Gastrointestinal Neoplasms clinical trials
The registry lists 696 studies for Gastrointestinal Neoplasms across more than 10 countries. 210 are recruiting or about to start. 314 of them are mainly about Gastrointestinal Neoplasms (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its 18 narrower conditions too, such as Colorectal Neoplasms: 15,626 studies, 4,281 open.
ClinicalTrials.gov finds 23,389 studies for Gastrointestinal Neoplasms. How that becomes 694 here
This page counts the studies the registry files under Gastrointestinal Neoplasms, and those it files under no condition that list Gastrointestinal Neoplasmsthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 23,389Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −13,850Filed under a narrower condition, counted on its own pageColorectal Neoplasms 5,982 · Stomach Neoplasms 2,762 · Colonic Neoplasms 1,384 · Rectal Neoplasms 1,285 · Esophageal Neoplasms 1,206 · Esophageal Squamous Cell Carcinoma 442 · 12 more
- −21List Gastrointestinal Neoplasms as a condition, but the registry did not file them under itMost often written as “Advanced Gastrointestinal Cancer” (5), “Gastrointestinal Cancer Metastatic” (3), and “Diabetic Patients With Gastrointestinal Cancer Undergoing Surgery and Receiving Parenteral Nutrition” (1). The registry filed 17 of them under no condition at all, and the others under other conditions only, most often Carcinoma, Hepatocellular (1) and Neuroendocrine Tumors (1).
- −8,824Match it another way41 name it in the title, 2 in a keyword, and 8,781 by a synonym or other text the search reads.
- 694The count on this page
Get an email when these change. Save the Gastrointestinal Neoplasms studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
M.D. Anderson Cancer Center (25) · National Cancer Institute (NCI) (23) · Dana-Farber Cancer Institute (12) · Baylor College of Medicine (9) · Revolution Medicines, Inc. (8) · GlaxoSmithKline (8) · Abramson Cancer Center at Penn Medicine (7) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (7)
What is being tested here
Drugs under test in Gastrointestinal Neoplasms studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| IDRX-42 | 6 | 1 | 7 |
| Daraxonrasib | 4 | 0 | 4 |
| Irinotecan | 3 | 3 | 11 |
| Oxaliplatin | 3 | 2 | 10 |
| Fluorouracil | 2 | 1 | 10 |
| Capecitabine | 2 | 1 | 7 |
| Pafolacianine | 2 | 0 | 2 |
| Zoldonrasib | 2 | 0 | 2 |
| Docetaxel | 2 | 1 | 2 |
| Pemigatinib | 2 | 0 | 2 |
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 11 open · Immune checkpoint inhibitors 6 open · Antimetabolites 4 open · Angiogenesis inhibitors 2 open · Antibody-drug conjugates (ADCs) 2 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026A Study of 2nd-line FOLFIRI ± Bevacizumab vs. Irinotecan ± Bevacizumab in mCRC · Phase 3 · Sun Yat-sen University
- Apr 2027Total Neoadjuvant FLOT Chemotherapy in Locally Advanced Gastric and Gastroesophageal Junction Cancer · Phase 3 · Ukrainian Society of Clinical Oncology
- May 2027Prophylactic or Preemptive Entecavir in Patients With Gastrointestinal Cancer Who Are Inactive Hepatitis B Carriers · Phase 3 · Sun Yat-sen University
- Nov 2026Prevalence of Types and Patterns of Gastrointestinal Polyps in Assiut University Hospitals ( Cross Sectional Study · Assiut University
- Nov 2026Anlotinib Hydrochloride Capsules Combined With TQB2450 Injection in Esophageal Squamous Cell Carcinoma Patients · Jiangxi Provincial Cancer Hospital
- Nov 2026Longitudinal Study on the Evolution Trend and Influencing Factors of Postoperative Reflux of Esophageal Cancer Based on PEPTEST Technique · Cancer Institute and Hospital, Chinese Academy of Medical Sciences
- Nov 2026A Study of GC203 TIL in Advanced Malignant Solid Tumors · Shanghai Juncell Therapeutics
- Nov 2026PhI Pilot Study Pafolacianine Inject for Intraoperative Imaging on Outcomes of GI Cancer Peritoneal Carcinomatosis · University of California, Irvine
- Dec 2026ChatBot and Activity Monitoring in Patients Undergoing Chemoradiotherapy · Abramson Cancer Center at Penn Medicine
- Dec 2026Sacituzumab Govitecan in Combination With Capecitabine for Advanced Gastrointestinal Cancers After Progression on Standard Therapy · Henry Ford Health System
Who these studies take
Of the 160 Gastrointestinal Neoplasms studies recruiting now, 122 (76%) set no upper age limit and 18 (11%) stop at 75 or younger. 8 (5%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 9 (6%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 7 (4%) | 7 (4%) |
| 18 | 148 (93%) | 148 (93%) |
| 30 | 152 (95%) | 152 (95%) |
| 40 | 152 (95%) | 152 (95%) |
| 50 | 154 (96%) | 154 (96%) |
| 65 | 159 (99%) | 159 (99%) |
| 75 | 154 (96%) | 154 (96%) |
| 85 | 136 (85%) | 136 (85%) |
Across all 696 studies, recruiting or not: 13% stop at 75 or younger and 2% at 65; 5% take children; 1% are for women only and <1% for men only; 8% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Gastrointestinal Neoplasms studies take
Of 55 phase 2 interventional studies under Gastrointestinal Neoplasms, half reached primary completion within 44 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 42 mo35–71 · 49 studies | — | — |
| Phase 1/2 | 64 mo42–… · 36 studies | — | — |
| Phase 2 | 44 mo32–73 · 55 studies | — | — |
| Interventional, no phase | 36 mo17–71 · 163 studies | — | 39 mo19–71 · 153 studies |
| Observational | 43 mo16–102 · 88 studies | — | 43 mo13–102 · 79 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Results posted2
- A Safety and Efficacy Study of ZW25 (Zanidatamab) Plus Combination Chemotherapy in HER2-expressing Gastrointestinal Cancers, Including Gastroesophageal Adenocarcinoma, Biliary Tract Cancer, and Colorectal CancerNov 4, 2026NCT03929666
- NAPOLI-2: Fluorouracil, Leucovorin, and Nanoliposomal Irinotecan in Biliary CancerOct 27, 2026NCT04005339
Newly registered4
- AI-Assisted Remote Monitoring for Patients With or at Risk of Malignant Bowel ObstructionNov 12, 2026NCT07931989
- MyPatientPal+: A Smartphone App and a Provider Dashboard to Manage Patient Care While on TreatmentNov 10, 2026NCT07928154
- T1 Colorectal Cancer After Local Excision: Decision Between Surgery and Active Surveillance (T1LDA Trial)Oct 28, 2026NCT07900620
- Immunonutrition for Surgical Prehabilitation of Patients With Upper GI CancerOct 20, 2026NCT07884214
Studies
Recruiting first, then most recently updated. Showing 50 of 696. Browse all 696 → or search them.
- Identification of Innovative Biomarkers Related to the Immune System or Tumor Microenvironment to Promote the Efficacy of ImmunotherapiesRecruitingNCT06626269Not applicable1 country
- AI-Assisted Remote Monitoring for Patients With or at Risk of Malignant Bowel ObstructionNot yet recruitingNCT07931989Not applicable1 country
- Harvesting Cells for Experimental Cancer TreatmentsEnrolling by invitationNCT000680031 country
- Virtual Reality for GI Cancer Pain to Improve Patient Reported OutcomesRecruitingNCT04907643Not applicable1 country
- Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal HistologiesRecruitingNCT04847063Phase 11 country
- A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid TumorsRecruitingNCT07020221Phase 1/24 countries
- Phase 2 Study of Daraxonrasib in Recurrent KRAS-Mutant Biliary Tract CancerNot yet recruitingNCT07793253Phase 21 country
- MyPatientPal+: A Smartphone App and a Provider Dashboard to Manage Patient Care While on TreatmentNot yet recruitingNCT07928154Not applicable1 country
- Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment DelaysRecruitingNCT07283939Not applicable3 countries
- A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)RecruitingNCT06760819Phase 211 countries
- A Study of JNJ-89402638 for Metastatic Colorectal and Gastric CancersRecruitingNCT06663319Phase 13 countries
- Study to Assess the Efficacy and Safety of Rina-S in Participants With Advanced Gastrointestinal (GI) CancersRecruitingNCT07539311Phase 211 countries
- Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 PatientsRecruitingNCT03190941Phase 1/21 country
- Immunotherapy Treating GI CancerNot yet recruitingNCT03614650Phase 1/21 country
- Intraoperative Imaging of Gastrointestinal Malignancies Using Pafolacianine (CYTALUX™)RecruitingNCT07124351Phase 41 country
- DESIR. Evaluation of the Pre-therapeutic Activity of Dihydropyrimidine dEShydrogenase (DPD) in Patients With Cancer and/or Renal FailureNot yet recruitingNCT07124403
- Perioperative Multicomponent Rehabilitation and Outcomes in Elderly Patients With FrailtyRecruitingNCT04715581Not applicable1 country
- Acquisition of Blood and Tumor Tissue Samples From Patients With Gastrointestinal CancerRecruitingNCT013134421 country
- Avera Cancer Sequencing and Analytics Protocol (ASAP)RecruitingNCT051420331 country
- T1 Colorectal Cancer After Local Excision: Decision Between Surgery and Active Surveillance (T1LDA Trial)Not yet recruitingNCT07900620Not applicable1 country
- MMR Status Modulates the Predictive Value of Lymphatic Invasion for Lymph Node Metastasis in Gastrointestinal CancersNot yet recruitingNCT07625735
- Safety, PK and Efficacy of QXL138AM in Patients With Solid Tumors and Multiple MyelomaRecruitingNCT06582017Phase 11 country
- Immunonutrition for Surgical Prehabilitation of Patients With Upper GI CancerEnrolling by invitationNCT07884214Not applicable1 country
- EUS Examination Using EndoSound Vision System vs. Standard EchoendoscopeRecruitingNCT06340620Not applicable1 country
- Phase 1/2 Study of BHB810 in Advanced Gastric and GEJ AdenocarcinomaRecruitingNCT07529808Phase 1/21 country
- A Study to Test the Safety and Effectiveness of GSK5764227, Alone or With Other Treatments, in Participants With Advanced Gastrointestinal Cancers That Cannot be Surgically Removed (EMBOLD PanGI-201)RecruitingNCT06885034Phase 1/219 countries
- Prospective Procurement of Tumor Tissue to Identify Novel Therapeutic Targets and Study the Tumor MicroenvironmentEnrolling by invitationNCT056009331 country
- Fucoidan for Preventing Chemotherapy-Related Fatigue in Patients With Gastrointestinal, Gynecological, Breast, or Lung CancerRecruitingNCT06855524Phase 21 country
- A Study to Investigate the Effects of Moderate or Severe Renal Impairment (RI) on VelzatinibNot yet recruitingNCT07867171Phase 1
- Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal CancerRecruitingNCT07222800Phase 317 countries
- A Study to Investigate the Effect of Omeprazole and Cyclosporine on Velzatinib in Healthy ParticipantsNot yet recruitingNCT07862114Phase 1
- A Study to Investigate the Effects of Impaired Hepatic Function on VelzatinibNot yet recruitingNCT07859735Phase 1
- Clinical Study on Using Laparoscopic Sentinel Lymph Node Navigation Combined With Dual Endoscopy Surgery for Early Gastric CancerRecruitingNCT07708012Not applicable1 country
- A Study of IDRX-42 (GSK6042981) Versus (vs) Sunitinib in Participants With Gastrointestinal Stromal Tumors After Imatinib TherapyRecruitingNCT07218926Phase 319 countries
- The Effects of SCFA Supplementation in Subjects Receiving Abdominopelvic RT: A Randomized Controlled StudyRecruitingNCT04700527Phase 1/21 country
- A Phase 1 Study Evaluating DISP-10 in Participants With Advanced Gastrointestinal CancersRecruitingNCT07544589Phase 11 country
- A Study of Velzatinib in Participants With Metastatic and/or Unresectable GIST After Imatinib, Sunitinib, Regorafenib, and PimitespibRecruitingNCT07689201Phase 21 country
- Clinical Investigator-Initiated Trial (IIT) of PD-L1-Targeted Radionuclide ProbesRecruitingNCT07848243Phase 21 country
- A Legacy Study in Participants With Gastrointestinal Stromal Tumors (GIST)Not yet recruitingNCT07843641Phase 2
- DESTINY-PANTUMOUR04RecruitingNCT071240001 country
- Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid TumorsRecruitingNCT06128551Phase 1/27 countries
- Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid TumorsRecruitingNCT06445062Phase 1/21 country
- Neratinib and Fam-Trastuzumab Deruxtecan in Advanced Gastro-esophageal Cancer PatientsRecruitingNCT05274048Phase 11 country
- Precision Navigation to Improve Community Cancer Screening ParticipationRecruitingNCT07676383Not applicable1 country
- GLP-1 RA Plus SOC Treatment in First-line, Metastatic Pancreatic, Colorectal, or Hepatocellular CancerRecruitingNCT07627191Early Phase 11 country
- Individual Patient Expanded Access for Velzatinib (GSK6042981) in Patients With Gastrointestinal Stromal Tumours With KIT MutationsAvailableNCT07825701
- Benefits of Early Collaboration Between Oncologists and Palliative Care Physicians in Cases of Unplanned Hospitalization for Patients With Metastatic CancerNot yet recruitingNCT07490106Not applicable1 country
- Investigating the Effects of Atezolizumab in People Whose Tumour DNA or RNA Indicates Possible SensitivityRecruitingNCT04273061Phase 21 country
- SURGE: Supporting Utility and Representation in Genomics-based Cancer Trial Enrollment (Intervention)RecruitingNCT05375643Not applicable1 country
- Fatigue and Molecular Mechanisms in Cancer Patients Receiving CCRTRecruitingNCT066332241 country