An observational study in Cigarette Smoking-Related Carcinoma and E-Cig Use, sponsored by Roswell Park Cancer Institute. Recruiting at 1 site in United States. Open to participants aged 18 Years to 25 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-08-26.
Sponsored by Roswell Park Cancer Institute · Observational
This study evaluates the amount of nicotine, cannabis, and toxicants linked to the use of nicotine e-cigarette and/or cannabis products in the blood and urine of young adult users as well as the cannabis and nicotine use behaviors of consumers.
PRIMARY OBJECTIVE:
I. To evaluate differences in self-reported nicotine and cannabis use behaviors and biomarkers of exposure to toxicants and carcinogens by product use status, to generate effect sizes required to calculate sample sizes needed for a larger study.
402 studies on the registry are indexed under Vaping; 95 are open to participants now.
This study's planned enrollment of 150 is above the median of 120 across 65 observational studies indexed under Vaping.
Browse Vaping studies →Roswell Park Cancer Institute is the lead sponsor of 419 studies on the registry; 65 are open to participants now.
Of its 38 completed or terminated interventional studies of FDA-regulated products, 21 (55%) have results posted.
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Young adults (18-25 year old) currently using cannabis products and/or electronic cigarettes containing nicotine.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Predominant e-cigarette consumers
Other: Effectiveness of different recruitment approaches · Other: Choice of study completion locations · Other: E-cigarette dependence Scale
Predominant cannabis consumers
Other: Effectiveness of different recruitment approaches · Other: Choice of study completion locations · Other: Cannabis Engagement Assessment
Consumers who use both e-cigarettes and cannabis .
Other: Effectiveness of different recruitment approaches · Other: Choice of study completion locations · Other: Cannabis Engagement Assessment · Other: E-cigarette dependence Scale
Predominant cigarette consumer
Other: Effectiveness of different recruitment approaches · Other: Choice of study completion locations · Other: Nicotine dependence Scale
Consumers who use both Cigarette and cannabis
Other: Effectiveness of different recruitment approaches · Other: Choice of study completion locations · Other: Cannabis Engagement Assessment · Other: Nicotine dependence Scale · Other: Co use practices QUestionnaire
Subjects will asked which type of recruitment material they've seen when completing the screening survey
subjects will choose location when coordinator calls to schedule appointment
Self reported measure of current cannabis use that contains 30 questions assessing quantity, frequency of use and method of consumption in the past 30 days.
A 22-item questionnaire measuring e-cigarette dependence. Higher scores indicate greater dependence.
Self reported measure of current nicotine use that contains 27 questions assessing quantity, frequency of use in past 6 months
Self reported measure of nicotine and cannabis use that contains 25 questions assessing quantity, frequency and practices of use in past 30 days
Differences in biomarker levels across groups
Will compare the mean biomarker levels between groups using a one-way ANOVA model, with Bonferroni-adjusted pairwise comparisons, as appropriate.
Time frame: 1 study session lasting 1 hour
Differences in self reported nicotine and cannabis use behaviors
Self reported questionnaire
Time frame: 1 study session (1 hour)
Differences in psychosocial characteristics by group
Will be compared between groups using the appropriate general linear models. All model and test assumptions will be verified graphically, with transformations applied as appropriate.
Time frame: 1 study session (1 hour)
Study interest
Study interest and eligibility Measured via number of contacts to inquire about the study, and number of eligible applicants. The eligibility and interest rates of the individuals approached and the completion rates of the enrolled individuals will be estimated overall and by relevant factors (recruitment channel, type of advertisement) using 90% credible regions obtained by Jeffrey's prior method.
Time frame: Up to 1 year
Recall of study recruitment advertisement type
Analyses will be primarily descriptive to evaluate the reach and effectiveness of recruitment strategies. Key endpoints will be summarized overall and by relevant factors (ex., recruitment channel) using the appropriate descriptive statistics, with comparisons made using the Mann-Whitney U and Kruskal Wallis or Fisher's exact and Pearson chi-square tests, as appropriate.
Time frame: 1 study session (1 hour)
Recall of recruitment channel
Will include where study information/advertisement was viewed. Analyses will be primarily descriptive to evaluate the reach and effectiveness of recruitment strategies. Key endpoints will be summarized overall and by relevant factors ex., recruitment channel) using the appropriate descriptive statistics.
Time frame: 1 study session (1 hour)
Completion method chosen by participants
On campus versus off-campus
Time frame: 1 study session (1 hour)
Started Apr 2025 (actual). Primary completion is estimated for Oct 2028, 41 months after the start.
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