A Phase 3 interventional study of ACE Inhibitors and β -Blockers in Cardiotoxicity, sponsored by Ain Shams University. Recruiting at 2 sites in Egypt. Open to participants aged 1 Year to 18 Years. Per ClinicalTrials.gov, last updated 2025-03-03.
Sponsored by Ain Shams University · Phase 3, Interventional, and Prevention
The aim of the present study is to evaluate the protective impact of cardioprotective medications on the chemotherapy- induced cardiotoxicity.
The goal of this interventional study is to evaluate the protective impact of Angiotensin-converting enzyme (ACE) inhibitors versus β-blockers on the cardiotoxicity profile of pediatric patients with acute leukemia. The impact is measured by evaluation of left ventricular ejection fraction (LVEF) by 2D echocardiography at baseline and at the end of Induction phase (42 days).
262 studies on the registry are indexed under Cardiotoxicity; 75 are open to participants now.
This study's planned enrollment of 30 is below the median of 93 across 137 interventional studies indexed under Cardiotoxicity.
Browse Cardiotoxicity studies →Ain Shams University is the lead sponsor of 1,950 studies on the registry; 429 are open to participants now.
Of its 35 completed or terminated interventional studies of FDA-regulated products, 0 (0%) have results posted.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
0.3 mg/kg/dose every 8 hours orally by either a caregiver or caring nurse.
Drug: ACE Inhibitors
0.05 mg/kg/dose every 12 hours orally by either a caregiver or caring nurse
Drug: β -Blockers
0.3 mg/kg/dose every 8 hours orally by either a caregiver or caring nurse.
Also known as: Captopril
0.05 mg/kg/dose every 12 hours orally by either a caregiver or caring nurse.
Also known as: Carvedilol
Change in Left Ventricular Ejection Fraction (LVEF)
he LVEF will be measure by 2D Echocardiography at baseline and at the end of Induction Phase (42 Days)
Time frame: LVEF will be measured at Baseline and at the end of Induction Phase (42 Days)
Plan to share: Yes
No publications or documents are linked to this record.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
Contact study teamGet an email when the registry record changes — status, dates, results — or when someone posts here.
Sign in to followQuestions and observations about this study, from anyone following it. Not medical advice, and not a channel to the study team — their contact details are on the registry record.
Sign in to join the discussion. Reading takes no account; posting does. You choose a display name, and a pseudonym is the default.
Nothing here yet. If you are running this trial, taking part in it, or weighing whether to, this is the place to say so.
Studies of the drugs tested here: ACE inhibitors · Carvedilol