Vasoplegia clinical trials
The registry lists 48 studies for Vasoplegia across more than 10 countries. 19 are recruiting or about to start. 36 of them are mainly about Vasoplegia (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-20.
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Who runs them
Centre Hospitalier Universitaire, Amiens (7) · Universität Münster (4) · Mayo Clinic (3) · Royal Surrey County Hospital NHS Foundation Trust (2) · University of California, San Francisco (1) · Medstar Health Research Institute (1) · Ain Shams University (1) · Australian and New Zealand Intensive Care Research Centre (1)
What is being tested here
Drugs under test in Vasoplegia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 7, phase 3 first
- Jan 2027Reducing Cardiac-surgery Associated Acute Kidney Injury Occurence by Administering Angiotensin II · Phase 3 · Universität Münster
- Dec 2026Effect Inhaled Nitric Oxide in Adult Liver Transplant · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
- Dec 2026Mic Mac: Micro- and Macrocirculatory Assessment During Cardiac Surgery in Patients at Risk of Vasoplegic Syndrome: A Prospective Study. · European Georges Pompidou Hospital
- Feb 2027Evaluation of the HPA Axis in Patients With Vasoplegic Syndrome After Cardiac Surgery · Assistance Publique - Hôpitaux de Paris
- Mar 2027Midodrine for the Early Liberation of Vasopressor Support in the ICU (LIBERATE Multi-Site) · University of Alberta
- Jun 2027Angiotensin II Stress Test. Renin Kinetics During Treatment of Vasoplegic Shock With Angiotensin II. · University Medical Centre Maribor
- Jul 2027Femoral Versus Radial Invasive Arterial Pressure Monitoring in Cardiac Surgery Patients · Guillaume BESCH
Who these studies take
Of the 13 Vasoplegia studies recruiting now, 12 (92%) set no upper age limit and 0 (0%) stop at 75 or younger. 1 (8%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (23%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (8%) | 1 (8%) |
| 18 | 13 (100%) | 13 (100%) |
| 30 | 13 (100%) | 13 (100%) |
| 40 | 13 (100%) | 13 (100%) |
| 50 | 13 (100%) | 13 (100%) |
| 65 | 13 (100%) | 13 (100%) |
| 75 | 13 (100%) | 13 (100%) |
| 85 | 12 (92%) | 12 (92%) |
Across all 48 studies, recruiting or not: 10% stop at 75 or younger and 4% at 65; 2% take children; 0% are for women only and 0% for men only; 8% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 48 of 48. search them.
- CytOSorb TreatMent Of Critically Ill PatientS RegistryRecruitingNCT051463366 countries
- Angiotensin II Stress Test. Renin Kinetics During Treatment of Vasoplegic Shock With Angiotensin II.RecruitingNCT065392341 country
- Effects of Hemoadsorption on Vascular Integrity in Septic ShockNot yet recruitingNCT07711197Not applicable1 country
- Angiotensin II for Post Cardiac Surgery Vasoplegia (ANGII_V)Not yet recruitingNCT07671365Phase 4
- Efficacy of the Alpha 2 Agonist Dexmedetomidine for Sympathetic Deactivation in REfractory Septic ShockNot yet recruitingNCT07569536Phase 31 country
- Evaluation of the HPA Axis in Patients With Vasoplegic Syndrome After Cardiac SurgeryRecruitingNCT063719761 country
- Midodrine for the Early Liberation of Vasopressor Support in the ICU (LIBERATE Multi-Site)RecruitingNCT05058612Phase 41 country
- GENECARD - the Use of Genetic, Epigenetic, Metabolomic, Proteomic and Microbiotic Markers, Image and Voice Biomarker Analyses, and Pre- and Intraoperative Clinical Data - to Predict Early Complications After Cardiac Surgery.Not yet recruitingNCT073454031 country
- Femoral Versus Radial Invasive Arterial Pressure Monitoring in Cardiac Surgery PatientsRecruitingNCT06952907Not applicable1 country
- Effect Inhaled Nitric Oxide in Adult Liver TransplantNot yet recruitingNCT07125443Not applicable
- Reducing Cardiac-surgery Associated Acute Kidney Injury Occurence by Administering Angiotensin IIRecruitingNCT06615102Phase 31 country
- Mic Mac: Micro- and Macrocirculatory Assessment During Cardiac Surgery in Patients at Risk of Vasoplegic Syndrome: A Prospective Study.RecruitingNCT070597151 country
- Differential Regulation of RAAS-axis in Patients Undergoing Cardiac SurgeryRecruitingNCT058338281 country
- Characterisation of Endothelial Cells in Different Inflammatory PathologiesRecruitingNCT066132561 country
- Norepinephrine Weaning Guided by the Hypotension Prediction Index in Vasoplegic Shock After Cardiac SurgeryRecruitingNCT05922982Not applicable1 country
- In Situ Exploration of Vascular Function in Vasoplegic Shock Following Cardiac Surgery With Cardiopulmonary BypassRecruitingNCT063186891 country
- Prevention of Low Blood Pressure After Cardiac Surgery in Heart Failure Patients With a Filter Called CytoSorb.RecruitingNCT04812717Not applicable1 country
- Endotoxinemia and Vasoplegia Following Cardiothoracic Surgery With Cardiopulmonary Bypass (CPB)RecruitingNCT059253481 country
- POLECAT: Perioperative Delta Renin ConcentrationNot yet recruitingNCT05942846
- Effects of Vitamin C on Shock Duration and Microcirculation in Patients With Vasoplegia Syndrome After Cardiac SurgeryCompletedNCT06723626Not applicable1 country
- Dynamic Arterial Elastance Measured by Uncalibrated Pulse Contour Analysis Predicts Arterial Pressure Response to a Decrease in NorepinephrineCompletedNCT034557381 country
- Hemodynamic Instability Prevented With Polaramine® Infusion Before Extracorporeal CirculationTerminatedNCT02675374Phase 31 country
- Occult Vasoplegia in Normotensive Sepsis: Early Prediction With Diastolic Index and LactateCompletedNCT076580141 country
- Vasoplegic Syndrome in Cardiac SurgeryActive, not recruitingNCT032813171 country
- Evaluation of the Association Between Pre-existing Endothelial Dysfunction and the Onset of Vasoplegia During Cardiac Surgery With Cardiopulmonary BypassWithdrawnNCT029653391 country
- Assessment of the Hemodynamic Effect of Hydroxocabalamin in Refractory Vasodilatory ShockCompletedNCT049644921 country
- Angiotensin II for Distributive ShockTerminatedNCT04904562Phase 41 country
- Angiotensin II in Liver TransplantationActive, not recruitingNCT04901169Phase 2/31 country
- Evaluation of the Superiority of VAsopressin Versus NOradrenaline in the Management of Patients at Risk of Kidney Failure Undergoing Cardiac Surgery With Extracorporeal CirculationActive, not recruitingNCT05568160Phase 31 country
- Weaning of Norepinephrine Guided by the Dynamic Arterial Compliance in Cardiac Surgery Post Operative.CompletedNCT02479529Phase 31 country
- Dynamic Arterial Elastance: an Indirect Marker of the Critical Capillary Pressure at the Microcirculatory LevelCompletedNCT034787091 country
- Methylene Blue vs Cyanokit for Intraoperative Vasoplegic Syndrome in Liver Transplant PatientsCompletedNCT04054999Phase 41 country
- Prophylactic Use of Hydroxycobolamin in Vasoplegic Syndrome in Adult Patients Undergoing Cardiopulmonary BypassCompletedNCT06160219Phase 2/31 country
- Vitamin B12a Vasoplegic SyndromeTerminatedNCT03735316Phase 21 country
- Reducing Acute Kidney Injury Occurence by Administering Angiotensin IICompletedNCT05199493Phase 31 country
- Reperfusion Syndrome and Vasoplegic Syndrome in Liver Transplant SurgeryCompletedNCT056581201 country
- Midodrine as Novel Treatment of Post-Cardiopulmonary Bypass Vasoplegic SyndromeTerminatedNCT04668859Phase 4
- Analysis of miRNAs Expression in Vasoplegic Syndrome After On-pump Coronary Artery Bypass SurgeryCompletedNCT053541931 country
- Impact of Ascorbic Acid Treatment on the Development and Treatment of Vasodilation in Cardiac SurgeryCompletedNCT03744702Early Phase 11 country
- RaGuS Trial by Postoperative PatientsStatus unknownNCT04440085Phase 4
- Hypotension During Extracorporeal Circulatory Support Indicated for Cardiogenic ShockStatus unknownNCT039689261 country
- Low Dose Corticosteroid Infusion in Vasoplegia After Cardiac Surgery (CORTIVAS-CS)Status unknownNCT04301479Phase 31 country
- Hemodynamic Effects of Methylene Blue vs Hydroxocobalamin in Patients at Risk of Vasoplegia During Cardiac SurgeryWithdrawnNCT03446599Phase 21 country
- The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock TrialCompletedNCT03333278Phase 23 countries
- Evaluating in Cirrhotics With Refractory Vasoplegia the Effect of Methylene BlueCompletedNCT03120637Phase 41 country
- Small Doses of Pituitrin Versus Norepinephrine for the Management of Vasoplegic Syndrome in Patients After Cardiac SurgeryStatus unknownNCT03106831Not applicable1 country
- Postoperative Hemodynamics Comparison After High Spinal Block With or Without Intrathecal Morphine.Status unknownNCT02825056Early Phase 1
- Catecholamine-O-Methyl-Transferase(COMT)-Polymorphism in Cardiac SurgeryCompletedNCT003340091 country