Hyperemia clinical trials
The registry lists 98 studies for Hyperemia across more than 10 countries. 44 are recruiting or about to start. 41 of them are mainly about Hyperemia (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
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Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Zhuan Zhang (3) · University Hospital, Basel, Switzerland (3) · Kala Pharmaceuticals, Inc. (3) · Georgia State University (3) · Bausch & Lomb Incorporated (3) · University of Iowa (2) · Insel Gruppe AG, University Hospital Bern (2) · Istanbul University - Cerrahpasa (2)
What is being tested here
Drugs under test in Hyperemia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Peanut | 1 | 0 | 1 |
| Loteprednol Etabonate | 0 | 2 | 3 |
| Brimonidine | 0 | 2 | 3 |
| Cabergoline | 0 | 0 | 2 |
| Travoprost | 0 | 0 | 2 |
| Beet | 0 | 0 | 1 |
| Diclofenac | 0 | 0 | 1 |
| Latanoprost | 0 | 0 | 1 |
| Dipyridamole | 0 | 0 | 1 |
| Curcumin | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Jan 2027An Investigation of FID 123472 Ophthalmic Solution to Vehicle for the Reduction of Ocular Redness in Adults · Phase 3 · Alcon Research
- Feb 2027Efficacy and Safety of FID 123472 Ophthalmic Solution for Ocular Redness in Adults · Phase 3 · Alcon Research
- Nov 2026Perceptions and Ultrasound Literacy for Sound Volume Management · University Hospital, Basel, Switzerland
- Dec 2026Evaluating Injection With the Use of Brimonidine Tartrate Ophthalmic 0.025% on Patients Using Netarsudil 0.02%/Latanoprost 0.005% to Treat Glaucoma · Insight Eyecare Specialties, Inc. dba Vision Source Eyecare,
- Dec 2026Training Medical Residents in the Use of the Venous Excess UltraSound (VExUS) Score for Bedside Volume Assessment. · Insel Gruppe AG, University Hospital Bern
- Dec 2026Simple Urine Composition-based Personalized Algorithm for Effective Congestion Relief in Decompensated Heart Failure · Wroclaw Medical University
- Jan 2027Wild Blueberries for Gut, Brain, and Heart Health in Adults With High Blood Pressure · Georgia State University
- Jan 2027Hemodynamic Venous Congestion Ultrasound (VExUS) by ICU Nurses in Sepsis Patients. · Region Örebro County
- Mar 2027VEXUS-REA : Evaluation of Ultrasound Parameters of Venous Congestion in Patients in a Medical Intensive Care Unit · Centre Hospitalier Universitaire de Besancon
- Jun 2027Association of Microcirculation, Vexus Score and Femoral Vein Doppler in Patients on the ICU After Non-emergency Cardiac Surgery · University Hospital, Basel, Switzerland
Who these studies take
Of the 28 Hyperemia studies recruiting now, 17 (61%) set no upper age limit and 7 (25%) stop at 75 or younger. 2 (7%) take children under 18. 2 (7%) are for women only and 0 (0%) for men only; 3 (11%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (7%) | 2 (7%) |
| 18 | 24 (86%) | 24 (86%) |
| 30 | 27 (96%) | 25 (89%) |
| 40 | 26 (93%) | 25 (89%) |
| 50 | 27 (96%) | 26 (93%) |
| 65 | 25 (89%) | 24 (86%) |
| 75 | 21 (75%) | 21 (75%) |
| 85 | 21 (75%) | 21 (75%) |
Across all 98 studies, recruiting or not: 19% stop at 75 or younger and 17% at 65; 8% take children; 9% are for women only and 0% for men only; 27% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Hyperemia studies take
Of 28 observational studies under Hyperemia, half reached primary completion within 21 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Observational | 21 mo16–27 · 28 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 50 of 98. Browse all 98 → or search them.
- VEXUS-REA : Evaluation of Ultrasound Parameters of Venous Congestion in Patients in a Medical Intensive Care UnitRecruitingNCT07438015Not applicable1 country
- Structured Hemodynamic Assessment to Guide Care After Cardiac SurgeryNot yet recruitingNCT07792707Not applicable1 country
- An Investigation of FID 123472 Ophthalmic Solution to Vehicle for the Reduction of Ocular Redness in AdultsRecruitingNCT07578363Phase 31 country
- Efficacy and Safety of FID 123472 Ophthalmic Solution for Ocular Redness in AdultsRecruitingNCT07531043Phase 31 country
- Portal and Splenic Venous Pulsatility in Postoperative Critically Ill PatientsNot yet recruitingNCT07826481
- Evaluation of the Association Between the VEXUS Score and Hemodynamic Status and the Occurrence of Acute Kidney Injury After Open-Heart SurgeryRecruitingNCT078055641 country
- Wild Blueberries for Gut, Brain, and Cardiometabolic Health in PrediabetesRecruitingNCT06735651Not applicable1 country
- Peanuts for Cardiometabolic, Brain, and Intestinal HealthRecruitingNCT06867198Not applicable1 country
- Wild Blueberries for Gut, Brain, and Heart Health in Adults With High Blood PressureRecruitingNCT06735599Not applicable1 country
- Perceptions and Ultrasound Literacy for Sound Volume ManagementRecruitingNCT072373471 country
- Association of Microcirculation, Vexus Score and Femoral Vein Doppler in Patients on the ICU After Non-emergency Cardiac SurgeryRecruitingNCT070524611 country
- Fluid-removal Guided by VeXUS Score With Usual Care in Patients With Acute Kidney Injury After Cardiac SurgeryRecruitingNCT06251713Not applicable1 country
- Changes in Portal Vein Pulsatility Variability During a Tidal Volume Challenge Can Predict Fluid ToleranceNot yet recruitingNCT07131228
- Right Ventriculo-Arterial Coupling During Fluid Loading in ICU PatientsRecruitingNCT075376211 country
- Vexus Assessment and Natriuresis-guided Diuretic Therapy in Acute Heart FailureNot yet recruitingNCT07558798Not applicable1 country
- The Prognostic Impact of Symptoms and Lesion Depth in Partial Removal of Carious TissueRecruitingNCT058165251 country
- Training Medical Residents in the Use of the Venous Excess UltraSound (VExUS) Score for Bedside Volume Assessment.RecruitingNCT07541768Not applicable1 country
- Evaluation of the Microcirculatory Response to Fluids in Critically Ill Patients With Venous Congestion: A Prospective Observational StudyRecruitingNCT074994011 country
- Renal and Hepatic Abnormal Doppler Patterns in TraumaRecruitingNCT074925111 country
- Venous Congestion And Cognitive Dysfunction After Cardiac SurgeryRecruitingNCT074831511 country
- Relationship Between the Level of Positive End-expiratory Pressure and Venous Congestion During Acute Respiratory Distress Syndrome.Not yet recruitingNCT074529521 country
- Hemodynamic Venous Congestion Ultrasound (VExUS) by ICU Nurses in Sepsis Patients.Not yet recruitingNCT07406750
- Natriuresis-guided Depletion After Cardiac SurgeryRecruitingNCT07077772Not applicable1 country
- Venous Congestion And Delirium After Cardiac SurgeryRecruitingNCT072851871 country
- Breastfeeding Education Through Clinical Demonstration for Primiparous Women to Prevent Sore Nipples and EngorgementNot yet recruitingNCT06770595Not applicable1 country
- Right Ventricular Function Changes After CIED Implantation: The RIGHT-CIED StudyRecruitingNCT072723951 country
- Evaluating Injection With the Use of Brimonidine Tartrate Ophthalmic 0.025% on Patients Using Netarsudil 0.02%/Latanoprost 0.005% to Treat GlaucomaRecruitingNCT07209410Phase 41 country
- Impact of Fluid Resuscitation on Venous Congestion in Cardiac Critically-ill PatientsNot yet recruitingNCT07183397
- Type 1 Diabetes Autonomic and Vascular FunctionEnrolling by invitationNCT067865461 country
- Simple Urine Composition-based Personalized Algorithm for Effective Congestion Relief in Decompensated Heart FailureRecruitingNCT07099885Not applicable1 country
- Evolution of Tissue Perfusion and Venous Congestion Markers in Fluid-Responsive Septic Shock PatientsNot yet recruitingNCT069588091 country
- Hepatic Doppler to Assess Venous Congestion During Invasive Mechanical Ventilation (DOHECOV)RecruitingNCT069143361 country
- Micro-doses of Physical Activity for COPDRecruitingNCT05553223Not applicable1 country
- Therapeutic Strategies to Reduce Endothelial Ischemia-reperfusion InjuryNot yet recruitingNCT06825143Early Phase 11 country
- VExUS in Ards Patients and Association with AKIRecruitingNCT068054091 country
- Fluid Responsiveness and Venous Congestion Evolution During Volume ExpansionRecruitingNCT067720382 countries
- Effect of Olive Leaf Extracts on Endothelial Dysfunction in Patients With Acute Coronary SyndromeNot yet recruitingNCT06723002Phase 2/3
- Venous Ultrasound Guided Organ Decongestion in Patients Hospitalized with Acute Decompensated Heart FailureRecruitingNCT06714409Not applicable1 country
- Venous Excess Ultrasound for Personalized Resuscitation in Septic ShockNot yet recruitingNCT06696391Phase 31 country
- Mechanical Ventilation-induced Acute Kidney Injury [AKI]Not yet recruitingNCT06638255Not applicable1 country
- VExUS Combined With CVP to Predict Clinical Outcomes in Sepsis ParticipantsRecruitingNCT065246221 country
- Renal Autotransplantation; Case SeriesEnrolling by invitationNCT051158121 country
- Effects of Manual Lymph Drainage on Breast Engorgement in Postpartum Period.RecruitingNCT06168630Not applicable1 country
- Correlation of Ultrasonography Indices of Venous Congestion With Intra-abdominal Pressure in ICU Patients.Not yet recruitingNCT06160856
- Venous Congestion and Cardiac Surgery-Associated Acute Kidney InjuryCompletedNCT072322771 country
- Wearable Tissue Oximetry During Arm Cuff Occlusion, Walking, and Standing Tests in Outpatients With Chronic Heart FailureCompletedNCT078743861 country
- Effects of Positive End-Expiratory Pressure (PEEP) and Prone Positioning in Healthy Volunteers on Venous Hemodynamics Including the Venous Excess Ultrasound (VExUS) ScoreCompletedNCT07273617Not applicable1 country
- Prevalence of Pelvic Venous Congestion Syndrome in Female Patients With Lower Extremity Varicose Veins and Its Impact on Postoperative Quality of Life Improvement Following Radiofrequency Ablation: A Single-Center Prospective Cohort Study(PCSRFStudy)Active, not recruitingNCT076804651 country
- Association Between Renal and Right Cardiac Functions After Urinary Sodium Depletion Following Cardiac SurgeryTerminatedNCT036848761 country
- Local Changes of Skin Characteristics After an Application of a Topical Product With a Warming or Cooling EffectCompletedNCT03016221Not applicable1 country