An interventional study of Brief individual counseling sessions in Tobacco-flavored EC, Sweet-Cooling EC and Sweet Non-cooling EC, sponsored by Prisma Health-Upstate. Recruiting at 1 site in United States. Open to participants aged 21 Years and older. Per ClinicalTrials.gov, last updated 2026-05-12.
Sponsored by Prisma Health-Upstate · Not applicable, Interventional, and Treatment
This project aims to investigate the impact of e-cigarette flavors and usage patterns on achieving harm-reduction milestones in a sample of cigarette smokers with opioid use disorder who are taking buprenorphine
Inclusion Criteria
Those randomized to the intervention group will be provided a free 12-week supply of sweet-cooling electronic cigarette (EC) liquid and five brief, individual counseling sessions, and asked to try to switch completely to EC.
Behavioral: Brief individual counseling sessions
Those randomized to the intervention group will be provided a free 12-week supply of sweet non-cooling electronic cigarette (EC) liquid and five brief, individual counseling sessions, and asked to try to switch completely to EC.
Behavioral: Brief individual counseling sessions
Those randomized to the intervention group will be provided a free 12-week supply of tobacco-flavored electronic cigarette (EC) liquid and five brief, individual counseling sessions, and asked to try to switch completely to EC.
Behavioral: Brief individual counseling sessions
Five brief, individual counseling sessions will provide education, behavioral support, and motivational strategies to facilitate switching from combustible cigarette use to EC
Change in cigarettes smoked per day
The average change in mean CPD on a 7-day TLFB assessment from baseline (week 0) to weeks 12
Time frame: Baseline to week 12
Change in cigarettes smoked per day
The average change in mean CPD on a 7-day TLFB assessment from baseline (week 0) to week 24
Time frame: Baseline to week 24
Percentage of participants with a ≥50% reduction in CPD
The rate of participants achieving an average ≥50% reduction in CPD from baseline (week 0) to weeks 12 and 26, based on a 7-day TLFB
Time frame: Baseline to weeks 12 and 26
Switching
Proportion of participants reporting exclusive EC use and no CC use on a 7-day TLFB with CO \<6 ppm.
Time frame: Weeks 12 and 24
Partial Switching
Proportion of participants reporting both EC and CC use on a 7-day TLFB with a ≥50% reduction in CPD.
Time frame: Weeks 12 and 24
7-Day CC Abstinence
Percentage of participants with biochemically verified 7-day abstinence (1 = abstinent, 0 = non-abstinent). Defined as self-reported no CC use on a 7-day TLFB with CO \<6 ppm.
Time frame: Weeks 12 and 26
Change in carbon monoxide levels
Change in exhaled CO levels from baseline (week 0) to weeks 12 and 26 (continuous variable).
Time frame: Baselone to weeks 12 and 26
Plan to share: Undecided
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Prisma Health-Upstate