Myeloproliferative Disorders clinical trials
The registry lists 668 studies for Myeloproliferative Disorders across more than 10 countries. 111 are recruiting or about to start. 218 of them are mainly about Myeloproliferative Disorders (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its 10 narrower conditions too, such as Leukemia, Myelogenous, Chronic, BCR-ABL Positive: 2,263 studies, 340 open.
ClinicalTrials.gov finds 2,563 studies for Myeloproliferative Disorders. How that becomes 665 here
This page counts the studies the registry files under Myeloproliferative Disorders, and those it files under no condition that list Myeloproliferative Disordersthemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 2,563Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −1,574Filed under a narrower condition, counted on its own pageLeukemia, Myelogenous, Chronic, BCR-ABL Positive 794 · Primary Myelofibrosis 306 · Leukemia, Myeloid, Chronic-Phase 142 · Leukemia, Erythroblastic, Acute 133 · Blast Crisis 74 · Polycythemia Vera 74 · 4 more
- −324Match it another way7 name it in the title and 317 by a synonym or other text the search reads.
- 665The count on this page1 of them list Myeloproliferative Disorders in their own words; the registry filed them under no condition.
Get an email when these change. Save the Myeloproliferative Disorders studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
See an example email
Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
One email a week for all your saved searches. Stop any time.
Who runs them
Fred Hutchinson Cancer Center (44) · National Cancer Institute (NCI) (27) · Incyte Corporation (25) · City of Hope Medical Center (21) · Memorial Sloan Kettering Cancer Center (20) · M.D. Anderson Cancer Center (20) · Case Comprehensive Cancer Center (18) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (17)
What is being tested here
Drugs under test in Myeloproliferative Disorders studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Fludarabine | 6 | 3 | 60 |
| Cyclophosphamide | 6 | 4 | 56 |
| Azacitidine | 5 | 0 | 15 |
| Busulfan | 4 | 3 | 34 |
| Pacritinib | 4 | 2 | 10 |
| Venetoclax | 4 | 0 | 8 |
| Mycophenolic Acid | 3 | 5 | 29 |
| CPX-351 | 3 | 0 | 4 |
| Ivosidenib | 3 | 0 | 4 |
| Tacrolimus | 2 | 2 | 24 |
Drug classes tested here Antimetabolites 12 open · Alkylating agents 11 open · Tyrosine kinase inhibitors (TKIs) 11 open · JAK inhibitors 6 open · Calcineurin inhibitors 3 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2027P1101 in Treating Patients With Early PMF or Overt PMF at Low or Intermediate-1 Risk · Phase 3 · PharmaEssentia
- Nov 2026Rollover Study to Provide Continued Treatment for Participants With B-Cell Malignancies Previously Enrolled in Studies of Parsaclisib (INCB050465) · Incyte Corporation
- Nov 2026An Optimal Dose Finding Study of N-Acetylcysteine in Patients With Myeloproliferative Neoplasms · University of California, Irvine
- Nov 2026Leukemia and Lymphoma Society (LLS) Services Impact on Outcomes and Care · University of Miami
- Dec 2026Long-term Study Evaluating the Effect of Givinostat in Patients With Chronic Myeloproliferative Neoplasms · Italfarmaco
- Dec 2026Trial of 2 Step ATG for Acute GVHD Prevention Post Myeloablative Allogeneic Stem Cell Transplant · University of Alabama at Birmingham
- Dec 2026Evaluation of Inflammatory Markers in ph Negative Myeloproliferative Neoplasms: Impact on Outcome and Response to Therapy. Multicenter Retro-prospective Observational Study. The INFLA-ME (INFLAmmation in Myeloproliferative Disease) Study. · University of Milano Bicocca
- Dec 2026A Study Using Subject-specific MRD to Adopt Treatment After HSCT for Subjects With MDS · Karolinska University Hospital
- Dec 2026Pharmacokinetic Study of Venetoclax Tablets Crushed and Dissolved Into a Solution · Children's Hospital Medical Center, Cincinnati
- Dec 2026A Phase 1 Trial of CIML NK Cell Infusion for Myeloid Disease Relapse After Hematopoietic Cell Transplantation · Dana-Farber Cancer Institute
Who these studies take
Of the 88 Myeloproliferative Disorders studies recruiting now, 64 (73%) set no upper age limit and 18 (20%) stop at 75 or younger. 22 (25%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 6 (7%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 19 (22%) | 19 (22%) |
| 18 | 85 (97%) | 85 (97%) |
| 30 | 85 (97%) | 85 (97%) |
| 40 | 82 (93%) | 82 (93%) |
| 50 | 82 (93%) | 82 (93%) |
| 65 | 79 (90%) | 79 (90%) |
| 75 | 77 (88%) | 77 (88%) |
| 85 | 69 (78%) | 69 (78%) |
Across all 668 studies, recruiting or not: 29% stop at 75 or younger and 16% at 65; 29% take children; <1% are for women only and <1% for men only; 5% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Myeloproliferative Disorders studies take
Of 87 phase 2 interventional studies under Myeloproliferative Disorders, half reached primary completion within 68 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 67 mo37–140 · 40 studies | — | — |
| Phase 1/2 | 62 mo30–125 · 23 studies | — | — |
| Phase 2 | 68 mo37–111 · 87 studies | — | 75 mo38–118 · 74 studies |
| Phase 3 | 51 mo37–77 · 20 studies | — | — |
| Interventional, no phase | 54 mo20–128 · 26 studies | — | — |
| Observational | 41 mo24–62 · 37 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Started recruiting2
- Study of ZE74-0282 in Patients With JAK2 V617F- or Calreticulin-Mutated Hematologic DisordersNov 12, 2026NCT07529951
- Brain MRF in Children, Adolescents and Young Adults With Acute LeukemiaOct 20, 2026NCT06421155
Newly registered3
- A Multicenter, Prospective, Observational Study of Jaktinib in Newly Diagnosed MyelofibrosisNov 9, 2026NCT07925632
- Jaktinib in Ruxolitinib-Treatment Failure Myelofibrosis: A Multicenter, Prospective, Real-World Observational StudyNov 9, 2026NCT07925671
- Phase 2 Study of Oral Epetraborole in Adults With Polycythemia VeraOct 23, 2026NCT07891533
Studies
Recruiting first, then most recently updated. Showing 50 of 668. Browse all 668 → or search them.
- Pacritinib, a Kinase Inhibitor of CSF1R, IRAK1, JAK2, and FLT3, in Adults and Pediatric Participants 12 Years of Age or Older With Myelodysplastic Syndromes or Myelodysplastic/Myeloproliferative NeoplasmsRecruitingNCT06303193Phase 1/21 country
- Study of ZE74-0282 in Patients With JAK2 V617F- or Calreticulin-Mutated Hematologic DisordersRecruitingNCT07529951Phase 12 countries
- Dexrazoxane Hydrochloride in Preventing Heart-Related Side Effects of Chemotherapy in Participants With Blood CancersRecruitingNCT03589729Phase 21 country
- Jaktinib in Ruxolitinib-Treatment Failure Myelofibrosis: A Multicenter, Prospective, Real-World Observational StudyNot yet recruitingNCT079256711 country
- Testing New Therapies for Patients With Acute Myeloid Leukemia Who Are Newly Diagnosed and Have Not Yet Started Treatment (A MyeloMATCH Treatment Trial)RecruitingNCT05554406Phase 23 countries
- A Multicenter, Prospective, Observational Study of Jaktinib in Newly Diagnosed MyelofibrosisNot yet recruitingNCT079256321 country
- Asciminib Roll-over StudyRecruitingNCT04877522Phase 429 countries
- Axatilimab With or Without Azacitidine for the Treatment of Patients With Advanced Phase Myeloproliferative Neoplasms, Myeloproliferative Neoplasm/Myelodysplastic Syndrome Overlap or High Risk Chronic Myelomonocytic LeukemiaRecruitingNCT06523556Phase 1/21 country
- Ropeginterferon Alfa-2b for the Treatment of Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes and Chronic Myelomonocytic LeukemiaNot yet recruitingNCT07468916Phase 21 country
- MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)RecruitingNCT05564390Phase 23 countries
- Study of INCA036978 in Participants With Myeloproliferative NeoplasmsRecruitingNCT07441694Phase 111 countries
- Functional and Phenotypic Characterization of Monocytes in Myeloproliferative SyndromesRecruitingNCT06361641Not applicable1 country
- A Phase 1 Study of PRT12396 in Participants With Select Myeloproliferative NeoplasmsRecruitingNCT07469891Phase 15 countries
- Trial of 2 Step ATG for Prevention of Acute GVHD Post Allogeneic Stem Cell TransplantRecruitingNCT06265584Phase 21 country
- Pharmacokinetic Study of Venetoclax Tablets Crushed and Dissolved Into a SolutionRecruitingNCT061318011 country
- Tissue, Blood, and Body Fluid Sample Collection From Patients With Hematologic CancerRecruitingNCT011376431 country
- A Study to Evaluate DMR-001 in Participants With CALR-mutant Myeloproliferative NeoplasmsRecruitingNCT07849231Phase 12 countries
- A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs)RecruitingNCT06661915Phase 21 country
- Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With High-Risk Hematologic DiseasesRecruitingNCT06013423Phase 21 country
- Phase 2 Study of Oral Epetraborole in Adults With Polycythemia VeraNot yet recruitingNCT07891533Phase 21 country
- CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell TransplantRecruitingNCT06059391Phase 21 country
- A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell TransplantRecruitingNCT07020533Phase 11 country
- Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and AnemiaRecruitingNCT05320198Phase 1/22 countries
- Phase I Trial of Pacritinib in Combination With Venetoclax and Azacitidine for the Treatment of Accelerated and Blast Phase Myeloproliferative NeoplasmsNot yet recruitingNCT07679334Phase 11 country
- Leading in MPNs Beyond Ruxolitinib in Combo With T-RegsRecruitingNCT05423691Phase 11 country
- Therapeutic RSK1 Targeting in Myeloid MalignanciesRecruitingNCT07379125Phase 11 country
- Brain MRF in Children, Adolescents and Young Adults With Acute LeukemiaRecruitingNCT06421155Not applicable1 country
- Graft Versus Host Disease-Reduction Strategies for Donor Blood Stem Cell Transplant Patients With Acute Leukemia or Myelodysplastic Syndrome (MDS)RecruitingNCT03970096Phase 21 country
- Leukemia and Lymphoma Society (LLS) Services Impact on Outcomes and CareRecruitingNCT05745285Not applicable1 country
- A Pragmatic Clinical Trial to Prevent Relapse for Myeloid Malignancies With Measurable Disease Prior to Allogeneic TransplantNot yet recruitingNCT07572929Phase 21 country
- Trial of 2 Step ATG for Acute GVHD Prevention Post Myeloablative Allogeneic Stem Cell TransplantRecruitingNCT06315309Phase 21 country
- Automated Total Marrow and Lymphoid Irradiation for Allogeneic Hematopoietic Cell TransplantNot yet recruitingNCT07634536Phase 21 country
- WELL-MPN: A Digital Lifestyle App for Patients With MPNsNot yet recruitingNCT07349134Not applicable1 country
- Pulmonary Hypertension and RV Dysfunction in Myeloproliferative NeoplasmsNot yet recruitingNCT07834918
- Study of Pregnancy in Patients With Myeloproliferative NeoplasmsNot yet recruitingNCT07832513
- Edetate Calcium Disodium or Succimer in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Undergoing ChemotherapyRecruitingNCT03630991Phase 11 country
- Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative NeoplasmsRecruitingNCT04282187Phase 21 country
- (Apex) Bezuclastinib in Patients With Advanced Systemic MastocytosisRecruitingNCT04996875Phase 214 countries
- Ivosidenib and Venetoclax With or Without Azacitidine in Treating Patients With IDH1 Mutated Hematologic MalignanciesRecruitingNCT03471260Phase 1/21 country
- Replacing Bone Marrow Diagnostics With Peripheral Blood Analysis in MPN PatientsNot yet recruitingNCT07648433
- Ivosidenib and Ruxolitinib in Patients With Advanced Myeloproliferative Neoplasms (MPNs) That Have an IDH1 Gene MutationRecruitingNCT06291987Phase 11 country
- Project: Every Child for Younger Patients With CancerRecruitingNCT024022446 countries
- CPX-351 and Ivosidenib for the Treatment of IDH1 Mutated Acute Myeloid Leukemia or High-Risk Myelodysplastic SyndromeRecruitingNCT04493164Phase 21 country
- Improving Cognitive Function in Older Adults Undergoing Stem Cell TransplantRecruitingNCT04898790Not applicable1 country
- Thiotepa-based Conditioning Regimen With De-escalated Post-graft Cyclophosphamide for Allogeneic Stem Cell Transplantation in Hematologic MalignanciesRecruitingNCT07565220Phase 11 country
- Exercise Training in Patients With Myeloproliferative NeoplasmsRecruitingNCT07384039Not applicable1 country
- Pathogenesis of Hematologic MalignanciesEnrolling by invitationNCT017284021 country
- A Study to Evaluate INCA035784 in Participants With Myeloproliferative NeoplasmsRecruitingNCT07008118Phase 15 countries
- Ropeginterferon for High Risk JAK2 Clonal HematopoiesisRecruitingNCT07249840Phase 11 country
- Evaluation of the Pathobiology of CALR-mutated MPN CellsRecruitingNCT064805911 country