Hot Flashes clinical trials
The registry lists 339 studies for Hot Flashes across more than 10 countries. 56 are recruiting or about to start. 240 of them are mainly about Hot Flashes (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-04.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Bayer (18) · Mayo Clinic (13) · Alliance for Clinical Trials in Oncology (10) · Massachusetts General Hospital (9) · Astellas Pharma Global Development, Inc. (7) · National Center for Complementary and Integrative Health (NCCIH) (6) · Cairo University (6) · Wake Forest University Health Sciences (6)
What is being tested here
Drugs under test in Hot Flashes studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Fezolinetant | 3 | 10 | 15 |
| Ashwagandha | 1 | 0 | 1 |
| Asimadoline | 1 | 0 | 1 |
| Tirzepatide | 1 | 0 | 1 |
| Asparagus racemosus | 1 | 0 | 1 |
| Nitroprusside | 1 | 0 | 1 |
| Acetylcholine | 1 | 0 | 1 |
| Terbutaline | 1 | 0 | 1 |
| Norepinephrine | 1 | 0 | 1 |
| Solifenacin | 1 | 0 | 1 |
Drug classes tested here Antimuscarinics 1 open · Estrogens 17 · SSRIs 12 · SNRIs 10
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Dec 2026A Clinical Trial to Evaluate the Effects of A Supplement on Symptoms of Menopause and Overall Well-being · Primal Harvest, LLC
- Dec 2026Transcranial Electrical Stimulation for Noninvasive Study of Menopausal/Perimenopausal Symptoms · Carnegie Mellon University
- Dec 2026Hot Flashes and Neurovascular Function in Women · Mayo Clinic
- Dec 2026Satavari and Ashoka for Menopause (SAM) Study · Vidya USA Corporation
- Dec 2026Men With Prostate Cancer: Optimizing Wellness by Enhanced Relief From Hot Flashes With Acupuncture · Inova Health Care Services
- Jan 2027Fezolinetant for Treating Hot Flashes in Men With Prostate Cancer · University of Vermont
- Jan 2027Time-Efficient Inspiratory Muscle Strength Training for Reducing Sympathetic Activity and Improving Sleep in Midlife Women · Mayo Clinic
- Feb 2027Effects of a Dietary Supplement in Women With Late Perimenopause or Early Postmenopause · University of Alicante
- Feb 2027A Study in Canada to Follow Outcomes of Women in Menopause Treated With Fezolinetant for Hot Flashes, When Given in Clinical Practice · Astellas Pharma Europe Ltd.
- Mar 2027The Effects of Resistance Training and a Plant-Based Supplement on Perimenopausal Symptoms and Muscle Health. · Leeds Beckett University
Who these studies take
Of the 36 Hot Flashes studies recruiting now, 13 (36%) set no upper age limit and 21 (58%) stop at 75 or younger. 2 (6%) take children under 18. 27 (75%) are for women only and 6 (17%) for men only; 11 (31%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (6%) | 0 (0%) |
| 18 | 9 (25%) | 7 (19%) |
| 30 | 10 (28%) | 8 (22%) |
| 40 | 18 (50%) | 9 (25%) |
| 50 | 30 (83%) | 9 (25%) |
| 65 | 16 (44%) | 9 (25%) |
| 75 | 10 (28%) | 8 (22%) |
| 85 | 10 (28%) | 8 (22%) |
Across all 339 studies, recruiting or not: 59% stop at 75 or younger and 50% at 65; 11% take children; 86% are for women only and 7% for men only; 31% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Hot Flashes studies take
Of 24 phase 2 interventional studies under Hot Flashes, half reached primary completion within 14 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 3 mo1–9 · 10 studies | — | — |
| Phase 2 | 14 mo12–54 · 24 studies | — | — |
| Phase 3 | 22 mo16–29 · 23 studies | — | — |
| Interventional, no phase | 22 mo10–34 · 65 studies | — | 23 mo10–40 · 56 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Started recruiting2
Newly registered3
- A Clinical Trial to Evaluate the Effects of A Supplement on Symptoms of Menopause and Overall Well-beingOct 29, 2026NCT07903480
- Self-Management Box on Hot Flash in Postmenopausal WomenOct 15, 2026NCT07874893
- Internet-Delivered CBT Program for Menopausal Vasomotor SymptomsOct 14, 2026NCT07873177
Studies
Recruiting first, then most recently updated. Showing 50 of 339. Browse all 339 → or search them.
- Focusing on the Menopausal Transition to Improve Mid-Life Women's HealthRecruitingNCT06975111Phase 2/31 country
- Lemborexant vs Clonidine vs Sedatives to Treat Insomnia in Chronic Pain PatientsRecruitingNCT056180021 country
- A Study to Confirm if Fezolinetant Helps to Reduce Hot Flashes in Indian Women Going Through MenopauseRecruitingNCT07829653Phase 31 country
- A Clinical Trial to Evaluate the Effects of A Supplement on Symptoms of Menopause and Overall Well-beingNot yet recruitingNCT07903480Not applicable1 country
- Internet-Delivered CBT Program for Menopausal Vasomotor SymptomsNot yet recruitingNCT07873177Not applicable1 country
- Self-Management Box on Hot Flash in Postmenopausal WomenNot yet recruitingNCT07874893Not applicable1 country
- Effects of a Dietary Supplement in Women With Late Perimenopause or Early PostmenopauseRecruitingNCT07863973Not applicable1 country
- Safety and Efficacy of Asimadoline (TP0052) in Patients With Vasomotor Symptoms (VMS).RecruitingNCT07042516Phase 21 country
- The Effect of Tirzepatide on Menopausal Vasomotor Symptoms and Biological Aging in Post-menopausal Women With ObesityRecruitingNCT07218445Phase 41 country
- Satavari and Ashoka for Menopause (SAM) StudyRecruitingNCT07861295Not applicable1 country
- Guided Digital Self-Hypnosis Solution for Managing Hot Flashes in Patients Undergoing Adjuvant Hormone TherapyRecruitingNCT06552091Not applicable1 country
- Reduce HEAT: A Randomized Trial of Wearable Thermal Devices for ADT-Induced Hot FlashesRecruitingNCT07729150Not applicable1 country
- Randomized Evaluation of Natural Extract for Menopausal Wellness (RENEW)RecruitingNCT07834463Not applicable1 country
- Thermoregulatory Physiology of Menopausal Hot FlashesRecruitingNCT07824648Not applicable1 country
- Haelan 951 for Menopause Symptoms in Peri- and Postmenopausal WomenRecruitingNCT07751029Not applicable1 country
- Fezolinetant and Vascular Health and Brain HealthNot yet recruitingNCT07606664Phase 31 country
- Goji Berry and Vasomotor Symptoms Pilot StudyNot yet recruitingNCT07660315Not applicable1 country
- Comparing Acupuncture vs. Sham Acupuncture for the Management of Hot Flashes in Prostate Cancer Patients Receiving Hormone TherapyRecruitingNCT07594002Not applicable1 country
- Proof-of-Concept Trial to Assess the Efficacy and Safety of Fezolinetant in Improving Vasomotor Symptoms in Men With Prostate Cancer Undergoing Androgen Deprivation TherapyRecruitingNCT06957691Phase 21 country
- Time-Efficient Inspiratory Muscle Strength Training for Reducing Sympathetic Activity and Improving Sleep in Midlife WomenRecruitingNCT06743269Not applicable1 country
- Hot Flashes and Neurovascular Function in WomenRecruitingNCT05193968Not applicable1 country
- A Feasibility Study of Biometric Measurements Via Wearable Smart Watch Technology for Evaluation of Vasomotor Symptoms in Patients Treated With Androgen Deprivation Therapy for Prostate Cancer (Prostate 007)RecruitingNCT07535541Not applicable1 country
- A Retrospective and Prospective Clinical Registry for Data Collection of Perimenopausal, Menopausal and Premature Ovarian Insufficiency WomenNot yet recruitingNCT07606326
- A Study in Canada to Follow Outcomes of Women in Menopause Treated With Fezolinetant for Hot Flashes, When Given in Clinical PracticeRecruitingNCT076025301 country
- Finding Links Between Hot flASHes and CardioVascular DiseaseRecruitingNCT07077395Phase 21 country
- The Cardiovascular Impact of Hot FlushesRecruitingNCT052513241 country
- Acupuncture With/Without Self-acupressure for Post-oophorectomy Hot Flashes in BRCA CarriersNot yet recruitingNCT05331209Not applicable1 country
- Intra Ovarian Muse Cell Injection for Perimenopause Symptom Relief and Ovarian Function Restoration (MUSE-OVARY)Enrolling by invitationNCT075116601 country
- The Effects of Resistance Training and a Plant-Based Supplement on Perimenopausal Symptoms and Muscle Health.RecruitingNCT07135232Not applicable1 country
- A Randomized Controlled Trial of Acupuncture for the Management of Hot Flashes in Patients With Hormone Receptor-Positive Breast CancerNot yet recruitingNCT07294339Not applicable1 country
- Solifenacin Compared to Clonidine for Reducing Hot Flashes Among Breast Cancer PatientsRecruitingNCT01530373Phase 21 country
- Targeting Insomnia to Prevent Depression in the Menopause TransitionNot yet recruitingNCT07443644Not applicable
- Impact of Cooling Mats on Vasomotor Symptoms in Patients Receiving Endocrine TherapyEnrolling by invitationNCT07422727Not applicable1 country
- Effect of High Power Laser Acupuncture on Post Menopausal Hot FlashesNot yet recruitingNCT07419542Not applicable1 country
- Effect of a Mindfulness-Based Stress Reduction Program on Hot Flashes and Sleep Quality in Menopausal Women: A Randomized Controlled TrialNot yet recruitingNCT07402096Not applicable
- Fezolinetant for Treating Hot Flashes in Men With Prostate CancerRecruitingNCT06972875Phase 21 country
- Men With Prostate Cancer: Optimizing Wellness by Enhanced Relief From Hot Flashes With AcupunctureRecruitingNCT07335224Not applicable1 country
- Transcranial Electrical Stimulation for Noninvasive Study of Menopausal/Perimenopausal SymptomsNot yet recruitingNCT07375732Not applicable
- Menopausal Symptoms Probiotic StudyRecruitingNCT06446869Not applicable1 country
- JDS-HF3.0 Supplementation on Menopause Related Quality of Life Outcomes in Postmenopausal WomenRecruitingNCT07238478Not applicable1 country
- The Effectiveness of a Proprietary Ashwagandha Extract on Menopausal Symptoms: A Three-Arm Randomized, Double-Blinded, Placebo Controlled Clinical TrialNot yet recruitingNCT07210229Not applicable1 country
- A Trial to Investigate the Accuracy of a Wearable Device in Collecting Data Related to Perimenopausal Symptoms in WomenRecruitingNCT070229251 country
- Effect of a Cepham Supplement on Hot Flashes and Menopausal Symptoms in Postmenopausal WomenNot yet recruitingNCT06939868Not applicable1 country
- Getting Under the Skin of the Menopausal Hot FlushRecruitingNCT062220731 country
- Evaluation of the Beneficial Effects of a Product Containing Γ-aminobutyric Acid (GABA) on Climacteric Syndrome DisordersRecruitingNCT06864520Not applicable1 country
- Strength and Aerobic Training Against Hot Flushes in Postmenopausal WomenRecruitingNCT06030388Not applicable1 country
- Efficacy and Safety of Shatavari for Treatment of Menopausal Symptoms in Women: A Randomized, Double-blind, Three-arm, Parallel, Placebo-controlled StudyRecruitingNCT06716554Not applicable1 country
- Reflexology Versus Acupressure on Sleep Disturbance and Hot FlashesRecruitingNCT06499311Not applicable1 country
- Virtual perI-/Menopause Registry of AusTrALiaRecruitingNCT064871301 country
- Evaluation of the Effects of Using Cooling Pillowcases, on the Symptoms of Hot Flushes, Sleep and Life QualityRecruitingNCT06415162Not applicable1 country