Respiratory Insufficiency clinical trials
The registry lists 1,369 studies for Respiratory Insufficiency across more than 10 countries. 264 are recruiting or about to start. 803 of them are mainly about Respiratory Insufficiency (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 7 narrower conditions too, such as Nasal Obstruction: 1,882 studies, 365 open.
ClinicalTrials.gov finds 3,030 studies for Respiratory Insufficiency. How that becomes 1,369 here
This page counts the studies the registry files under Respiratory Insufficiency, and those it files under no condition that list Respiratory Insufficiencythemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 3,030Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −503Filed under a narrower condition, counted on its own pageNasal Obstruction 170 · Airway Obstruction 138 · Hypoventilation 73 · Obesity Hypoventilation Syndrome 59 · Respiratory Paralysis 31 · Patient-Ventilator Asynchrony 18 · 1 more
- −23List Respiratory Insufficiency as a condition, but the registry did not file them under itMost often written as “Chronic Respiratory Insufficiency” (7), “Respiratory Insufficiency Syndrome of Newborn” (5), and “Chronic Hypercapnic Respiratory Failure” (4). The registry filed them under other conditions only, most often Pulmonary Disease, Chronic Obstructive (7) and Bronchopulmonary Dysplasia (3).
- −1,135Match it another way74 name it in the title, 3 in a keyword, and 1,058 by a synonym or other text the search reads.
- 1,369The count on this page22 of them list Respiratory Insufficiency in their own words; the registry filed them under no condition.
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Who runs them
Assistance Publique - Hôpitaux de Paris (19) · Massachusetts General Hospital (19) · Assiut University (14) · University Health Network, Toronto (14) · Unity Health Toronto (13) · University of Sao Paulo General Hospital (13) · Southeast University, China (12) · National Taiwan University Hospital (10)
What is being tested here
Drugs under test in Respiratory Insufficiency studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Propofol | 3 | 1 | 10 |
| Remimazolam | 3 | 0 | 4 |
| Dexmedetomidine | 2 | 4 | 13 |
| Cisatracurium | 2 | 0 | 3 |
| Norepinephrine | 2 | 1 | 2 |
| Dexamethasone | 1 | 3 | 7 |
| Fentanyl | 1 | 0 | 4 |
| Tocilizumab | 1 | 1 | 3 |
| Midazolam | 1 | 0 | 2 |
| Argatroban | 1 | 0 | 2 |
Drug classes tested here Opioids 2 open · Neuromuscular blockers 2 open · Stimulants 2 open · Corticosteroids 1 open · NSAIDs 5
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026AI-Assisted Bronchoscopy Navigation and Diagnostic System for Severe Pneumonia: A Multicenter Prospective Study · Chinese Medical Association
- Nov 2026Heart Rate VAriability as a MaRker for tItrATing hIgh flOw Nasal Cannula Therapy · University Health Network, Toronto
- Nov 2026Long Term Outcomes of Patients With COVID-19 · University of Chicago
- Nov 2026Compliance-Guided Abdominal Wall Closure Strategy in Large Ventral Hernia Repair · Swissmed Hospital
- Nov 2026Management of Post-operative Respiratory Failure by Using NIV and High Velocity Nasal Insufflation (HVNI) · Assiut University
- Nov 2026Respiratory Monitoring System That Detects & Predicts OIRD · Thomas Jefferson University
- Dec 2026Effectiveness and Efficiency of Home Telemonitoring and Non-invasive Ventilation in Patients With COPD and Hypercapnia (EVALECO) · Air Liquide Healthcare Spain
- Dec 2026Ventilator-based Inspiratory Muscle Training for Patients With Respiratory Failure · Cairo University
- Dec 2026Permian Health Women's Lung Health Study · Permian Health Lung Institute
- Dec 2026Effects of PBMT-sMF in Mechanically Ventilated Patients · University of Nove de Julho
Who these studies take
Of the 178 Respiratory Insufficiency studies recruiting now, 134 (75%) set no upper age limit and 18 (10%) stop at 75 or younger. 21 (12%) take children under 18. 1 (1%) are for women only and 1 (1%) for men only; 19 (11%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 15 (8%) | 15 (8%) |
| 18 | 162 (91%) | 162 (91%) |
| 30 | 164 (92%) | 164 (92%) |
| 40 | 165 (93%) | 165 (93%) |
| 50 | 165 (93%) | 165 (93%) |
| 65 | 165 (93%) | 165 (93%) |
| 75 | 163 (92%) | 163 (92%) |
| 85 | 153 (86%) | 153 (86%) |
Across all 1,369 studies, recruiting or not: 18% stop at 75 or younger and 15% at 65; 17% take children; 2% are for women only and <1% for men only; 9% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Respiratory Insufficiency studies take
Of 30 phase 2 interventional studies under Respiratory Insufficiency, half reached primary completion within 12 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 11 mo3–16 · 12 studies | — | — |
| Phase 2 | 12 mo10–37 · 30 studies | — | — |
| Phase 3 | 25 mo12–53 · 21 studies | — | — |
| Phase 4 | 14 mo7–25 · 23 studies | — | — |
| Interventional, no phase | 24 mo10–46 · 375 studies | — | 24 mo11–47 · 359 studies |
| Observational | 22 mo12–44 · 248 studies | — | 22 mo12–54 · 232 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting6
- Apneic Oxygenation With High-flow Nasal Oxygenation After Preoxygenation With Noninvasive Ventilation Before Intubation in Hypoxemic Patients in Intensive Care Unit.Nov 9, 2026NCT07189338
- Comparison of Several Oxygenation Targets With Different Oxygen Interfaces - Impact on Oxygen Flow RatesNov 5, 2026NCT06646991
- Validation of the Turkish Version of the S3-NIV QuestionnaireNov 4, 2026NCT07610122
- Humidification Effects on Airway Complications and Clinical Outcomes in Trauma ICU Patients on Mechanical VentilationOct 27, 2026NCT07713238
- Bedside Spirometry for Acute Lung InjuryOct 19, 2026NCT07750717
Show 1 moreShow fewer
- Spontaneous vs Controlled Mechanical Ventilation in Acute Hypoxemic Respiratory FailureOct 15, 2026NCT07463885
Results posted1
- Delayed Cord Clamping With Oxygen In Extremely Low Gestation InfantsOct 15, 2026NCT04413097
Stopped1
- Automated Oxygen Titration With the EMILY.AI Device in a Respiratory Intermediate Care UnitSuspendedNov 2, 2026NCT06952816
Newly registered6
- Lactate/Albumin Ratio and Mortality in Respiratory FailureNov 2, 2026NCT07909226
- Oxytocin for Respiratory Compromise and Hypoventilation Induced by DrugsOct 29, 2026NCT07902752
- Diaphragm Ultrasound and Rapid Shallow Breathing Index for Predicting Extubation SuccessOct 27, 2026NCT07897617
- Development and Prospective Validation of the AutoEIT Foundation Model for ARDSOct 27, 2026NCT07898319
- Respiratory Progression in Adults With Duchenne Muscular Dystrophy.Oct 19, 2026NCT07879989
Show 1 moreShow fewer
- Role of HFNC During FOB in Patients With Respiratory FailureOct 19, 2026NCT07880964
Studies
Recruiting first, then most recently updated. Showing 50 of 1,369. Browse all 1,369 → or search them.
- Supraglottic Airway for Resuscitation in PreemiesRecruitingNCT07419438Not applicable1 country
- Apneic Oxygenation With High-flow Nasal Oxygenation After Preoxygenation With Noninvasive Ventilation Before Intubation in Hypoxemic Patients in Intensive Care Unit.RecruitingNCT07189338Not applicable1 country
- Personalized Ventilator Settings for Patients on ECMOEnrolling by invitationNCT07673250Not applicable1 country
- Mechanical Ventilator Adjustments and Patient DyspneaNot yet recruitingNCT07701850Not applicable1 country
- Comparison of Pulse Oximetry (SpO2) With Different Oximeters and Arterial Saturation (SaO2): Oxygap2 StudyRecruitingNCT061024993 countries
- Comparison of Several Oxygenation Targets With Different Oxygen Interfaces - Impact on Oxygen Flow RatesRecruitingNCT06646991Not applicable1 country
- WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency DepartmentRecruitingNCT07558265Not applicable1 country
- Comparison of Two Oxygenation Targets With Two Different Oximeters - Impact on Oxygen Flow Rates and OxygenationRecruitingNCT05590130Not applicable1 country
- Validation of the Turkish Version of the S3-NIV QuestionnaireRecruitingNCT076101221 country
- Lactate/Albumin Ratio and Mortality in Respiratory FailureNot yet recruitingNCT079092261 country
- Oxytocin for Respiratory Compromise and Hypoventilation Induced by DrugsNot yet recruitingNCT07902752Phase 2
- Effectiveness and Efficiency of Home Telemonitoring and Non-invasive Ventilation in Patients With COPD and Hypercapnia (EVALECO)Not yet recruitingNCT076796461 country
- Diaphragm Ultrasound and Rapid Shallow Breathing Index for Predicting Extubation SuccessNot yet recruitingNCT07897617
- Humidification Effects on Airway Complications and Clinical Outcomes in Trauma ICU Patients on Mechanical VentilationRecruitingNCT07713238Not applicable1 country
- Development and Prospective Validation of the AutoEIT Foundation Model for ARDSNot yet recruitingNCT078983191 country
- Platform of Randomized Adaptive Clinical Trials in Critical IllnessRecruitingNCT05440851Not applicable10 countries
- Rhu-pGSN for Acute Respiratory Distress Syndrome (ARDS)RecruitingNCT05947955Phase 213 countries
- Bedside Spirometry for Acute Lung InjuryRecruitingNCT07750717Not applicable1 country
- Role of HFNC During FOB in Patients With Respiratory FailureRecruitingNCT07880964Not applicable1 country
- Respiratory Progression in Adults With Duchenne Muscular Dystrophy.RecruitingNCT078799891 country
- Spontaneous vs Controlled Mechanical Ventilation in Acute Hypoxemic Respiratory FailureRecruitingNCT07463885Not applicable1 country
- TORCH-LATAM-003: Regional Advanced-Therapy Pathways for Congenital Heart DiseaseNot yet recruitingNCT07837024Not applicable
- Interleukin-6 Guided Treatment With Dexamethasone or Tocilizumab in Patients Hospitalized With Acute Respiratory Symptoms - a Feasibility StudyRecruitingNCT07334379Phase 21 country
- Predicting High-Flow Nasal Oxygen Failure Within 72 Hours Using a Physiology-Informed Dual-Domain Model at 30 MinutesRecruitingNCT073665411 country
- Compliance-Guided Abdominal Wall Closure Strategy in Large Ventral Hernia RepairRecruitingNCT07422441Not applicable1 country
- Physiological Effect High-flow Tracheal Oxygen on Viscosity of Airway Mucus and Respiratory Effort in Patients Weaning From Invasive Mechanical VentilationRecruitingNCT06776939Not applicable1 country
- Physiological Effects of Continuous Negative External Pressure for Acute Hypoxemic Respiratory FailureRecruitingNCT05675345Not applicable1 country
- Developing New Ways to Detect Respiratory Impairment Early in ALSRecruitingNCT078445901 country
- Protocolized Weaning of High-Flow Nasal Cannula in Adult PatientsNot yet recruitingNCT07452406Not applicable1 country
- The Effect of Hyperoxia on Ventilation During Recovery From General AnesthesiaRecruitingNCT05379673Not applicable1 country
- Management of Post-operative Respiratory Failure by Using NIV and High Velocity Nasal Insufflation (HVNI)RecruitingNCT06988111Not applicable1 country
- Predictors of Prolonged Mechanical Ventilation in Preterm InfantsNot yet recruitingNCT07821632
- Diaphragm Hibernation and Its Driving Factors in Mechanically Ventilated ICU PatientsNot yet recruitingNCT078198641 country
- Dynamic POCUS of Diaphragm Function to Predict Respiratory Failure in Septic ShockNot yet recruitingNCT078202671 country
- Diaphragm Atrophy and Dysfunction in Mechanical VentilationRecruitingNCT052116611 country
- EndotyPIng PreHospitAl de Novo Acute hYpoxemic Respiratory FailureRecruitingNCT051504831 country
- Phase Resolved Functional Lung MRI and Oscillometry for the Observation of Healthy Lung FunctionRecruitingNCT076146851 country
- Combined Lung and Diaphragmatic Ultrasound to Predict Respiratory Failure in Blunt Chest TraumaNot yet recruitingNCT07807566
- HERMES: Quality and Safety of Advanced Respiratory Support During Patient TransportNot yet recruitingNCT078056034 countries
- Epidural Spinal Cord Stimulation for Respiratory Recovery in Cervical SCIRecruitingNCT07722130Not applicable1 country
- The Impact of Low Versus High Positive End-expiratory Pressure on Diaphragm Function, Ventilation Efficiency, and Lung MechanicsRecruitingNCT07188038Not applicable1 country
- Flow-Controlled vs. Pressure-Controlled Ventilation in CABG: Effects on Lung Aeration and Diaphragm FunctionNot yet recruitingNCT07800741Not applicable1 country
- Clinical Evaluation of an Alarm Activated Detection System to Enable Early Intervention of Emerging Respiratory Decline With the Linshom Medical Continuous Predictive Respiratory Sensor (CPRS)Not yet recruitingNCT07793981Not applicable1 country
- Evaluation of the FreeO2 System for Oxygen Weaning After Acute Hypoxemic Respiratory FailureNot yet recruitingNCT07794124Not applicable
- EARLY-SARDS: Early AlveolaR Lung biologY Underling Sepsis-Associated ARDSNot yet recruitingNCT072819111 country
- Mode of Ventilation During Critical Illness at Multiple CentersEnrolling by invitationNCT07313956Not applicable1 country
- Brain Blood Flow and Cerebral Autoregulation Monitoring in Critically Ill ChildrenRecruitingNCT076139181 country
- Nutritional Risk and Diaphragmatic Thickness in Mechanically Ventilated COPD PatientsNot yet recruitingNCT07788170
- Extracorporeal Carbon Dioxide Removal Plus Noninvasive Ventilation in Patients With COPD Not Eligible for IntubationNot yet recruitingNCT07785375Not applicable1 country
- Respiratory Variability in Patients With Acute Hypoxemic Respiratory Failure and Placed on High Flow Oxygen TherapyRecruitingNCT06675045Not applicable1 country