening hospital stays.
Drug: Saccharomyces Boulardii Probiotic Supplement
Treatment should follow standard protocols with fluid replacement and zinc supplementation, but no additional Saccharomyces boulardii should be added until discharge.
Drug: The child will be treated with standard method
Children will receive standard treatment including fluid and zinc supplementation. In addition, they will receive Saccharomyces boulardii supplementation from admission to discharge.
Children will be treated with standard methods involving fluid and zinc supplementation, without the use of any probiotics.
Duration of diarrhea
The cessation of acute diarrhea is determined when children met following criteria: 1. Passing soft or formed stools twice in a row. 2. No bowel movements recorded for 12 consecutive hours. 3. Stool consistency returns to normal, corresponding to categories 3 to 5 on the Bristol stool scale.
Time frame: Immediately after the intervention
The frequency of stool
Total number of bowel movements per day
Time frame: At day 1, 3, 5
Stool consistency assessed by Bristol stool chart
The Bristol stool chart has 7 pictures of stool appearance. The number 1 mean hard stool and number 7 mean watery stool.
Time frame: At day 1, 3, 5
Length of hospitalization
The total length of hospitalization, measured in days
Time frame: Immediately after the intervention
Adverse events
The occurrence of adverse events during treatment, including such as rash and bloating.
Time frame: Immediately after the intervention
Cost effectiveness
Total Cost per child from date of admission until discharge
Time frame: Immediately after the intervention
Rate of Hospital readmission
The proportion of participants who were readmitted to the hospital after discharge
Time frame: At day 14 and 28 after discharge from the hospital.
Plan to share: No
No publications or documents are linked to this record.
Start is estimated for Aug 2026; primary completion for Aug 2028, 23 months later.
Of 129 non-industry interventional studies with no phase under Diarrhea, half reached primary completion within 17 months of starting (the median), counting those still running; a quarter within 6 and three quarters within 36. This study's planned 23 months is above that.
Counting every sponsor, half of 164 studies reached it within 14 months; a quarter within 5 and three quarters within 35.
How these figures are worked out, and which studies are left out of them.
This study is not yet recruiting, as verified in Sep 2026. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Saccharomyces boulardii Probiotic Supplement
Can Tho University of Medicine and Pharmacy