Trismus clinical trials
The registry lists 107 studies for Trismus across more than 10 countries. 19 are recruiting or about to start. 38 of them are mainly about Trismus (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-03.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
University of Medicine and Pharmacy at Ho Chi Minh City (4) · Konya Necmettin Erbakan Üniversitesi (4) · Federal University of the Valleys of Jequitinhonha and Mucuri (3) · Universidad Complutense de Madrid (3) · Yuzuncu Yıl University (3) · Cairo University (3) · Hacettepe University (2) · University of Sao Paulo (2)
What is being tested here
Drugs under test in Trismus studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Dexamethasone | 2 | 1 | 8 |
| P-prf | 1 | 0 | 3 |
| Escin | 1 | 1 | 2 |
| Dexamethasone phosphate | 1 | 0 | 2 |
| Triamcinolone Acetonide | 1 | 0 | 1 |
| Triamcinolone | 1 | 0 | 1 |
| Platelet rich plasma | 1 | 0 | 1 |
| Sugammadex | 1 | 0 | 1 |
| Tea Tree Oil | 1 | 0 | 1 |
| Dexketoprofen | 0 | 0 | 2 |
Drug classes tested here Corticosteroids 3 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 3
- Dec 2026Swallowing Rehabilitation Program for Head and Neck Tumor Patients · Delta University for Science and Technology
- Dec 2026Web-Based Program in Helping Patients With Head and Neck Cancer Adhere to Swallowing Exercises and Coping Strategies · M.D. Anderson Cancer Center
- May 2027Evaluating a Low-Cost Therapeutic Device in Managing Head and Neck Cancer Patients With Radiation-Related Trismus · University of California, San Francisco
Who these studies take
Of the 15 Trismus studies recruiting now, 5 (33%) set no upper age limit and 9 (60%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 5 (33%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 13 (87%) | 13 (87%) |
| 30 | 14 (93%) | 14 (93%) |
| 40 | 13 (87%) | 13 (87%) |
| 50 | 11 (73%) | 11 (73%) |
| 65 | 9 (60%) | 9 (60%) |
| 75 | 6 (40%) | 6 (40%) |
| 85 | 6 (40%) | 6 (40%) |
Across all 107 studies, recruiting or not: 64% stop at 75 or younger and 60% at 65; 8% take children; 0% are for women only and 0% for men only; 47% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Trismus studies take
Of 58 interventional studies with no phase under Trismus, half reached primary completion within 8 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 8 mo4–21 · 58 studies | — | 8 mo4–21 · 57 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Newly registered2
- Autologous PRP Versus Triamcinolone Acetate in Patients With Oral Submucous FibrosisNov 3, 2026NCT07914504
- Oral Bromelain After Bilateral Mandibular Third Molar SurgeryOct 26, 2026NCT07894913
Studies
Recruiting first, then most recently updated. Showing 50 of 107. Browse all 107 → or search them.
- Autologous PRP Versus Triamcinolone Acetate in Patients With Oral Submucous FibrosisNot yet recruitingNCT07914504Not applicable1 country
- Aescin-Based Herbal Extract (Reparil) for Postoperative Sequelae After Mandibular Third Molar SurgeryRecruitingNCT07244029Not applicable1 country
- Swallowing Rehabilitation Program for Head and Neck Tumor PatientsRecruitingNCT07795294Not applicable1 country
- Web-Based Program in Helping Patients With Head and Neck Cancer Adhere to Swallowing Exercises and Coping StrategiesRecruitingNCT04003051Phase 21 country
- Feasibility of Prospective Surveillance and Early Physical Therapy for TrismusRecruitingNCT06531083Not applicable1 country
- Comparison of PRF and Corticosteroids in Impacted Third Molar SurgeryRecruitingNCT07742826Not applicable1 country
- Management of Postoperative Complications After Mandibular Third Molar Extraction Using Submucosal Triamcinolone Injection, Kinesiology Taping, and Standard CareNot yet recruitingNCT07719270Not applicable1 country
- Sugammadex-Induced Clenching During Neuromuscular Blockade ReversalRecruitingNCT06962007Not applicable1 country
- "Effect of Preoperative Submucosal Dexamethasone on Postoperative Discomfort After Mandibular Third Molar Surgery"Not yet recruitingNCT07554963Phase 4
- Alternating Triamcinolone and Platelet-Rich Plasma Therapy for Oral Submucous FibrosisNot yet recruitingNCT07277998Not applicable1 country
- Evaluation of the Effect of Tea Tree and Chlorhexidine Mouthwashes on Healing After Third Molar ExtractionRecruitingNCT07180498Not applicable1 country
- Hilotherapy vs. Kinesio Taping in Orthognathic Surgery RecoveryRecruitingNCT07006610Not applicable1 country
- Manual Therapy on Oral Opening, Swallow Function and Upper Quarter Mobility on Head and Neck Cancer SurvivorsRecruitingNCT06148077Not applicable1 country
- The Effect of Dexamethasone Submucosal Injection After Surgical Extraction of Lower Impacted Third Molars on Trismus and EdemaRecruitingNCT06953440Phase 41 country
- Efficacy of Botox Injection of the Masticatory Muscles in Head &Neck Cancer Patients with Trismus After RadiotherapyRecruitingNCT06734598Phase 41 country
- Effect of Laser Photobiomodulation in Improving Mouth Opening in Oral Submucous FibrosisRecruitingNCT06639009Not applicable1 country
- Effects of the Application of a Hyper-oxygenated Gel After Oral SurgeryRecruitingNCT06458478Not applicable1 country
- Evaluation of the Effect of Systemic Proteolytic Enzyme Therapy on Postoperative Inflammatory Response and QoL After Surgical Extraction of Impacted Mandibular Third MolarsRecruitingNCT05681312Phase 31 country
- Pain and Trismus Control in Third Molar Surgery: Ibuprofen, Ketamine, and Their CombinationRecruitingNCT05923775Not applicable1 country
- Oral Bromelain After Bilateral Mandibular Third Molar SurgeryCompletedNCT07894913Not applicable1 country
- Effects of Hyaluronic Acid Complex and Dexamethasone on Pain, Swelling, and Trismus After Mandibular Third Molar SurgeryCompletedNCT07853196Not applicable1 country
- Preoperative Versus Postoperative Amoxicillin in Impacted Third Molar SurgeryCompletedNCT078578631 country
- Comparison of Two Different Suture Knot Techniques on Post-Operative Trismus and Swelling After Impacted Third Molar SurgeryCompletedNCT07327762Not applicable1 country
- Maitland Mobilization Versus Therapeutic Ultrasound on Trismus Following Third Molar SurgeryActive, not recruitingNCT07575100Not applicable1 country
- Natural Enzyme Mouthwash After Third Molar SurgeryCompletedNCT07627945Not applicable1 country
- Effect of Platelet-Rich Fibrin on Postoperative Pain, Trismus, and Edema After Mandibular Third Molar SurgeryCompletedNCT07672951Not applicable1 country
- Single-Session Extraoral PBM After Third Molar ExtractionCompletedNCT07522918Not applicable1 country
- Effects of Platelet-Rich Fibrin After Mandibular Third Molar Surgery in Smokers and NonsmokersCompletedNCT07604584Not applicable1 country
- Effectiveness of Serratiopeptidase After Mandibular Third Molar SurgeryCompletedNCT07543146Not applicable1 country
- Effect of Preoperative Long-Acting Corticosteroids on Pain, Swelling, and Trismus After Impacted Lower Third Molar SurgeryActive, not recruitingNCT07450638Not applicable1 country
- Effect of Kinesio Tape Versus Systemic Dexamethasone on Postsurgical Sequels Following Extraction of Impacted Mandibular Third MolarsCompletedNCT07353593Phase 11 country
- Evaluating a Low-Cost Therapeutic Device in Managing Head and Neck Cancer Patients With Radiation-Related TrismusActive, not recruitingNCT05671861Not applicable1 country
- A Comparison of Recovery After Impacted Wisdom Tooth RemovalCompletedNCT07304882Phase 31 country
- Submucosal Dexamethasone for Control of Post-operative Pain, Trismus, and Swelling After Mandibular Third Molar SurgeryCompletedNCT07258498Phase 41 country
- Ultrasonic vs Rotary Instruments in Impacted Mandibular Third Molar Surgery: Clinical and Salivary CRP OutcomesCompletedNCT07196904Not applicable1 country
- Evaluation of the French Translation of Gothenburg Trismus Questionnaire (GTQ)CompletedNCT056151811 country
- Combination of Mixed Drugs vs Ibuprofen: a Randomized Clinical TrialCompletedNCT07133360Not applicable1 country
- Dexamethasone-PRF in Mandibular Third Molar Surgery: Effect on Pain, Edema, and Trismus (DEXPRF-3M)CompletedNCT07045350Not applicable1 country
- Does Vitamin C Improve Postoperative HealingCompletedNCT07012564Not applicable1 country
- Investigating the Effects of Smartphone Use on the Masseter MuscleCompletedNCT064087661 country
- Effect of Kinesio Taping of Pain, Swelling and Trismus After Mandibular Third Molar SurgeryCompletedNCT06967246Not applicable1 country
- Effect of Inula Viscosa Extract on Postoperative Bleeding and Healing After Lower Third Molar SurgeryCompletedNCT06947603Not applicable1 country
- Mouth Opening, Prevention, Education, Nutrition (OPEN)Active, not recruitingNCT03979924Not applicable1 country
- Effect of Manual Massage Technique on Swelling, Pain and Mouth Opening After Bilateral Lower Third Molar SurgeryCompletedNCT06787027Not applicable1 country
- Exercise Therapy and Jaw-Mobilizing Device for Trismus in Head and Neck Cancer PatientsCompletedNCT06719388Not applicable1 country
- Dexketoprofen Dosage According to ChronotherapyCompletedNCT05176158Not applicable1 country
- Randomized Study Regarding Preventive Jaw- and Swallowing Intervention for Patients with Head and Neck CancerActive, not recruitingNCT04005521Not applicable1 country
- Effect of Autologous Platelet Rich Fibrin on Post-Operative Complications and Healing Following the ExtractionCompletedNCT06609967Not applicable1 country
- Comparison of the Effects of Intraoral Postoperative Dexamethasone Applications After Mandibular Third Molar SurgeryCompletedNCT06604286Phase 41 country
- Additional Effects of Joint Mobilization in Addition to Rocabado Exercises on Alleviating Trismus Following Third Molar ExtractionActive, not recruitingNCT06534619Not applicable1 country