Drug
Brimonidine clinical trials
Also written Alphagan and Mirvaso.
- studies test it
- 110
- open now
- 5
- in phase 3
- 29
- first study started
- 1998
Keep track of what changes. Save the brimonidine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Development codes
Studies by the year they started
105 studies that test it; most in 2016 (11); 1 more planned to start later
| Year | Studies |
|---|---|
| 1998 | 1 |
| 1999 | 1 |
| 2003 | 3 |
| 2004 | 1 |
| 2005 | 5 |
| 2006 | 4 |
| 2008 | 8 |
| 2009 | 7 |
| 2010 | 6 |
| 2011 | 8 |
| 2012 | 4 |
| 2013 | 2 |
| 2014 | 6 |
| 2015 | 1 |
| 2016 | 11 |
| 2017 | 3 |
| 2018 | 4 |
| 2019 | 6 |
| 2020 | 1 |
| 2021 | 3 |
| 2022 | 9 |
| 2023 | 5 |
| 2024 | 1 |
| 2025 | 4 |
| 2026 | 1 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 4
- Phase 1
- 8
- Phase 2
- 25
- Phase 3
- 29
- Phase 4
- 32
- No phase
- 15
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 50 · Other 60
Allergan (17) · Galderma R&D (9) · Bausch & Lomb Incorporated (7) · LENZ Therapeutics, Inc (6) · Visus Therapeutics (3) · Wake Forest University Health Sciences (3) · Ocugen (3) · Massachusetts Eye and Ear Infirmary (3)
Often tested with
Tested in the same studies.
Timolol (9) · Aceclidine (7) · Dorzolamide (6) · Latanoprost (5) · Carbachol (3) · Bimatoprost (3) · Acetazolamide (3) · Brinzolamide (3)
Studies
Open first, then newest update. How each study uses brimonidine is read from its arms, and is right about nine times in ten.
Testing it · 110
- The Effect of Lumify™ on Ocular Redness, Intraocular Pressure, and Eyelid Position in Glaucoma PatientsNot yet recruitingPhase 4Tulane UniversityNCT04007276Written as brimonidine tartrate ophthalmic solution 0.025%
- Upneeq vs. Lumify PtosisNot yet recruitingPhase 4Duke UniversityNCT07390578Written as Brimonidine 0.025% (Lumify)
- Safety and Efficacy Study of TAR-0520 Gel in Prevention of Taxane-induced Peripheral NeuropathyNot yet recruitingPhase 2Tarian PharmaNCT07082764Written as Brimonidine gel
- Brimonidine Eye Drops in the Prevention of Myopia ProgressionNot yet recruitingPhase 2Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y CajalNCT06996236Written as Treatment with brimonidine eye drops 0.025%
- TAR-0520 Gel in EGFR Inhibitor-induced FolliculitisRecruitingPhase 2Tarian PharmaNCT06818058Written as Brimonidine tartrate Gel
- Phase 3 Efficacy Study of LNZ100 & LNZ101 for the Treatment of PresbyopiaCompletedPhase 3LENZ Therapeutics, IncNCT05728944Written as Aceclidine+Brimonidine combination ophthalmic solution
- Phase 3 Evaluation of the Safety and Efficacy of LNZ100 & LNZ101 for the Treatment of PresbyopiaCompletedPhase 3LENZ Therapeutics, IncNCT05656027Written as Aceclidine+Brimonidine combination ophthalmic solution
- Phase 3 Safety Study of LNZ100 and LNZ101 for the Treatment of Presbyopia SubjectsCompletedPhase 3LENZ Therapeutics, IncNCT05753189Written as Aceclidine+Brimonidine combination ophthalmic solution
- Safety and Efficacy Study of BRIMOCHOL™, BRIMOCHOL™ F, and Carbachol in Subjects With Emmetropic Phakic and Pseudophakic PresbyopiaCompletedPhase 2Visus TherapeuticsNCT04774237Written as BRIMOCHOL™ F
- Brimonidine 0.33% for Rosacea-Related Facial ErythemaCompletedPhase 4Istanbul Training and Research HospitalNCT07431476Written as Brimonidine 0.33% gel
- Safety and Efficacy Study of BRIMOCHOL™ PF and Carbachol PF in Subjects With Emmetropic Phakic and Pseudophakic PresbyopiaCompletedPhase 3Visus TherapeuticsNCT05135286Written as BRIMOCHOL™ PF
- Evaluation of the Safety and Pharmacokinetics of Brimonidine Tartrate 0.025%/Ketotifen Fumarate 0.035% Combination Ophthalmic SolutionCompletedPhase 3Bausch & Lomb IncorporatedNCT05815758Written as Brimonidine Tartrate 0.025%/Ketotifen Fumarate 0.035% Ophthalmic Solution (Combo)
- Evaluation of Brimonidine Tartrate/Ketotifen Fumarate Combination in Adults With Seasonal Allergic ConjunctivitisCompletedPhase 3Bausch & Lomb IncorporatedNCT05591755Written as Brimonidine Tartrate 0.025%/ Ketotifen Fumarate 0.035% Ophthalmic Solution
- Evaluation of the Efficacy and Safety of LNZ101 and LNZ100 for the PresbyopiaCompletedPhase 3Corxel PharmaceuticalsNCT06045299Written as Aceclidine+Brimonidine combination ophthalmic solution
- Evaluation of Brimonidine Tartrate/Ketotifen Fumarate Combination for the Treatment of Allergic ConjunctivitisCompletedPhase 3Bausch & Lomb IncorporatedNCT05579730Written as Brimonidine tartrate 0.025%/ketotifen fumarate 0.035%
- Brimonidine for Intraoperative HemostasisWithdrawnPhase 4University of LouisvilleNCT05480098Written as Brimonidine Topical
- Optic Nerve Perfusion Following Treatment with Latanoprost Versus Brimionidin TartrateCompletedEarly Phase 1Zagazig UniversityNCT06730516Written as Brimonidine 0.2 %
- Safety and Efficacy Study BRIMOCHOL™ PF and Carbachol PF in Subjects With Emmetropic Phakic or Pseudophakic PresbyopiaCompletedPhase 3Visus TherapeuticsNCT05270863Written as BRIMOCHOL™ PF
- Evaluation of the Safety and Effectiveness of Aceclidine (LNZ101) and Aceclidine + Brimonidine (LNZ100) in the Treatment of PresbyopiaCompletedPhase 2LENZ Therapeutics, IncNCT05431543Written as Aceclidine+Brimonidine combination ophthalmic solution
- Evaluation of the Safety and Effectiveness of Aceclidine/Brimonidine (LNZ101) and Aceclidine (LNZ100) in the Treatment of PresbyopiaCompletedPhase 2LENZ Therapeutics, IncNCT05294328Written as Aceclidine+Brimonidine combination ophthalmic solution
See all 110 studies that test brimonidine →
Given in every arm · 1 — brimonidine is usual care beside what is tested
As the comparator · 9 — what is tested is compared with brimonidine
- A Study Comparing the Efficacy and Safety of Brimonidine Tartrate Ophthalmic Solution 0.025% With Sodium Hyaluronate Relative to Lumify in Adult Subjects With Ocular RednessCompletedPhase 3Bausch & Lomb IncorporatedNCT06803654Written as Lumify®
- Effect of Netarsudil vs Brimonidine in NTG Patients on LatanoprostCompletedPhase 4Westlake Eye SpecialistsNCT06449352Written as Brimonidine
- PRO-122 Versus Concomitant Therapy in Subjects With Uncontrolled Primary Open-angle Glaucoma (PRO-122LATAM)TerminatedPhase 3Laboratorios Sophia S.A de C.V.NCT03193333Written as Brimonidine Ophthalmic Solution
- Efficacy and Safety of Brinzolamide/Brimonidine Fixed Combination BID Compared to Brinzolamide BID Plus Brimonidine BID in Subjects With Open-Angle Glaucoma (OAG) or Ocular Hypertension (OHT)CompletedPhase 3Alcon ResearchNCT02339584Written as Brimonidine 2 mg/mL eye drops, solution
- A Safety and Efficacy Study of Fixed-Combination Bimatoprost and Brimonidine in Chronic Glaucoma or Ocular HypertensionCompletedPhase 2AllerganNCT01863953Written as Brimonidine Tartrate Ophthalmic Solution 0.2%
- Brinzolamide/Brimonidine Twice a Day (BID) Fixed Combination (FC) vs Brinzolamide BID Plus Brimonidine BID in Patients With Open Angle Glaucoma or Ocular HypertensionCompletedPhase 3Alcon ResearchNCT01309204Written as Brimonidine tartrate 0.2% ophthalmic solution
- Brinzolamide/Brimonidine Twice a Day (BID) Fixed Combination (FC) vs Brinzolamide BID and Brimonidine BID in Patients With Open Angle Glaucoma or Ocular HypertensionCompletedPhase 3Alcon ResearchNCT01310777Written as Brimonidine tartrate 0.2% ophthalmic solution
- Intraocular Pressure (IOP) Lowering Effect of Selective Laser Trabeculoplasty Versus Prostaglandin Analogues in Angle Closure GlaucomaStatus unknownPhase 3Singapore Eye Research InstituteNCT01004900Written as Travoprost/ Timolol/ Azopt/ Brimonidine
- Safety and Efficacy Study of Brimonidine/Timolol Fixed Combination in Patients With Glaucoma or Ocular HypertensionCompletedPhase 3AllerganNCT00652106Written as Brimonidine 0.2% ophthalmic solution
Codes
What other systems call brimonidine · ClinicalTrials.gg INT006513
- MeSH (NLM) D000068438Brimonidine TartrateConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) E6GNX3HHTEBRIMONIDINEConfirmed FDA, NLM, Wikidata
- RxNorm 134615Confirmed FDA, Wikidata
- Wikidata Q577377brimonidineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C65269BrimonidineOne source FDA
- DrugBank DB00484One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D000068438 | Brimonidine Tartrate | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | E6GNX3HHTE | BRIMONIDINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 134615 | — | Confirmed FDA, Wikidata |
| Wikidata | Q577377 | brimonidine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C65269 | Brimonidine | One source FDA |
| DrugBank | DB00484 | — | One source Wikidata |
Also registered as brimonidine tartrate (UNII 4S9CL2DY2H · RxNorm 39171).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.