Dyspareunia clinical trials
The registry lists 158 studies for Dyspareunia across more than 10 countries. 40 are recruiting or about to start. 81 of them are mainly about Dyspareunia (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Kissei Pharmaceutical Co., Ltd. (4) · Medstar Health Research Institute (3) · BC Women's Hospital & Health Centre (3) · Kanuni Sultan Suleyman Training and Research Hospital (3) · Abbott (3) · Ohio State University Comprehensive Cancer Center (3) · Riphah International University (3) · University of Sao Paulo (2)
What is being tested here
Drugs under test in Dyspareunia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Estradiol | 2 | 5 | 9 |
| Testosterone | 1 | 1 | 3 |
| Platelet rich plasma | 1 | 0 | 1 |
| Lasofoxifene | 1 | 0 | 1 |
| Linzagolix | 0 | 4 | 5 |
| Dehydroepiandrosterone | 0 | 2 | 3 |
| Botulinum toxin type A | 0 | 1 | 3 |
| Asoprisnil | 0 | 0 | 3 |
| Onabotulinum toxin A | 0 | 0 | 2 |
| Lidocaine | 0 | 0 | 2 |
Drug classes tested here Estrogens 2 open · Local anesthetics 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Dec 2026Physiotherapeutic Approach to Superficial and Deep Dyspareunia in Women With Chronic Pelvic Pain: Comparison Between In-person and Telehealth Care. · University of Sao Paulo
- Dec 2026The PANHIS Study: Sexual Health in Spanish-Speaking Adults - A Cross-Sectional Online Survey · Menoclinica by Palacios
- Dec 2026Changes in the Impact of Genitourinary Syndrome of Menopause With a Novel Nonhormonal Vulvovaginal Gel Assessed by PROMs. · Mucosa Innovations, S.L.
- Dec 2026Proof of Concept Study of Vaginal AZU-101 in Vulvovaginal Atrophy in Postmenopausal Women · Azure Biotech Inc.
- Dec 2026Postpartum Vaginal Estrogen for Breastfeeding Patients · University Hospitals Cleveland Medical Center
- Jan 2027Effects of Photobiomodulation on Pain and Sexual Function in Women With Dyspareunia: Randomized Clinical Trial · Federal University of Health Science of Porto Alegre
- Jul 2027Pre-Rehabilitation for Female Patients Undergoing Pelvic Radiotherapy · Indiana University
- Aug 2027F-GYN for Vaginal Dryness and Vulvovaginal Atrophy · Biovico Sp. z o.o.
- Sep 2027Repeated Pudendal Nerve Block and Physiotherapy for Prevention of Chronic Post-Episiotomy Pain · Vinmec Healthcare System
- Sep 2027Pelvic Floor Physical Therapy and Exercise for Women With Endometriosis and Chronic Pelvic Pain · Hospital de Clinicas de Porto Alegre
Who these studies take
Of the 28 Dyspareunia studies recruiting now, 11 (39%) set no upper age limit and 14 (50%) stop at 75 or younger. 1 (4%) take children under 18. 25 (89%) are for women only and 0 (0%) for men only; 8 (29%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (4%) | 1 (4%) |
| 18 | 20 (71%) | 3 (11%) |
| 30 | 22 (79%) | 3 (11%) |
| 40 | 24 (86%) | 3 (11%) |
| 50 | 23 (82%) | 3 (11%) |
| 65 | 19 (68%) | 3 (11%) |
| 75 | 14 (50%) | 3 (11%) |
| 85 | 14 (50%) | 3 (11%) |
Across all 158 studies, recruiting or not: 57% stop at 75 or younger and 46% at 65; 6% take children; 94% are for women only and 0% for men only; 27% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Dyspareunia studies take
Of 10 phase 3 interventional studies under Dyspareunia, half reached primary completion within 13 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 3 | 13 mo5–28 · 10 studies | — | — |
| Interventional, no phase | 33 mo13–38 · 59 studies | — | 33 mo14–48 · 51 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered3
- Halova Vaginal Ovules Versus Placebo for Genitourinary Symptoms in Premenopausal WomenNov 9, 2026NCT07927088
- Rigid Hymenal Ring as a Cause for Insertional DyspareuniaNov 3, 2026NCT07913386
- PRECISION-E2: Teverelix in Women With Endometriosis - Pharmacodynamics, Safety and Precision Medicine CorrelatesNov 3, 2026NCT07914062
Studies
Recruiting first, then most recently updated. Showing 50 of 158. Browse all 158 → or search them.
- The PANHIS Study: Sexual Health in Spanish-Speaking Adults - A Cross-Sectional Online SurveyRecruitingNCT077462971 country
- PRECISION-E2: Teverelix in Women With Endometriosis - Pharmacodynamics, Safety and Precision Medicine CorrelatesNot yet recruitingNCT07914062Phase 2
- Rigid Hymenal Ring as a Cause for Insertional DyspareuniaRecruitingNCT079133861 country
- Proof of Concept Study of Vaginal AZU-101 in Vulvovaginal Atrophy in Postmenopausal WomenRecruitingNCT06197568Phase 21 country
- Association of Ultrasound Features of the Myometrium Suggestive of Adenomyosis and Clinical SymptomsRecruitingNCT073977154 countries
- F-GYN for Vaginal Dryness and Vulvovaginal AtrophyRecruitingNCT07701863Not applicable1 country
- Impact of Early Physiotherapy on Pain, Quality of Life, Pelvic Floor Function, and Sexual Health Post-EpisiotomyRecruitingNCT06568406Not applicable1 country
- Use of tDCS Stimulation in Neurological and Gynaecological ConditionsRecruitingNCT06891690Not applicable1 country
- VEDA Study (DHEA vs Estradiol)RecruitingNCT07574216Not applicable1 country
- Pre-Rehabilitation for Female Patients Undergoing Pelvic RadiotherapyRecruitingNCT06059586Not applicable1 country
- Repeated Pudendal Nerve Block and Physiotherapy for Prevention of Chronic Post-Episiotomy PainNot yet recruitingNCT07814183Not applicable
- Comparing Decidual Inclusion vs. Exclusion in Uterine Suture Techniques During Cesarean Section to Improve Scar Thickness and Reduce Isthmocele Risk in Primiparous WomenRecruitingNCT07608874Not applicable1 country
- Retrospective Cohort Study of Symptoms and Quality of Life in Women With Genitourinary Syndrome of Menopause.Not yet recruitingNCT077377821 country
- Pelvic Floor Physical Therapy and Exercise for Women With Endometriosis and Chronic Pelvic PainRecruitingNCT07733583Not applicable1 country
- RELIEVE Study- Platelet-Rich Plasma to Reduce Postpartum Pain After Perineal Tears or EpisiotomyNot yet recruitingNCT07727213Not applicable1 country
- Postpartum Vaginal Estrogen for Breastfeeding PatientsRecruitingNCT05457972Phase 41 country
- Genetic Study of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS)RecruitingNCT004993171 country
- Impact of Ehlers-Danlos Syndrome on Gynaecological HealthRecruitingNCT071512741 country
- Biomodulation and Rehabilitation Interventions to tarGet Pelvic HealthRecruitingNCT06660212Not applicable1 country
- Effectiveness of Radiofrequency Combined With Ultrasound for the Treatment of Postpartum DyspareuniaRecruitingNCT07504991Not applicable1 country
- Changes in the Impact of Genitourinary Syndrome of Menopause With a Novel Nonhormonal Vulvovaginal Gel Assessed by PROMs.RecruitingNCT06962345Not applicable1 country
- Effects of Pelvic Floor Muscle Training With & Without Hypopressive ExercisesRecruitingNCT07440875Not applicable1 country
- Bipolar Radiofrequency for Genitourinary Syndrome of MenopauseNot yet recruitingNCT07419035Not applicable1 country
- Use of Topical Testosterone and Estrogen vs Estrogen Alone in Vulvodynia: a Randomized Controlled TrialNot yet recruitingNCT07260825Phase 2/31 country
- Study of Sexual Quality of Life in Women With Breast Cancer Who Had Multidisciplinary Management With Photobiomodulation for Genitourinary Syndrome of the MenopauseRecruitingNCT06347926Not applicable1 country
- Effect of Respiratory Exercises With Pelvic Floor Rehab on Dyspareunia & Autonomic Function in WomenNot yet recruitingNCT07078318Not applicable
- Effectiveness of a Telerehabilitation Program for Improving Sexual Function and Reducing Pain in Menopausal WomenRecruitingNCT06710002Not applicable1 country
- VIBRating vs Traditional Therapy for Treatment of ENTry DyspareuniaRecruitingNCT06840314Not applicable1 country
- Genitourinary Syndrome of Menopause in Breast CancerRecruitingNCT06721936Not applicable1 country
- Assessment of Women's Sexual Quality of Life After Benign Adnexal Surgery Using vNOTES ApproachRecruitingNCT05761275Not applicable1 country
- Treatment of Vulvo-vaginal Atrophy (VVA) Using Vaginal Dilator in Addition to Usual TreatmentRecruitingNCT06828640Not applicable1 country
- Pelvic Health Rehabilitation After Breast and Gynecologic CancerRecruitingNCT06822582Not applicable1 country
- Effect of Transcutaneous Electrical Acupoint Stimulation on DyspareuniaNot yet recruitingNCT06730776Not applicable1 country
- Endometriosis Pelvic Pain Interdisciplinary Cohort Data RegistryEnrolling by invitationNCT029110901 country
- Effects of Photobiomodulation on Pain and Sexual Function in Women With Dyspareunia: Randomized Clinical TrialNot yet recruitingNCT06460415Not applicable1 country
- Comparative Effects of Wurn Technique and Mercier Therapy in Women With EndometriosisNot yet recruitingNCT06460376Not applicable1 country
- A Study of Participants Ages 21-65 Diagnosed With Dyspareunia and the Effects of Low Intensity Shockwave TreatmentRecruitingNCT05806203Not applicable1 country
- Management of Women With Superficial DyspareuniaNot yet recruitingNCT061428511 country
- Somatocognitive Therapy in Treatment of Provoked (Localized) Vestibulodynia - Randomized Clinical Trial (ProLoVe Study)RecruitingNCT04613713Not applicable1 country
- ENDOMET - Novel Diagnostic Tools and Treatments for EndometriosisRecruitingNCT013018851 country
- Halova Vaginal Ovules Versus Placebo for Genitourinary Symptoms in Premenopausal WomenCompletedNCT07927088Not applicable1 country
- Effects of Clinical Pilates on Pain and Quality of Life in Women With DyspareuniaCompletedNCT07540195Not applicable1 country
- Study Comparing Estradiol Vaginal Inserts 4mcg To IMVEXXY ® (Estradiol Vaginal Inerts 4 mcg) In The Treatment Of Dyspareunia in Women With Vulvur and Vaginal AtrophyCompletedNCT05617820Phase 33 countries
- Examination of the Effects of Pelvic Floor Exercises on Vaginal and Sexual Health in Postmenopausal Women.CompletedNCT06294197Not applicable1 country
- Laser Therapy for Treatment of Urogenital Symptoms in WomenCompletedNCT036816781 country
- Physiotherapeutic Approach to Superficial and Deep Dyspareunia in Women With Chronic Pelvic Pain: Comparison Between In-person and Telehealth Care.Active, not recruitingNCT07658703Not applicable1 country
- Effect of Radiofrequency in the Treatment of de Novo Dyspareunia at 4 to 12 Months Postpartum.CompletedNCT05417334Not applicable1 country
- Psychometric Validation of the Portuguese DIVAS-Q in Women With Vulvovaginal Atrophic SymptomsCompletedNCT072504901 country
- Dyspareunia and Central SensitizationCompletedNCT032163301 country
- Manual Therapy in Improving Quality of Life in Women With DyspareuniaCompletedNCT07495085Not applicable1 country