An interventional study of Vitamin C and Placebo in Impacted Mandibular Third Molar, sponsored by Hacettepe University. Completed at 1 site in Turkey. Open to participants aged 18 Years to 35 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2025-06-10.
Sponsored by Hacettepe University · Not applicable, Interventional, and Treatment
This randomized, split-mouth clinical trial investigates the effect of oral vitamin C supplementation on postoperative recovery following the surgical extraction of impacted mandibular third molars. Fifty-six healthy patients underwent bilateral extractions, with each side randomly assigned to receive either 1000 mg of oral vitamin C or a placebo. The supplementation began one day before surgery and continued through postoperative day 7. The outcome measures included facial swelling assessed through linear measurements (tragus-pogonion, tragus-commissure labiorum, and lateral canthus of the eye-angulus mandible), pain using a visual analog scale (VAS), trismus based on maximum interincisal opening, and early wound healing assessed with the Landry healing index. Analgesic consumption was also recorded. Pain was evaluated using VAS on days 1, 2, and 7. Edema, trismus, and early wound healing were evaluated on postoperative days 2 and 7. The study aims to determine whether vitamin C reduces edema, pain, and trismus, and enhances early soft tissue healing compared to placebo.
This randomized, split-mouth clinical trial aimed to investigate the effect of oral vitamin C supplementation on postoperative recovery following the surgical extraction of impacted mandibular third molars. A total of 56 healthy patients requiring bilateral lower third molar extractions were included in the study. Each patient underwent two separate surgeries on both sides, with each side randomly assigned to receive either 1000 mg of oral vitamin C or a placebo.
Vitamin C supplementation started one day prior to surgery and continued for seven days postoperatively. The primary outcomes of the study were facial swelling, pain, trismus, and early soft tissue healing. Facial swelling was assessed using three linear measurements between specific anatomical landmarks: tragus-pogonion, tragus-labial commissure, and lateral canthus of the eye-angulus mandible. Trismus was measured based on maximum interincisal distance. Pain was evaluated using the visual analog scale (VAS) on postoperative days 1, 2, and 7. Edema, trismus, and early wound healing were assessed on postoperative days 2 and 7. Early wound healing was scored using the Landry healing index. Analgesic consumption was also recorded during the postoperative period.
This study was designed to evaluate whether vitamin C supplementation could reduce postoperative edema, pain, and trismus, and improve early soft tissue healing in comparison to placebo in the context of oral surgical procedures. The findings may provide evidence to support the use of vitamin C as an adjunctive therapy in oral surgery.
107 studies on the registry are indexed under Trismus; 19 are open to participants now.
This study's enrollment of 56 is close to the median of 52 across 99 interventional studies indexed under Trismus.
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Exclusion Criteria:
Patients received 1000 mg of oral vitamin C daily starting one day before surgery through postoperative day 7.
Dietary Supplement: Vitamin C
Patients received an identical-looking placebo tablet once daily for the same duration.
Other: Placebo
1000 mg oral vitamin C tablet taken daily from one day before surgery to postoperative day 7.
Identical-appearing oral tablet taken on the same schedule as the vitamin C group.
Postoperative Facial Swelling
Facial swelling was measured using three linear distances: tragus-pogonion, tragus-labial commissure, and lateral canthus-mandibular angle.
Time frame: Postoperative Day 2 and Day 7
Postoperative Pain Score (VAS)
Pain intensity was assessed using a 10-cm visual analog scale (VAS), with 0 = no pain and 10 = worst possible pain.
Time frame: Postoperative Days 1, 2, and 7
Trismus (Maximum Interincisal Opening)
Trismus was assessed by measuring the maximum interincisal distance in millimeters using a caliper.
Time frame: Postoperative Days 2 and 7
Early Wound Healing (Landry Healing Index)
Soft tissue healing was evaluated using the Landry healing index, which scores wound healing on a 5-point scale based on tissue color, bleeding, and granulation.
Time frame: Postoperative Days 2 and 7
Analgesic Consumption
: The number of analgesic tablets consumed was recorded for each participant.
Time frame: Postoperative Days 1,2 and 7
Plan to share: No
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This study is completed, as verified in May 2025. You cannot join it, but the record below documents what was studied.
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