Simvastatin: all 386 studies that test it

Page 1 of 4. Open to participants first (27), then studies with results posted, then the rest; newest registration first within each.

• VISTA: Valproic Acid, Irinotecan, and Simvastatin for Recurrent GliomaRecruitingNCT07831369Phase 2
• Precision Medicine Adaptive Network Platform Trial in Hypoxemic Acute Respiratory FailureNot yet recruitingNCT07779642Phase 2
• New Topical Treatment in Patchy Alopecia AreataNot yet recruitingNCT07696585Not applicable
• Topical 2% Simvastatin for Xanthelasma PalpebrarumNot yet recruitingNCT07662785Phase 2
• RESTAGE (REpurposing STAtins to Improve Outcomes in GastroEsophageal Cancer) TrialNot yet recruitingNCT07625930Phase 2
• Adebrelimab Combined With Gemcitabine, Cisplatin, and Simvastatin for Advanced Biliary Tract CancerRecruitingNCT07392541Phase 1/2
• Effects of Selected Statins on Blood Glucose Levels in Healthy VolunteersNot yet recruitingNCT07378293Phase 1
• Topic Simvastatin for Bone RegenerationRecruitingNCT07031778Early Phase 1
• Envafolimab With Chemotherapy and Simvastatin in Advanced Biliary Tract CancerNot yet recruitingNCT07003815Phase 2
• Carvedilol + Simvastatin vs. Carvedilol Alone for Cirrhosis and Cirrhotic Cardiomyopathy and Impact on Hepatic Decompensation and SurvivalRecruitingNCT06431919Not applicable
• Topical Simvastatin Versus Topical Steroid in Treatment of Alopecia AreataNot yet recruitingNCT06399783Phase 4
• Drug-Drug Interaction (DDI) Study of Leramistat in Healthy Adult SubjectsRecruitingNCT06379958Phase 1
• Topical Simvastatin for Treating Infantile HemangiomaNot yet recruitingNCT06273111Early Phase 1
• Bioequivalence Study of Simvastatin 40 mg Film-coated Tablets in Healthy Thai VolunteersNot yet recruitingNCT06178640Phase 1
• Simvastatin Versus MTA in Pulpotomy of Immature Permanent MolarsRecruitingNCT05878158Early Phase 1
• Valproic Acid/Simvastatin Plus Gemcitabine/Nab-paclitaxel Based Regimens in Untreated Metastatic Pancreatic Adenocarcinoma PatientsRecruitingNCT05821556Phase 2
• Simvastatin Treatment to Improve Patient-reported Outcomes in Patients With Chronic PancreatitisRecruitingNCT05771675Early Phase 1
• Statin and Bone HealthEnrolling by invitationNCT05613400Phase 4
• T-reg Function Changes: a Novel Immune Regulatory Effect Underlying Benefit of Statin Use on Lethal Prostate CancerRecruitingNCT05586360Phase 2
• The Role of Simvastatin in The Epithelial-Mesenchymal Transition Process of Breast CancerRecruitingNCT05550415Phase 2
• Letrozole With and Without Simvastatin for the Treatment of Stage I-III Hormone Receptor Positive, HER2 Negative Breast CancerRecruitingNCT05464810Early Phase 1
• Endometriosis and Microvascular Dysfunction; Simvastatin and DuaveeEnrolling by invitationNCT05059626Phase 4
• Efficacy of Simvastatin in Alcoholic Liver FibrosisRecruitingNCT04971577Phase 2/3
• Pharmacokinetics of Simvastatin Post Laparoscopic Sleeve Gastrectomy (LSG)RecruitingNCT03571802Phase 4
• Treatment of Graves´ophthalmopathy with Simvastatin (GO-S)RecruitingNCT03131726Phase 3
• Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired PneumoniaRecruitingNCT02735707Phase 3
• Myocardial Protection Effect of Simvastatin Undergoing Cardiac SurgeryRecruitingNCT01653223Not applicable
• A Drug-Drug Interaction Study of Orforglipron (LY3502970) in Healthy Overweight and Obese ParticipantsCompletedNCT06186622Phase 1Results posted
• Anti-inflammatory Effects of SimvastatinTerminatedNCT04638400Phase 4Results posted
• 7 Tesla MRI Study in Patients With Statin Related Muscle ComplaintsCompletedNCT04575090Not applicableResults posted
• 7T Magnetic Resonance Spectroscopy and Skeletal Muscle Biopsy Findings in Statin Associated Adverse Muscle EventsTerminatedNCT04507373Phase 4Results posted
• Simvastatin in Secondary Progressive Multiple SclerosisCompletedNCT03896217Phase 2Results posted
• An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Heterozygous Familial HypercholesterolemiaCompletedNCT03510884Phase 3Results posted
• An Efficacy and Safety Study of Alirocumab in Children and Adolescents With Homozygous Familial HypercholesterolemiaCompletedNCT03510715Phase 3Results posted
• The Effect of Simvastatin on Breast Cancer Cell Growth in Women With Stage I-II Breast CancerCompletedNCT03454529Phase 2Results posted
• Effect of Locally-Applied Simvastatin on Clinical Attachment Level and Alveolar Bone in Periodontal Maintenance PatientsCompletedNCT03452891Phase 4Results posted
• Use of Topical Subgingival Application of Simvastatin Gel in the Treatment of Peri-Implant MucositisCompletedNCT03400475Phase 2Results posted
• Simvastatin in Preventing Liver Cancer in Patients With Liver CirrhosisCompletedNCT02968810Phase 2Results posted
• Simvastatin in Reducing Pancreatitis in Patients With Recurrent, Acute or Chronic PancreatitisCompletedNCT02743364Phase 2Results posted
• A Study to Evaluate LY3202328 in Overweight Healthy Participants and DyslipidemiaCompletedNCT02714569Phase 1Results posted
• Safety, Tolerability, and Effect of Alirocumab in High Cardiovascular Risk Patients With Severe Hypercholesterolemia Not Adequately Controlled With Conventional Lipid-modifying Therapies (ODYSSEY APPRISE)CompletedNCT02476006Phase 3Results posted
• Effects of Simvastatin and Ezetimibe on Cardiovascular Risk Markers in Patients With DyslipidemiaCompletedNCT02304926Not applicableResults posted
• A Study of LY2623091 in Healthy ParticipantsCompletedNCT02300259Phase 1Results posted
• Study to Assess the Effect of AZD9291 on the Blood Levels of Simvastatin in Patients With EGFRm+ NSCLCCompletedNCT02197234Phase 1Results posted
• Fixed Dose Intervention Trial of New England Enhancing Survival in SMI PatientsCompletedNCT02188121Phase 4Results posted
• A Study of Evacetrapib With Selected Statins in Healthy Chinese ParticipantsCompletedNCT02156492Phase 1Results posted
• Detection and Prevention of Anthracycline-Related Cardiac Toxicity With Concurrent SimvastatinTerminatedNCT02096588Phase 2Results posted
• Safety of Simvastatin in LAM and TSCCompletedNCT02061397Phase 1/2Results posted
• Effect of Vitamin D Supplementation on Exercise Adaptations in Patients on Statin TherapyCompletedNCT02030041Phase 3Results posted
• Effect of SSP-004184 (SPD602) on the Pharmacokinetics of Simvastatin in Healthy Adult SubjectsCompletedNCT01979185Phase 1Results posted
• Simvastatin for mTBICompletedNCT01952288Phase 4Results posted
• Overcoming Chemotherapy Resistance In Refractory Multiple Myeloma With Simvastatin and Zoledronic AcidTerminatedNCT01772719Not applicableResults posted
• LDL-C Assessment With PCSK9 Monoclonal Antibody Inhibition Combined With Statin Therapy-2CompletedNCT01763866Phase 3Results posted
• Effect of Simvastatin Treatment on Vaso-occlusive Pain in Sickle Cell DiseaseCompletedNCT01702246Phase 1/2Results posted
• A Study of the Efficacy and Safety of MK-0431D (a Fixed-dose Combination of Sitagliptin and Simvastatin) for the Treatment of Participants With Type 2 Diabetes Mellitus (T2DM) With Inadequate Glycemic Control on Metformin Monotherapy (MK-0431D-266)TerminatedNCT01678820Phase 3Results posted
• A 12-week Study to Compare the Efficacy and Safety of Fixed Combinations of Fenofibrate/Simvastatin 145/20mg and Fenofibrate/Simvastatin 145/40mg Tablets Versus Fenofibrate or Simvastatin Monotherapies in Subjects With Abnormal Blood Levels of Fats (Lipids) and at High Risk of Cardiovascular DiseaseCompletedNCT01674712Phase 3Results posted
• Simvastatin Augmentation of Lithium Treatment in Bipolar DepressionTerminatedNCT01665950Phase 2Results posted
• Clinical Trial of Simvastatin to Treat Generalized VitiligoCompletedNCT01517893Phase 2Results posted
• Endothelial Facilitation in Alzheimer's DiseaseCompletedNCT01439555Phase 2Results posted
• SLOS: The Effect of Simvastatin in Patients Receiving Cholesterol SupplementationTerminatedNCT01434745Not applicableResults posted
• Efficacy and Safety of Extended-Release Niacin/ Laropiprant/Simvastatin Tablets in Participants With Hypercholesterolemia or Mixed Dyslipidemia (MK-0524B-143)TerminatedNCT01335997Phase 3Results posted
• Drug-drug Interaction of Empagliflozin (BI 10773) and SimvastatinCompletedNCT01304329Phase 1Results posted
• A Study to Evaluate Efficacy and Safety of Extended-Release Niacin + Laropiprant + Simvastatin in Participants With Primary Hypercholesterolemia or Mixed Dyslipidemia (MK-0524B-118)TerminatedNCT01294683Phase 3Results posted
• Effects of Simvastatin on BiomarkersCompletedNCT01142336Phase 4Results posted
• A Study of LY2484595 in Patients With High LDL-C or Low HDL-CCompletedNCT01105975Phase 2Results posted
• Targeting Sympathetic Overactivity in Heart Failure Patients With StatinsCompletedNCT01097785Not applicableResults posted
• Simvastatin Therapy for Moderate and Severe COPDTerminatedNCT01061671Phase 3Results posted
• Effects of Ezetimibe, Simvastatin, and Vytorin on Reducing L5 a Subfraction of LDL in Patients With Metabolic Syndrome.CompletedNCT00988364Phase 4Results posted
• Effect of Repeated Administration of Eslicarbazepine Acetate on the Pharmacokinetics of Simvastatin in Healthy SubjectsCompletedNCT00987558Phase 1Results posted
• MK0524B Bioequivalence Study (0524B-070)CompletedNCT00943124Phase 1Results posted
• Statin Effects on Beta-Amyloid and Cerebral Perfusion in Adults at Risk for Alzheimer's DiseaseCompletedNCT00939822Phase 2Results posted
• Lipid Biomarker Study in Men With Dyslipidemia After Simvastatin Treatment (Study MK-0000-140)(COMPLETED)CompletedNCT00935259Phase 1Results posted
• Comparison of Simvastatin Versus Simvastatin/Ezetimibe on Small Dense Low -Density Lipoprotein (LDL)CompletedNCT00932620Phase 4Results posted
• Ezetimibe/Simvastatin (MK-0653A) Versus Rosuvastatin Versus Doubling Statin Dose in Participants With Cardiovascular Disease and Diabetes Mellitus (MK-0653A-133)(COMPLETED)CompletedNCT00862251Phase 3Results posted
• Simvastatin With or Without Ezetimibe and Atherothrombotic Biomarker AssessmentCompletedNCT00819403Phase 4Results posted
• The PostprAndial eNdothelial Function After Combination of Ezetimibe and simvAstatin StudyCompletedNCT00817843Phase 4Results posted
• Statins and Cerebral Blood Flow in Subarachnoid Hemorrhage (SAH)CompletedNCT00795288Phase 1/2Results posted
• Comparison of the Effect of Vytorin 10/80 Tablet Split Into 4 and Simvastatin 20 Milligrams on Low-density Lipoprotein (LDL) CholesterolCompletedNCT00762164Phase 4Results posted
• Feasibility Study of Simvastatin in Hodgkin's Lymphoma SurvivorsTerminatedNCT00746603Not applicableResults posted
• Women With Chest Pain and Normal Coronary Arteries StudyTerminatedNCT00743197Not applicableResults posted
• Effect of Simvastatin on Endothelial Function in Premenopausal Women With Systemic Lupus Erythematosus (0733-271)(TERMINATED)TerminatedNCT00739050Phase 4Results posted
• Left Ventricular Hypertrophy Reduction With Statins in Hypertensives Patients (MK0653A-168)TerminatedNCT00738972Phase 3Results posted
• Simvastatin For Intracerebral Hemorrhage StudyTerminatedNCT00718328Phase 2Results posted
• An Open-label Extension to Assess the Continued Efficacy of Omacor Plus SimvastatinCompletedNCT00678743Phase 4Results posted
• Statin Therapy in the Treatment of SepsisCompletedNCT00676897Phase 2/3Results posted
• Begin With The Right Patients With Dual-Inhibition Action Therapy Through Vytorin for Newly Diagnosed Dyslipidemia Patients (0653A-172)(COMPLETED)CompletedNCT00654628Phase 4Results posted
• Coadministration of Ezetimibe and Simvastatin in Patients With Primary Hypercholesterolemia (P05457)CompletedNCT00653523Phase 3Results posted
• Investigation of Simvastatin in Secondary Progressive Multiple SclerosisCompletedNCT00647348Phase 2Results posted
• Effect of Acute Statin Treatment in Patients Undergoing Percutaneous Coronary InterventionTerminatedNCT00588471Not applicableResults posted
• Comprehensive Magnetic Resonance of Peripheral Arterial DiseaseCompletedNCT00587678Not applicableResults posted
• Simvastatin in Waldenstrom's MacroglobulinemiaTerminatedNCT00575965Phase 2Results posted
• Statin Therapy Versus Placebo Prior to ProstatectomyCompletedNCT00572468Not applicableResults posted
• Evaluating How the Treatments in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Study Affect Diabetic Retinopathy (The ACCORD Eye Study)CompletedNCT00542178Phase 3Results posted
• Nephropathy In Type 2 Diabetes and Cardio-renal EventsCompletedNCT00535925Phase 4Results posted
• Pilot Mouthwash Study of Pioglitazone and Simvastatin in Healthy VolunteersCompletedNCT00531882Not applicableResults posted
• Statins for the Early Treatment of SepsisTerminatedNCT00528580Phase 2Results posted
• 12-week Open-label, Phase IIIb Comparing Efficacy and Safety of Rosuvastatin (CRESTOR™) in Combination With EzetimibeCompletedNCT00525824Phase 3Results posted
• Simvastatin (Zocor) Therapy in Sickle Cell DiseaseCompletedNCT00508027Phase 1/2Results posted
• A Multicenter, Randomized, Open Label Study to Evaluate the Lipid Lowering Efficacy and Safety of Vytorin® 10/20 vs. Atorvastatin 10mg in Hypercholesterolemia Patients With Metabolic Syndrome in Korea (0653A-129)(COMPLETED)CompletedNCT00496730Phase 3Results posted
• Use of Simvastatin for the Prevention of Vasospasm in Aneurysmal Subarachnoid HemorrhageTerminatedNCT00487461Not applicableResults posted

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