Mesothelioma, Malignant clinical trials
The registry lists 339 studies for Mesothelioma, Malignant across more than 10 countries. 64 are recruiting or about to start. 247 of them are mainly about Mesothelioma, Malignant (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.
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Who runs them
National Cancer Institute (NCI) (33) · Memorial Sloan Kettering Cancer Center (15) · M.D. Anderson Cancer Center (9) · Alliance for Clinical Trials in Oncology (7) · European Organisation for Research and Treatment of Cancer - EORTC (7) · Ain Shams University (6) · Abramson Cancer Center at Penn Medicine (5) · University of Chicago (5)
What is being tested here
Drugs under test in Mesothelioma, Malignant studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Nivolumab | 2 | 0 | 8 |
| Atezolizumab | 2 | 1 | 7 |
| Ivonescimab | 2 | 0 | 3 |
| Interleukin-2 | 2 | 0 | 3 |
| Cadonilimab | 2 | 0 | 2 |
| Cisplatin | 1 | 2 | 27 |
| Pemetrexed | 1 | 2 | 18 |
| Pembrolizumab | 1 | 0 | 6 |
| Carboplatin | 1 | 0 | 4 |
| Decitabine | 1 | 0 | 4 |
Drug classes tested here Immune checkpoint inhibitors 14 open · Tyrosine kinase inhibitors (TKIs) 3 open · Antimetabolites 2 open · PARP inhibitors 1 open · Angiogenesis inhibitors 6
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Jul 2027Atezolizumab Versus Placebo for the Adjuvant Treatment of Malignant Pleural Mesothelioma (Atezomeso) · Phase 3 · Gruppo Oncologico Italiano di Ricerca Clinica
- Dec 2026Phase II Trial of Radical Pleurectomy With or Without Intraoperative PDT for Malignant Pleural Mesothelioma · Abramson Cancer Center at Penn Medicine
- Jan 2027Pembrolizumab Plus Autologous Dendritic Cell Vaccine in Patients with PD-L1 Negative Advanced Mesothelioma Who Have Failed Prior Therapies · Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
- Jan 2027SW-682 in Advanced Solid Tumors · SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany
- Feb 2027INTEGRATIVE "MULTI-OMICS" AND FUNCTIONAL PLATFORM FOR THE COMPLETE DIAGNOSTIC CHARACTERIZATION OF TUMORS: THE ITALIAN TUMOR CHEMOGENOMIC PROFILER (IT-TCP) · Azienda Ospedaliero-Universitaria di Parma
- Feb 2027Pembrolizumab in Combination With Chemotherapy and Image-Guided Surgery for Malignant Pleural Mesothelioma (MPM) · Abramson Cancer Center at Penn Medicine
- Mar 2027Dual-Target MSLN/FAP CAR-NK Cells for Pleural and Peritoneal Mesothelioma · Beijing Biotech
- Mar 2027Identification of Prognostic and Predictive Biomarkers of Toxicity in Patients With Malignant Pleural Mesothelioma and Treated With High Doses of Radiotherapy (MESORTIBO) · Centro di Riferimento Oncologico - Aviano
- Apr 2027The Diagnostic Accuracy and Clinical Value of FAPI PET in Pleural Mesothelioma · Aalborg University Hospital
- May 2027Brentuximab Vedotin in Treating Patients With CD30+ Malignant Mesothelioma That Cannot Be Removed by Surgery · M.D. Anderson Cancer Center
Who these studies take
Of the 55 Mesothelioma, Malignant studies recruiting now, 43 (78%) set no upper age limit and 5 (9%) stop at 75 or younger. 2 (4%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (5%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (4%) | 2 (4%) |
| 18 | 54 (98%) | 54 (98%) |
| 30 | 55 (100%) | 55 (100%) |
| 40 | 55 (100%) | 55 (100%) |
| 50 | 55 (100%) | 55 (100%) |
| 65 | 55 (100%) | 55 (100%) |
| 75 | 54 (98%) | 54 (98%) |
| 85 | 48 (87%) | 48 (87%) |
Across all 339 studies, recruiting or not: 8% stop at 75 or younger and 2% at 65; 8% take children; 1% are for women only and <1% for men only; 2% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Mesothelioma, Malignant studies take
Of 48 phase 2 interventional studies under Mesothelioma, Malignant, half reached primary completion within 48 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 63 mo39–89 · 40 studies | — | — |
| Phase 1/2 | 67 mo43–85 · 30 studies | — | — |
| Phase 2 | 48 mo29–87 · 48 studies | — | 67 mo27–100 · 41 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
Stopped1
- CT-95 in Advanced Cancers Associated With Mesothelin ExpressionTerminatedNov 5, 2026NCT06756035
Newly registered2
- Safety and Preliminary Antitumor Activity of Ivonescimab Plus Pemetrexed and Platinum-Based Chemotherapy in Advanced Malignant Pleural MesotheliomaOct 21, 2026NCT07885306
- Efficacy and Safety of Ivonescimab Plus Pemetrexed and Platinum-Based Chemotherapy in Advanced Malignant Pleural MesotheliomaOct 21, 2026NCT07885319
Studies
Recruiting first, then most recently updated. Showing 50 of 339. Browse all 339 → or search them.
- Chemotherapy With or Without Immunotherapy for Peritoneal MesotheliomaRecruitingNCT05001880Phase 21 country
- The Diagnostic Accuracy and Clinical Value of FAPI PET in Pleural MesotheliomaRecruitingNCT06790082Phase 21 country
- Efficacy and Safety of Ivonescimab Plus Pemetrexed and Platinum-Based Chemotherapy in Advanced Malignant Pleural MesotheliomaRecruitingNCT07885319Phase 1/21 country
- SW-682 in Advanced Solid TumorsRecruitingNCT06251310Phase 11 country
- Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell ManufacturingRecruitingNCT049811191 country
- Decitabine/Cedazuridine (INQOVI), an Oral DNA Demethylating Agent, in Subjects With BAP1 Cancer Predisposition Syndrome and Subclinical, Early-Stage MesotheliomaRecruitingNCT05960773Phase 21 country
- Evaluation of Cell Changes in Blood and Tissue in Cancers of the Lung, Esophagus and Lung LiningRecruitingNCT002427231 country
- TLN-499 in Combination With Venetoclax in Patients With Relapsed/Refractory Solid TumorsRecruitingNCT07713732Phase 11 country
- HTL0039732 in Participants With Advanced Solid TumoursRecruitingNCT05944237Phase 1/21 country
- dENdritic Cell Therapy Combined With SURgEry in MesotheliomaRecruitingNCT05304208Phase 11 country
- A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid TumorsRecruitingNCT07277413Phase 11 country
- Using E-Nose Technology to Measure Response to Treatment in People With Malignant Pleural MesotheliomaRecruitingNCT06037941Not applicable1 country
- A Study of Additional Chemotherapy After Surgery for People With Malignant Peritoneal MesotheliomaRecruitingNCT06057935Phase 21 country
- A Phase 3 Trial in Advanced Epithelioid MesotheliomaNot yet recruitingNCT07824986Phase 3
- Study of ISM6331 in Participants With Advanced/Metastatic Mesothelioma or Other Advanced Solid TumorsRecruitingNCT06566079Phase 1/22 countries
- TT-4 and TT-10 as Single Agents and in Combination in Subjects With Advanced Selected Solid Tumors and Pleural MesotheliomaRecruitingNCT04969315Phase 1/21 country
- A Study of Tulmimetostat DZR123 (CPI-0209) in Patients With Advanced Solid Tumors and LymphomasRecruitingNCT04104776Phase 1/27 countries
- Trial Assessing Fianlimab Plus Cemiplimab Plus Chemotherapy or Cemiplimab Plus Chemotherapy in Patients With Pleural MesotheliomaRecruitingNCT07234058Phase 21 country
- Evaluating Ivonescimab as a Potential Treatment for Pleural Mesothelioma Patients Whose Cancer Has Returned After Previous Immunotherapy and ChemotherapyRecruitingNCT06840834Phase 21 country
- Fast TILs to Treat Metastatic Cancer Patients With Pleural DiseaseRecruitingNCT07192900Phase 11 country
- APG-2449 in Patients With Advanced Solid TumorsRecruitingNCT03917043Phase 11 country
- TRAcking Thoracic Cancer Evolution Through Therapy (Rx) EVORecruitingNCT056283761 country
- SynKIR-110 for Mesothelin Expressing Ovarian Cancer, Cholangiocarcinoma or MesotheliomaRecruitingNCT05568680Phase 11 country
- Evaluation of Skin Tests in Biotherapy AllergiesRecruitingNCT06971848Not applicable1 country
- A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 ExpressionRecruitingNCT06051695Phase 1/21 country
- Integration of the PD-L1 Inhibitor Atezolizumab and WT1/DC Vaccination Into Platinum/Pemetrexed-based First-line Treatment for Epithelioid Malignant Pleural MesotheliomaRecruitingNCT05765084Phase 1/21 country
- A Study of Sacituzumab Govitecan in People With MesotheliomaRecruitingNCT06477419Phase 21 country
- Multidimensional Omics Analysis in Malignant Pleural MesotheliomaRecruitingNCT075611901 country
- Comprehensive Oncogenomic Mapping and Exploration in Thoracic and Head & Neck OncologyNot yet recruitingNCT07550049
- A Study of Oral 7HP349 (Alintegimod) in Combination With Ipilimumab Followed by Nivolumab MonotherapyRecruitingNCT06362369Phase 1/21 country
- Fast TILs to Treat Metastatic Pleural Effusions From Epithelial or Mesothelial Primary TumorsRecruitingNCT07443020Phase 11 country
- Dual-Target MSLN/FAP CAR-NK Cells for Pleural and Peritoneal MesotheliomaRecruitingNCT07510815Phase 1/21 country
- Hemithoracic Irradiation With Proton Therapy in Malignant Pleural MesotheliomaRecruitingNCT05655078Not applicable1 country
- INTEGRATIVE "MULTI-OMICS" AND FUNCTIONAL PLATFORM FOR THE COMPLETE DIAGNOSTIC CHARACTERIZATION OF TUMORS: THE ITALIAN TUMOR CHEMOGENOMIC PROFILER (IT-TCP)RecruitingNCT07403630Not applicable1 country
- Partial Pleurectomy (Surgery) for Unresectable Pleural MesotheliomaRecruitingNCT07126509Not applicable1 country
- Study of TYK-01054 Capsules in Patients With Advanced Solid TumorsNot yet recruitingNCT07282873Phase 1/21 country
- Pembrolizumab in Combination With Chemotherapy and Image-Guided Surgery for Malignant Pleural Mesothelioma (MPM)RecruitingNCT03760575Phase 11 country
- Using CICS-1 and SPM-011 and [18F]FBPA Commissioned by CICS and Sumitomo Heavy Industries and STELLA PHARMAEnrolling by invitationNCT06603987Phase 1/21 country
- The IMmunotherapy Pleural 5-ALA PDTRecruitingNCT04400539Phase 21 country
- A Study of NX-1607 in Adults With Advanced MalignanciesRecruitingNCT05107674Phase 12 countries
- TTFields in General Routine Clinical Care in Patients With Pleural Mesothelioma StudyRecruitingNCT055388063 countries
- Study of Iparomlimab and Tuvonralimab Plus Chemotherapy in Malignant MesotheliomaNot yet recruitingNCT07131345Phase 1/2
- NEoadjuvant Chemotherapy and Immunotherapy for a Selected Group of Inoperable Pleural Mesothelioma Patients (NECIM): a Feasibility StudyRecruitingNCT07121374Phase 1/21 country
- First Line Sintilimab Combined With Anlotinib and Platinum Doublet Chemotherapy in Malignant Pleural MesotheliomaRecruitingNCT05188859Phase 21 country
- Olaparib in Patients With HRD Malignant MesotheliomaRecruitingNCT04515836Phase 21 country
- First Local Anaesthesia Thoracoscopy for Pleural Effusion Diagnosis.RecruitingNCT06946498Not applicable1 country
- Genetic Susceptibility in MAlignant Pleural Mesothelioma: Clinical Implication of GermliNE VariaTionSRecruitingNCT068866721 country
- Atezolizumab Versus Placebo for the Adjuvant Treatment of Malignant Pleural Mesothelioma (Atezomeso)RecruitingNCT04996017Phase 31 country
- A Study of MT027 in Patients with Pleural Malignant TumorsRecruitingNCT06726564Phase 11 country
- Identification of Prognostic and Predictive Biomarkers of Toxicity in Patients With Malignant Pleural Mesothelioma and Treated With High Doses of Radiotherapy (MESORTIBO)RecruitingNCT066373451 country