An observational study in Chorioamnionitis and Cerebral Palsy, sponsored by Sheba Medical Center. Status unknown at 1 site in Israel. Open to female participants aged 18 Years to 55 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2013-01-29.
Sponsored by Sheba Medical Center · Observational
Premature breaking of the amniotic fluids during pregnancy caries high risk for infection of the amniotic fluid. One of the results of chorioamnionitis is brain injury of the fetus. Fetus' brain is highly vulnerable and could be harmed even by mild inflammation before fulminant infection is developed. The aim of this study is to identify, as early as, possible signs of brain injury. S100B protein will be used as a marker for brain insult. S100b level were associated with the occurrence and size of stroke and brain trauma in adults and children. Moreover, S100B crosses the membrane and its level in women with preterm labor was associated with brain injury of preterm infant.
The study question is whether the levels of S100B in women with early amniotic fluids breakdown are associated with future brain injury of the infant, as assessed by head ultrasound and neurological examination.
39 studies on the registry are indexed under Chorioamnionitis; 9 are open to participants now.
This study's planned enrollment of 90 is below the median of 125 across 14 observational studies indexed under Chorioamnionitis.
Browse Chorioamnionitis studies →Sheba Medical Center is the lead sponsor of 678 studies on the registry; 63 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Pregnant women with premature rupture of the amniotic sac.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Developmental assessment
Developmental assessment at 18 month 1. Vineland Adaptive Behavior Scales 2. Griffith Mental Development Scales
Time frame: 18 month
Developmental assessment
Developmental assessment at term and 3 month 1. Neurological examination 2. Test of infant motor performance
Time frame: 3 month
This study is status unknown, as verified in Jan 2013. You cannot join it, but the record below documents what was studied.
Get an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.