Chlorhexidine gluconate clinical trials
Also written Hibiclens and Peridex.
A product of Chlorhexidine; its studies count on that page too.
Related medicines add 1 study
Counted the way a researcher would: Chlorhexidine gluconate with its salts, dosage forms, brands and biosimilars. Looking for a trial to join? Including related medicines shows more you could take part in.
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How each study uses chlorhexidine gluconate is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
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Approvals
The first approval found in each region, with its record
- United States
- 17 Sept 1976 · HIBICLENS · NDA 017768 (FDA, Drugs@FDA)
- European Union
- Not in EMA's list of EU-wide authorisations
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Studies by the year they started
108 studies that test it; most in 2014 (11)
| Year | Studies |
|---|---|
| 2003 | 1 |
| 2004 | 1 |
| 2005 | 1 |
| 2006 | 1 |
| 2007 | 5 |
| 2008 | 6 |
| 2009 | 2 |
| 2010 | 5 |
| 2011 | 5 |
| 2012 | 5 |
| 2013 | 7 |
| 2014 | 11 |
| 2015 | 8 |
| 2016 | 3 |
| 2017 | 7 |
| 2018 | 4 |
| 2019 | 2 |
| 2020 | 5 |
| 2021 | 7 |
| 2022 | 4 |
| 2023 | 7 |
| 2024 | 4 |
| 2025 | 6 |
| 2026 | 1 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 28 · Other 82
Medline Industries (8) · Solventum US LLC (4) · Colgate Palmolive (4) · Molnlycke Health Care AB (3) · Ohio State University (2) · University of North Carolina, Chapel Hill (2) · C. R. Bard (2) · King Abdulaziz University (2)
Often tested with
Tested in the same studies.
Mupirocin (10) · Povidone-Iodine (9) · 2-Propanol (4) · Triclosan (4) · Fluorides (3) · Vancomycin (2) · Ethanol (2) · Metronidazole (2)
Related medicines
As reviewed, each with the page that says it.
- A salt or form of Chlorhexidine
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Reaching primary completion within a year · 3
Studies that test chlorhexidine gluconate.
- Dec 2026The Effect of Different Types of Mouthwash on Extraction Sockets' HealingPhase 4 · University of Jordan
- Dec 2026Optimizing Infection Prophylaxis Prior to Shoulder SurgeryNot applicable · University of Washington
- Jun 2027Decolonization to Reduce After-Surgery Events of Surgical Site InfectionPhase 4 · University of California, Irvine
Studies
Open first, then newest update. How each study uses chlorhexidine gluconate is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 110
- Decolonization to Reduce After-Surgery Events of Surgical Site InfectionRecruitingPhase 4University of California, IrvineNCT05586776Written as 4% Chlorhexidine Gluconate
- Infection Prophylaxis in Total Joint ReplacementRecruitingPhase 3Hamilton Health Sciences CorporationNCT06126614Written as Chlorhexidine Gluconate
- The Effect of Different Types of Mouthwash on Extraction Sockets' HealingRecruitingPhase 4University of JordanNCT06587880Written as Chlorhexidine Gluconate
- The Effect of Bacterial Decolonization Before Skin Cancer Surgery on Infection Rate of Lower Extremity Wounds Left Open to HealRecruitingPhase 3The Cooper Health SystemNCT07142408Written as Chlorhexidine gluconate (4%)
- Effectiveness of Povidone-Iodine Versus Chlorhexidine Gluconate Solutions in Reducing Microbial Contamination in Spinal Surgery Wounds During Intraoperative Soaking.RecruitingNot applicableNational Cheng-Kung University HospitalNCT06284174Written as Povidone-iodine solution; chlorhexidine gluconate
- Optimizing Infection Prophylaxis Prior to Shoulder SurgeryRecruitingNot applicableUniversity of WashingtonNCT06464770Written as Chlorhexidine Gluconate
- Efficacy of Chlorhexidine and Morus Nigra Mouthwashes After Periodontal TreatmentCompletedNot applicableInonu UniversityNCT07540624Written as 0.12% Chlorhexidine Gluconate Mouthwash
- Bacterial Decolonization Plus Intraoperative Angiography for Soft Tissue Sarcomas Receiving Preoperative Radiotherapy (CONCERTO)WithdrawnPhase 2Adam OlsonNCT06712433Written as 4% chlorhexidine gluconate body cleanser
- STaph Aureus Resistance-Treat Early and Repeat (STAR-TER)CompletedPhase 2University of North Carolina, Chapel HillNCT03489629Written as Chlorhexidine Gluconate
- Topical Chlorhexidine and Metronidazole Gels for Gingival InflammationCompletedNot applicableH.P. Government Dental College and Hospital ShimlaNCT07776197Written as Chlorhexidine Gluconate Gel 1%
- Staph Intervention for Effective Local DefenseCompletedPhase 4Johns Hopkins Bloomberg School of Public HealthNCT06210594Written as Mupirocin + Nozin + chlorhexidine gluconate
- Cleaning Methods for Clear AlignersCompletedNot applicableRiyadh Elm UniversityNCT07610603Written as Chlorhexidine gluconate 0.2% oral rinse
- Effect of Bed Bathing Methods on VRE Colonization in ICU PatientsCompletedNot applicableÖzkan KasapNCT07364435Written as Chlorhexidine gluconate 4%
- Checklist to Prevent MRSA Surgical Site InfectionsCompletedNot applicableVA Office of Research and DevelopmentNCT02216227Written as Chlorhexidine gluconate
- Comparison of Oral Care Solutions on Oral Microbial Colonization in Neurosurgical ICU PatientsCompletedNot applicableHarran UniversityNCT07365956Written as Chlorhexidine gluconate (CHG)
- Aqueous vs Alcohol Chlorhexidine Skin Preparation for Prevention of Cesarean Section Wound InfectionsCompletedPhase 4Hyagriv SimhanNCT05920122Written as 2% Chlorhexidine gluconate with 70% alcohol
- Microderm for Root Coverage ProceduresActive, not recruitingPhase 4Ohio State UniversityNCT07203326Written as MicroDerm
- Comparison of Frequency of Calcium Hydroxide Mixed With 0.2% Chlorhexidine Versus Saline as Intracanal Medicament in Periapical Periodontitis-A Randomized Controlled TrialActive, not recruitingNot applicableAqsa AfzalNCT07252258Written as Calcium Hydroxide + 0.2% Chlorhexidine Digluconate
- Preoperative Skin Preparation EvaluationCompletedPhase 3C. R. BardNCT00636480Written as Chlorhexidine gluconate
- Pilot Evaluation of the Application Procedure on the Antimicrobial Effects of 2 AntisepticsCompletedPhase 3C. R. BardNCT00692484Written as Chlorhexidine gluconate
See all 110 studies that test chlorhexidine gluconate →
Given beside what is tested · 9 — chlorhexidine gluconate is usual care or a partner of the new treatment
- Immersive VR to Reduce Stress, Anxiety, and Pain During PICC/Midline PlacementNot yet recruitingNot applicablediana garciaNCT07696156Written as Chlorhexidine Gluconate 2%
- Skin Preparation for Elective Foot and Ankle SurgeryRecruitingPhase 4University of Missouri-ColumbiaNCT05401292Written as Hibiclens
- Rose Bengal Electromagnetic Activation With Green Light for Infection ReductionCompletedPhase 3University of California, San FranciscoNCT05110001Written as Chlorhexidine Gluconate
- Comparison of Chlorhexidine and Hypochlorous Acid Mouthwash After Impacted Third Molar SurgeryCompletedNot applicableYuzuncu Yil UniversityNCT07466992Written as Chlorhexidine Gluconate Mouthwash
- Persistent Methicillin Resistant Staphylococcus Aureus Eradication Protocol (PMEP)CompletedPhase 2Johns Hopkins UniversityNCT01594827Written as 4% chlorhexidine gluconate liquid skin cleanser
- Effect of Postsurgical Systemic Doxycycline After Regenerative Periodontal TherapyTerminatedPhase 4Peter EickholzNCT01030666Written as 0.12% chlorhexidine gluconate solution
- Clinical Evaluation of Single-stage Advanced Versus Rotated Flaps in the Treatment of Gingival RecessionsCompletedPhase 4Universidade Federal FluminenseNCT02433912Written as chlorhexidine gluconate
- Microsurgical Versus Conventional Semilunar Coronally Advanced FlapCompletedPhase 4Universidade Federal FluminenseNCT02433899Written as Chlorhexidine gluconate
- "The Efficacy of Acacia Catechu Mouthrinse as Antiplaque and Antigingivitis Agent in Fixed Orthodontic Appliance Patients.CompletedPhase 4Tatyasaheb Kore Dental CollegeNCT02154594Written as Chlorhexidine gluconate
As the comparator · 16 — what is tested is compared with chlorhexidine gluconate
- Microbiological Evaluation of the Effectiveness of Different Surface Decontamination Protocols for Dental ImplantsRecruitingNot applicableUniversity of ZagrebNCT07529444Written as 0.2% Chlorhexidine Gluconate
- Evaluation of the Anti-Plaque Effect of a Resveratrol-Based Mouthwash Using a 24-Hour Plaque Re-GrowthNot yet recruitingPhase 3University of BaghdadNCT07393802Written as Chlorhexidine Gluconate 0.12 % Mouthwash
- Evaluation of the Effect of Tea Tree and Chlorhexidine Mouthwashes on Healing After Third Molar ExtractionRecruitingNot applicableHarran UniversityNCT07180498Written as Chlorhexidine Gluconate 0.12% Mouthwash
- Chlorhexidine vs Essential Oil Mouthwash for Plaque ControlCompletedNot applicableRehman Medical Institute - RMINCT07822256Written as Chlorhexidine Gluconate Mouthwash
- MOUTHRİNSES AND PALATAL DONOR SİTE HEALİNG AFTER FREE GİNGİVAL GRAFTCompletedNot applicableYuzuncu Yil UniversityNCT07689695Written as Chlorhexidine gluconate 0.2%
- Natural Enzyme Mouthwash After Third Molar SurgeryCompletedNot applicableMBD MARKETING SDN. BHD.NCT07627945Written as 0.2% Chlorhexidine Gluconate Mouthwash
- Effectiveness of Herbal vs Chlorhexidine Mouthwashes in Improving Oral Health in SchoolchildrenCompletedNot applicableMansoura UniversityNCT07309679Written as Chlorhexidine Digluconate 0.2% Mouthwash
- Test for Pre Operative Skin PreparationsCompletedPhase 3C. R. BardNCT00799812Written as Aqueous CHG 4% w/v applied according to mfr's directions
- Evaluating Safety and Effectiveness of Octenidine DihydrochlorideCompletedPhase 2C. R. BardNCT03140254Written as Chlorhexidine gluconate
- Comparison of Two Preoperative Antiseptic Solutions Alcohol Based in Abdominal Elective SurgeriesTerminatedPhase 4Universidad de El SalvadorNCT03859908Written as Chlorhexidine Gluconate 20 MG/ML / Isopropyl Alcohol 0.7 ML/ML
- Antimicrobial Efficacy of Biogenic Gold Nano Particle From Pelargonium Graveolens Leaves Extract Mouthwash for ChildrenStatus unknownNot applicableAhmed Yousif MahdiNCT05816512Written as Chlorhexidine gluconate mouthwash .
- BPO vs Hibiclens Soap for Surgical PreparationCompletedPhase 4University of WashingtonNCT04021524Written as Chlorhexidine Gluconate
- Resolution of Pain and Swelling After the Use of Neem Leaf Extract Compared to Chlorhexidine Gluconate as an Intracanal Irrigant During PulpectomyCompletedPhase 2/3Cairo UniversityNCT02943759Written as Chlorhexidine gluconate
- Chitosan,Chitosan Nanoparticles,and Chlorhexidine Gluconate, as Intra Canal Medicaments in Primary TeethStatus unknownNot applicableAin Shams UniversityNCT03588351Written as chlorhexidine gluconate
- Cinnamon and Ginger in Comparison to Chlorhexidine Gluconate 0.2% on Oral Streptococcus MutansStatus unknownPhase 3Cairo UniversityNCT03061916Written as Chlorhexidine Gluconate
- The Use of Antimicrobial Agents in the Inhibition of Mutans Streptococci in Children With Dental CariesCompletedNot applicableUniversidade Federal do CearaNCT00612469Written as chlorhexidine digluconate
What changed recently
From the registry's own updates since Oct 15, 2026.
Stopped1
- Bacterial Decolonization Plus Intraoperative Angiography for Soft Tissue Sarcomas Receiving Preoperative Radiotherapy (CONCERTO)WithdrawnOct 26, 2026NCT06712433
Codes
What other systems call chlorhexidine gluconate · ClinicalTrials.gg INT002509
- MeSH (NLM) C010882chlorhexidine gluconateConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) MOR84MUD8ECHLORHEXIDINE GLUCONATEConfirmed FDA, NLM, Wikidata
- RxNorm 20791Confirmed FDA, Wikidata
- Wikidata Q15709152chlorhexidine gluconateConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C47974Chlorhexidine GluconateOne source FDA
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | C010882 | chlorhexidine gluconate | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | MOR84MUD8E | CHLORHEXIDINE GLUCONATE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 20791 | — | Confirmed FDA, Wikidata |
| Wikidata | Q15709152 | chlorhexidine gluconate | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C47974 | Chlorhexidine Gluconate | One source FDA |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.