Ocular Hypertension clinical trials
The registry lists 659 studies for Ocular Hypertension across more than 10 countries. 48 are recruiting or about to start. 45 of them are mainly about Ocular Hypertension (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its 6 narrower conditions too, such as Glaucoma: 2,223 studies, 315 open.
ClinicalTrials.gov finds 2,323 studies for Ocular Hypertension. How that becomes 659 here
This page counts the studies the registry files under Ocular Hypertension, and those it files under no condition that list Ocular Hypertensionthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 2,323Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −1,503Filed under a narrower condition, counted on its own pageGlaucoma 1,045 · Glaucoma, Open-Angle 334 · Glaucoma, Angle-Closure 49 · Hydrophthalmos 27 · Glaucoma, Neovascular 25 · Low Tension Glaucoma 22
- −161Match it another way9 name it in the title and 152 by a synonym or other text the search reads.
- 659The count on this page4 of them list Ocular Hypertension in their own words; the registry filed them under no condition.
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A study of drug A after surgery for early breast cancer
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· Enrollment: 300 → 450 participants
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Who runs them
Alcon Research (106) · Allergan (74) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (24) · Aerie Pharmaceuticals (22) · Glaukos Corporation (17) · Santen Pharmaceutical Co., Ltd. (13) · Mati Therapeutics Inc. (12) · Santen Inc. (12)
What is being tested here
Drugs under test in Ocular Hypertension studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Latanoprost | 2 | 15 | 52 |
| Bimatoprost | 2 | 14 | 45 |
| Netarsudil | 2 | 6 | 16 |
| Bimatoprost Ophthalmic Solution | 2 | 1 | 4 |
| Travoprost | 1 | 20 | 57 |
| Eplerenone | 1 | 0 | 1 |
| Ketorolac | 1 | 0 | 1 |
| Drugs, Investigational | 1 | 0 | 1 |
| Brinzolamide | 0 | 14 | 34 |
| Timolol | 0 | 8 | 27 |
Drug classes tested here Beta blockers 40 · Corticosteroids 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Mar 2027[KJ-TFC-005] Phase 3 Study, Evaluate the Efficacy and Safety of TFC-003 in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension · Phase 3 · Kukje Pharma
- Jun 2027Clarifying the Optimal Application of SLT Therapy Trial · Phase 3 · University of Pittsburgh
- Nov 2027Efficacy and Safety of HUC3-637 in Patients With Primary Open Angle Glaucoma or Ocular Hypertension · Phase 3 · Huons Co., Ltd.
- Nov 2027A Study to Evaluate Efficacy and Safety of YSBP Compared to Lumigan in Patients With Glaucoma or Ocular Hypertension · Phase 3 · YS Life Science Co., Ltd.
- Nov 2026Evaluate Efficacy and Safety of PA5108 Ocular Implants in Primary Open Angle Glaucoma or Ocular Hypertension · PolyActiva Pty Ltd
- Dec 2026A Real-World Evidence Study of Goniotomy With the C-REX™ Instrument in Patients With Primary Open Angle Glaucoma · Iantrek, Inc.
- Dec 2026MINIject Global Long-Term Follow-up Study · iSTAR Medical
- Dec 2026Automated Applanation Tonometry - Updated · Duke University
- Dec 2026Effect of Benzalkonium Chloride Preserved and Preservative-free Latanoprost Eye Drops on Conjunctival Goblet Cells · Rigshospitalet, Denmark
- Jan 2027Safety and Efficacy of TimoD Sustained-Release Implant in Participants With Glaucoma or Ocular Hypertension Undergoing Cataract Surgery · EyeD Pharma
Who these studies take
Of the 36 Ocular Hypertension studies recruiting now, 31 (86%) set no upper age limit and 0 (0%) stop at 75 or younger. 1 (3%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 4 (11%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (3%) | 1 (3%) |
| 18 | 29 (81%) | 29 (81%) |
| 30 | 33 (92%) | 33 (92%) |
| 40 | 35 (97%) | 35 (97%) |
| 50 | 36 (100%) | 36 (100%) |
| 65 | 36 (100%) | 36 (100%) |
| 75 | 36 (100%) | 36 (100%) |
| 85 | 35 (97%) | 35 (97%) |
Across all 659 studies, recruiting or not: 7% stop at 75 or younger and 4% at 65; 7% take children; 0% are for women only and 1% for men only; 12% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Ocular Hypertension studies take
Of 57 phase 3 interventional studies under Ocular Hypertension, half reached primary completion within 23 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 11 mo5–14 · 36 studies | 10 mo5–14 · 35 studies | — |
| Phase 3 | 23 mo12–38 · 57 studies | 20 mo12–33 · 54 studies | — |
| Phase 4 | 30 mo14–66 · 31 studies | — | — |
| Interventional, no phase | 31 mo10–55 · 47 studies | — | — |
| Observational | 25 mo9–62 · 27 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Studies
Recruiting first, then most recently updated. Showing 50 of 659. Browse all 659 → or search them.
- Long-term Vascular, Functional and Morphological Changes in Glaucoma and Ocular Hypertensive PatientsEnrolling by invitationNCT068275351 country
- Implementing AI-based Glaucoma Screening Within Federally Qualified Health CentersRecruitingNCT06629649Not applicable1 country
- Automated Applanation Tonometry - UpdatedRecruitingNCT07298356Not applicable1 country
- A Phase 2a Study Comparing the Efficacy, Safety and Tolerability of Pregabalin Eye Drops Comparing With Timolol Eye Drops in Adults With Glaucoma or High Eye Pressure.RecruitingNCT07913074Phase 21 country
- iDose TR Administration in an Office-Based Surgery SettingRecruitingNCT078166921 country
- REGN22530 for Adults With Primary Open Angle Glaucoma or Ocular HypertensionRecruitingNCT07675824Phase 1/21 country
- A Study to Evaluate Efficacy and Safety of YSBP Compared to Lumigan in Patients With Glaucoma or Ocular HypertensionRecruitingNCT07661329Phase 32 countries
- Changes in Intraocular Pressure After Intravitreal InjectionNot yet recruitingNCT07826286
- Phase 2 Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral ImplantRecruitingNCT07075718Phase 21 country
- Eplerenone and IOP in Healthy AdultsNot yet recruitingNCT07795762Phase 11 country
- Know Your Pressures NYCNot yet recruitingNCT05992415Not applicable1 country
- Clarifying the Optimal Application of SLT Therapy TrialRecruitingNCT04967989Phase 32 countries
- Safety and Efficacy of TimoD Sustained-Release Implant in Participants With Glaucoma or Ocular Hypertension Undergoing Cataract SurgeryRecruitingNCT07036510Phase 1/21 country
- Measuring the Effects of Netarsudil, Latanoprost, and Combination Therapy on Episcleral and Retinal Blood Flow in Ocular Hypertension and Glaucoma SuspectsRecruitingNCT04401982Phase 41 country
- [KJ-TFC-005] Phase 3 Study, Evaluate the Efficacy and Safety of TFC-003 in Patients With Primary Open-Angle Glaucoma or Ocular HypertensionRecruitingNCT07662759Phase 31 country
- Evaluation of the Safety, Efficacy, Dose Response of the Bimatoprost Drug Ring System (BIM-DRS) in Pseudophakic Patients Diagnosed With Open Angle Glaucoma or Ocular HypertensionNot yet recruitingNCT07641296Phase 1
- Imaging the Effects of Netarsudil (Rhopressa) on the Trabecular Meshwork in Glaucoma and Ocular HypertensionRecruitingNCT07588152Phase 41 country
- Efficacy and Safety of DNN.31.19.026 for Ocular Hypertension or Primary Open-Angle GlaucomaNot yet recruitingNCT07617532Phase 3
- Direct Selective Laser Trabeculoplasty (DSLT) for Patients With Glaucoma or Ocular Hypertension Previously Treated With SLTNot yet recruitingNCT07589270Not applicable1 country
- Direct vs Standard SLT for Glaucoma: A Noninferiority TrialRecruitingNCT07408154Not applicable1 country
- 24-hour Effect of Rocklatan Compared With Latanoprost in Open Angle Glaucoma and Ocular Hypertension PatientsRecruitingNCT07325240Phase 41 country
- Intraocular Pressure Measured by a Novel Sensing Contact Lens Versus TonometryRecruitingNCT04024293Not applicable1 country
- DSLT for Reducing Medication in GlaucomaRecruitingNCT073908901 country
- Trial to Evaluate the Safety and Efficacy of the Second Generation Travoprost Intracameral ImplantRecruitingNCT07495852Phase 31 country
- Biomarkers of Ocular Surface Damage in the Setting of Topical Ocular Hypotensive Medication UseRecruitingNCT07217678Phase 41 country
- Observational Trial of the Updated Inserter for the Travoprost Intracameral Implant 75mcgRecruitingNCT074009261 country
- Safety and Efficacy of iDose® TR With Cataract Surgery vs. Cataract Surgery AloneRecruitingNCT06848946Phase 41 country
- Efficacy and Safety of HUC3-637 in Patients With Primary Open Angle Glaucoma or Ocular HypertensionRecruitingNCT07335211Phase 31 country
- A Comparative Study of Intraocular Pressure Control Using Selective Laser Trabeculoplasty and Latanoprost as Initial Treatments for Primary Open Angle Glaucoma and Ocular Hypertension in Lagos State University Teaching HospitalRecruitingNCT07310719Not applicable1 country
- Evaluation of the Safety and Efficacy of the Bimatoprost Implant System Used in Combination With the SpyGlass IOL Compared to Timolol Ophthalmic Solution (Rhone)RecruitingNCT07218796Phase 31 country
- Evaluation of the Safety and Efficacy of the Bimatoprost Implant System Used in Combination With the SpyGlass IOL Compared to Timolol Ophthalmic Solution (Rhine)RecruitingNCT07218783Phase 31 country
- GLAUcoma Diagnostic and Imaging Analysis (GLAUDIA) StudyNot yet recruitingNCT07210216
- Optimal Treatment Protocol for Selective Laser Trabeculoplasty - Repeat TrialEnrolling by invitationNCT05159960Not applicable1 country
- Association Between Limbal Function and Tear Proteomics in Chronic Ocular Diseases: Focusing on GlaucomaRecruitingNCT071195801 country
- A Prospective Study on the Efficacy of Direct Selective Laser Trabeculoplasty (DSLT) in Achieving >20% Intraocular Pressure (IOP) Reduction Without Medications at 6 Months in Naive, Untreated Glaucoma PatientsRecruitingNCT070763031 country
- Investigation of Neurovascular Coupling in Glaucoma Patients and Healthy SubjectsRecruitingNCT03870230Not applicable1 country
- Long-term Safety and Efficacy of a Modified Suprachoroidal Silicone Tube (SST) ShuntRecruitingNCT066915551 country
- Inflammatory Biomarkers in Ocular Surface in Primary Open Angle Glaucoma or Ocular Hypertension Under Topical ProstaglandinsRecruitingNCT050396841 country
- A Randomized, Double-blind, Parallel-group, Two-arm, Multiple Dose, Multicenter, Bioequivalence Study With Clinical Endpoint in the Treatment of Subjects With Chronic Open-angle Glaucoma or Ocular Hypertension in Both EyesRecruitingNCT06267274Phase 11 country
- Efficacy of NSAID vs. Steroid-NSAID Combo Post-Selective Laser Trabeculoplasty: Phase 4, Single-Center RCTNot yet recruitingNCT06498440Phase 41 country
- The A D A G I O StudyNot yet recruitingNCT06455683
- CLAD Deconvolved PERG Responses in Glaucoma PatientsRecruitingNCT06388096Not applicable1 country
- A Randomized, Open-label, Active-controlled, Phase 2a Clinical Trial to Evaluate the Efficacy and Safety of TFC-003 in Patients With Primary Open-angle Glaucoma or Ocular HypertensionNot yet recruitingNCT06177678Phase 21 country
- Travoprost Ophthalmic Topical Cream for Open-angle Glaucoma or Ocular HypertensionRecruitingNCT06152861Phase 21 country
- Effect of Benzalkonium Chloride Preserved and Preservative-free Latanoprost Eye Drops on Conjunctival Goblet CellsRecruitingNCT04957329Phase 41 country
- Endoscopic Assisted Anterior Hyaloid Peeling in Boston Type 1 Keratoprosthesis (KPro-HP-Endo)RecruitingNCT04337944Not applicable1 country
- Bioequivalence Study With Clinical Endpoint Comparing Bimatoprost Ophthalmic Solution 0.01% and LUMIGAN® in the Treatment of Chronic Open-Angle Glaucoma or Ocular Hypertension in Both Eyes.RecruitingNCT05401357Phase 31 country
- Use of Nanodropper vs. Standard Eyedropper in Patients With Glaucoma and Ocular HypertensionRecruitingNCT05277870Not applicable1 country
- Next Generation RocklatanCompletedNCT06441643Phase 21 country
- Safety and Efficacy of Ophthalmic Phentolamine Mesylate in GlaucomaCompletedNCT03960866Phase 21 country