An observational study in Intrapartum Maternal Fever, Clinical Chorioamnionitis and Neonatal Infection, sponsored by Peking University First Hospital. Active, not recruiting. Open to female participants. Per ClinicalTrials.gov, last updated 2026-08-07.
Sponsored by Peking University First Hospital · Observational
The goal of this retrospective observational cohort study is to explore the associations between neuraxial labor analgesia and maternal-neonatal infectious outcomes among women attempting vaginal delivery, and to distinguish genuine infectious risks from clinical fever-related diagnostic and treatment pathways. The main question it aims to answer is:
Does neuraxial labor analgesia increase the risk of composite neonatal infectious outcomes in singleton live birth women attempting vaginal delivery? Participants who met inclusion criteria with clear neuraxial labor analgesia exposure status (exposed group receiving neuraxial labor analgesia during labor; unexposed group without such analgesia) were extracted from the hospital's delivery database covering 2015 to 2022, and their pre-delivery baseline characteristics, labor course records, maternal fever, intrapartum antibiotic administration, clinical chorioamnionitis diagnosis and neonatal infectious diagnosis data were retrospectively analyzed via multiple statistical adjustment approaches including propensity score weighting, sensitivity analysis and negative control analysis.
39 studies on the registry are indexed under Chorioamnionitis; 9 are open to participants now.
This study's planned enrollment of 49,000 is above the median of 125 across 14 observational studies indexed under Chorioamnionitis.
Browse Chorioamnionitis studies →Peking University First Hospital is the lead sponsor of 390 studies on the registry; 186 are open to participants now.
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The study participants consisted of parturients and their neonates who delivered at Peking University First Hospital between January 1, 2015 and December 31, 2022.
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Exclusion Criteria:
Mothers and their neonates who received neuraxial labor analgesia
Procedure: neuraxial labor analgesia
Mothers and their neonates who didn't receive neuraxial labor analgesia
The studied intervention, neuraxial labor analgesia, is defined as epidural or combined spinal-epidural pain relief delivered by spinal canal puncture during active vaginal labor.
Composite outcome of neonatal infection
Neonatal sepsis, pneumonia, necrotizing enterocolitis (NEC), or unspecified site infection documented during postnatal hospitalization.
Time frame: From birth until neonatal hospital discharge, assessed up to 90 days after birth
No study locations are listed for this record.
Ran from Jan 2015 to primary completion in Dec 2022, 95 months.
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This study is active, not recruiting, as verified in Jul 2026. You cannot join it, but the record below documents what was studied.
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