Geographic Atrophy clinical trials
The registry lists 188 studies for Geographic Atrophy across more than 10 countries. 52 are recruiting or about to start. 154 of them are mainly about Geographic Atrophy (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Who runs them
Novartis Pharmaceuticals (15) · Apellis Pharmaceuticals, Inc. (9) · Genentech, Inc. (9) · Hoffmann-La Roche (7) · Gyroscope Therapeutics Limited (5) · Alcon Research (5) · Janssen Research & Development, LLC (5) · National Eye Institute (NEI) (5)
What is being tested here
Drugs under test in Geographic Atrophy studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Pegcetacoplan | 1 | 3 | 7 |
| Onzemipgene parvec | 1 | 1 | 4 |
| Vonaprument | 1 | 2 | 3 |
| ONL1204 | 1 | 0 | 2 |
| Cemdisiran | 1 | 1 | 1 |
| Dapagliflozin | 1 | 0 | 1 |
| Pozelimab | 1 | 0 | 1 |
| Lampalizumab | 0 | 3 | 7 |
| Avacincaptad pegol | 0 | 3 | 5 |
| Brolucizumab | 0 | 3 | 5 |
Drug classes tested here Angiogenesis inhibitors 5
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Jun 2027Phase 3, Randomized, Placebo-Controlled Study of Tinlarebant to Explore Safety and Efficacy in Geographic Atrophy · Phase 3 · Belite Bio, Inc
- Jul 2027A Study Investigating the Efficacy and Safety of Intravitreal (IVT) Injections of Vonaprument (Formerly ANX007) in Participants With Dry Age-Related Macular Degeneration (AMD) With Geographic Atrophy (GA) · Phase 3 · Annexon, Inc.
- Dec 2026A Study to Test Different Doses of BI 1584862 in People With a Distinct Form of Age-related Macular Degeneration (AMD) Called Geographic Atrophy · Boehringer Ingelheim
- Feb 2027Adaptive Optics Scanning Light Ophthalmoscopy (AOSLO) and Microperimetry (MP) Sub-study · University of Wisconsin, Madison
- Mar 2027A Non-Interventional Study Observing Short-Term Progression in Geographic Atrophy (GA) · Complement Therapeutics
- Mar 2027Microcurrent Stimulation Therapy for Intermediate to Advanced Nonexudative Age-related Macular Degeneration · i-Lumen Scientific AUS PTY LTD
- Apr 2027Validation of Virtual Reality Tests for the Assessment of Patients With Age-related Macular Degeneration as Clinical Endpoints · Streetlab
- May 2027Post-market Clinical Investigation of the SING IMT System, Model NG SI IMT 3X in Patients With End-stage Age-related Macular Degeneration · VisionCare, Inc.
- Jun 2027A Prospective, Multicenter, Open-Label, Observational Phase 4 Study to Evaluate Real-World Safety, Tolerability, and Treatment Patterns of Pegcetacoplan (Syfovre) in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration · Apellis Pharmaceuticals, Inc.
- Jun 2027Central micrOperimetry and Radial OCT Evaluation in Geographic Atrophy (CORE-GA): a Prospective Pilot Study · University of California, San Francisco
Who these studies take
Of the 40 Geographic Atrophy studies recruiting now, 31 (78%) set no upper age limit and 0 (0%) stop at 75 or younger. 2 (5%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 4 (10%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (5%) | 2 (5%) |
| 18 | 7 (18%) | 7 (18%) |
| 30 | 7 (18%) | 7 (18%) |
| 40 | 7 (18%) | 7 (18%) |
| 50 | 20 (50%) | 20 (50%) |
| 65 | 40 (100%) | 40 (100%) |
| 75 | 40 (100%) | 40 (100%) |
| 85 | 39 (98%) | 39 (98%) |
Across all 188 studies, recruiting or not: 1% stop at 75 or younger and 1% at 65; 3% take children; 0% are for women only and 0% for men only; 9% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Geographic Atrophy studies take
Of 24 phase 2 interventional studies under Geographic Atrophy, half reached primary completion within 36 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 13 mo8–28 · 13 studies | — | — |
| Phase 2 | 36 mo25–54 · 24 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
- Study in Human iPSCs-derived RPE Cells Transplantation for Advanced (Late-stage) AMDOct 19, 2026NCT07418177
Results posted1
Studies
Recruiting first, then most recently updated. Showing 50 of 188. Browse all 188 → or search them.
- A Phase 2 Efficacy and Safety Study of GAL-101, 2% Ophthalmic Solution in Non-foveal Geographic Atrophy Secondary to Non-neovascular AMDRecruitingNCT06659549Phase 28 countries
- A Study to Investigate Efficacy and Safety of FWY003 Compared With Placebo in Participants With Geographic Atrophy Secondary to Age-related Macular DegenerationRecruitingNCT07441642Phase 219 countries
- A Clinical Trial to Evaluate the Efficacy and Safety of Bevemipretide Ophthalmic Topical Solution in Subjects Who Have Dry Age-Related Macular Degeneration (Dry AMD)Not yet recruitingNCT07927010Phase 2/3
- A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic AtrophyRecruitingNCT06541704Phase 311 countries
- Autologous Transplantation of Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium for Geographic Atrophy Associated With Age-Related Macular DegenerationRecruitingNCT04339764Phase 1/21 country
- A Long-term Extension Study of JNJ-81201887 (AAVCAGsCD59) Parent Studies in Participants With Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)RecruitingNCT06635148Phase 2/318 countries
- Phase 1 Study of C.001 in Retinal DegenerationRecruitingNCT07594236Phase 11 country
- A Study to Assess the Efficacy and Safety of RO7965032 in Participants With Geographic Atrophy Secondary to Age-Related Macular DegenerationRecruitingNCT07851259Phase 21 country
- Adaptive Optics Scanning Light Ophthalmoscopy (AOSLO) and Microperimetry (MP) Sub-studyEnrolling by invitationNCT07747662Not applicable1 country
- A Safety and Efficacy Study of a One-time Intravitreal Injection of SAR446597 in Participants With Geographic Atrophy Secondary to Age-related Macular DegenerationRecruitingNCT07215234Phase 1/23 countries
- Study in Human iPSCs-derived RPE Cells Transplantation for Advanced (Late-stage) AMDRecruitingNCT07418177Phase 1/21 country
- A Non-Interventional Study Observing Short-Term Progression in Geographic Atrophy (GA)RecruitingNCT071441372 countries
- An Optimised GA Interventional Trial (Opti-GAIN) to Test if Treatment With CTx001 is Safe and Works for People With Geographic Atrophy (GA)RecruitingNCT07392255Phase 1/22 countries
- A Study to Optimize Subretinal Surgical Delivery and to Evaluate Safety and Activity of Opregen in Participants With Geographic Atrophy Secondary to Age-Related Macular Degeneration (GAlette); Adaptive Optics (AO) Retinal Imaging Substudy in Association With Study GR44251RecruitingNCT05626114Phase 22 countries
- ORACLE: A Long-term Follow-up Study to Evaluate the Safety of GT005 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration Treated in a Gyroscope-sponsored Antecedent StudyEnrolling by invitationNCT05481827Phase 26 countries
- A Phase IIb Randomized, Multicenter Trial of Subretinal CPCB-RPE1 in Advanced Dry AMD (Geographic Atrophy)RecruitingNCT06557460Phase 21 country
- A Phase 1/2 Study of the Safety and Efficacy of BRX011 Oral Administration Once Daily in Subjects With Geographic Atrophy Secondary to Age-Related Macular DegenerationRecruitingNCT07029945Phase 1/22 countries
- A Study in Adults With Geographic AtrophyRecruitingNCT07606365Phase 27 countries
- Study to Evaluate Efficacy and Safety of ONL1204 in Patients With GA Associated With AMDRecruitingNCT06659445Phase 212 countries
- An Open-label Extension Study of the Long-Term Safety of Vonaprument (ANX007) in Participants With Dry Age-Related Macular Degeneration (AMD) With Geographic Atrophy (GA)Not yet recruitingNCT07807969Phase 31 country
- A Study of the Safety and Tolerability of ASP7317 in Senior Adults Who Are Losing Their Clear, Sharp Central Vision Due to Geographic Atrophy Secondary to Dry Age-related Macular DegenerationRecruitingNCT03178149Phase 11 country
- Phase 2 Study of ADX-038 in Participants With Geographic AtrophyRecruitingNCT06990269Phase 212 countries
- SGLT2 Inhibitors in Geographic AtrophyRecruitingNCT07174687Phase 21 country
- Microcurrent Stimulation Therapy for Intermediate to Advanced Nonexudative Age-related Macular DegenerationRecruitingNCT06662162Not applicable4 countries
- A Study to Evaluate KRIYA-825 (VV-14295) in Adults With Geographic Atrophy Secondary to Age-related Macular DegenerationRecruitingNCT06765980Phase 1/24 countries
- Intravitreal (IVT) Pozelimab for Geographic Atrophy (GA) in Adult ParticipantsRecruitingNCT07230834Phase 14 countries
- Safety and Efficacy Study of Novel Gene Therapy AGX-08 for Geographic AtrophyNot yet recruitingNCT07602127Early Phase 1
- Safety and Clinical Applicability of Transcorneal Electrical Stimulation (TES) in Geographic AtrophyRecruitingNCT07531927Not applicable1 country
- An Open-label Safety, Tolerability and Exploratory Efficacy Clinical Trial of PST-611 in Geographic AtrophyNot yet recruitingNCT07705568Phase 21 country
- Study to Assess the Adverse Events and How Intravitreal ABBV-6628 Moves Through the Body of Adult Participants With Geographic Atrophy Secondary to Age-Related Macular DegenerationRecruitingNCT07160179Phase 1/21 country
- Stem Cell Ophthalmology Treatment Study IIRecruitingNCT03011541Not applicable3 countries
- A Study to Evaluate the Safety and Effect of TO-O-1007 Intravitreal Implant in Subjects With Geographic AtrophyRecruitingNCT07668804Phase 1/21 country
- A Phase 2, Randomized, Placebo Controlled, Multicenter, Masked Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacodynamics of Multidose APL 3007 in Combination With Syfovre/Pegcetacoplan (APL-2) in Patients Diagnosed With Geographic Atrophy Secondary to Age Related Macular DegeneratioRecruitingNCT07215390Phase 21 country
- Lesion-tailored, Fundus-controlled Perimetry in Geographic Atrophy (GA).RecruitingNCT075820421 country
- Pterygopalatine Ganglion Stimulation for the Treatment of Geographic AtrophyNot yet recruitingNCT07570355Not applicable1 country
- High Resolution Retinal ImagingRecruitingNCT018663711 country
- Central micrOperimetry and Radial OCT Evaluation in Geographic Atrophy (CORE-GA): a Prospective Pilot StudyRecruitingNCT075564061 country
- Real-time Acoustic Biofeedback for Enhancing Fixation Stability: A Proof-of-concept Study to Improve Ophthalmic Imaging Diagnostic QualityEnrolling by invitationNCT07529041Not applicable1 country
- Progression of Early Atrophic LesionsRecruitingNCT059590051 country
- Validation of Virtual Reality Tests for the Assessment of Patients With Age-related Macular Degeneration as Clinical EndpointsNot yet recruitingNCT07433088Not applicable
- A Phase 1/2 Study to Evaluate the Safety and Efficacy of Intravitreal Administration of BS01 in Patients With Geographic Atrophy Secondary to Dry AMDRecruitingNCT07158775Phase 1/21 country
- Wide Field OCTA in Ocular DiseasesNot yet recruitingNCT07298174
- Microperimetry Changes in Retinal Function in Macular DisordersEnrolling by invitationNCT071706831 country
- Retinal Photoreceptor Outer Segment Length Before and After Light Stimulation - a Pilot StudyRecruitingNCT03921931Not applicable1 country
- Personalized Monitoring of Non-foveal, Non-vision Compromising Atrophic Age-related Macular Degeneration With Artificial Intelligence and Identification of Disease ProgressionRecruitingNCT063516576 countries
- A Prospective Observational Study to Assess the Reliability and Validity of the MLSDTRecruitingNCT068054741 country
- Subthreshold Laser Treatment for Reticular Pseudodrusen Secondary to Age-related Macular DegenerationRecruitingNCT04847635Not applicable1 country
- Multicenter Clinical Study of the SING-IMT in Patients with Late-stage AMDRecruitingNCT05438732Not applicable1 country
- Safety & Efficacy of Eyecyte-RPE™ in Patients With Geographic Atrophy Secondary to Dry Age-related Macular Degeneration.RecruitingNCT06394232Phase 1/21 country
- Project AMD: Comprehensive Characterisation of Age-Related Macular Degeneration and Its ProgressionRecruitingNCT047393191 country