An interventional study of zinacef tretment and Placebo in Meconium-stained Amniotic Fluid and Chorioamnionitis, sponsored by Western Galilee Hospital-Nahariya. Recruiting at 1 site in Israel. Open to female participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-15.
Sponsored by Western Galilee Hospital-Nahariya · Not applicable, Interventional, and Treatment
Our randomized controlled double blind clinical trail aims to compare maternal and neonatal infectious morbidity between women with meconium-stained amniotic fluid treated with zinacef vs. placebo.
The relationship between meconium staining and chorioamnionitis, as well as neonatal sepsis, has been documented, yet the precise mechanisms remain unclear. Additionally, the correlation between prolonged labor and meconium staining was described in the past. In light of these findings, our randomized controlled double blind trail aims to compare maternal and neonatal infectious morbidity between women with meconium-stained amniotic fluid treated with zinacef vs. placebo. Additionally, we aimed to assess the distribution of pathogens in chorioamnionitic swab cultures relative to the antibiotic treatment
39 studies on the registry are indexed under Chorioamnionitis; 9 are open to participants now.
This study's planned enrollment of 182 is above the median of 157 across 22 interventional studies indexed under Chorioamnionitis.
Browse Chorioamnionitis studies →Western Galilee Hospital-Nahariya is the lead sponsor of 89 studies on the registry; 15 are open to participants now.
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Exclusion Criteria:
women with meconium-stained amniotic fluid treated with zinacef 750 mg X3/d
Drug: zinacef tretment
women with meconium-stained amniotic fluid treated with I.V SALINE 100 CCX3/d
Other: Placebo
prophylactic antibiotic treatment with zinacef
I.V SALINE 100 CC X3/d
peripartum infections
chorioamnionitis and endometritis
Time frame: 7 days
intrapartum fever
fever \> 38
Time frame: during labor up to 2 hours postpartum
neonatal antibiotic treatment
antibiotic treatment
Time frame: 7 days
NICU admission
neonatal admission to the NICU after delivery
Time frame: 1 week
Plan to share: Yes
Supporting information: Study protocol, Clinical study report
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Western Galilee Hospital-Nahariya