Drug class
Histamine H1 Antagonists clinical trials
A class of medicines: the studies that test any of its 28 members, each study once. Members are as MeSH files each medicine’s actions, and as the NCI Thesaurus classes newer ones.
Keep track of what changes. Save the histamine h1 antagonists studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesMedicines in this class
Studies that test each. A study of two counts under both, and once above.
- Dicyclomine, doxylamine, pyridoxine drug combination
- 4
- Pyrilamine
- 2
- Isospaglumic acid
- 2
- Cinnarizine
- 2
- Brompheniramine
- 2
- Antazoline
- 2
- Tripelennamine
- 1
- Oxatomide
- 1
- Dexbrompheniramine
- 1
Studies by the year they started
341 studies that test it; most in 2024 (23); 1 more planned to start later
| Year | Studies |
|---|---|
| 1999 | 1 |
| 2000 | 1 |
| 2001 | 6 |
| 2002 | 3 |
| 2003 | 6 |
| 2004 | 8 |
| 2005 | 9 |
| 2006 | 13 |
| 2007 | 15 |
| 2008 | 21 |
| 2009 | 12 |
| 2010 | 18 |
| 2011 | 17 |
| 2012 | 15 |
| 2013 | 18 |
| 2014 | 11 |
| 2015 | 11 |
| 2016 | 9 |
| 2017 | 13 |
| 2018 | 12 |
| 2019 | 19 |
| 2020 | 7 |
| 2021 | 17 |
| 2022 | 17 |
| 2023 | 16 |
| 2024 | 23 |
| 2025 | 11 |
| 2026 | 12 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it.
- Nausea
- 14
Who runs them
Industry 92 · Other 258
Merck Sharp & Dohme LLC (13) · Ain Shams University (6) · University of California, San Francisco (5) · Bausch & Lomb Incorporated (5) · Vistakon Pharmaceuticals (5) · Boehringer Ingelheim (5) · Mantecorp Industria Quimica e Farmaceutica Ltd. (5) · Montefiore Medical Center (4)
Studies
Open first, then newest update. How each study uses a medicine is read from its arms, and is right about nine times in ten.
Testing one of them · 350
- Metronomic Temozolomide With Dexbrompheniramine for Recurrent High-Grade Glioma/GlioblastomaNot yet recruitingPhase 1/2University of NebraskaNCT07859059Written as Dexbrompheniramine
- A SMART Approach to Evaluating the Benefits of Common Prescription and OTC Medications for InsomniaRecruitingPhase 4University of PennsylvaniaNCT07542756Written as Diphenhydramine, 25 mg
- Diphenhydramine as an Adjunct to Moderate Sedation for Procedural First Trimester AbortionsRecruitingPhase 4University of RochesterNCT07542730Written as Diphenhydramine
- Ebastine for Adjuvant Treatment of Tumor Budding-Positive Liver Cancer After SurgeryNot yet recruitingPhase 4Second Affiliated Hospital of Xi'an Jiaotong UniversityNCT07734766Written as Ebastine
- Neonatal White Matter Injury Trial (WRAP)RecruitingPhase 1Bridget LaMonica Ostrem, M.D., Ph.D.NCT07688746Written as Clemastine fumarate
- Assessing Changes in Multi-parametric MRI in MS Patients Taking Clemastine Fumarate as a Myelin Repair TherapyRecruitingPhase 1/2University of California, San FranciscoNCT05359653Written as Clemastine Fumarate
- Mirtazapine for the Treatment of Methamphetamine Use in Opioid Use Disorder Patients Receiving Medication Assisted TreatmentRecruitingPhase 2Washington State UniversityNCT06323837Written as Mirtazapine
- Clemastine for Improving White Matter and Boosting Antidepressant Response in Late-life DepressionRecruitingPhase 2University of Illinois at ChicagoNCT06591091Written as Clemastine Fumarate
- Comparison of Propranolol, Flunarizine and Their Combination in Preventing Migraine in Adults in a Tertiary Care Hospital in BangladeshNot yet recruitingPhase 4Chittagong Medical CollegeNCT07655700Written as Flunarizine 10 mg
- Toripalimab Combined With Platinum-based Chemotherapy With or Without H1 Receptor Antagonist in the Perioperative Treatment of Resectable Non-small Cell Lung CancerNot yet recruitingPhase 2Tianjin Medical University Cancer Institute and HospitalNCT07358689Written as Diphenhydramine
- Anticholinergics for Cervical Edema in LaborRecruitingPhase 2/3The University of Texas Health Science Center, HoustonNCT06702670Written as Treatment with Diphenhydramine
- Antihistamine for Prevention of HTR After Blood Primed CPBRecruitingPhase 4Kasr El Aini HospitalNCT07536152Written as Antihestamine
- Mast Cell Treatment in Post-tick Bite Illness (PTBI)Not yet recruitingPhase 2University of North Carolina, Chapel HillNCT07526558Written as Ketotifen
- Trial of Diphenhydramine for Sleep in Children With AutismRecruitingPhase 2Stanford UniversityNCT05501678Written as Diphenhydramine
- Topical Ketotifen 0.25% for Secondary VestibulodyniaRecruitingPhase 2Center for Vulvovaginal DisordersNCT07257029Written as Ketotifen Fumarate 0.25% Cream
- Assessing Changes in Multi-parametric MRI in Patients With Acute Demyelinating Lesions Taking Clemastine Fumarate as a Myelin Repair TherapyNot yet recruitingPhase 1/2University of California, San FranciscoNCT06065670Written as Clemastine Fumarate
- Assessment of Clemastine Fumarate as a Remyelinating Agent in Acute Optic Neuritis (ReCOVER)RecruitingPhase 2University of California, San FranciscoNCT02521311Written as Clemastine
- Repurposing Mirtazapine in Rett SyndromeRecruitingPhase 2University of TriesteNCT07430046Written as mirtazapine
- Stem Cell Transplantation in Crohn's DiseaseRecruitingPhase 1/2Cedars-Sinai Medical CenterNCT04224558Written as Diphenhydramine
- Comparative Efficacy of Flunarizine and Propanolol in Pediatric MigraineRecruitingNot applicableMuhammad Aamir LatifNCT07354126Written as Flunarizine
See all 350 studies that test one of the histamine h1 antagonists →
Codes
What other systems call Histamine H1 Antagonists · ClinicalTrials.gg INT007615
- MeSH (NLM) D006634Histamine H1 AntagonistsOne source ClinicalTrials.gov
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D006634 | Histamine H1 Antagonists | One source ClinicalTrials.gov |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.