An observational study in High Risk, Depression / Major Depressive Disorder and Anxiety Disease, sponsored by Shanghai Mental Health Center. Not yet recruiting at 1 site in China. Open to participants aged 7 Years to 17 Years. Per ClinicalTrials.gov, last updated 2026-08-04.
Sponsored by Shanghai Mental Health Center · Observational
This prospective observational cohort study will enroll approximately 200 children and adolescents aged 7-17 years who are at elevated risk for common mental disorders, including depressive disorders, anxiety disorders, and obsessive-compulsive disorder, based on family history or subthreshold emotional or behavioral symptoms. Participants will be followed for two years. Clinical assessments, questionnaires, EEG, biological samples, and MRI will be collected at scheduled intervals. The study aims to identify factors associated with the onset and progression of these disorders and support early risk identification.
Approximately 200 children and adolescents aged 7-17 years who are at elevated risk for depressive disorders, anxiety disorders, or obsessive-compulsive disorder will be enrolled. Elevated risk is defined by a relevant family history or clinically significant subthreshold emotional or repetitive behavioral symptoms. Participants will not meet the full diagnostic criteria for the target disorders at baseline and will be followed prospectively for two years.
Exclusion Criteria:
Children and adolescents aged 7-17 years who are at elevated risk for depressive disorders, anxiety disorders, or obsessive-compulsive disorder because of a relevant family history or subthreshold emotional or behavioral symptoms. Participants will be followed prospectively for two years and will undergo scheduled clinical, psychological, neurophysiological, neuroimaging, and biological assessments. No intervention or treatment will be assigned as part of this observational study.
Cumulative Incidence of Depressive Disorders, Anxiety Disorders, or Obsessive-Compulsive Disorder
The proportion of participants who newly meet the diagnostic criteria for at least one depressive disorder, anxiety disorder, or obsessive-compulsive disorder during follow-up, as determined using the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL).
Time frame: From baseline through 24 months
Time to Onset of a Depressive Disorder, Anxiety Disorder, or Obsessive-Compulsive Disorder
Time from baseline to the first follow-up assessment at which a participant meets the diagnostic criteria for any target disorder, as determined using the K-SADS-PL.
Time frame: From baseline through 24 months
Plan to share: No
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This study is not yet recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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Shanghai Mental Health Center