DrugBiological
Antilymphocyte Serum clinical trials
Also written ATGAM and Equine Anti-Thymocyte Globulin.
A group of medicines. Thymoglobulin (116 studies) is counted on its own page; this page counts the studies that name Antilymphocyte Serum itself.
How each study uses Antilymphocyte Serum is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
Get an email when these change. Save the Antilymphocyte Serum studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Approvals
The first approval found in each region, with its record
- United States
- 4 Dec 1996 · Atgam · BLA 103676 (FDA, Purple Book)
- European Union
- Not in EMA's list of EU-wide authorisations
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Medicines filed under Antilymphocyte Serum
As reviewed, so not every one. Each counts its studies on its own page, not here.
Studies by the year they started
157 studies that test it; most in 2005 (11); 1 more planned to start later
| Year | Studies |
|---|---|
| 1992 | 1 |
| 1995 | 2 |
| 1997 | 3 |
| 1998 | 4 |
| 1999 | 2 |
| 2000 | 8 |
| 2001 | 2 |
| 2002 | 10 |
| 2003 | 5 |
| 2004 | 5 |
| 2005 | 11 |
| 2006 | 8 |
| 2007 | 11 |
| 2008 | 8 |
| 2009 | 8 |
| 2010 | 5 |
| 2011 | 7 |
| 2012 | 6 |
| 2013 | 6 |
| 2014 | 1 |
| 2015 | 4 |
| 2016 | 4 |
| 2017 | 7 |
| 2018 | 8 |
| 2019 | 2 |
| 2020 | 1 |
| 2021 | 1 |
| 2022 | 2 |
| 2023 | 4 |
| 2024 | 2 |
| 2025 | 5 |
| 2026 | 4 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 3 · Other 156
Masonic Cancer Center, University of Minnesota (11) · Fred Hutchinson Cancer Center (9) · Stanford University (8) · National Heart, Lung, and Blood Institute (NHLBI) (6) · National Institute of Allergy and Infectious Diseases (NIAID) (6) · M.D. Anderson Cancer Center (5) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (4) · Memorial Sloan Kettering Cancer Center (4)
Often tested with
Tested in the same studies.
Fludarabine (54) · Cyclophosphamide (49) · Busulfan (36) · Mycophenolic Acid (25) · Tacrolimus (24) · Cyclosporine (24) · Fludarabine phosphate (22) · Melphalan (18)
Related medicines
As reviewed, each with the page that says it.
- One of Immunologic Factors source
- One of Immunosuppressive Agents source
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Tested against it · 2 phase 3 studies under way
Antilymphocyte Serum is the comparator. A study of two new drugs counts under both.
- 2Cyclophosphamide · DKMS gemeinnützige GmbH, Hospital Israelita Albert Einstein
Reaching primary completion within a year · 6, 1 in phase 3
Studies that test Antilymphocyte Serum, phase 3 first.
- Nov 2026Randomized Autologous heMatopoietic Stem Cell Transplantation Versus Alemtuzumab, Cladribine or Ocrelizumab for RRMS (RAM-MS)Phase 3 · Haukeland University Hospital
- Dec 2026Population PK-guided ATG Dosing in Haplo-HSCTPhase 2 · Chinese PLA General Hospital
- May 2027T Cell Depleted Allogeneic Hematopoietic Stem Cell Transplantation Conditioned With a Reduced Intensity Regimen in Patients With Hematologic Malignancies and Aplastic AnemiaPhase 1 · Memorial Sloan Kettering Cancer Center
- Jun 2027A Reduced-Intensity Conditioning Regimen (Cyclophosphamide, Pentostatin, Anti-thymocyte Globulin) Followed by Haploidentical Hematopoietic Stem Cell Transplant for the Treatment of Patients With Refractory or Recurrent Severe Aplastic AnemiaPhase 1 · City of Hope Medical Center
- Aug 2027Allogeneic Hematopoietic Stem Cell Transplantation for 4/M NeuroblastomaPhase 2 · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Sep 2027Stem Cell Transplantation in Crohn's DiseasePhase 1/2 · Cedars-Sinai Medical Center
Studies
Open first, then newest update. How each study uses Antilymphocyte Serum is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 159
- Conditioning Regimen Containing Low-Dose ATG for the Treatment of AA Receiving sUCBTNot yet recruitingPhase 2Anhui Provincial HospitalNCT07885982Written as Anti-Thymocyte Globulin (Rabbit) (Thymoglobulin®)
- Allogeneic Hematopoietic Stem Cell Transplant for GATA2 MutationsRecruitingPhase 2National Cancer Institute (NCI)NCT01861106Written as Equine Anti-Thymocyte Globulin
- Population PK-guided ATG Dosing for Haploidentical Hematopoietic Stem Cell TransplantationRecruitingPhase 3Daihong LiuNCT07862127Written as Anti-Thymocyte Globulin (ATG)
- Platform Trial to Delay Stage 3 Diabetes: Comparing Teplizumab With ATGRecruitingPhase 2National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NCT07216391Written as Antithymocyte Globulin (ATG)
- Population PK-guided ATG Dosing in Haplo-HSCTRecruitingPhase 2Chinese PLA General HospitalNCT07791576Written as Anti Thymocyte Globulin
- A Study of VABu Conditioning Regimen in Allo-HSCT for AML PatientsNot yet recruitingNot applicableThe First Affiliated Hospital of Soochow UniversityNCT07762508Written as Antithymocyte Globulin (ATG)
- Autologous Stem Cell Transplantation in Patients With Systemic SclerosisRecruitingPhase 2Paul SzabolcsNCT03630211Written as Anti Thymocyte Globulin
- Study of HLA-Haploidentical Stem Cell Transplantation to Treat Clinically Aggressive Sickle Cell DiseaseRecruitingPhase 2University of Illinois at ChicagoNCT03121001Written as ATG
- Methylprednisolone, Horse Anti-Thymocyte Globulin, Cyclosporine, Filgrastim, and/or Pegfilgrastim or Pegfilgrastim Biosimilar in Treating Patients With Aplastic Anemia or Low or Intermediate-Risk Myelodysplastic SyndromeRecruitingPhase 2M.D. Anderson Cancer CenterNCT01624805Written as Anti-Thymocyte Globulin
- Individualized Application of Anti-Thymocyte Globulin(ATG)in Unrelated Donor Hematopoietic Stem Cell TransplantationRecruitingPhase 4Daihong LiuNCT07648992Written as Anti-Thymocyte Globulin
- Haplo-Cord HSCT for AML/MDSRecruitingNot applicableFujian Medical University Union HospitalNCT07588360Written as Fludarabine, Cytarabine, Busulfan, Antithymocyte Globulin (ATG), Melphalan, Cyclophosphamide (CTX)
- Low-Dose ATG/PTCy Plus Ivarmacitinib for aGVHD Prevention in Haplo-PBSCT From Parous Female DonorsRecruitingPhase 2Shanghai General Hospital, Shanghai Jiao Tong University School of MedicineNCT07570745Written as Low-dose ATG + PTCy + Ivarmacitinib
- Stem Cell Transplantation in Crohn's DiseaseRecruitingPhase 1/2Cedars-Sinai Medical CenterNCT04224558Written as lymphocyte immune globulin
- A Reduced-Intensity Conditioning Regimen (Cyclophosphamide, Pentostatin, Anti-thymocyte Globulin) Followed by Haploidentical Hematopoietic Stem Cell Transplant for the Treatment of Patients With Refractory or Recurrent Severe Aplastic AnemiaRecruitingPhase 1City of Hope Medical CenterNCT05757310Written as Anti-Thymocyte Globulin
- Precision Administration of Anti-thymocyte Globulin With or Without VerapamilRecruitingPhase 2University of FloridaNCT06455319Written as Anti-thymocyte globulin (ATG)
- Phase 1b/2a Trial of Allogeneic HSCT From an HLA-partially Matched Related or Unrelated Donor After TCRab+ T-cell/CD19+ B-cell Depletion for Patients With Monogenic and/or Early-onset Medically Refractory Crohn DiseaseNot yet recruitingPhase 1/2Stanford UniversityNCT06986382Written as ATG
- Allogeneic Hematopoietic Stem Cell Transplantation for 4/M NeuroblastomaNot yet recruitingPhase 2Sun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityNCT05303727Written as Anti Thymocyte Globulin
- Decitabine Plus mBU/CY for High Risk Acute Leukemia With MRD Pre-HSCTRecruitingPhase 2/3Peking University People's HospitalNCT03793517Written as mBU/CY and ATG
- A Randomized, Controlled Clinical Study on the Efficacy and Safety of Umbilical Cord Mesenchymal Stem Cells Combined With Standard Immunosuppressants in the Treatment of Children With Severe Aplastic AnemiaCompletedPhase 2Institute of Hematology & Blood Diseases Hospital, ChinaNCT07903649Written as ATG/ALG
- A Trial Comparing Unrelated Donor BMT With IST for Pediatric and Young Adult Patients With Severe Aplastic Anemia (TransIT, BMT CTN 2202)TerminatedPhase 3Boston Children's HospitalNCT05600426Written as horse anti-thymocyte globulin (ATG)
See all 159 studies that test Antilymphocyte Serum →
Given beside what is tested · 84 — Antilymphocyte Serum is usual care or a partner of the new treatment
- Lanoracopan to Prevent Acute GVHD Following Haploidentical Peripheral Blood Stem Cell Transplantation: A Prospective Multicenter Single-Arm Exploratory StudyNot yet recruitingPhase 2The First Affiliated Hospital of Soochow UniversityNCT07926698Written as Anti-thymocyte globulin (ATG)
- Personalized NK Cell Therapy in CBTRecruitingPhase 2M.D. Anderson Cancer CenterNCT02727803Written as Anti-Thymocyte Globulin
- Advancing Transplantation Outcomes in ChildrenRecruitingPhase 2National Institute of Allergy and Infectious Diseases (NIAID)NCT06055608Written as Anti-Thymocyte Globulin (ATG)
- Sirolimus+Ruxolitinib+Mycophenolate Mofetil for Prophylaxis of aGVHD in Patients Receiving Haplo-HSCT Who Are Intolerant to CNINot yet recruitingPhase 1/2Peking University People's HospitalNCT07796620Written as ATG
- Study Comparing the Efficacy of 2 RIC Regimens (Clofarabine vs Fludarabine) in Adults With AML Eligible to Allo-SCTRecruitingPhase 2Nantes University HospitalNCT05917405Written as ATG
- Study Testing Two Conditioning Regimen With a Single Prophylaxis of GVHD by Cyclophosphamide and Methotrexate Post-transplant in Patients Eligible for Matched-donor Allograft TransplantationRecruitingPhase 2Nantes University HospitalNCT06252870Written as Anti-Thymoglobulin
- Autologous Stem Cell Transplantation for Crohn's DiseaseRecruitingPhase 1/2Paul SzabolcsNCT00692939Written as ATG
- Prophylaxis of Graft-versus-host Disease With Anti-CD25 Antibody in Patients Underwent HSCTNot yet recruitingPhase 2Wang XinNCT06334367Written as low-dose ATG
- Sirolimus+Abatacept+Mycophenolate Mofetil for Prophylaxis of aGVHD in Patients Receiving Haplo-HSCT Who Are Intolerant to Calcineurin InhibitorsNot yet recruitingPhase 1/2Peking University People's HospitalNCT06279494Written as ATG
- Early Trial of Allogeneic Hematopoietic Stem Cell Transplantation for Patients Who Will Receive a Kidney Transplant From the Same DonorRecruitingPhase 1/2Alice BertainaNCT05508009Written as ATG
- Outcomes of Patients After Allo-HSCT With Decitabine and NACNot yet recruitingPhase 3The First Affiliated Hospital of Soochow UniversityNCT04945096Written as Anti-thymocyte globulin
- Giving Chemotherapy for a Shortened Amount of Time Before a Stem Cell TransplantationActive, not recruitingPhase 1Memorial Sloan Kettering Cancer CenterNCT04098393Written as Antithymocyte globulin (ATG)
- Study of Intensity Modulated Total Marrow Irradiation (IM-TMI) in Addition to Fludarabine/Busulfan Conditioning for Allogeneic Transplantation in High Risk AML and Myelodysplastic SyndromesActive, not recruitingPhase 2University of Illinois at ChicagoNCT03121014Written as ATG
- Treg Modulation With CD28 and IL-6 Receptor AntagonistsCompletedPhase 1/2National Institute of Allergy and Infectious Diseases (NIAID)NCT04066114Written as antithymocyte globulin (rabbit)
- BIVV020 (SAR445088) in Prevention and Treatment of Antibody-mediated Rejection (AMR)Active, not recruitingPhase 2SanofiNCT05156710Written as Antithymocyte globulin (ATG)
- Cytokine-Treated Veto Cells in Treating Patients With Hematologic Malignancies Following Stem Cell TransplantActive, not recruitingPhase 1/2M.D. Anderson Cancer CenterNCT03622788Written as Anti-Thymocyte Globulin
- hATG+CsA vs hATG+CsA+Eltrombopag for SAACompletedPhase 3European Society for Blood and Marrow TransplantationNCT02099747Written as hATG
- UCB Transplant for Hematological Diseases Using a Non Myeloablative PrepCompletedPhase 2Masonic Cancer Center, University of MinnesotaNCT02722668Written as ATG
- ATG Plus Low-dose PT-Cy for GVHD PreventionTerminatedPhase 3Peking University People's HospitalNCT06108739Written as ATG
- Hematopoietic Stem Cell Transplant for Dyskeratosis Congenita or Severe Aplastic AnemiaCompletedNot applicableMasonic Cancer Center, University of MinnesotaNCT02162420Written as Anti-thymocyte globulin
Showing 20 of 84.
As the comparator · 13 — what is tested is compared with Antilymphocyte Serum
- GVHD Prophylaxis by Addition of CD20 Monoclonal Antibody to the Conditioning Regimen in SAA With Treatment of Allo-HSCTRecruitingPhase 2The First Affiliated Hospital of Soochow UniversityNCT05510505Written as ATG
- Post Transplant Cyclophosphamide in Matched Unrelated Donor Stem Cell Transplantation for Hematological MalignanciesRecruitingPhase 2/3Hospital Israelita Albert EinsteinNCT03818334Written as ATG
- GvHD Prophylaxis in Unrelated Donor HCT: Randomized Trial Comparing PTCY Versus ATGActive, not recruitingPhase 3DKMS gemeinnützige GmbHNCT05153226Written as ATG
- A Study of TCD601 in de Novo Renal Transplant RecipientsCompletedPhase 2ITB-Med LLCNCT05669001Written as ATG
- A Dose Escalation Study of TCD601 Compared to ATG in de Novo Renal TransplantationTerminatedPhase 2ITB-Med LLCNCT06365437Written as ATG
- Targeted Dose Study of ATG in Haploidentical Hematopoietic Stem Cell TransplantationCompletedPhase 3Chinese PLA General HospitalNCT05166967Written as Antithymocyte globulin
- A Dose Escalation Study in de Novo Renal TransplantationCompletedPhase 2ITB-Med LLCNCT04311632Written as ATG
- M-PTCy vs BuCy in Haploidentical HSCT for Acute LeukemiaStatus unknownPhase 2/3The First Affiliated Hospital of Soochow UniversityNCT05739630Written as ATG
- Clinical Study of rATG Individualized Administration in Haploidentical Hematopoietic Stem Cell TransplantationStatus unknownPhase 4The First Affiliated Hospital of Soochow UniversityNCT05634915Written as ATG
- Cyclophosphamide Versus Anti-thymocyte Globulin for GVHD Prophylaxis After RIC Allo-SCTCompletedPhase 2Assistance Publique - Hôpitaux de ParisNCT02876679Written as Anti-Thymocyte Globulin
- Observational Study to Evaluate the Safety and Efficacy of Polyclonal Antibodies in Simultaneous Pancreas Kidney Transplant RecipientsStatus unknownPhase 4Tianjin First Central HospitalNCT03470961Written as Anti-Thymocyte Globulins
- Visilizumab for the Prevention of Graft-versus-Host Disease After Allogeneic Hematopoietic Cell TransplantationTerminatedPhase 2H. Lee Moffitt Cancer Center and Research InstituteNCT00720629Written as Antithymocyte globulin (ATG)
- Evaluating Safety and Efficacy of TOL101 Induction Versus Anti-Thymocyte Globulin to Prevent Kidney Transplant RejectionStatus unknownPhase 1/2Tolera Therapeutics, IncNCT01154387Written as Anti-Thymocyte Globulin
What changed recently
From the registry's own updates since Oct 16, 2026.
Stopped1
Newly registered2
- A Randomized, Controlled Clinical Study on the Efficacy and Safety of Umbilical Cord Mesenchymal Stem Cells Combined With Standard Immunosuppressants in the Treatment of Children With Severe Aplastic AnemiaOct 29, 2026NCT07903649
- Conditioning Regimen Containing Low-Dose ATG for the Treatment of AA Receiving sUCBTOct 21, 2026NCT07885982
Codes
What other systems call Antilymphocyte Serum · ClinicalTrials.gg INT007004
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D000961 | Antilymphocyte Serum | One source ClinicalTrials.gov |
| RxNorm | 973 | — | One source FDA |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.