An interventional study of High resolution oesophageal manometry with impedance and 24-hour pH metry in Extraesophageal Reflux, Laryngopharyngeal Reflux and Dysphagia, sponsored by University Hospital Ostrava. Not yet recruiting at 1 site in Czechia. Open to participants aged 18 Years to 75 Years. Per ClinicalTrials.gov, last updated 2026-01-23.
Sponsored by University Hospital Ostrava · Not applicable, Interventional, and Diagnostic
The aim of this project is to perform a detailed evaluation of upper esophageal sphincter function and the swallowing mechanism in patients with swallowing disorders or suspected extraesophageal reflux using high-resolution manometry with impedance and 24-hour pH-impedance monitoring.
The project seeks to improve diagnostic accuracy, identify functional abnormalities that are not detectable by conventional diagnostic methods, and establish a foundation for more effective and targeted therapeutic strategies.
The upper esophageal sphincter (UES) represents a crucial functional structure at the junction of the digestive and respiratory tracts. Its proper function is essential for the coordination of the swallowing process and for the protection of the upper airways. Disorders of the UES may be associated with a wide range of otorhinolaryngological symptoms, including dysphagia, globus pharyngeus, chronic cough, hoarseness, laryngeal dysfunction, and voice disorders. Modern diagnostic techniques, such as 24-hour esophageal impedance monitoring and high-resolution manometry (HRM), enable detailed assessment of gastroesophageal reflux and esophageal pressure dynamics, thereby offering new possibilities for the diagnosis and understanding of these conditions.
56 studies on the registry are indexed under Laryngopharyngeal Reflux; 8 are open to participants now.
This study's planned enrollment of 160 is above the median of 72 across 41 interventional studies indexed under Laryngopharyngeal Reflux.
Browse Laryngopharyngeal Reflux studies →University Hospital Ostrava is the lead sponsor of 148 studies on the registry; 50 are open to participants now.
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Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Patients with extraoesophageal reflux will be enrolled in this study arm.
Diagnostic Test: High resolution oesophageal manometry with impedance · Diagnostic Test: 24-hour pH metry
Patients with dysphagia reflux will be enrolled in this study arm.
Diagnostic Test: High resolution oesophageal manometry with impedance
Patients with extraoesophageal reflux and dysphagia will undergo high resolution oesophageal manometry with impedance.
Patients with extraoesophageal reflux will undergo 24-hour pH-metry.
PAET (Proximal Acid Exposure Time)
PAET (Proximal Acid Exposure Time) - acid exposure to the proximal oesophageus will be measured in per cent of the whole 24-h period.
Time frame: 24 hours
Upper esophageal sphincter (UES) Integrated Relaxation Pressure (IRP)
UES IRP is a measure of the extent of UES relaxation measured in mmHg
Time frame: 15 minutes
UES Maximum Admittance
UES MaxAd is the highest admittance value recorded during trans-sphincteric bolus flow measured in milliseconds.
Time frame: 15 minutes
Plan to share: No — There is no plan to make individual participant data available to other researchers. The data may be provided upon reasonable request.
This study is not yet recruiting, as verified in Jan 2026. You cannot join it, but the record below documents what was studied.
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