Vaping clinical trials
The registry lists 402 studies for Vaping across more than 10 countries. 95 are recruiting or about to start. 206 of them are mainly about Vaping (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
Get an email when these change. Save the Vaping studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
Yale University (22) · University of Southern California (19) · University of California, San Francisco (16) · Virginia Commonwealth University (14) · Medical University of South Carolina (9) · Juul Labs, Inc. (9) · University of Vermont (8) · Massachusetts General Hospital (8)
What is being tested here
Drugs under test in Vaping studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Nov 2026Phase 3 Trial Evaluating the Efficacy and Safety of Cytisinicline for Vaping Cessation in Adults Using Nicotine-Containing E Cigarettes · Phase 3 · Achieve Life Sciences
- Apr 2027Nicotine Patch Plus Nicotine Mouth Spray Versus Nicotine Reduction for Vaping Cessation · Phase 3 · University of Auckland, New Zealand
- Dec 2026Vaping Cessation Using the Ottawa Model for Smoking Cessation Among E-Cigarette Users · Ottawa Heart Institute Research Corporation
- Dec 2026The CONQUER Trial - Cessation Of Nicotine, QUitting With E-cigarette Reduction · VapeAway
- Dec 2026Sex Differences in the Vascular Effects of E-cigarette Use · Anna Stanhewicz, PhD
- Dec 2026A Behavioral Circuit Breathing Training Intervention on Smoking Cessation and Respiratory Function Among Youth Who Use E-cigarettes · Chulalongkorn University
- Dec 2026Secondhand Effects of Hookah (i.e., Waterpipe) Smoke and Aerosol · University of California, Los Angeles
- Dec 2026Survey to Test the Nicotine Concentration and Nicotine Flux Labels for E-cigarettes · Yale University
- Dec 2026Developing and Testing Health Warning Labels on the ENDS Device · Florida International University
- Dec 2026Smoking Cessation With Wearables to Improve General, Oral Health and Quality of Life · University of Salerno
Who these studies take
Of the 64 Vaping studies recruiting now, 32 (50%) set no upper age limit and 31 (48%) stop at 75 or younger. 13 (20%) take children under 18. 2 (3%) are for women only and 0 (0%) for men only; 40 (63%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (3%) | 2 (3%) |
| 18 | 40 (63%) | 38 (59%) |
| 30 | 48 (75%) | 46 (72%) |
| 40 | 44 (69%) | 42 (66%) |
| 50 | 40 (63%) | 39 (61%) |
| 65 | 39 (61%) | 38 (59%) |
| 75 | 33 (52%) | 32 (50%) |
| 85 | 33 (52%) | 32 (50%) |
Across all 402 studies, recruiting or not: 59% stop at 75 or younger and 55% at 65; 19% take children; 1% are for women only and 2% for men only; 73% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Vaping studies take
Of 16 phase 2 interventional studies under Vaping, half reached primary completion within 19 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 19 mo15–37 · 16 studies | — | — |
| Interventional, no phase | 18 mo6–31 · 208 studies | 2 mo1–6 · 24 studies | 20 mo9–35 · 184 studies |
| Observational | 36 mo32–46 · 32 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Results posted2
- Switching Individuals in Treatment for Opioid Use Disorder Who Smoke Cigarettes to the SRECOct 21, 2026NCT05881304
- Tobacco Product Susceptibility and Substitutability by Rurality and Alcohol UseOct 15, 2026NCT07010601
Stopped1
- Testing the Feasibility and Acceptability of Social Media and Digital Therapeutics to Decrease Vaping BehaviorsTerminatedOct 26, 2026NCT05994209
Newly registered7
- Cardiopulmonary Complications of Electronic CigarettesNov 9, 2026NCT07924007
- §SMOKE Nicotine and Tobacco Youth CohortNov 2, 2026NCT07910331
- Flavored Electronic Nicotine Delivery Systems to Lower Smoking and Exposure to Tobacco Toxicants Among Cigarette Smokers Interested in Quitting, REFLECT TrialOct 27, 2026NCT07896330
- Project E-Shift: A Harm Reduction Intervention for Chronically Unhoused Smokers.Oct 27, 2026NCT07897058
- Circuit Breathing Exercise on Smoking Cessation Among Youth E-Cigarette UsersOct 21, 2026NCT07886099
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Studies
Recruiting first, then most recently updated. Showing 50 of 402. Browse all 402 → or search them.
- Cardiopulmonary Complications of Electronic CigarettesNot yet recruitingNCT07924007Not applicable1 country
- §SMOKE Nicotine and Tobacco Youth CohortRecruitingNCT079103311 country
- Lung Health and Breath Biomarkers: Acute Effects of Inhaled CannabisNot yet recruitingNCT07694466Early Phase 11 country
- Social Media Support Groups for Adolescent Vaping CessationRecruitingNCT07540780Not applicable1 country
- Young Adult Tobacco/Nicotine and Cannabis Co-useRecruitingNCT06239350Not applicable1 country
- Role of Inflammation in Vascular Phenotype Associated With E-cigarette UseRecruitingNCT06489249Early Phase 11 country
- Flavored Electronic Nicotine Delivery Systems to Lower Smoking and Exposure to Tobacco Toxicants Among Cigarette Smokers Interested in Quitting, REFLECT TrialNot yet recruitingNCT07896330Not applicable1 country
- Circuit Breathing Exercise on Smoking Cessation Among Youth E-Cigarette UsersRecruitingNCT07886099Not applicable1 country
- A Behavioral Circuit Breathing Training Intervention on Smoking Cessation and Respiratory Function Among Youth Who Use E-cigarettesRecruitingNCT07882407Not applicable1 country
- Cardiovascular Impacts of E-cigarettes Among Older AdultsNot yet recruitingNCT07880704Not applicable1 country
- Study of Vaping Use Among Adolescent and Young Adult Patients With CancerEnrolling by invitationNCT078608011 country
- Clinical Alternatives for Reducing Harm Using E-cigarettesEnrolling by invitationNCT07039292Not applicable1 country
- DOSE-UP: Dose Optimization for Smoking and E-Cigarette Use PharmacotherapyNot yet recruitingNCT07754578Phase 21 country
- The Avenues Study: Dual Use CessationRecruitingNCT06474299Phase 41 country
- A Text Messaging Trial to Test Vaping Health Messages Optimized to Young Adults' Vaping StatusEnrolling by invitationNCT07038317Not applicable1 country
- Flavored Ready-to-Drink Alcohol Restriction in Young Adults: Behavioral and Biomarker OutcomesNot yet recruitingNCT07840625Not applicable
- Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine and Nicotine AnaloguesRecruitingNCT07348224Not applicable1 country
- E-cigarettes for Harm Reduction Among Smokers With Serious Mental IllnessRecruitingNCT05815199Not applicable1 country
- Impact of Electronic Cigarette Temperature and Solvent on BiomarkersNot yet recruitingNCT07612696Not applicable1 country
- Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study)RecruitingNCT07145866Phase 41 country
- Vaped PhenanthreneRecruitingNCT07134426Not applicable1 country
- Evaluating Narrative Vaping Prevention Video Ads for Adolescents and Young AdultsNot yet recruitingNCT07767929Not applicable1 country
- Sex Differences in E-Cigarette PerceptionRecruitingNCT07398976Not applicable1 country
- Parents Helping Parents for Youth Vaping CessationRecruitingNCT07207850Not applicable1 country
- Evaluation of Dependence and Nicotine Replacement Therapy-Supported Cessation Efforts Among Regular Electronic Cigarette UseNot yet recruitingNCT07786896Phase 41 country
- Carcinogen and Toxicant Exposure Among Young Adults Who Co-Use Cigarettes, E-cigarettes and Cannabis (Co-Tox Study)RecruitingNCT071672251 country
- Screening, Evaluation and Assessment (SEA) Protocol at the NIDA IRPRecruitingNCT065527411 country
- Survey to Test the Nicotine Concentration and Nicotine Flux Labels for E-cigarettesNot yet recruitingNCT07553585Not applicable1 country
- Just-in-Time Support for Smoking, Vaping, and Eating Urges During High-Stress Moments Among Gender and Sexual Minority Adults in DhakaNot yet recruitingNCT07746492Not applicable1 country
- Kick-Nic! Youth Quit Vaping AppRecruitingNCT06662305Phase 21 country
- The Villainous Vape: Advancing Vaping Prevention Among Adolescents Through a Comic BookNot yet recruitingNCT07737080Not applicable1 country
- Puff Topography and Sensory Effects Across IQOS Device GenerationsRecruitingNCT07712887Not applicable1 country
- Social Media Influences on Engagement and Susceptibility to Non-combustible Tobacco Product Use Among Youth and Young Adults (AYA)RecruitingNCT07721883Not applicable1 country
- E-cigarette Social Media Marketing and Its Perceptions by YouthNot yet recruitingNCT07694739Not applicable1 country
- Evaluation of the Electronic Cigarette Withdrawal SyndromeRecruitingNCT06066996Early Phase 11 country
- Behavioral Intervention for Youth to Promote Vaping CessationRecruitingNCT06765291Not applicable1 country
- Effects of Novel E-cigarette Constituents on Adults TCORS 3.0RecruitingNCT05932745Not applicable1 country
- E-cigarette Cessation in Adults Who Co-use CannabisRecruitingNCT06688539Phase 41 country
- The Development and Evaluation of a Culturally Grounded ENDS Intervention for Rural Hawaiian YouthRecruitingNCT06929520Not applicable1 country
- Developing and Testing Health Warning Labels on the ENDS DeviceRecruitingNCT04907136Not applicable1 country
- An Online Intervention to Reduce E-cigarette Use and Cigarette Smoking Risk in AdolescentsNot yet recruitingNCT07624292Not applicable
- Reduce Tobacco Use in People Living With HIV in SwitzerlandRecruitingNCT06789692Not applicable1 country
- Smoking Cessation With Wearables to Improve General, Oral Health and Quality of LifeNot yet recruitingNCT07593742Not applicable
- Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine TherapyRecruitingNCT06948058Not applicable1 country
- Early Detection of Vaping-related Vascular DiseasesRecruitingNCT054542671 country
- Comparative Pharmacokinetics and Pharmacodynamics of Synthetic NicotineRecruitingNCT05962229Phase 11 country
- Electronic Cigarettes as a Harm Reduction Strategy Among People With Opioid Use Disorder on BuprenorphineRecruitingNCT07202039Not applicable1 country
- TUBSIS 2.0 - Tobacco Use Behavioral Support and Intervention SystemRecruitingNCT07568483Not applicable1 country
- Development of a Mobile Health Intervention for Electronic Cigarette Use Among Young AdultsRecruitingNCT06395415Not applicable1 country
- Effect of Cannabis on E-Cigarette Use BehaviorRecruitingNCT06609109Phase 11 country