Drug
Lofexidine clinical trials
Also written Lucemyra.
- studies test it
- 33
- open now
- 2
- in phase 3
- 5
- first study started
- 1996
Keep track of what changes. Save the lofexidine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Brand
Combined with it in one product
Studies by the year they started
32 studies that test it; most in 2019 (5)
| Year | Studies |
|---|---|
| 1996 | 2 |
| 2001 | 1 |
| 2003 | 1 |
| 2005 | 2 |
| 2006 | 1 |
| 2010 | 2 |
| 2011 | 2 |
| 2012 | 4 |
| 2013 | 2 |
| 2014 | 2 |
| 2015 | 2 |
| 2016 | 1 |
| 2019 | 5 |
| 2021 | 3 |
| 2024 | 1 |
| 2025 | 1 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 17
- Phase 2
- 9
- Phase 3
- 5
- Phase 4
- 3
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 15 · Other 18
USWM, LLC (dba US WorldMeds) (15) · National Institute on Drug Abuse (NIDA) (6) · New York State Psychiatric Institute (3) · Pharmacotherapies for Alcohol and Substance Use Disorders Alliance (1) · Medical University of South Carolina (1) · Zagazig University (1) · Mayo Clinic (1) · Institute of Mental Health, Singapore (1)
Often tested with
Tested in the same studies.
Dronabinol (2) · Venlafaxine (1) · Paroxetine (1) · Naltrexone (1) · Cannabis sativa subsp. indica TOP (1) · Hydromorphone (1)
Studies
Open first, then newest update. How each study uses lofexidine is read from its arms, and is right about nine times in ten.
Testing it · 33
- Pregabalin Plus Lofexidine for the Outpatient Treatment of Opioid WithdrawalRecruitingPhase 2University of PennsylvaniaNCT05995535Written as LFX/PGB
- Assessing a Clinically-meaningful Opioid Withdrawal PhenotypeRecruitingPhase 2University of Maryland, BaltimoreNCT05027919Written as Lofexidine
- Lofexidine Combined With Buprenorphine for Reducing Symptoms of PTSD and OU Relapse in VeteransCompletedPhase 2Pharmacotherapies for Alcohol and Substance Use Disorders AllianceNCT04360681Written as Lofexidine
- A Pharmacokinetic, Safety, and Tolerability Study of LUCEMYRA in the Treatment of Opioid Withdrawal Management in Adolescent SubjectsWithdrawnPhase 1USWM, LLC (dba US WorldMeds)NCT06711640Written as LUCEMYRA (lofexidine) tablets
- Impact of Lofexidine on Stress, Craving and Opioid UseCompletedPhase 2Medical University of South CarolinaNCT03718065Written as Lofexidine
- Randomized, Double-Blind, Placebo-Controlled Pilot Study on the Safety and Effectiveness of LUCEMYRA During an Opioid Taper in Treatment of WithdrawalTerminatedPhase 2USWM, LLC (dba US WorldMeds)NCT04070157Written as Lofexidine
- Treatment of Withdrawal Symptoms and Prevention of Relapse in Patients With Tramadol AbuseCompletedPhase 4Zagazig UniversityNCT05569031Written as Lofexidine
- A Study Evaluating the Relative Bioavailability of Lofexidine Granules for Reconstitution Compared to LUCEMYRA (Lofexidine) Tablets and the Effect of Food on the Bioavailability of the Lofexidine Granules for ReconstitutionCompletedPhase 1USWM, LLC (dba US WorldMeds)NCT04188730Written as Lofexidine (granules for reconstitution)
- Efficacy, Safety and Dose-Response Study Followed by Open-Label Study of Lofexidine Treatment of Opioid WithdrawalCompletedPhase 3USWM, LLC (dba US WorldMeds)NCT01863186Written as Lofexidine HCl
- Open-Label, Safety Study of LofexidineCompletedPhase 3USWM, LLC (dba US WorldMeds)NCT02363998Written as Lofexidine
- Lofexidine for Adults Undergoing Lumbar Spine SurgeryCompletedPhase 4Mayo ClinicNCT04126083Written as Lofexidine Oral Tablet
- Lofexidine for Management of Opioid Withdrawal With XR-NTX TreatmentCompletedPhase 2New York State Psychiatric InstituteNCT04056182Written as Lofexidine 0.18 MG
- Combined Pharmacotherapy for Cannabis DependencyCompletedPhase 2/3New York State Psychiatric InstituteNCT01020019Written as Lofexidine
- Pilot Study of Lofexidine and Methadone Pharmacodynamic Interaction in Methadone Maintained PatientsCompletedPhase 1USWM, LLC (dba US WorldMeds)NCT01558934Written as Lofexidine HCl
- Single-Dose Pharmacokinetics and Safety of Oral Lofexidine in Hepatically-Impaired SubjectsCompletedPhase 1USWM, LLC (dba US WorldMeds)NCT02318836Written as Lofexidine Hydrochloride (HCl) tablets
- Lofexidine Food Effect Study in Healthy VolunteersCompletedPhase 1USWM, LLC (dba US WorldMeds)NCT01437306Written as Lofexidine HCl
- Pharmacokinetic & Pharmacodynamic Interaction of Lofexidine and Buprenorphine in Buprenorphine Maintained PatientsCompletedPhase 1USWM, LLC (dba US WorldMeds)NCT01820442Written as Lofexidine HCl
- Lofexidine Pharmacokinetics in the Presence of Paroxetine in Healthy VolunteersCompletedPhase 1USWM, LLC (dba US WorldMeds)NCT02681198Written as Lofexidine
- Lofexidine ADME & Mass Balance in VolunteersCompletedPhase 1USWM, LLC (dba US WorldMeds)NCT01310296Written as Lofexidine hydrochloride
- Lofexidine Mass Balance in VolunteersCompletedPhase 1USWM, LLC (dba US WorldMeds)NCT01629446Written as Lofexidine hydrochloride
See all 33 studies that test lofexidine →
Given in every arm · 1 — lofexidine is usual care beside what is tested
As the comparator · 2 — what is tested is compared with lofexidine
Codes
What other systems call lofexidine · ClinicalTrials.gg INT002820
- MeSH (NLM) C025655lofexidineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) UI82K0T627LOFEXIDINEConfirmed FDA, NLM, Wikidata
- RxNorm 28863Confirmed FDA, Wikidata
- Wikidata Q3836403lofexidineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C87578LofexidineOne source FDA
- DrugBank DB04948One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | C025655 | lofexidine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | UI82K0T627 | LOFEXIDINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 28863 | — | Confirmed FDA, Wikidata |
| Wikidata | Q3836403 | lofexidine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C87578 | Lofexidine | One source FDA |
| DrugBank | DB04948 | — | One source Wikidata |
Also registered as lofexidine hydrochloride (UNII V47G1SDI1B · RxNorm 235853).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.