An observational study in Chorioamnionitis, Placenta Diseases and Thrombocytopenia, sponsored by Guangdong Women and Children Hospital. Completed. Open to participants aged 1 Hour and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2018-08-17.
Sponsored by Guangdong Women and Children Hospital · Observational
Objective:The purpose of this study was to explore the effect and mechanism of maternal chorioamnionitis on placental microvasculature and platelet activation among preterm infants by activating Wnt-Flt1 signal pathway .
Methods:With clinical randomized controlled trial (RCT), the cases were matched with 1:1 according to gestational age and divided into 2 groups according to the placental pathology result: chorioamnionitis group and control group. (1) To observe the platelet parameter, birth weight, thrombrocytopenia and hemorrhage complication, such as intracranial hemorrhage, retinal hemorrhage, pulmonary hemorrhage and gastrointestinal hemorrhage. (2) To observe the miscrovascular density (MVD) in placenta, platelet activating factor (CD62p,CD63) and thrombopotetin (TPO) in preterrn infants.The placental MVD was assessed by immunohistochemical method. The platelet activating factors were detected by flow cytometry. TPO was detected by ELISA. (3) To observe Wnt5a, Flt1 and VEGF in placenta and fetal circulation.The measurement data were analyzed by pair t test and conditional logistic regression. Pearson correlation analysis was used for relationship.
The exclusive criteria included :(1) born to mother with no any other maternal complications; (2) no congenital abnormalities and neonatal asphyxia; (3) died or discharged within 72 hours.
39 studies on the registry are indexed under Chorioamnionitis; 9 are open to participants now.
This study's enrollment of 64 is below the median of 125 across 14 observational studies indexed under Chorioamnionitis.
Browse Chorioamnionitis studies →Guangdong Women and Children Hospital is the lead sponsor of 25 studies on the registry; 5 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Chorioamnionitis contributes to the high morbidity and mortality in preterm infants, thrombocytopenia is one of the acute morbidity
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
preterm infants were born to mothers with chorioamnionitis
Other: chorioamnionitis
preterm infants were born to mothers without chorioamnionitis
Other: chorioamnionitis
It is a observation research. We didn't intervene anything. The chorioamnionitis groups included the infants whose mothers were diagnosed chorioamnionitis by placental histopathology.
Placental Microvascular Density(%)
Placental Microvascular Density (by placental histopathology)
Time frame: 24 hours
Incidence Hemorrhage Disease (%)
intraventricular hemorrhage (IVH), retinal hemorrhage, pulmonary hemorrhage and gastrointestinal hemorrhage
Time frame: through study completion, an average of half year
Wnt5a in Placenta(IOD)
by placental histopathology
Time frame: 24 hours
mean platelet volume(MPV)
MPV (Fl)
Time frame: 24 hours
platelet distribution width(PDW)
PDW (%)
Time frame: 24 hours
Platelet counts (PLT)
PLT (10\^9/L)
Time frame: 24 hours
Thrombopoietin (cord blood)
TPO(ng/ml)
Time frame: 24 hours
Platelets Activation Factors in cord blood
CD62p(%)
Time frame: 24 hours
Flt1 in Placenta(IOD)
by placental histopathology
Time frame: 24 hours
VEGF in Placenta(IOD)
by placental histopathology
Time frame: 24 hours
Wnt5 in infants (ng/ml)
test them by Elisa from cord blood
Time frame: 24 hours
Flt1 in infants (ng/ml)
test them by Elisa from cord blood
Time frame: 24 hours
VEGF in infants (ng/ml)
test them by Elisa from cord blood
Time frame: 24 hours
No study locations are listed for this record.
This study is completed, as verified in Jun 2016. You cannot join it, but the record below documents what was studied.
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Guangdong Women and Children Hospital