Leukemia, Myelogenous, Chronic, BCR-ABL Positive clinical trials
The registry lists 894 studies for Leukemia, Myelogenous, Chronic, BCR-ABL Positive across more than 10 countries. 109 are recruiting or about to start. 516 of them are mainly about Leukemia, Myelogenous, Chronic, BCR-ABL Positive (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-13. Counting its 3 narrower conditions too, such as Leukemia, Myeloid, Chronic-Phase: 1,316 studies, 129 open.
ClinicalTrials.gov finds 1,303 studies for Leukemia, Myelogenous, Chronic, BCR-ABL Positive. How that becomes 894 here
This page counts the studies the registry files under Leukemia, Myelogenous, Chronic, BCR-ABL Positive, and those it files under no condition that list Leukemia, Myelogenous, Chronic, BCR-ABL Positivethemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 1,303Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −418Filed under a narrower condition, counted on its own pageLeukemia, Myeloid, Chronic-Phase 314 · Blast Crisis 96 · Leukemia, Myeloid, Accelerated Phase 8
- −1List Leukemia, Myelogenous, Chronic, BCR-ABL Positive as a condition, but the registry did not file them under itMost often written as “Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative” (1) and “Childhood Chronic Myelogenous Leukemia, BCR-ABL1 Positive” (1). The registry filed them under other conditions only, most often Leukemia, Biphenotypic, Acute (1) and Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative (1).
- −6Match it another way3 name it in the title and 3 by a synonym or other text the search reads.
- 878Counted here and found by its search
- +16
Counted here, but its search does not find them
- Efficacy and Safety of Dose Redution of Radotinib as a First Line Treament in Ph+ CMLNCT06665412
- Real-world Effectiveness of Asciminib and Treatment Patterns in Patients With Chronic Myeloid Leukemia With T315I Mutation - a Chart Review Study of Patients Treated in the Asciminib Managed Access Program (MAP)NCT06211153
- ENDURE - Efficacy and Safety of AOP2014 With CML Patients in RemissionNCT03117816
- Combination of Dasatinib and Peg-Interferon Alpha 2b in First Line for Chronic Myeloid Leukemia in Chronic PhaseNCT01872442
- De-escalation Strategy of Tyrosine Kinase Inhibitors Before Treatment Discontinuation in Patients With Chronic Myeloid LeukemiaNCT07839988
- Metabolic Syndrome and Risk of Chronic Philadelphia Negative Myeloproliferative NeoplasmsNCT07814560
- Asciminib & Standard-of-Care Integration in Maintenance Therapy for POST Allogeneic Stem Cell Transplant (Allo-HSCT) of Patient With Ph+ B-ALL or Blastic Transformed CMLNCT07493408
- Chronic Kidney Disease Patient in Chronic Myloied LeukemiaNCT06266975
- A Phase I Study of Decitabine, Lisaftoclax, and Olverembatinib in Patients With Advanced Chronic Myeloid Leukemia and Philadelphia Chromosome-Positive Acute Myeloid LeukemiaNCT06401603
- Real-world Study of Scemblix in the Treatment of Chronic Myeloid Leukemia in ChinaNCT07375355
- RWE,NIS,Prospective Study for the Effectiveness, Tolerability and Adherence of Asciminib in Saudi Arabia. (ASC4REAL)NCT06684964
- European CML Blast Crisis RegisterNCT03869502
- ABL001 for the Treatment of Chronic Myeloid Leukemia in Patients Who Are on Therapy With Tyrosine Kinase InhibitorNCT04216563
- Efficacy and Safety of LBH589 in Adult Patients With Refractory Chronic Myeloid Leukemia (CML) in Chronic PhaseNCT00451035
- The Efficacy and Safety of Switching to Flumatinib Versus Dasatinib After Imatinib-related Low-grade Adverse Events in CML-CP PatientsNCT04933526
- Myeloid Derived Suppressor Cells and Chronic Myeloid LeukemiaNCT03214718
- 894The count on this page
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· Enrollment: 300 → 450 participants
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Who runs them
Novartis Pharmaceuticals (86) · M.D. Anderson Cancer Center (75) · Fred Hutchinson Cancer Center (30) · National Cancer Institute (NCI) (27) · Bristol-Myers Squibb (23) · National Heart, Lung, and Blood Institute (NHLBI) (23) · Masonic Cancer Center, University of Minnesota (22) · Gruppo Italiano Malattie EMatologiche dell'Adulto (21)
What is being tested here
Drugs under test in Leukemia, Myelogenous, Chronic, BCR-ABL Positive studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Asciminib | 8 | 5 | 20 |
| Fludarabine | 5 | 3 | 58 |
| Cyclophosphamide | 5 | 4 | 55 |
| Dasatinib | 4 | 4 | 44 |
| Meribatinib | 3 | 1 | 6 |
| Relcobatinib | 3 | 1 | 3 |
| Embibatinib | 3 | 1 | 3 |
| Nilotinib | 2 | 16 | 66 |
| Fludarabine phosphate | 2 | 0 | 25 |
| Ponatinib | 2 | 2 | 17 |
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 26 open · Alkylating agents 7 open · Antimetabolites 6 open · Calcineurin inhibitors 2 open · JAK inhibitors 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Jun 2027Study of Olverembatinib (HQP1351) in Patients With CML-CP · Phase 3 · Ascentage Pharma Group Inc.
- Jun 2027A Phase 3 Study for the Efficacy and Safety of Radotinib in CP-CML Patients With Failure or Intolerance to Previous TKIs · Phase 3 · Il-Yang Pharm. Co., Ltd.
- Nov 2026A Study of MGD024 in Patients With Relapsed or Refractory Hematologic Malignancies · MacroGenics
- Nov 2026Safety and Tolerability of ZE74-0282 in Healthy Volunteers · Eilean Therapeutics AU Pty Ltd
- Nov 2026Chronic Kidney Disease Patient in Chronic Myloied Leukemia · Sahar Mohammed Gad
- Nov 2026Muscle Dysfunction in Patients With Hematological Diseases Referred to Stem Cell Transplant · Rigshospitalet, Denmark
- Nov 2026ABL001 + Dasatinib + Prednisone + Blinatumomab in BCR-ABL+ B-ALL or CML · Marlise Luskin, MD
- Dec 2026A Potential Relationship Between Treatment With Tyrosine Kinase Inhibitors and Erectile Dysfunction in Male Patients With Chronic Myeloid Leukemia · Azienda USL Reggio Emilia - IRCCS
- Dec 2026The Prospective Collection, Storage and Reporting of Data on Patients Undergoing Hematopoietic Stem Cell Transplantation Utilizing a Standard Preparative Regimen · Wake Forest University Health Sciences
- Dec 2026Pharmacokinetic Study of Venetoclax Tablets Crushed and Dissolved Into a Solution · Children's Hospital Medical Center, Cincinnati
Who these studies take
Of the 79 Leukemia, Myelogenous, Chronic, BCR-ABL Positive studies recruiting now, 48 (61%) set no upper age limit and 20 (25%) stop at 75 or younger. 20 (25%) take children under 18. 0 (0%) are for women only and 1 (1%) for men only; 7 (9%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 17 (22%) | 17 (22%) |
| 18 | 75 (95%) | 76 (96%) |
| 30 | 73 (92%) | 74 (94%) |
| 40 | 72 (91%) | 73 (92%) |
| 50 | 72 (91%) | 73 (92%) |
| 65 | 70 (89%) | 71 (90%) |
| 75 | 63 (80%) | 64 (81%) |
| 85 | 56 (71%) | 56 (71%) |
Across all 894 studies, recruiting or not: 35% stop at 75 or younger and 20% at 65; 29% take children; <1% are for women only and 1% for men only; 5% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Leukemia, Myelogenous, Chronic, BCR-ABL Positive studies take
Of 126 phase 2 interventional studies under Leukemia, Myelogenous, Chronic, BCR-ABL Positive, half reached primary completion within 73 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 58 mo41–95 · 56 studies | — | — |
| Phase 1/2 | 69 mo56–94 · 26 studies | — | — |
| Phase 2 | 73 mo43–124 · 126 studies | 44 mo33–69 · 25 studies | 75 mo50–130 · 101 studies |
| Phase 3 | 38 mo30–79 · 24 studies | — | — |
| Interventional, no phase | 41 mo22–123 · 25 studies | — | — |
| Observational | 53 mo39–103 · 67 studies | — | 58 mo46–142 · 45 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 15, 2026.
Started recruiting3
- Allogeneic iNKT Cell Therapy (agenT-797) After SCTNov 12, 2026NCT07758218
- Efficacy of Asciminib in Chronic Phase CML Patients With T315I MutationsNov 10, 2026NCT07789574
- Prophylactic DLI-X for Leukemia Relapse After HCTOct 29, 2026NCT07254793
Results posted1
Newly registered3
- Maintenance Treatment With Imetelstat in Patients With High-Risk Myeloid Neoplasms After Allo-SCTNov 2, 2026NCT07909733
- A Randomized Study of ELVN-001 Versus Investigator-Selected TKI, in CP-CML Previously Treated With One or More TKIsOct 29, 2026NCT07905183
- A Study of HS-10382 Versus Investigator-selected TKIs in Adult Patients With Newly Diagnosed Ph+ CML-CPOct 21, 2026NCT07885293
Studies
Recruiting first, then most recently updated. Showing 50 of 894. Browse all 894 → or search them.
- Allogeneic iNKT Cell Therapy (agenT-797) After SCTRecruitingNCT07758218Phase 11 country
- Cladribine, Idarubicin, Cytarabine, and Venetoclax in Treating Patients With Acute Myeloid Leukemia, High-Risk Myelodysplastic Syndrome, or Blastic Phase Chronic Myeloid LeukemiaRecruitingNCT02115295Phase 21 country
- A Study of Patient Characteristics, Co-Morbidities, and Treatment Patterns in Chronic Myeloid Leukemia Patients in KuwaitNot yet recruitingNCT07454850
- Efficacy of Asciminib in Chronic Phase CML Patients With T315I MutationsRecruitingNCT07789574Phase 21 country
- A Study of Asciminib Safety and Efficacy in Young Adults With Chronic Myeloid Leukemia in the Gulf RegionNot yet recruitingNCT07681258
- Study to Determine the Efficacy and Safety of Asciminib in Pediatric Patients With Ph+ CML-CPRecruitingNCT07354074Phase 217 countries
- A Study on the Tolerability, Safety and Effectiveness of Asciminib in Patients With Philadelphia Chromosome-positive Chronic Myeloid Leukemia in the Chronic Phase in GermanyRecruitingNCT075495161 country
- Asciminib Roll-over StudyRecruitingNCT04877522Phase 429 countries
- HPC Offered for PRESERVE ExpansionRecruitingNCT071454111 country
- Vididencel in CML-CP Patients With MRDRecruitingNCT07651878Phase 11 country
- Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer DetectionRecruitingNCT053340691 country
- Maintenance Treatment With Imetelstat in Patients With High-Risk Myeloid Neoplasms After Allo-SCTNot yet recruitingNCT07909733Phase 11 country
- Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic MalignanciesRecruitingNCT06904066Phase 11 country
- Phase II Study Assessing Efficacy and Safety of Asciminib in Patients With Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase.RecruitingNCT06236724Phase 21 country
- Pharmacokinetic Study of Venetoclax Tablets Crushed and Dissolved Into a SolutionRecruitingNCT061318011 country
- Prophylactic DLI-X for Leukemia Relapse After HCTRecruitingNCT07254793Phase 11 country
- Cancer Experience Registry (CER) for Cancer Patients and CaregiversRecruitingNCT023336041 country
- A Randomized Study of ELVN-001 Versus Investigator-Selected TKI, in CP-CML Previously Treated With One or More TKIsNot yet recruitingNCT07905183Phase 3
- Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With High-Risk Hematologic DiseasesRecruitingNCT06013423Phase 21 country
- CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell TransplantRecruitingNCT06059391Phase 21 country
- A Study of HS-10382 Versus Investigator-selected TKIs in Adult Patients With Newly Diagnosed Ph+ CML-CPNot yet recruitingNCT07885293Phase 31 country
- TGRX-678 US Phase I for Chronic Myelogenous Leukemia PatientsRecruitingNCT06088888Phase 11 country
- A Clinical Study of MK-4208/TERN-701 in Participants With Chronic Myeloid Leukemia (CML) (MK-4208-003/Tern701-1012/CARDINAL)RecruitingNCT06163430Phase 1/29 countries
- Phase II Study Assessing the Safety and Efficacy of Dasatinib in Combination With Ropeginterferon in Patients With Newly Diagnosed Chronic Myeloid Leukemia in Chronic PhaseRecruitingNCT07269470Phase 21 country
- Interest of PHARMaceutical Conciliation to Understand Drug Interactions, Phytotherapy, and Targeted Therapies in Chronic Myeloid LeukemiaRecruitingNCT05130138Not applicable1 country
- Chart Review Study of Chronic Myelogenous Leukemia (CML) Patients Treated With Imatinib Outside of a Clinical TrialRecruitingNCT008161141 country
- Darzalex Faspro (Daratumumab and Hyaluronidase-fihj) Before Standard Desensitization and Allogeneic Bone Marrow or Peripheral Blood Stem Cell Transplantation in Adult Patients at High-risk for Primary Graft Failure Secondary to Donor Specific AntibodiesRecruitingNCT06398457Early Phase 11 country
- Phase II Study Assessing the Efficacy and Toxicity of Olverembatinib Monotherapy in Patients With Chronic Myeloid Leukemia in Chronic Phase After Failing One Prior Therapy With a Second Generation Tyrosine Kinase Inhibitor or AsciminibRecruitingNCT06817720Phase 21 country
- A Phase I Study of Decitabine, Lisaftoclax, and Olverembatinib in Patients With Advanced Chronic Myeloid Leukemia and Philadelphia Chromosome-Positive Acute Myeloid LeukemiaRecruitingNCT06401603Phase 11 country
- De-escalation Strategy of Tyrosine Kinase Inhibitors Before Treatment Discontinuation in Patients With Chronic Myeloid LeukemiaNot yet recruitingNCT07839988Phase 41 country
- Edetate Calcium Disodium or Succimer in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Undergoing ChemotherapyRecruitingNCT03630991Phase 11 country
- Ponatinib Hydrochloride as Second Line Therapy in Treating Patients With Chronic Myeloid Leukemia in Chronic Phase Resistant or Intolerant to Imatinib Mesylate, Dasatinib, or NilotinibRecruitingNCT01746836Phase 21 country
- Study of Olverembatinib (HQP1351) in Patients With CML-CPRecruitingNCT06423911Phase 316 countries
- Depletion of CD45RA Positive Naive T Cells for the Prevention of Graft Versus Host Disease in Older Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia or Myelodysplastic SyndromeNot yet recruitingNCT07819396Phase 21 country
- Metabolic Syndrome and Risk of Chronic Philadelphia Negative Myeloproliferative NeoplasmsNot yet recruitingNCT07814560
- Study to Characterize Mismatched to Fully HLA-Matched Ossium HPC, Marrow and Living Donor Transplantation in Patients With Hematologic MalignanciesNot yet recruitingNCT07710781Not applicable
- Asciminib Frontline Risk AdaptedNot yet recruitingNCT07804901Phase 21 country
- A Phase 3 Study for the Efficacy and Safety of Radotinib in CP-CML Patients With Failure or Intolerance to Previous TKIsRecruitingNCT03459534Phase 34 countries
- Ex Vivo Drug Sensitivity Testing and Multi-Omics ProfilingRecruitingNCT05857969Phase 11 country
- Protocol Number: HJKC3-0003. Treatment Free Remission After Asciminib Based Therapy in Chronic Phase Chronic Myeloid Leukemia (CP-CML) Patients Who Relapsed After a Prior Attempt at TKI DiscontinuationRecruitingNCT04838041Phase 21 country
- TACrolimus Targeted Immunosuppression Cessation in ALlogeneic HCTRecruitingNCT07302776Phase 11 country
- A Potential Relationship Between Treatment With Tyrosine Kinase Inhibitors and Erectile Dysfunction in Male Patients With Chronic Myeloid LeukemiaRecruitingNCT070611451 country
- Study of CD38 and CD56 in Chronic Myeloid LeukemiaNot yet recruitingNCT07740603
- Safety and Tolerability of ZE74-0282 in Healthy VolunteersRecruitingNCT07527221Phase 11 country
- Second STOP After Pioglitazone Priming in CML PatientsRecruitingNCT02889003Phase 21 country
- Allo HSCT Using RIC and PTCy for Hematological DiseasesRecruitingNCT05805605Phase 21 country
- A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)RecruitingNCT013515451 country
- Myeloablative Allo HSCT With Related or Unrelated Donor for Heme DisordersRecruitingNCT03314974Phase 21 country
- Efficacy of Asciminib in Real-world in Patients With Chronic Myeloid Leukemia in Second or Subsequent LinesNot yet recruitingNCT07640750
- Impact of Targeted Therapy on Cancer-Related Cognitive ImpairmentRecruitingNCT076380071 country